Phylogenetic tree analysis of G protein-coupled 5-HT receptors: implications for receptor nomenclature.

abstract：:Adinazolam (ADI) is a new benzodiazepine with anxiolytic and antidepressant properties. To assess its effects on the acute stress response, rats were given a single intraperitoneal injection of 2.5 or 5.0 mg/kg of ADI and stressed for 1 hr by restraint. Neither dose of ADI had any effect on heart rate, blood pressure ...

journal_title：Neuropharmacology

authors： Krieman MJ,Hershock DM,Greenberg IJ,Vogel WH

更新日期：1992-01-01 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt)/mechanistic target of rapamycin (mTOR) signaling pathway has been associated with several pathologies in the central nervous system (CNS), including epilepsy. There is evidence supporting the hypothesis that the PI3Kγ signaling pathway may mediate the...

journal_title：Neuropharmacology

authors： Lima IVA,Bellozi PMQ,Batista EM,Vilela LR,Brandão IL,Ribeiro FM,Moraes MFD,Moreira FA,de Oliveira ACP

更新日期：2020-10-01 00:00:00

abstract：:A neuronal nicotinic acetylcholine receptor (nAChR) subunit, Dalpha4, has been identified and cloned from the fruit fly Drosophila melanogaster, together with several alternatively spliced transcripts. Intron-exon boundaries within the gene encoding Dalpha4 (nAcRalpha-80B) have been identified by comparison of cDNA an...

journal_title：Neuropharmacology

authors： Lansdell SJ,Millar NS

更新日期：2000-10-01 00:00:00

abstract：:The effects of intravenously administered mephenesin, tolperisone, baclofen, diazepam and midazolam on reflex activity were studied in unanesthetized spinal cats. Monosynaptic, as well as polysynaptic ventral root reflexes, the dorsal root potential and the dorsal root reflex were recorded simultaneously from L6-S1 se...

journal_title：Neuropharmacology

authors： Farkas S,Tarnawa I,Berzsenyi P

更新日期：1989-02-01 00:00:00

abstract：:The United States is in the midst of an opiate epidemic, with abuse of prescription and illegal opioids increasing steadily over the past decade. While it is clear that there is a genetic component to opioid addiction, there is a significant portion of heritability that cannot be explained by genetics alone. The curre...

journal_title：Neuropharmacology

authors： Vassoler FM,Oliver DJ,Wyse C,Blau A,Shtutman M,Turner JR,Byrnes EM

更新日期：2017-02-01 00:00:00

abstract：:The effects of a variety of 5-hydroxytryptamine (5-HT) receptor agonists and antagonists on behaviour in 5- and 20-day old rat pups have been investigated. Increased locomotion and head-weaving responses were induced in both age groups by 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin; 5-HT1A agonist); 5-MeODMT (5-...

journal_title：Neuropharmacology

authors： Jackson HC,Kitchen I

更新日期：1989-06-01 00:00:00

abstract：:The effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), an alkylating agent producing irreversible blockade of various membrane bound receptors in brain, were investigated on four different types of serotonin receptors, 5-HT1A, 5-HT1B, 5-HT2A and 5-HT3, in various brain regions in the rat. In addition, t...

journal_title：Neuropharmacology

authors： Gozlan H,Laporte AM,Thibault S,Schechter LE,Bolaños F,Hamon M

更新日期：1994-03-01 00:00:00

abstract：:GABAA and glycine receptors are close relatives in the "gene superfamily" of ligand-gated ion channels, but have distinctly different pharmacology. For example, barbiturates have two effects on GABAA receptors (GABAA-R): at low micromolar concentrations (2-5 microM), the anesthetic barbiturate methohexital potentiates...

journal_title：Neuropharmacology

authors： Koltchine VV,Ye Q,Finn SE,Harrison NL

更新日期：1996-01-01 00:00:00

abstract：:Group II metabotropic glutamate (mGlu) receptor agonists were efficacious in randomized clinical research trials for schizophrenia and generalized anxiety disorder. The regional quantification of mGlu(2) and mGlu(3) receptors remains unknown. A selective and structurally novel mGlu(2/3) receptor agonist, 2-amino-4-flu...

journal_title：Neuropharmacology

authors： Wright RA,Johnson BG,Zhang C,Salhoff C,Kingston AE,Calligaro DO,Monn JA,Schoepp DD,Marek GJ

更新日期：2013-03-01 00:00:00

abstract：:Adenosine 5'-triphosphate-sensitive potassium channel (KATP channel) activator, minoxidil sulfate (MS), can selectively increase the permeability of the blood-tumor barrier (BTB); however, the mechanism by which this occurs is still under investigation. Using a rat brain glioma (C6) model, we first examined the expres...

journal_title：Neuropharmacology

authors： Gu YT,Xue YX,Wang YF,Wang JH,Chen X,ShangGuan QR,Lian Y,Zhong L,Meng YN

更新日期：2013-12-01 00:00:00

abstract：:Hypoxic-ischemic encephalopathy (HI) accounts for the majority of developmental, motor and cognitive deficits in children, leading to life-long neurological impairments. Since the plasmamembrane sodium/calcium exchanger (NCX) plays a fundamental role in maintaining ionic homeostasis during adult brain ischemia, in the...

journal_title：Neuropharmacology

authors： Cerullo P,Brancaccio P,Anzilotti S,Vinciguerra A,Cuomo O,Fiorino F,Severino B,Di Vaio P,Di Renzo G,Annunziato L,Pignataro G

更新日期：2018-06-01 00:00:00

abstract：:Alcohol use disorder (AUD) affects all sexes, however women who develop AUD may be particularly susceptible to cravings and other components of the disease. While many brain regions are involved in AUD etiology, proper prefrontal cortex (PFC) function is particularly important for top-down craving management and the m...

journal_title：Neuropharmacology

authors： Joffe ME,Winder DG,Conn PJ

更新日期：2020-11-01 00:00:00

abstract：:The group II metabotropic glutamate receptor (mGluR) antagonists LY341495 and LY366457 were profiled for their effects on locomotor activity in mice. Both compounds significantly increased locomotor activity. Observational studies showed that rearing was also selectively increased. LY366457-induced hyperactivity was s...

journal_title：Neuropharmacology

authors： O'Neill MF,Heron-Maxwell C,Conway MW,Monn JA,Ornstein P

更新日期：2003-10-01 00:00:00

abstract：:Multiple administrations of methamphetamine to rats produced elevated concentrations of substance P-like immunoreactivity within the substantia nigra, an effect which is believed to be mediated by increases in dopaminergic activity induced by methamphetamine. The results reported here demonstrate that the effect of me...

journal_title：Neuropharmacology

authors： Sonsalla PK,Gibb JW,Hanson GR

更新日期：1986-11-01 00:00:00

abstract：:The N-methyl-d-aspartate (NMDA) receptor is a key target of ethanol action in the central nervous system. Alcohol inhibition of NMDA receptor function involves small clusters of residues in the third and fourth membrane-associated (M) domains. Previous results from this laboratory have shown that two adjacent position...

journal_title：Neuropharmacology

authors： Ren H,Zhao Y,Wu M,Dwyer DS,Peoples RW

更新日期：2017-03-01 00:00:00

abstract：:The effect of acute or repeated treatment with the antidepressant clomipramine (CIM) on N-methyl-D-aspartate (NMDA) evoked changes in extracellular 5-hydroxytryptamine (5-HT) in the raphe nuclei and frontal cortex of the same rat has been studied using microdialysis. Acute injection of CIM (10 or 20 mg/kg) caused an i...

journal_title：Neuropharmacology

authors： Pallotta M,Segieth J,Sadideen F,Whitton PS

更新日期：2001-09-01 00:00:00

abstract：:Alpidem is a new anxiolytic of imidazopyridine structure which has a high affinity for the omega 1 (BZ1) modulatory site of the GABAA receptor. The present study investigated whether tolerance and physical dependence develop after repeated treatment with alpidem, as is observed with benzodiazepines. Mice were given al...

journal_title：Neuropharmacology

authors： Perrault G,Morel E,Sanger DJ,Zivkovic B

更新日期：1993-09-01 00:00:00

abstract：:The effect of 5-(2-cyclohexylideneethyl)-5-ethyl barbituric acid (CHEB) on the isolated spinal cord of the immature rat was examined using extracellular recording. At concentrations less than 20 microM CHEB increased the monosynaptic reflex (MSR) but depressed the reflex at greater concentrations (30-100 microM). At c...

journal_title：Neuropharmacology

authors： Nicholson GM,Spence I,Johnston GA

更新日期：1985-06-01 00:00:00

abstract：:Downregulation of the astroglial glutamate transporter GLT-1 is observed in the nucleus accumbens (NAc) following administration of multiple drugs of abuse. The decrease in GLT-1 protein expression following cocaine self-administration is dependent on both the amount of cocaine self-administered and the length of with...

journal_title：Neuropharmacology

authors： Kim R,Sepulveda-Orengo MT,Healey KL,Williams EA,Reissner KJ

更新日期：2018-01-01 00:00:00

abstract：:Inhibition in the brain is dominated by the neurotransmitter gamma-aminobutyric acid (GABA); operating through GABA(A) receptors. This form of neural inhibition was presumed to be mediated by synaptic receptors, however recent evidence has highlighted a previously unappreciated role for extrasynaptic GABA(A) receptors...

journal_title：Neuropharmacology

authors： Wafford KA,van Niel MB,Ma QP,Horridge E,Herd MB,Peden DR,Belelli D,Lambert JJ

更新日期：2009-01-01 00:00:00

abstract：:A pharmacological study using monkeys, in which parkinsonism was induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was undertaken to elucidate the mechanism underlying urinary bladder dysfunctions in Parkinson's disease. Under ketamine anesthesia, cystometrograms showed that, in MPTP-treated monkeys, a c...

journal_title：Neuropharmacology

authors： Yoshimura N,Mizuta E,Kuno S,Sasa M,Yoshida O

更新日期：1993-04-01 00:00:00

abstract：:The role of the sympathetic nervous system in the mediation of cardiovascular function, following administration of histamine centrally was investigated. Intracerebroventricular (i.c.v.) injections of histamine into the lateral ventricle of conscious rats caused a dose-dependent increase in blood pressure as well as a...

journal_title：Neuropharmacology

authors： Klein MC,Gertner SB

更新日期：1983-09-01 00:00:00

abstract：:The aim of the present study was to evaluate functional changes of mGluR5 expression in advanced Alzheimer's disease (AD) using positron emission tomography (PET) with an mGluR5 specific radiotracer ([18F]FPEB) in 5xFAD AD model. Subsequently, in the same animal, mGluR5 expression was quantified by immunoassay techniq...

journal_title：Neuropharmacology

authors： Lee M,Lee HJ,Park IS,Park JA,Kwon YJ,Ryu YH,Kim CH,Kang JH,Hyun IY,Lee KC,Choi JY

更新日期：2018-05-01 00:00:00

abstract：:In dorsal horn neurones of the cat spinal cord iontophoretically administered (+/-)-beta-p-chlorophenylglutamate (chlorpheg) markedly enhanced the excitatory responses induced by L-homocysteate, L-homocysteine sulphinate, S-sulpho L-cysteine, L-cysteate and quisqualate, while responses to NMDA, kainate, L-glutamate, L...

journal_title：Neuropharmacology

authors： Davies J,Francis AA,Oakes DJ,Sheardown MJ,Watkins JC

更新日期：1985-02-01 00:00:00

abstract：:Receptor-mediated signal transduction is thought to play an important role in neuronal differentiation and the modification of synaptic connections during brain development. The intracellular signalling molecule phospholipase C-beta1 (PLC-beta1), which is activated via specific neurotransmitter receptors, has recently...

journal_title：Neuropharmacology

authors： Hannan AJ,Kind PC,Blakemore C

更新日期：1998-04-01 00:00:00

abstract：:Chlorpromazine, given either subcutaneously (0.375 mg/kg) or unilaterally into the preoptic/anterior hypothalamic area through a chronically implanted cannula (20 micrograms), was found to enhance the hypothermic response to delta-9-tetrahydrocannabinol (THC; 5 mg/kg i.p.) in unrestrained adult male MF1 mice, kept at ...

journal_title：Neuropharmacology

authors： Pertwee RG,Hedley D,McQueen AS,Gentleman SM

更新日期：1988-02-01 00:00:00

abstract：:We present an overview of our studies on the differential role of serotonergic projections from the median raphe nucleus (MRN) and dorsal raphe nucleus (DRN) in behavioural animal models with relevance to schizophrenia. Stereotaxic microinjection of the serotonin neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) into the M...

journal_title：Neuropharmacology

authors： Adams W,Kusljic S,van den Buuse M

更新日期：2008-11-01 00:00:00

abstract：:G protein-coupled receptor 35 (GPR35) is an orphan G protein-coupled receptor (GPCR) that can be activated by kynurenic acid at high micromolar concentrations. A previously unappreciated mechanism of action of GPR35 has emerged as a Gαi/o-coupled inhibitor of synaptic transmission, a finding that has significant impli...

journal_title：Neuropharmacology

authors： Mackenzie AE,Milligan G

更新日期：2017-02-01 00:00:00

abstract：:Evidence indicates that angiotensin II type 2 receptors (AT2R) exert cerebroprotective actions during stroke. A selective non-peptide AT2R agonist, Compound 21 (C21), has been shown to exert beneficial effects in models of cardiac and renal disease, as well as hemorrhagic stroke. Here, we hypothesize that C21 may exer...

journal_title：Neuropharmacology

authors： Joseph JP,Mecca AP,Regenhardt RW,Bennion DM,Rodríguez V,Desland F,Patel NA,Pioquinto DJ,Unger T,Katovich MJ,Steckelings UM,Sumners C

更新日期：2014-06-01 00:00:00

abstract：:The sedative effect of SCH 34826, an enkephalinase inhibitor, was evaluated by studying electroencephalographic (EEG) activity, behaviour and the sleep-waking cycle in the rat. The reference opioid, morphine, was used for comparison. After administration of morphine (10 mg/kg s.c.) the rats were motionless and stuporo...

journal_title：Neuropharmacology

authors： Trampus M,Conti A,Marzanatti M,Monopoli A,Ongini E

更新日期：1990-03-01 00:00:00