Aβ pathology downregulates brain mGluR5 density in a mouse model of Alzheimer.

abstract：:Transgenic mice that accumulate Aβ peptides in the CNS are commonly used to interrogate functional consequences of Alzheimer's disease-associated amyloidopathy. In addition to changes to synaptic function, there is also growing evidence that changes to intrinsic excitability of neurones can arise in these models of am...

journal_title：Neuropharmacology

authors： Kerrigan TL,Brown JT,Randall AD

更新日期：2014-04-01 00:00:00

abstract：:Tobacco smoking is a preventable cause of morbidity and mortality throughout the world. Very high rates of tobacco smoking are seen in patients with schizophrenia. Importantly, smokers with schizophrenia generally have higher nicotine dependence scores, experience more severe withdrawal symptoms upon smoking cessation...

journal_title：Neuropharmacology

authors： D'Souza MS,Markou A

更新日期：2012-03-01 00:00:00

abstract：:Amphetamine has been shown to either potentiate or protect against MPTP neurotoxicity. The time course of changes in dopamine and its metabolites was examined after MPTP, amphetamine, or MPTP plus amphetamine administration. Results suggest that under conditions of granular depletion and release of dopamine by 10 mg/k...

journal_title：Neuropharmacology

authors： Sershen H,Mason MF,Reith ME,Hashim A,Lajtha A

更新日期：1986-08-01 00:00:00

abstract：:We studied the neuroprotective effect of lubeluzole, a NOS (nitric oxide synthase) pathway modulator, on the development of ischemic damage within the first six hours after a photochemically induced neocortical infarct in rats using diffusion-weighted MRI and Apparent Diffusion Coefficient (ADC) maps. A unilateral pho...

journal_title：Neuropharmacology

authors： De Ryck M,Verhoye M,Van der Linden AM

更新日期：2000-02-14 00:00:00

abstract：:We previously reported that elevated pressure induces axonal swelling and facilitates the synthesis of the neurosteroid, allopregnanolone (AlloP), in the ex vivo rat retina. Exogenously applied AlloP attenuates the axonal swelling, suggesting that the neurosteroid plays a neuroprotective role against glaucomatous pres...

journal_title：Neuropharmacology

authors： Ishikawa M,Yoshitomi T,Covey DF,Zorumski CF,Izumi Y

更新日期：2016-12-01 00:00:00

abstract：:Adolescence is a critical period for postnatal brain maturation and a time during which there is increased susceptibility to developing emotional and cognitive-related disorders. Exercise during adulthood has been shown to increase hippocampal plasticity and enhance cognition. However, the impact of exercise initiated...

journal_title：Neuropharmacology

authors： O'Leary JD,Hoban AE,Cryan JF,O'Leary OF,Nolan YM

更新日期：2019-02-01 00:00:00

abstract：:Cadmium (Cd) is a highly toxic metal that affects the central nervous system. Recently we have demonstrated that inhibition of mTOR by rapamycin rescues neuronal cells from Cd-poisoning. Here we show that rapamycin inhibited Cd-induced mitochondrial ROS-dependent neuronal apoptosis. Intriguingly, rapamycin remarkably ...

journal_title：Neuropharmacology

authors： Xu C,Wang X,Zhu Y,Dong X,Liu C,Zhang H,Liu L,Huang S,Chen L

更新日期：2016-06-01 00:00:00

abstract：:In several strains of mice: Swiss CD1, BALB, DBA2, C57, the mixed D1/D2 direct dopamine receptor agonist, apomorphine, elicited a marked and virtually similar hypothermic effect. By contrast, in C3H mice, this effect was obviously less and shorter. Similarly, the hypothermic effects of two direct D2 dopamine agonists ...

journal_title：Neuropharmacology

authors： Suaudeau C,Bousselmame R,Costentin J

更新日期：1992-11-01 00:00:00

abstract：:Putative kappa binding was investigated in homogenates of the brain of the rat using [3H]ethylketocylazocine and [3H]diprenorphine under conditions where mu and delta sites were blocked. Under blocked conditions, the binding of [3H]ethylketocyclazocine labelled a single site, as defined by kinetic and equilibrium anal...

journal_title：Neuropharmacology

authors： Weyhenmeyer JA,Mack KJ

更新日期：1985-02-01 00:00:00

abstract：:Dopamine (DA)-replacement therapy utilizing l-DOPA is the gold standard symptomatic treatment for Parkinson's disease (PD). A critical complication of this therapy is the development of l-DOPA-induced dyskinesia (LID). The endogenous opioid peptides, including enkephalins and dynorphin, are co-transmitters of dopamine...

journal_title：Neuropharmacology

authors： Flores AJ,Bartlett MJ,Root BK,Parent KL,Heien ML,Porreca F,Polt R,Sherman SJ,Falk T

更新日期：2018-10-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) are considered to be viable targets to enhance cognition in patients diagnosed with schizophrenia. Activation of nAChRs with selective nicotinic receptor agonists may provide effective means to pharmacologically treat cognitive deficits observed in schizophrenia. Cognitive fl...

journal_title：Neuropharmacology

authors： Wood C,Kohli S,Malcolm E,Allison C,Shoaib M

更新日期：2016-06-01 00:00:00

abstract：:More studies are required to develop therapeutic agents for treating spinocerebellar ataxia type 3 (SCA3), which is caused by mutant polyglutamine-expanded ataxin-3 and is the most prevalent subtype of spinocerebellar ataxias. T1-11 [N6-(4-Hydroxybenzyl) adenosine], isolated from a Chinese medicinal herb Gastordia ela...

journal_title：Neuropharmacology

authors： Chou AH,Chen YL,Chiu CC,Yuan SJ,Weng YH,Yeh TH,Lin YL,Fang JM,Wang HL

更新日期：2015-12-01 00:00:00

abstract：:The effects of phospholipase A2, cyclooxygenase-1, cyclooxygenase-2, and 5-lipoxygenase inhibitors on acute opiate withdrawal induced by selective mu, kappa and delta receptor agonists was investigated in vitro. After a 4 min in vitro exposure to D-Ala2-N-methyl-Phe-Gly5-ol)enkephalin (DAMGO; a highly selective mu ago...

journal_title：Neuropharmacology

authors： Capasso A

更新日期：1999-06-01 00:00:00

abstract：:Tobacco addiction is highly co-morbid with a variety of mental health conditions, including schizophrenia, mood and anxiety disorders. Nicotine, the primary psychoactive compound in tobacco-related products is known to functionally modulate brain circuits that are disturbed in these disorders. Nicotine can potently re...

journal_title：Neuropharmacology

authors： Laviolette SR

更新日期：2021-02-15 00:00:00

abstract：:The role of orexin receptors in the nucleus accumbens shell in rat turning behaviour of rats was studied. Unilateral injection of neither the orexin 1 and 2 receptor agonist orexin A (2 microg) nor the orexin 1 receptor antagonist SB 334867 (20 ng) into the nucleus accumbens shell elicited turning behaviour. Unilatera...

journal_title：Neuropharmacology

authors： Kotani A,Ikeda H,Koshikawa N,Cools AR

更新日期：2008-03-01 00:00:00

abstract：:Biochemical, behavioral and electrophysiological evidence suggests interactions between pathways containing neuronal nicotinic acetylcholine receptors (NAChRs) and excitatory amino acid receptors. Recently, protective effects of nicotine against N-methyl-D-aspartate (NMDA)-induced toxicity in primary cortical cultures...

journal_title：Neuropharmacology

authors： Rao TS,Correa LD,Lloyd GK

更新日期：1997-01-01 00:00:00

abstract：:The effects of pretreatment of rats with an intrahypothalamic injection of 6-hydroxydopamine on the thermal responses induced by intrahypothalamic injection of noradrenaline, prostaglandin E2, thyrotropin-releasing hormone or beta-endorphin were assessed. Administration of either noradrenaline (2-10 micrograms), prost...

journal_title：Neuropharmacology

authors： Lin MT,Chern YF,Chen SY

更新日期：1985-11-01 00:00:00

abstract：:Microdialysis studies in animals have shown that addictive drugs preferentially increase extracellular dopamine (DA) in the n. accumbens (NAc). Brain imaging studies, while extending these finding to humans, have shown a correlation between psychostimulant-induced increase of extracellular DA in the striatum and self-...

journal_title：Neuropharmacology

authors： Di Chiara G,Bassareo V,Fenu S,De Luca MA,Spina L,Cadoni C,Acquas E,Carboni E,Valentini V,Lecca D

更新日期：2004-01-01 00:00:00

abstract：:A condition of excess activity in the hippocampal formation is observed in the aging brain and in conditions that confer additional risk during aging for Alzheimer's disease. Compounds that act as positive allosteric modulators at GABA(A) α5 receptors might be useful in targeting this condition because GABA(A) α5 rece...

journal_title：Neuropharmacology

authors： Koh MT,Rosenzweig-Lipson S,Gallagher M

更新日期：2013-01-01 00:00:00

abstract：:An elevated plus-maze, used to identify anxiolytic effects of drugs (Pellow et al., 1985), reflected as increased open-arm exploration, was employed in cycling and ovariectomised rats, to determine the effect of diazepam on the cycle and, after ovariectomy, to investigate possible influences of treatment with oestradi...

journal_title：Neuropharmacology

authors： Nomikos GG,Spyraki C

更新日期：1988-07-01 00:00:00

abstract：:Serotonin (5-HT)1A and σ1 receptors have been implicated in psychiatric disorders. We previously found that combined 5-HT reuptake inhibition and σ1 receptor activation has a synergistic effect on prefrontal dopaminergic transmission in adrenalectomized/castrated mice lacking circulating steroid hormones. In the prese...

journal_title：Neuropharmacology

authors： Hiramatsu N,Ago Y,Hasebe S,Nishimura A,Mori K,Takuma K,Matsuda T

更新日期：2013-12-01 00:00:00

abstract：:Radioligand binding assays were used to demonstrate the presence of alpha 1, alpha 2 and beta receptors in rat spinal cord. Specific and saturable binding was exhibited for [3H]-WB 4101 (alpha 1), [3H]-aminoclonidine (alpha 2) and [3H]-dihydroalprenolol (beta). Binding was of high affinity and the total number of bind...

journal_title：Neuropharmacology

authors： Jones DJ,Kendall DE,Enna SJ

更新日期：1982-02-01 00:00:00

abstract：:Brain preconditioning is a protective mechanism, which can be activated by sub-lethal stimulation of the NMDA receptors (NMDAR) and be used to achieve neuroprotection against stroke and neurodegenerative diseases models. Inhibitors of glycine transporters type 1 modulate glutamatergic neurotransmission through NMDAR, ...

journal_title：Neuropharmacology

authors： Pinto MC,Lima IV,da Costa FL,Rosa DV,Mendes-Goulart VA,Resende RR,Romano-Silva MA,de Oliveira AC,Gomez MV,Gomez RS

更新日期：2015-02-01 00:00:00

abstract：:The surface expression and metabolic turnover time of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors are important factors in determining the involvement of these proteins in synaptic function. We used the membrane-impermeant chemical crosslinking reagent BS3 and subsequent immunoblot analysis t...

journal_title：Neuropharmacology

authors： Archibald K,Perry MJ,Molnár E,Henley JM

更新日期：1998-10-01 00:00:00

abstract：:An important feature of cocaine addiction in humans is the emergence of negative affect (e.g., dysphoria, irritability, anhedonia), postulated to play a key role in craving and relapse. Indeed, the DSM-IV recognizes that social, occupational and/or recreational activities become reduced as a consequence of repeated dr...

journal_title：Neuropharmacology

authors： Carelli RM,West EA

更新日期：2014-01-01 00:00:00

abstract：:The tryptophan metabolite kynurenic acid (KYNA) is an endogenous antagonist of the α7 nicotinic acetylcholine receptor (α7nAChR) and, at higher concentrations, inhibits ionotropic glutamate receptors. Increases in KYNA levels are seen in brain and cerebrospinal fluid in individuals with schizophrenia (SZ) and may be c...

journal_title：Neuropharmacology

authors： Beggiato S,Tanganelli S,Fuxe K,Antonelli T,Schwarcz R,Ferraro L

更新日期：2014-07-01 00:00:00

abstract：:In this study we investigate the presence, modulation and biological function of P2 receptors and extracellular ATP in cultured cerebellar granule neurons. As we demonstrate by RT-PCR and western blotting, both P2X and P2Y receptor subtypes are expressed and furthermore regulated as a function of neuronal maturation. ...

journal_title：Neuropharmacology

authors： Amadio S,D'Ambrosi N,Cavaliere F,Murra B,Sancesario G,Bernardi G,Burnstock G,Volonté C

更新日期：2002-03-01 00:00:00

abstract：:We have examined the regulation of neuronal nitric oxide synthase (NOS) by phosphorylation with cyclic-GMP (PKG) and cyclic-AMP-dependent (PKA) protein kinases. In vitro phosphorylation studies indicate that both PKG and PKA phosphorylate NOS on a single site. Phosphoamino-acid analysis and peptide mapping demonstrate...

journal_title：Neuropharmacology

authors： Dinerman JL,Steiner JP,Dawson TM,Dawson V,Snyder SH

更新日期：1994-11-01 00:00:00

abstract：:G-protein coupled dopamine and metabotropic glutamate receptors (mGlu) can modulate neurotransmission during Parkinson's disease (PD)-like neurodegeneration. PET imaging studies in a unilateral dopamine denervation model (6-OHDA) showed a significant inverse correlation of presynaptic mGlu4 and postsynaptic mGlu5 expr...

journal_title：Neuropharmacology

authors： Jenkins BG,Zhu A,Poutiainen P,Choi JK,Kil KE,Zhang Z,Kuruppu D,Aytan N,Dedeoglu A,Brownell AL

更新日期：2016-09-01 00:00:00

abstract：:High-frequency stimulation of afferents to the supraoptic nucleus (SON) results in a robust increase in the frequency and amplitude of pharmacologically isolated, tetrodotoxin-resistant, miniature excitatory postsynaptic currents (mEPSCs) lasting for 5-20 min. This increase in mEPSC frequency, termed short-term potent...

journal_title：Neuropharmacology

authors： Kombian SB,Hirasawa M,Matowe WC,Pittman QJ

更新日期：2001-10-01 00:00:00