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Selective potentiating effect of beta-p-chlorophenylglutamate on responses induced by certain sulphur-containing excitatory amino acids and quisqualate.

Abstract：

:In dorsal horn neurones of the cat spinal cord iontophoretically administered (+/-)-beta-p-chlorophenylglutamate (chlorpheg) markedly enhanced the excitatory responses induced by L-homocysteate, L-homocysteine sulphinate, S-sulpho L-cysteine, L-cysteate and quisqualate, while responses to NMDA, kainate, L-glutamate, L-aspartate and L-cysteine sulphinate were generally unaffected. Preliminary data obtained on frog spinal cord in vitro supports the possibility that such selective potentiation may be due to differential inhibition by chlorpheg of amino acid uptake. No potentiating effects of chlorpheg were observed on spinal synaptic excitation.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Davies J,Francis AA,Oakes DJ,Sheardown MJ,Watkins JC

doi

10.1016/0028-3908(85)90178-9

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

177-80

issue

2

eissn

0028-3908

issn

1873-7064

journal_volume

24

pub_type

杂志文章

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