Abstract：
:The effects of a variety of 5-hydroxytryptamine (5-HT) receptor agonists and antagonists on behaviour in 5- and 20-day old rat pups have been investigated. Increased locomotion and head-weaving responses were induced in both age groups by 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin; 5-HT1A agonist); 5-MeODMT (5-methoxy-N,N-dimethyltryptamine; 5-HT1) and RU 24969 (5-methoxy-3(1,2,3,6-tetrahydropyrindin-4-yl)-1H-indole; 5-HT1B/5-5HT1A). The putative 5-HT1A-agonist LY165163 (1-2-(4-aminophenyl)ethyl 4-(3-trifluoromethylphenyl)piperazine) also produced hyperactivity in the developing pups. In contrast, locomotion was not affected by buspirone (5-HT1A); mCPP (1-(3-chlorophenyl)piperazine; 5-HT1B/5-HT1C) and DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane; 5-HT2) though buspirone produced a small increase in head-weaving at 5- and 20-days. The full 5-HT syndrome was induced in older animals (but not neonates) by both 8-OH-DPAT and 5-MeODMT. Large doses of buspirone, mCPP and DOI also produced signs of reciprocal forepaw treading and flattened body posture at 20-days. In addition, mCPP induced grooming and stereotyped mouthing, while DOI increased sniffing behaviour in the young rats. Catecholaminergic mechanisms were implicated in the head-weaving and locomotor responses to 8-OH-DPAT and RU 24969, following experiments with a number of monoamine receptor antagonists. Preliminary findings with (-)-pindolol, which was high affinity for 5-HT1-receptors, suggested that this subtype of receptor may play a role in hyperlocomotion induced by RU 24969.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Jackson HC,Kitchen Idoi
10.1016/0028-3908(89)90143-3subject
Has Abstractpub_date
1989-06-01 00:00:00pages
635-42issue
6eissn
0028-3908issn
1873-7064journal_volume
28pub_type
杂志文章abstract：:The effect of varying the ratio of extraction volume to tissue weight (EVR) on the apparent concentration of histamine (HA) in the hypothalamus of the rat was examined. Increasing the weight of tissue (by pooling 1, 2 or 3 hypothalami), in a constant extraction volume, resulted in progressive decreases in apparent con...
journal_title：Neuropharmacology
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更新日期：1987-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1983-06-01 00:00:00
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更新日期：2004-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-01-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/0028-3908(89)90023-3
更新日期：1989-12-01 00:00:00
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更新日期：2017-05-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.neuropharm.2008.07.024
更新日期：2009-01-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：1990-03-01 00:00:00
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更新日期：2010-07-01 00:00:00
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更新日期：1982-11-01 00:00:00
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更新日期：2007-03-01 00:00:00
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journal_title：Neuropharmacology
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更新日期：1990-03-01 00:00:00
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更新日期：2012-07-01 00:00:00
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更新日期：2016-12-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
