The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors.

abstract：:Mice were injected bilaterally into the septum with 6-hydroxydopamine and 6 weeks later the hippocampi were assayed for activity of choline acetyltransferase, muscarinic receptor binding capabilities and for formation of inositol phosphate in response to direct (carbachol) or presynaptically elicited (K+) stimulation ...

journal_title：Neuropharmacology

authors： Yanai J,Rogel-Fuchs Y,Pick CG,Slotkin T,Seidler FJ,Zahalka EA,Newman ME

更新日期：1993-02-01 00:00:00

abstract：:Nicotine stimulates the secretion of catecholamines from sympathetic nerve endings and adrenal medulla by acting on peripheral nicotinic cholinergic receptors. Nicotine is also a potent stimulant in the central nervous system but the significance of nicotinic receptors in brain in mediating cardiovascular and sympatho...

journal_title：Neuropharmacology

authors： Kiritsy-Roy JA,Mousa SA,Appel NM,Van Loon GR

更新日期：1990-06-01 00:00:00

abstract：:Tarantula Chilobrachys jingzhao is one of the most venomous species distributed in China. In this study, we have isolated and characterized a novel neurotoxin named Jingzhaotoxin-IX (JZTX-IX) from the venom of the tarantula. JZTX-IX is a C-terminally amidated peptide composed of 35 amino acid residues. The toxin shows...

journal_title：Neuropharmacology

authors： Deng M,Kuang F,Sun Z,Tao H,Cai T,Zhong L,Chen Z,Xiao Y,Liang S

更新日期：2009-08-01 00:00:00

abstract：:Neuropeptide S (NPS) is a peptide recently recognized to be present in the CNS, and believed to play a role in vigilance and mood control, as behavioral studies have shown it promotes arousal and has an anxiolytic effect. Although NPS precursor is found in very few neurons, NPS positive fibers are present throughout t...

journal_title：Neuropharmacology

authors： Roncacè V,Polli FS,Zojicic M,Kohlmeier KA

更新日期：2017-11-01 00:00:00

abstract：:The presence of ethanol, 100 microM, in the superfusate enhanced the spontaneous release of previously uptaken [3H]-dopamine from slices of rat corpus striatum, but produced a small inhibition of K+-stimulated release. The concomitant presence of picrotoxin, 10 microM, in the superfusate prevented the enhancement of s...

journal_title：Neuropharmacology

authors： Samuel D,Lynch MA,Littleton JM

更新日期：1983-12-01 00:00:00

abstract：:Agonists and positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (nAChRs) are currently being considered as novel therapeutic approaches for managing cognitive deficits in schizophrenia and Alzheimer's disease. Though α7 agonists were recently found to possess antinociceptive and anti-inflamm...

journal_title：Neuropharmacology

authors： Freitas K,Ghosh S,Ivy Carroll F,Lichtman AH,Imad Damaj M

更新日期：2013-02-01 00:00:00

abstract：:The present study, using the in vivo intracerebral microdialysis method, investigated the role of different serotonin receptor subtypes in the control of dopamine (DA) release exerted by serotonin (5-HT) in the striatum of halothane-anesthetized rats. Striatal dialysate DA content was reduced following the blockade of...

journal_title：Neuropharmacology

authors： Bonhomme N,De Deurwaèrdere P,Le Moal M,Spampinato U

更新日期：1995-03-01 00:00:00

abstract：:Activation of the kappa opioid receptor (KOR) system mediates negative emotional states and considerable evidence suggests that KOR and their natural ligand, dynorphin, are involved in ethanol dependence and reward. The central amygdala (CeA) plays a major role in alcohol dependence and reinforcement. Dynorphin peptid...

journal_title：Neuropharmacology

authors： Gilpin NW,Roberto M,Koob GF,Schweitzer P

更新日期：2014-02-01 00:00:00

abstract：:Opiates addiction is characterized by its long-term persistence. In order to study the enduring changes in long-term memory in hippocampus, a pivotal region for this process, we used suppression subtractive hybridization to compare hippocampal gene expression in morphine and saline-treated rats. Animals were subjected...

journal_title：Neuropharmacology

authors： Marie-Claire C,Courtin C,Robert A,Gidrol X,Roques BP,Noble F

更新日期：2007-02-01 00:00:00

abstract：:Repeated stress exposure can lead to the development of anxiety and mood disorders. An emerging biological substrate of depression and associated pathology is the nucleus accumbens (NAc), which through interactions with limbic, cognitive and motor circuits can regulate a variety of stress responses. Within these circu...

journal_title：Neuropharmacology

authors： Azogu I,Plamondon H

更新日期：2017-10-01 00:00:00

abstract：:The effect of the inhibition of aminopeptidase and enkephalinase A on the pain threshold of mice and rats was investigated, using bestatin and thiorphan as selective peptidase inhibitors. The results indicate that both enzymes are relevant to the catabolism of enkephalins in vivo; however, their simultaneous activatio...

journal_title：Neuropharmacology

authors： Carenzi A,Frigeni V,Reggiani A,Della Bella D

更新日期：1983-11-01 00:00:00

abstract：:The role of monamine oxidase (MAO), type A and B, on the deamination of dopamine in the striatum, nucleus accumbens and frontal cortex of the rat was studied. Levels of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) tissue were quantified by means of high pressure liquid chromatography wi...

journal_title：Neuropharmacology

authors： Garrett MC,Soares-da-Silva P

更新日期：1990-10-01 00:00:00

abstract：:Following its binding to somatodendritic receptors, the neuropeptide neurotensin (NT) internalizes via a clathrin-mediated process. In the present study, we investigated whether NT also internalizes presynaptically using synaptosomes from rat neostriatum, a region in which NT1 receptors are virtually all presynaptic. ...

journal_title：Neuropharmacology

authors： Nguyen HM,Cahill CM,McPherson PS,Beaudet A

更新日期：2002-06-01 00:00:00

abstract：:Convection-enhanced delivery (CED) of GDNF and NTN was employed to determine the tissue clearance of these factors from the rat striatum and the response of the dopaminergic system to a single infusion. Two doses of GDNF (15 and 3 microg) and NTN (10 microg and 2 microg) were infused into the rat striatum. Animals wer...

journal_title：Neuropharmacology

authors： Hadaczek P,Johnston L,Forsayeth J,Bankiewicz KS

更新日期：2010-06-01 00:00:00

abstract：:The present study used pharmacological and gene ablation techniques to examine the involvement of kappa opioid receptors (KOPr) in modulating the convulsant effects of two mechanistically different drugs: cocaine and pentylenetetrazol (PTZ; GABA-A receptor antagonist) in mice. Systemic administration of the selective ...

journal_title：Neuropharmacology

authors： Kaminski RM,Witkin JM,Shippenberg TS

更新日期：2007-03-01 00:00:00

abstract：:Methylphenidate (MPH, Ritalin©) is widely used in the treatment of Attention Deficit Hyperactivity Disorder and recently as a drug of abuse. Although the effect of MPH has been studied in brain regions such as striatum and prefrontal cortex (PFC), the hippocampus has received relatively little attention. It is known t...

journal_title：Neuropharmacology

authors： Rozas C,Carvallo C,Contreras D,Carreño M,Ugarte G,Delgado R,Zeise ML,Morales B

更新日期：2015-12-01 00:00:00

abstract：:The loci coeruleus of freely moving cats were perfused bilaterally with acetylcholine at a dose of 0.001 microgram/microliter per min, while the animals were recorded polygraphically. The controls consisted of experiments in which no perfusions were done, and experiments in which the loci coeruleus were perfused bilat...

journal_title：Neuropharmacology

authors： Masserano JM,King C

更新日期：1982-11-01 00:00:00

abstract：:Postsynaptic induction of long-term potentiation (LTP) at cortical and thalamic afferent synapses onto lateral amygdala (LA) projection neurons not only involves NMDA receptor activation, but also depends on L-type voltage-dependent calcium channels (L-VDCCs). Here we show, using whole cell recordings and two-photon C...

journal_title：Neuropharmacology

authors： Humeau Y,Lüthi A

更新日期：2007-01-01 00:00:00

abstract：:Glutamic acid is the major excitatory amino acid of the central nervous system which interacts with two receptor families, the ionotropic and metabotropic glutamate receptors. The metabotropic glutamate receptors (mGluRs) are coupled to G proteins and can be divided into three subgroups based on their sequence homolog...

journal_title：Neuropharmacology

authors： Emile L,Mercken L,Apiou F,Pradier L,Bock MD,Menager J,Clot J,Doble A,Blanchard JC

更新日期：1996-05-01 00:00:00

abstract：:Long-term memory formation requires the coordinated regulation of gene expression. Until recently nucleosome remodeling, one of the major epigenetic mechanisms for controlling gene expression, had been largely unexplored in the field of neuroscience. Nucleosome remodeling is carried out by chromatin remodeling complex...

journal_title：Neuropharmacology

authors： Vogel-Ciernia A,Wood MA

更新日期：2014-05-01 00:00:00

abstract：:The effect of the D1 dopamine receptor antagonist SCH 23390 on sleep patterns was studied in rats by means of the electroencephalographic (EEG) technique. Haloperidol, an established D2 antagonist neuroleptic, was used for comparison. Over a very small dose range (0.003-0.03 mg/kg, subcutaneously), SCH 23390 significa...

journal_title：Neuropharmacology

authors： Trampus M,Ongini E

更新日期：1990-10-01 00:00:00

abstract：:The aim of the present study was to evaluate, by means of quantitative and multivariate analyses, the effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test as well as whether such changes are associated with drug-induced effects on anxiety and/or nociception. To this purpo...

journal_title：Neuropharmacology

authors： Casarrubea M,Sorbera F,Santangelo A,Crescimanno G

更新日期：2012-08-01 00:00:00

abstract：:Ifenprodil, which is clinically used as a cerebral vasodilator, inhibited rat brain type A (MAO-A) and type B (MAO-B) monoamine oxidase activity. It did not, however, affect rat lung semicarbazide-sensitive amine oxidase. The degree of inhibition of either form of MAO was not changed by 30 min preincubation of the enz...

journal_title：Neuropharmacology

authors： Arai Y,Nakazato K,Kinemuchi H,Tadano T,Satoh N,Oyama K,Kisara K

更新日期：1991-07-01 00:00:00

abstract：:Amphetamine-type stimulants (ATS) are the second most consumed illicit drug worldwide and lack good treatments for associated substance use disorders, lagging behind other addictive drugs. For this reason, a deeper understanding of the pharmacodynamics of ATS is required. The present study seeks to determine amphetami...

journal_title：Neuropharmacology

authors： Garton DR,Ross SG,Maldonado-Hernández R,Quick M,Lasalde-Dominicci JA,Lizardi-Ortiz JE

更新日期：2019-01-01 00:00:00

abstract：:Etomidate and propofol have clearly distinguishable effects on the central nervous system. However, studies in knock-in mice provided evidence that these agents produce anesthesia via largely overlapping molecular targets, namely GABA(A) receptors containing beta3 subunits. Here the authors address the question as to ...

journal_title：Neuropharmacology

authors： Drexler B,Jurd R,Rudolph U,Antkowiak B

更新日期：2009-09-01 00:00:00

abstract：:Owing to a broad spectrum of functions performed by neuropeptides, this class of signaling molecules attracts an increasing interest. One of the key steps in the regulation of biological activity of neuropeptides is proteolytic conversion or degradation by proteinases that change or terminate biological activity of na...

journal_title：Neuropharmacology

authors： Hartman K,Mielczarek P,Smoluch M,Silberring J

更新日期：2020-09-15 00:00:00

abstract：:Drugs that alter the function of gamma-aminobutyric acid (GABA) neurotransmission seem to reduce cocaine reinforcement, and as such may be useful in pharmacologically treating cocaine addiction. In the present experiment, the anti-cocaine effects of CGP 44532, a phosphinic acid analogue of GABA, and a highly selective...

journal_title：Neuropharmacology

authors： Dobrovitsky V,Pimentel P,Duarte A,Froestl W,Stellar JR,Trzcińska M

更新日期：2002-04-01 00:00:00

abstract：:Phylogenetic research can help to elucidate the structure of the GABA/benzodiazepine receptor complex. In this study the evolution of the beta-carboline binding site was traced to see whether it paralleled that of the benzodiazepine binding site. The ratio of [3H]ethyl-beta-carboline-3-carboxylate (beta-CCE) to [3H]fl...

journal_title：Neuropharmacology

authors： Friedl W,Hebebrand J,Rabe S,Propping P

更新日期：1988-02-01 00:00:00

abstract：:Treatment-related sexual dysfunction is a common side effect of antidepressants and contributes to patient non-compliance or treatment cessation. However, the multimodal antidepressant, vortioxetine, demonstrates low sexual side effects in depressed patients. To investigate the mechanisms involved, sexual behavior was...

journal_title：Neuropharmacology

authors： Li Y,Pehrson AL,Oosting RS,Gulinello M,Olivier B,Sanchez C

更新日期：2017-07-15 00:00:00

abstract：:Oxytocin (100 ng) injected unilaterally into the ventral subiculum of the hippocampus induces penile erection episodes, which started 30 min after treatment and were abolished by the prior injection of d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin (2 μg), an oxytocin receptor antagonist, into the ventral subiculum. Oxytocin-...

journal_title：Neuropharmacology

authors： Succu S,Sanna F,Argiolas A,Melis MR

更新日期：2011-07-01 00:00:00