GABAB, not GABAA receptors play a role in cortical postictal refractoriness.

Abstract:

:Postictal refractoriness may be taken as an expression of lasting activity of inhibitory systems arresting seizures. We tested drugs interfering with GABAergic inhibitory system in pairs of cortical epileptic afterdischarges induced with 1-min interval in rats. Under control conditions the second stimulation failed to elicit an afterdischarge. This postictal refractoriness was not affected by antagonists of GABAA receptors acting at three binding sites (bicuculline, picrotoxin, benzodiazepine inverse agonist Ro 19-4603) as well as by a less specific antagonist pentetrazol. In contrast, antagonist of GABAB receptors CGP35348 partially blocked the refractoriness. Cooperation of different inhibitory systems is probably necessary to abolish postictal refractoriness in neocortex. This article is part of the Special Issue entitled 'GABAergic Signaling in Health and Disease'.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Mareš P,Kubová H

doi

10.1016/j.neuropharm.2014.09.007

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

99-102

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(14)00314-1

journal_volume

88

pub_type

杂志文章
  • Antipsychotic regulation of dopamine D1, D2 and D3 receptor mRNA.

    abstract::A range of antipsychotic drugs, both "typical" and "atypical", was administered to rats over a time course and at several different dosages. The mRNA levels of dopamine D1, D2 and D3 receptor were measured in either whole brain or dissected brain regions. D3 receptor mRNA was up-regulated in whole brain by clozapine (...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/s0028-3908(97)00163-9

    authors: D'Souza U,McGuffin P,Buckland PR

    更新日期:1997-11-01 00:00:00

  • Effects of competitive N-methyl-D-aspartate antagonists on midbrain dopamine neurons: an electrophysiological and behavioral comparison to phencyclidine.

    abstract::Electrophysiological and behavioral methods were used to evaluate and compare the effects of the competitive N-methyl-D-aspartate (NMDA) receptor blocker, NPC 12626, with the non-competitive NMDA antagonist, phencyclidine (PCP), on the activity of mesolimbic dopamine neurons. NPC 12626 (50 mg/kg, i.p.) produced a degr...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(91)90131-t

    authors: French ED,Ferkany J,Abreu M,Levenson S

    更新日期:1991-10-01 00:00:00

  • Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides.

    abstract::Dopamine denervation in Parkinson's disease and repeated Levodopa (L-DOPA) administration that induces dyskinesias are associated with an enhancement of basal ganglia neuropeptide transmission. Various adjunct non-dopaminergic treatments to Levodopa were shown to reduce and/or prevent dyskinesias. The aim of this stud...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2009.06.030

    authors: Tamim MK,Samadi P,Morissette M,Grégoire L,Ouattara B,Lévesque D,Rouillard C,Di Paolo T

    更新日期:2010-01-01 00:00:00

  • The GABA(A) receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors.

    abstract::For a number of years it has been known that the CNS convulsant picrotoxin inhibits the GABA(A) receptor, an anion-selective member of the ligand-gated ion channel (LGIC) superfamily. PTX also inhibits other anion-selective LGIC members, such as GABA(C), glycine and glutamate-gated Cl(-) channels. In the present repor...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/s0028-3908(03)00032-7

    authors: Das P,Bell-Horner CL,Machu TK,Dillon GH

    更新日期:2003-03-01 00:00:00

  • Amplification of neuromuscular transmission by methylprednisolone involves activation of presynaptic facilitatory adenosine A2A receptors and redistribution of synaptic vesicles.

    abstract::The mechanisms underlying improvement of neuromuscular transmission deficits by glucocorticoids are still a matter of debate despite these compounds have been used for decades in the treatment of autoimmune myasthenic syndromes. Besides their immunosuppressive action, corticosteroids may directly facilitate transmitte...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2014.09.004

    authors: Oliveira L,Costa AC,Noronha-Matos JB,Silva I,Cavalcante WL,Timóteo MA,Corrado AP,Dal Belo CA,Ambiel CR,Alves-do-Prado W,Correia-de-Sá P

    更新日期:2015-02-01 00:00:00

  • Neuroadaptive changes and behavioral effects after a sensitization regime of MDPV.

    abstract::3,4-methylenedioxypyrovalerone (MDPV) is a synthetic cathinone with cocaine-like properties. In a previous work, we exposed adolescent mice to MDPV, finding sensitization to cocaine effects, and a higher vulnerability to cocaine abuse in adulthood. Here we sought to determine if such MDPV schedule induces additional b...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2018.10.005

    authors: Duart-Castells L,López-Arnau R,Buenrostro-Jáuregui M,Muñoz-Villegas P,Valverde O,Camarasa J,Pubill D,Escubedo E

    更新日期:2019-01-01 00:00:00

  • Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain.

    abstract::Clinically effective antidepressants are thought to exert their therapeutic effects by facilitating central monoamine neurotransmission. However, recent data showing that neurokinin-1 receptor (NK1R) antagonists have antidepressant properties in both animal and clinical studies raise the possibility that classical ant...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2004.02.013

    authors: Sartori SB,Burnet PWJ,Sharp T,Singewald N

    更新日期:2004-06-01 00:00:00

  • Opioid receptors: from binding sites to visible molecules in vivo.

    abstract::Opioid drugs such as heroin interact directly with opioid receptors whilst other addictive drugs, including marijuana, alcohol and nicotine indirectly activate endogenous opioid systems to contribute to their rewarding properties. The opioid system therefore plays a key role in addiction neurobiology and continues to ...

    journal_title:Neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuropharm.2008.07.033

    authors: Kieffer BL,Evans CJ

    更新日期:2009-01-01 00:00:00

  • CNS distribution of metabotropic glutamate 2 and 3 receptors: transgenic mice and [³H]LY459477 autoradiography.

    abstract::Group II metabotropic glutamate (mGlu) receptor agonists were efficacious in randomized clinical research trials for schizophrenia and generalized anxiety disorder. The regional quantification of mGlu(2) and mGlu(3) receptors remains unknown. A selective and structurally novel mGlu(2/3) receptor agonist, 2-amino-4-flu...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2012.01.019

    authors: Wright RA,Johnson BG,Zhang C,Salhoff C,Kingston AE,Calligaro DO,Monn JA,Schoepp DD,Marek GJ

    更新日期:2013-03-01 00:00:00

  • High affinity, heterogeneous displacement of [3H]EBOB binding to cerebellar GABA A receptors by neurosteroids and GABA agonists.

    abstract::Heterogeneous binding interactions of cerebellar GABA(A) receptors were investigated with GABA agonists and neurosteroids. GABA(A) receptors of rat cerebellum were labelled with [(3)H]ethynylbicycloorthobenzoate (EBOB), a convulsant radioligand. Saturation analysis revealed a homogenous, nanomolar population of [(3)H]...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2005.04.003

    authors: Maksay G,Bíró T

    更新日期:2005-09-01 00:00:00

  • Erythropoietin protects PC12 cells from beta-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway.

    abstract::Although the etiology of Alzheimer's disease (AD) is not fully understood, multiple lines of evidence suggests the importance of amyloid-beta (Abeta) in the initiation/progression of the disease. In this study, we investigated protective effects of erythropoietin (EPO) on Abeta(25-35)-induced cell death in cultured ra...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2009.02.006

    authors: Ma R,Xiong N,Huang C,Tang Q,Hu B,Xiang J,Li G

    更新日期:2009-05-01 00:00:00

  • Effect of plasma from patients containing bupropion and its metabolites on the uptake of norepinephrine.

    abstract::The uptake of norepinephrine into cortical punches from the brain of the rat was studied in the presence of buffer and plasma from patients containing bupropion and its metabolites. Even though bupropion and its metabolite (compound II) were equipotent in inhibiting the uptake of NE in buffer, compound II was twice as...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(86)90041-9

    authors: Perumal AS,Smith TM,Suckow RF,Cooper TB

    更新日期:1986-02-01 00:00:00

  • Modulation of long-term potentiation in CA1 region of mouse hippocampal brain slices by GABAA receptor benzodiazepine site ligands.

    abstract::Enhancement of GABAA receptor function with benzodiazepine (BZ) site agonists can disrupt memory formation and hippocampal synaptic plasticity. To investigate this further the effects of the agonist, flunitrazepam, were contrasted with that of the inverse agonist, methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxyl...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/s0028-3908(97)00040-3

    authors: Seabrook GR,Easter A,Dawson GR,Bowery BJ

    更新日期:1997-06-01 00:00:00

  • Identification of P2X receptors in cultured mouse and rat parasympathetic otic ganglion neurones including P2X knockout studies.

    abstract::We have used patch-clamp recording from cultured neurones, immunohistochemistry and gene deletion techniques to characterize the P2X receptors present in mouse otic ganglion neurones, and demonstrated the presence of similar receptors in rat neurones. All neurones from wild-type (WT) mice responded to ATP (EC(50) 109 ...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2004.01.009

    authors: Ma B,Ruan HZ,Cockayne DA,Ford AP,Burnstock G,Dunn PM

    更新日期:2004-06-01 00:00:00

  • Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats: A dual mechanism?

    abstract::A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alcohol-induced brain neuroinflammation/oxidative stress. Recently, it wa...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2018.12.001

    authors: Rivera-Meza M,Vásquez D,Quintanilla ME,Lagos D,Rojas B,Herrera-Marschitz M,Israel Y

    更新日期:2019-03-01 00:00:00

  • BDNF and NT-3 but not CNTF counteract the Ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways.

    abstract::The effect of neurotrophic factors on apoptosis induced by ionomycin, a potent Ca2+ ionophore, was investigated using cultured cortical neurons from embryonic rats. Brain-derived neurotophic factor (BDNF) and neurotrophin-3 (NT-3) prevented the ionomycin-mediated cell death in a dose-dependent manner. In contrast to t...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/s0028-3908(98)00189-0

    authors: Takei N,Tanaka O,Endo Y,Lindholm D,Hatanaka H

    更新日期:1999-02-01 00:00:00

  • The effect of a glycine derivative (CP 1552-S) on kindled seizures in rats.

    abstract::The effects of the glycine derivative, CP 1552-S (2-N-pentylaminoacetamide hydrochloride) were evaluated for potential anticonvulsant activity in rats which were cortically- or amygdaloid-kindled. Large doses (300-600 mg/kg, i.p.) of CP 1552 given 30 min before stimulation resulted in significant reductions in duratio...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(84)90012-1

    authors: Albertson TE,Stark LG,Joy RM

    更新日期:1984-08-01 00:00:00

  • Pharmacology and structure of P2Y receptors.

    abstract::P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). P2Y receptors are widely expressed and play important roles in physiology and pathophysiology. One important example is the ADP-...

    journal_title:Neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuropharm.2015.10.030

    authors: von Kügelgen I,Hoffmann K

    更新日期:2016-05-01 00:00:00

  • Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior.

    abstract::Phosphodiesterase 2 (PDE2) plays an important role in treatment of stress-related depression through regulation of antioxidant defense and neuroprotective mechanisms. However, the causal relationship between PDE2 and the prevalence of depression and anxiety upon exposure to oxidative stress has not been investigated. ...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2018.09.039

    authors: Huang X,Xiaokaiti Y,Yang J,Pan J,Li Z,Luria V,Li Y,Song G,Zhu X,Zhang HT,O'Donnell JM,Xu Y

    更新日期:2018-12-01 00:00:00

  • Stimulation of α2-adrenergic receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking in rats.

    abstract::Tobacco addiction is a chronic disorder that is characterized by craving for tobacco products, withdrawal upon smoking cessation, and relapse after periods of abstinence. Previous studies demonstrated that systemic administration of α2-adrenergic receptor agonists attenuates stress-induced reinstatement of drug seekin...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2010.09.013

    authors: Yamada H,Bruijnzeel AW

    更新日期:2011-02-01 00:00:00

  • Comparison of the effects of sumatriptan and the NK1 antagonist CP-99,994 on plasma extravasation in Dura mater and c-fos mRNA expression in trigeminal nucleus caudalis of rats.

    abstract::Dural plasma extravasation produced by electrical stimulation of the trigeminal ganglion was measured in rats and the concomitant expression of c-fos mRNA produced in the trigeminal nucleus caudalis (NtV) was measured using in situ hybridization techniques. The non-peptide NK1 receptor selective antagonist CP-99,994 (...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(94)00153-j

    authors: Shepheard SL,Williamson DJ,Williams J,Hill RG,Hargreaves RJ

    更新日期:1995-03-01 00:00:00

  • Fluoxetine and vitamin C synergistically inhibits blood-spinal cord barrier disruption and improves functional recovery after spinal cord injury.

    abstract::Recently we reported that fluoxetine (10 mg/kg) improves functional recovery by attenuating blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). Here we investigated whether a low-dose of fluoxetine (1 mg/kg) and vitamin C (100 mg/kg), separately not possessing any protective effect, prevents BS...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2016.05.018

    authors: Lee JY,Choi HY,Yune TY

    更新日期:2016-10-01 00:00:00

  • Dynamism of GABA(A) receptor activation shapes the "personality" of inhibitory synapses.

    abstract::The kinetics of synaptic currents is largely determined by the postsynaptic receptor gating and the concentration time course of synaptic neurotransmitter. While the analysis of current responses to rapid agonist application provides the means to study the ligand-gated receptor gating, no direct tools are available to...

    journal_title:Neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuropharm.2004.07.003

    authors: Mozrzymas JW

    更新日期:2004-12-01 00:00:00

  • Histamine induces KCNQ channel-dependent gamma oscillations in rat hippocampus via activation of the H1 receptor.

    abstract::Histamine is an aminergic neurotransmitter, which regulates wakefulness, arousal and attention in the central nervous system. Histamine receptors have been the target of efforts to develop pro-cognitive drugs to treat disorders such as Alzheimer's disease and schizophrenia. Cognitive functions including attention are ...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2017.03.003

    authors: Andersson R,Galter D,Papadia D,Fisahn A

    更新日期:2017-05-15 00:00:00

  • Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics.

    abstract::Due in part to their rich behavioral repertoire rats have been widely used in behavioral studies of drug abuse-related traits for decades. However, the mouse became the model of choice for researchers exploring the genetic underpinnings of addiction after the first mouse study was published demonstrating the capabilit...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2013.05.047

    authors: Parker CC,Chen H,Flagel SB,Geurts AM,Richards JB,Robinson TE,Solberg Woods LC,Palmer AA

    更新日期:2014-01-01 00:00:00

  • Ethanol withdrawal seizure susceptibility is associated with upregulation of L- and P-type Ca2+ channel currents in rat inferior colliculus neurons.

    abstract::Calcium currents in the inferior colliculus (IC) are thought to play an important role in ethanol withdrawal hyperexcitability. Here, we report on the modulation of Ca(2+) channel currents in acutely dissociated IC neurons of rats, exhibiting higher incidence of audiogenic seizures when subjected to ethanol withdrawal...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/s0028-3908(03)00191-6

    authors: N'Gouemo P,Morad M

    更新日期:2003-09-01 00:00:00

  • Neurocircuitry of drug reward.

    abstract::In recent years, neuroscientists have produced profound conceptual and mechanistic advances on the neurocircuitry of reward and substance use disorders. Here, we will provide a brief review of intracranial drug self-administration and optogenetic self-stimulation studies that identified brain regions and neurotransmit...

    journal_title:Neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuropharm.2013.04.031

    authors: Ikemoto S,Bonci A

    更新日期:2014-01-01 00:00:00

  • Inhibition of rat brain monoamine oxidase activity by cerebral anti-ischemic agent, ifenprodil.

    abstract::Ifenprodil, which is clinically used as a cerebral vasodilator, inhibited rat brain type A (MAO-A) and type B (MAO-B) monoamine oxidase activity. It did not, however, affect rat lung semicarbazide-sensitive amine oxidase. The degree of inhibition of either form of MAO was not changed by 30 min preincubation of the enz...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(91)90190-m

    authors: Arai Y,Nakazato K,Kinemuchi H,Tadano T,Satoh N,Oyama K,Kisara K

    更新日期:1991-07-01 00:00:00

  • Pentylenetetrazol-induced seizure is not mediated by benzodiazepine receptors in vivo.

    abstract::The selective benzodiazepine antagonist RO 15-1788, labelled with carbon 11 [11C] RO 15-1788, as a specific marker, together with positron emission tomography, allows the in vivo study of benzodiazepine receptors in primates. In addition, when coupled with recordings of electroencephalographic activity, this method of...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(87)90171-7

    authors: Hantraye P,Brouillet E,Guibert B,Chavoix C,Fukuda H,Prenant C,Crouzel M,Naquet R,Maziere M

    更新日期:1987-10-01 00:00:00

  • Fluoride-stimulated adenylate cyclase activity in rat brain following chronic treatment with psychotropic drugs.

    abstract::Chronic treatment with imipramine and reserpine increased fluoride-stimulated activity of adenylate cyclase in homogenates of cerebral cortex and "limbic" forebrain of the rat. Concomitant treatment with lithium counteracted this effect, while lithium alone had no effect on the activity of adenylate cyclase. ...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(84)90253-3

    authors: Andersen PH,Klysner R,Geisler A

    更新日期:1984-04-01 00:00:00