Abstract:
:The effect of varying the ratio of extraction volume to tissue weight (EVR) on the apparent concentration of histamine (HA) in the hypothalamus of the rat was examined. Increasing the weight of tissue (by pooling 1, 2 or 3 hypothalami), in a constant extraction volume, resulted in progressive decreases in apparent concentration of histamine in the hypothalamus. These concentrations were 642, 450 and 282 ng/g, respectively. Morphine (10 mg/kg, i.p.) significantly reduced the concentration of histamine in the hypothalamus. Expressed as percentages of the saline-control values (obtained for the extraction volume to tissue weight of 35.7, 57.2 and 118.4 ml/g), treatment with morphine resulted in 24, 17 and 11% reductions in the concentration of histamine in the hypothalamus, respectively. However, expressed in terms of ng/g, the reductions in histamine induced by morphine were 68, 75 and 69 ng/g, respectively. It is concluded that morphine may consistently affect a single pool of histamine. The possibility that de novo histamine is formed in the homogenate during the extraction process is discussed.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Lewis SJ,Verberne AJ,Fennessy MR,Jarrott Bdoi
10.1016/0028-3908(87)90263-2subject
Has Abstractpub_date
1987-08-01 00:00:00pages
1167-71issue
8eissn
0028-3908issn
1873-7064journal_volume
26pub_type
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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pub_type: 杂志文章
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journal_title:Neuropharmacology
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更新日期:2014-12-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:1991-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1982-11-01 00:00:00