Abstract：
:Vasopressin V1a receptors in the rat brain have been studied for their role in modulating aggression and anxiety. In the current study blood-oxygen-level-dependent (BOLD) functional MRI was used to test whether V1a receptors modulate neural processing in the maternal brain when dams are exposed to a male intruder. Primiparous females were given an intracerebroventricular (ICV) injection of vehicle or V1a receptor antagonist ([beta-Mercapto-beta,beta-cyclopentamethylenepropionyl(1), O-me-Tyr(2),Arg(8)]-Vasopressin, [corrected] 125 ng/10 microL) 90-120 min before imaging. During fMRI, awake dams were presented with a male intruder threat to pups using a specialized chamber that contained separate compartments for pups and a male intruder. Our results indicate that the number of activated voxels was reduced in the cortical amygdala with V1a receptor blockade, while an increase was observed in the anterior olfactory nucleus and other areas. Dams treated with V1a antagonist showed significantly greater BOLD responses in the anterior olfactory nucleus, infralimbic prefrontal cortex, gustatory cortex, somatosensory cortex, and substantia innominata when presented with a novel male intruder. BOLD responses were reduced in the cortical amygdala and ventromedial hypothalamus. The V1a receptor sensitive areas play roles in the processing of smell, taste and touch and emotional reactivity. Thus one interpretation of the present fMRI data is that vasopressin, acting through V1a receptors, may modulate sensory processing and perhaps coordinate this effect with changes in visceromotor activity during the initial stages of maternal aggressive motivation and/or anxiogenic responses.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Caffrey MK,Nephew BC,Febo Mdoi
10.1016/j.neuropharm.2009.06.023subject
Has Abstractpub_date
2010-01-01 00:00:00pages
107-16issue
1eissn
0028-3908issn
1873-7064pii
S0028-3908(09)00179-8journal_volume
58pub_type
杂志文章abstract：:Serotonergic hallucinogens produce profound changes in perception, mood, and cognition. These drugs include phenylalkylamines such as mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM), and indoleamines such as (+)-lysergic acid diethylamide (LSD) and psilocybin. Despite their differences in chemical structure, the...
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更新日期：1994-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1987-06-01 00:00:00
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journal_title：Neuropharmacology
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更新日期：2020-11-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
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更新日期：2015-11-01 00:00:00
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journal_title：Neuropharmacology
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更新日期：2006-04-01 00:00:00
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更新日期：1989-07-01 00:00:00
