Abstract：
:2-[p-(2-carboxyethyl)-phenylethylamino]-5'-N-ethylcarboxamidoadeno sine (CGS 21680) is considered a selective ligand for adenosine A2A receptors, which are known to be enriched in striatum and olfactory tubercle. We have investigated the characteristics of [3H]CGS 21680 binding in several brain regions using quantitative autoradiography. In agreement with previous data the radioligand was found to label the caudate-putamen, accumbens nucleus, olfactory tubercle and globus pallidus, but also many other structures, e.g. cerebral and cerebellar cortex, hippocampus, thalamus and some brainstem nuclei, were labelled. Cortical and striatal binding of [3H]CGS 21680 was unaltered by high concentrations of the adenosine transport inhibitor dipyridamole or the phosphodiesterase inhibitor rolipram but was displaced by 1,3-diethyl-8-phenylxanthine, the A2 selective adenosine antagonist CP 66,713, and the A2A selective agonist SHA 118. These three agents were approximately equipotent in striatum, cortex and hippocampus. The A2 selective agonist CV 1808 was a 4-5 times more potent displacer in cortex and hippocampus than in the striatum. [3H]CGS 21680 binding was strongly magnesium-dependent in all the studied brain regions, in contrast to the binding of adenosine A1 agonists. The binding of [3H]CGS 21680 to cerebral cortex and hippocampus, but not the binding to striatum, was displaced by the adenosine receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine in nanomolar concentrations. The present study provides evidence that in cerebral cortex and hippocampus, most of the [3H]CGS 21680 binds to a receptor site that is distinct from the striatal A2A receptor and the classical adenosine A1 receptor and may represent a hitherto unrecognized binding site.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Johansson B,Fredholm BBdoi
10.1016/0028-3908(95)00009-usubject
Has Abstractpub_date
1995-04-01 00:00:00pages
393-403issue
4eissn
0028-3908issn
1873-7064pii
002839089500009Ujournal_volume
34pub_type
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pub_type： 杂志文章,评审
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更新日期：2009-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0028-3908(95)00180-8
更新日期：1996-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-02-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2004.12.023
更新日期：2005-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-04-03 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2011-05-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2004.12.024
更新日期：2005-09-01 00:00:00
