BDNF and NT-3 but not CNTF counteract the Ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways.

abstract：:The risk of Alzheimer's disease (AD) is higher in patients with type 2 diabetes mellitus (T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain insulin resistance in these animals leads to the accumulation of amyloid beta (Aβ) and the reduction in GSK-3β phosphorylation, which promote...

journal_title：Neuropharmacology

authors： Kang S,Kim CH,Jung H,Kim E,Song HT,Lee JE

更新日期：2017-02-01 00:00:00

abstract：:Many studies have demonstrated that negative allosteric modulators (NAM) of metabotropic glutamate receptor 5 (mGlu5) reduce cocaine and methamphetamine seeking in extinction-reinstatement animal models of addiction. Less is known about effects of mGlu5 NAMs in abstinence models, particularly for methamphetamine. We u...

journal_title：Neuropharmacology

authors： Murray CH,Christian DT,Milovanovic M,Loweth JA,Hwang EK,Caccamise AJ,Funke JR,Wolf ME

更新日期：2021-01-12 00:00:00

abstract：:Schizophrenic patients have been shown to exhibit abnormal cortical gamma band oscillation (GBO), which is thought to be related to the symptoms of schizophrenia, including cognitive impairment. Recently, non-competitive NMDA receptor (NMDAr) antagonists such as MK-801 and ketamine have been reported to increase the b...

journal_title：Neuropharmacology

authors： Hiyoshi T,Kambe D,Karasawa J,Chaki S

更新日期：2014-10-01 00:00:00

abstract：:The effect of U-50,488H, a selective kappa opioid receptor agonist on the intake of food in food-deprived and non-deprived spontaneously hypertensive and normotensive Wistar-Kyoto rats was determined. In food deprived Wistar-Kyoto rats, intraperitoneal administration of U-50,488H, produced a bell-shaped curve on the i...

journal_title：Neuropharmacology

authors： Bhargava HN,Ramarao P,Richter CM,Bieniarz AA

更新日期：1989-01-01 00:00:00

abstract：:The sedative effect of SCH 34826, an enkephalinase inhibitor, was evaluated by studying electroencephalographic (EEG) activity, behaviour and the sleep-waking cycle in the rat. The reference opioid, morphine, was used for comparison. After administration of morphine (10 mg/kg s.c.) the rats were motionless and stuporo...

journal_title：Neuropharmacology

authors： Trampus M,Conti A,Marzanatti M,Monopoli A,Ongini E

更新日期：1990-03-01 00:00:00

abstract：:Neural circuit engagement within the nucleus accumbens (NAc) shell is implicated in the regulation of both negative and positive affect. Classically, the dynorphin/kappa opioid receptor (KOR) system in the NAc was believed to promote aversion, while dopamine was viewed as interacting with reward behavior, and KOR acti...

journal_title：Neuropharmacology

authors： Pirino BE,Spodnick MB,Gargiulo AT,Curtis GR,Barson JR,Karkhanis AN

更新日期：2020-12-15 00:00:00

abstract：:Traumatic injuries to peripheral nerves are frequent, however, specific pharmacological treatments are currently lacking. Curcumin has antioxidant, anti-inflammatory and neuroprotective properties but high oral doses are required for therapeutic use, particularly due to its low bioavailability. The aim of the present ...

journal_title：Neuropharmacology

authors： Caillaud M,Chantemargue B,Richard L,Vignaud L,Favreau F,Faye PA,Vignoles P,Sturtz F,Trouillas P,Vallat JM,Desmoulière A,Billet F

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:After neonatal ventral hippocampal lesions (NVHLs), adult rats exhibit evidence of neural processing deficits relevant to schizophrenia, including reduced prepulse inhibition (PPI) of acoustic startle and impaired sensory processing. In intact rats, the regulation of PPI by the ventral hippocampus (VH) is me...

journal_title：Neuropharmacology

authors： Swerdlow NR,Powell SB,Breier MR,Hines SR,Light GA

更新日期：2013-12-01 00:00:00

abstract：:γ-Aminobutyric acid type A receptors that contain the δ subunit (δGABAA receptors) are expressed in multiple types of neurons throughout the central nervous system, where they generate a tonic conductance that shapes neuronal excitability and synaptic plasticity. These receptors regulate a variety of important behavio...

journal_title：Neuropharmacology

authors： Whissell PD,Lecker I,Wang DS,Yu J,Orser BA

更新日期：2015-01-01 00:00:00

abstract：:Cyclic nucleotide-gated (CNG) channels, which are directly activated by cAMP and cGMP, have long been known to play a key role in retinal and olfactory signal transduction. Emerging evidence indicates that CNG channels are also involved in signaling pathways important for pain processing. Here, we found that the expre...

journal_title：Neuropharmacology

authors： Kallenborn-Gerhardt W,Metzner K,Lu R,Petersen J,Kuth MS,Heine S,Drees O,Paul M,Becirovic E,Kennel L,Flauaus C,Gross T,Wack G,Hohmann SW,Nemirovski D,Del Turco D,Biel M,Geisslinger G,Michalakis S,Schmidtko A

更新日期：2020-07-01 00:00:00

abstract：:Selective inhibitors of the glycine transporter 1 (GlyT1) have been implicated in central nervous system disorders related to hypoglutamatergic function such as schizophrenia. The selective GlyT1 inhibitors ALX5407 (NFPS) and LY2365109 {[2-(4-benzo[1,3]dioxol-5-yl-2-tert-butylphenoxy)ethyl]-methylamino}-acetic acid in...

journal_title：Neuropharmacology

authors： Perry KW,Falcone JF,Fell MJ,Ryder JW,Yu H,Love PL,Katner J,Gordon KD,Wade MR,Man T,Nomikos GG,Phebus LA,Cauvin AJ,Johnson KW,Jones CK,Hoffmann BJ,Sandusky GE,Walter MW,Porter WJ,Yang L,Merchant KM,Shannon HE,S

更新日期：2008-10-01 00:00:00

abstract：:Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortunately, the developmental parameters of susceptibility to general...

journal_title：Neuropharmacology

authors： Landin JD,Palac M,Carter JM,Dzumaga Y,Santerre-Anderson JL,Fernandez GM,Savage LM,Varlinskaya EI,Spear LP,Moore SD,Swartzwelder HS,Fleming RL,Werner DF

更新日期：2019-05-15 00:00:00

abstract：:Alterations in motor functions are well-characterized features observed in humans and experimental animals with thyroid hormone dysfunctions during development. We have previously suggested the implication of the endocannabinoid system in the hyperlocomotor phenotype observed in developmentally induced hypothyroidism ...

journal_title：Neuropharmacology

authors： Giné E,Echeverry-Alzate V,Lopez-Moreno JA,Rodriguez de Fonseca F,Perez-Castillo A,Santos A

更新日期：2017-04-01 00:00:00

abstract：:Phosphodiesterases (PDE) are the only enzymes that degrade cAMP and cGMP which are second messengers crucial to memory consolidation. Different PDE inhibitors have been developed and tested for their memory-enhancing potential, but the occurrence of side effects has hampered clinical progression. As separate inhibitio...

journal_title：Neuropharmacology

authors： Paes D,Xie K,Wheeler DG,Zook D,Prickaerts J,Peters M

更新日期：2021-02-15 00:00:00

abstract：:Anti-emetic drugs such as the tachykinin NK(1) receptor antagonists are useful to control emesis induced by diverse challenges. Evidence suggests pungent capsaicin-like TRPV1 activators also have broad inhibitory anti-emetic activity. However, pungent compounds are associated with undesirable effects including adverse...

journal_title：Neuropharmacology

authors： Chu KM,Ngan MP,Wai MK,Yeung CK,Andrews PL,Percie du Sert N,Rudd JA

更新日期：2010-02-01 00:00:00

abstract：:Acromelic acid, a kainate derivative of natural origin, markedly increased intracellular Ca2+ concentration ([Ca2+]i) in cultured rat spinal neurons in a concentration dependent manner; the half effective concentration (EC50) was 1.3 microM. Acromelic acid was more potent in increasing [Ca2+]i than any other glutamate...

journal_title：Neuropharmacology

authors： Ogata T,Nakamura Y,Tsuji K,Shibata T,Kataoka K,Ishida M,Shinozaki H

更新日期：1994-09-01 00:00:00

abstract：:Neuronal hyperexcitability in the anterior cingulate cortex (ACC) is considered as one of the most important pathological changes responsible for the chronification of neuropathic pain. However, the underlying mechanisms remain elusive. In the present study, we investigated the possible mechanisms using a rat model of...

journal_title：Neuropharmacology

authors： Gao SH,Wen HZ,Shen LL,Zhao YD,Ruan HZ

更新日期：2016-06-01 00:00:00

abstract：:Rats were trained to recognize a discriminative stimulus (DS) elicited by the dopamine D(2)/D(3) receptor agonist, PD128,907 (0.16 mg/kg, i.p.), which suppressed frontocortical release of dopamine (DA) but not 5-HT. The selective 5-HT1A receptor agonists, 8-OH-DPAT and flesinoxan, dose-dependently generalized to PD128...

journal_title：Neuropharmacology

authors： Dekeyne A,Rivet JM,Gobert A,Millan MJ

更新日期：2001-06-01 00:00:00

abstract：:We studied the neuroprotective effect of lubeluzole, a NOS (nitric oxide synthase) pathway modulator, on the development of ischemic damage within the first six hours after a photochemically induced neocortical infarct in rats using diffusion-weighted MRI and Apparent Diffusion Coefficient (ADC) maps. A unilateral pho...

journal_title：Neuropharmacology

authors： De Ryck M,Verhoye M,Van der Linden AM

更新日期：2000-02-14 00:00:00

abstract：:The effects of (S)-4-amino-5-[(4,4-dimethylcyclohexyl)amino]-5-oxo-pentanoic acid ((S)CR 2249), a new chemical entity selected among a series of glutamic acid derivatives, were investigated on N-methyl-D-aspartate (NMDA)-evoked release of [3H]noradrenaline from rat hippocampal slices. (S)CR 2249 facilitated glycine-me...

journal_title：Neuropharmacology

authors： Lanza M,Bonnafous C,Colombo S,Revel L,Makovec F

更新日期：1997-08-01 00:00:00

abstract：:This study was performed to investigate the effects of exercise on the synthesis of dopamine (DA) and 5-hydroxytryptamine (5-HT) in the brain of the trained rat. The consequences on the relationships between these two systems were also examined. The sum of the levels of free 3,4-dihydroxyphenyl acetic acid (DOPAC) plu...

journal_title：Neuropharmacology

authors： Chaouloff F,Laude D,Merino D,Serrurrier B,Guezennec Y,Elghozi JL

更新日期：1987-08-01 00:00:00

abstract：:The Mouse Defense Test Battery (MDTB) has been designed to investigate defensive responses of Swiss-Webster mice confronted with a natural predator, a rat. These behaviors include flight, avoidance, defensive threat/attack responses, and risk assessment activities. Previous studies with the MDTB have suggested that th...

journal_title：Neuropharmacology

authors： Griebel G,Blanchard DC,Jung A,Lee JC,Masuda CK,Blanchard RJ

更新日期：1995-12-01 00:00:00

abstract：:The role in ligand recognition and receptor activation of two adjacent charged residues (lysine 195 and aspartate 196) in the first extracellular loop of the human VPAC(1) receptor was investigated in stably transfected CHO cells expressing the wild type or point mutated receptors.Replacement of lysine 195 by glutamin...

journal_title：Neuropharmacology

authors： Langer I,Vertongen P,Perret J,Waelbroeck M,Robberecht P

更新日期：2003-01-01 00:00:00

abstract：:The central amygdala (CeA) is a critical regulator of emotional behavior that has been implicated in psychiatric illnesses, including anxiety disorders and addiction. The CeA corticotropin releasing factor receptor 1 (CRF1) system has been implicated in alcohol use disorder (AUD) and mood disorders, and has been shown...

journal_title：Neuropharmacology

authors： Agoglia AE,Tella J,Herman MA

更新日期：2020-12-01 00:00:00

abstract：:Phylogenetic research can help to elucidate the structure of the GABA/benzodiazepine receptor complex. In this study the evolution of the beta-carboline binding site was traced to see whether it paralleled that of the benzodiazepine binding site. The ratio of [3H]ethyl-beta-carboline-3-carboxylate (beta-CCE) to [3H]fl...

journal_title：Neuropharmacology

authors： Friedl W,Hebebrand J,Rabe S,Propping P

更新日期：1988-02-01 00:00:00

abstract：:We studied the effect of YM-39558, orotic acid ethylester, in a focal cerebral ischemia model in anesthetized cats. YM-39558 has good permeability across the blood brain barrier, and in the brain is hydrolyzed to orotic acid, the main active substance. Cats were subjected to permanent occlusion of the middle cerebral ...

journal_title：Neuropharmacology

authors： Akiho H,Iwai A,Tsukamoto S,Koshiya K,Yamaguchi T

更新日期：1998-01-01 00:00:00

abstract：:Effects of alaproclate, an inhibitor of the uptake of serotonin, on muscarinic cholinergic responses in N1E-115 neuroblastoma cells were studied using intracellular recording techniques. Application of carbachol activates an inward calcium channel, through an action on muscarinic receptors. The influx of calcium activ...

journal_title：Neuropharmacology

authors： Hedlund B

更新日期：1987-10-01 00:00:00

abstract：:The central nucleus of the amygdala (CeA) is a component of the limbic fear-anxiety circuit, and has also been implicated in regulation of the hypothalamic-pituitary-adrenal (HPA) stress axis. The CeA receives dense noradrenergic innervation, and is rich in expression of alpha(1)-adrenergic receptors. We hypothesized ...

journal_title：Neuropharmacology

authors： Cecchi M,Khoshbouei H,Morilak DA

更新日期：2002-12-01 00:00:00

abstract：:Psycho-genetic studies have revealed a role for the brain serotonin system in gambling proneness and poor decision-making. We assessed whether manipulation of brain serotonin levels in rats affected performance in operant-based tasks for decision-making and gambling proneness. Male Wistar rats were exposed to an l-try...

journal_title：Neuropharmacology

authors： Koot S,Zoratto F,Cassano T,Colangeli R,Laviola G,van den Bos R,Adriani W

更新日期：2012-03-01 00:00:00

abstract：:Peristaltic reflex activity in the guinea-pig isolated ileum was elicited by slow intraluminal infusion of Tyrode solution. The reflex was abolished by the ganglionic blocking drug hexamethonium. However, in more than half of the preparations, the peristaltic reflex was restored by the opioid antagonist naloxone. Hexa...

journal_title：Neuropharmacology

authors： Barthó L,Holzer P,Lembeck F

更新日期：1987-11-01 00:00:00