Dihydroergocristine-induced stimulation of the 5-HT autoreceptor in the hypothalamus of the rat.

abstract：:The functional expression of H4 receptors (H4R) within neurons of the central nervous system has been recently reported, but their role is poorly understood. The present study aims to elucidate the role of neuronal H4R by providing the first description of the behavioural phenotype of H4R-deficient (H4R knockout, H4R-...

journal_title：Neuropharmacology

authors： Sanna MD,Ghelardini C,Thurmond RL,Masini E,Galeotti N

更新日期：2017-03-01 00:00:00

abstract：:Differences in overall cocaine intake can directly affect neuroadaptations, and this relationship can make it difficult to interpret neurobiological changes seen in drug-choice studies, since drug intake varies between subjects. Herein, a choice procedure that controls for cocaine intake was utilized to explore if neu...

journal_title：Neuropharmacology

authors： Chow JJ,Hofford RS,Beckmann JS

更新日期：2021-02-15 00:00:00

abstract：:The GABA(B) receptor has been shown to consist of a heterodimer of two related 7-transmembrane receptors GABAB-R1 and GABA(B)-R2. These receptors share close homology to the Ca2+-sensing receptor and also to the metabotropic glutamate receptors, which have also been shown to respond to extracellular calcium. We show h...

journal_title：Neuropharmacology

authors： Wise A,Green A,Main MJ,Wilson R,Fraser N,Marshall FH

更新日期：1999-11-01 00:00:00

abstract：:There are no pharmacological interventions to prevent the development of epilepsy, although many promising compounds have been identified in the animal laboratory. Clinical trials to validate their effectiveness, however, would currently be prohibitively expensive due to the large subject population and duration of fo...

journal_title：Neuropharmacology

authors： Engel J Jr,Pitkänen A

更新日期：2020-05-01 00:00:00

abstract：:Intraventricular administration of amphetamine in mice produced hypothermia. Pretreatment with the dopaminergic (DA) receptor antagonist haloperidol reduced this response, whereas pretreatment with pimozide, sulpiride or cis-flupentixol did not. The direct DA agonist apomorphine strongly potentiated the hypothermia. P...

journal_title：Neuropharmacology

authors： Boschi G,Launay N

更新日期：1985-02-01 00:00:00

abstract：:Zatosetron (13 mg or 0.19 mg/kg), a potent and selective 5-HT3 receptor antagonist was studied with a 30 min infusion in a crossover double-blind placebo-controlled trial for acute migraine therapy. Groups receiving zatosetron and placebo were demographically similar and zatosetron was well-tolerated in all patients w...

journal_title：Neuropharmacology

authors： Chappell AS,Bay JM,Botzum GD,Cohen ML

更新日期：1994-03-01 00:00:00

abstract：:Disruptions in synaptic plasticity in the dorsal striatum may contribute to the pathophysiology underlying Parkinson's disease. Here we report a novel, chemically-induced form of plasticity induced by application of the potassium channel blocker tetraethylammonium (TEA) in the dorsolateral striatum of the adult rat. T...

journal_title：Neuropharmacology

authors： Norman ED,Egli RE,Colbran RJ,Winder DG

更新日期：2005-02-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is characterized by avoidance of trauma-associated stimuli and amygdala hyperreactivity, and is highly co-morbid with alcohol use disorder (AUD). Our lab uses a predator odor (bobcat urine) stress model that produces conditioned avoidance of an odor-paired context in a subset of r...

journal_title：Neuropharmacology

authors： Weera MM,Schreiber AL,Avegno EM,Gilpin NW

更新日期：2020-04-01 00:00:00

abstract：:Mechanisms underlying the neuroprotective properties of the weak MAO-A inhibitor moclobemide are not understood. Increasing evidence suggests that a moderate increase in intracellular free protons may contribute to neuroprotective properties due to a proton-mediated decrease in neuronal activity. Therefore, we studied...

journal_title：Neuropharmacology

authors： Bonnet U,Leniger T,Wiemann M

更新日期：2000-08-23 00:00:00

abstract：:Psycho-genetic studies have revealed a role for the brain serotonin system in gambling proneness and poor decision-making. We assessed whether manipulation of brain serotonin levels in rats affected performance in operant-based tasks for decision-making and gambling proneness. Male Wistar rats were exposed to an l-try...

journal_title：Neuropharmacology

authors： Koot S,Zoratto F,Cassano T,Colangeli R,Laviola G,van den Bos R,Adriani W

更新日期：2012-03-01 00:00:00

abstract：:Using juvenile rat brain slices, we examined the possibility that strychnine-sensitive receptors for glycine-like amino acids contributed to synaptic inhibition in ventrobasal thalamus, where gamma-aminobutyrate (GABA) is the prevalent inhibitory transmitter. Ventrobasal nuclei showed staining for antibodies against a...

journal_title：Neuropharmacology

authors： Ghavanini AA,Mathers DA,Puil E

更新日期：2005-09-01 00:00:00

abstract：:In rat brain, the number of beta-adrenoceptors and activity of noradrenaline-dependent adenylate cyclase were examined after treatment with desipramine (7.5 mg kg-1 day-1) for three days alone or in combination with the alpha 2-adrenoceptor antagonist, yohimbine (2 mg kg-1 12 hr-1), or with phenoxybenzamine (7.5 mg kg...

journal_title：Neuropharmacology

authors： Campbell IC,McKernan RM,Smokcum RW,Stephenson JD,Weeramanthri TB

更新日期：1984-12-01 00:00:00

abstract：:The monosynaptic reflex (MSR), recorded in vitro from the neonatal rat spinal cord, was depressed by 5-hydroxytryptamine (5-HT) and 5-HT receptor agonists. The results, together with our previous findings, indicate an apparent rank order of potency: 5-carboxamidotryptamine (5-CT) > sumatriptan > methysergide > 5-HT > ...

journal_title：Neuropharmacology

authors： Crick H,Manuel NA,Wallis DI

更新日期：1994-07-01 00:00:00

abstract：:Cannabidiol (CBD), the main non-psychotomimetic component of marihuana, exhibits anxiolytic-like properties in many behavioural tests, although its potential for treating major depression has been poorly explored. Moreover, the mechanism of action of CBD remains unclear. Herein, we have evaluated the effects of CBD fo...

journal_title：Neuropharmacology

authors： Linge R,Jiménez-Sánchez L,Campa L,Pilar-Cuéllar F,Vidal R,Pazos A,Adell A,Díaz Á

更新日期：2016-04-01 00:00:00

abstract：:In general, N-methyl-D-aspartate (NMDA) receptor antagonists inhibit learning and long term potentiation (LTP). However, it has been suggested that direct tonic, i.e. non-temporal, activation of NMDA receptors, in contrast to learning, may lead to an increase in synaptic "noise" and, in turn, to a loss of association ...

journal_title：Neuropharmacology

authors： Zajaczkowski W,Frankiewicz T,Parsons CG,Danysz W

更新日期：1997-07-01 00:00:00

abstract：:The effect of neurotrophic factors on apoptosis induced by ionomycin, a potent Ca2+ ionophore, was investigated using cultured cortical neurons from embryonic rats. Brain-derived neurotophic factor (BDNF) and neurotrophin-3 (NT-3) prevented the ionomycin-mediated cell death in a dose-dependent manner. In contrast to t...

journal_title：Neuropharmacology

authors： Takei N,Tanaka O,Endo Y,Lindholm D,Hatanaka H

更新日期：1999-02-01 00:00:00

abstract：:R(-)11-Hydroxy-N-n-propylnoraporphine (11-OH-NPa) induced stereotyped behavior in the rat as potently (ED50 = 0.80 mg/kg, i.p.) as R(-)apomorphine (APO) and this effect was blocked by haloperidol; the 11-methoxy congener, R(-)11-MeO-NPa, had a weak effect (ED50 greater than 10 mg/kg) and the S(+) isomers had none. The...

journal_title：Neuropharmacology

authors： Campbell A,Baldessarini RJ,Gao Y,Zong R,Neumeyer JL

更新日期：1990-06-01 00:00:00

abstract：:The effects of chronic treatment with haloperidol on [3H]PK 11195 binding and labelling of the peripheral-type benzodiazepine receptor (PBR) in the rat brain and peripheral tissues were investigated using an in vitro receptor binding technique. The intraperitoneal injection with haloperidol (0.3 or 1.0 mg/kg) for 21 d...

journal_title：Neuropharmacology

authors： Kurumaji A,Kaneko K,Toru M

更新日期：1996-01-01 00:00:00

abstract：:Depression is a polygenic and highly complex psychiatric disorder that is currently a major burden on society. Depression is highly heterogeneous in presentation and frequently exhibits high comorbidity with other psychiatric and somatic disorders. Commonly used treatments, such as selective serotonin reuptake inhibit...

journal_title：Neuropharmacology

authors： Samuels BA,Leonardo ED,Gadient R,Williams A,Zhou J,David DJ,Gardier AM,Wong EH,Hen R

更新日期：2011-09-01 00:00:00

abstract：:The modulatory effects exerted by the glucocorticoid hydrocortisone (HC) on the nicotinic acetylcholine receptor (AChR) were studied in mutants of the alpha subunit M4 transmembrane region. Based on the photoaffinity labeling of alpha M4 412 with the steroid promegestone this position was mutated to different residues...

journal_title：Neuropharmacology

authors： Garbus I,Roccamo AM,Barrantes FJ

更新日期：2002-07-01 00:00:00

abstract：:Intrauterine inflammation is a major risk for offspring neurodevelopmental brain damage and may result in cognitive limitations and poor cognitive and perceptual outcomes. Pro-inflammatory cytokines, stimulated during inflammatory response, have a pleotrophic effect on neurons and glia cells. They act in a dose-depend...

journal_title：Neuropharmacology

authors： Golan HM,Lev V,Hallak M,Sorokin Y,Huleihel M

更新日期：2005-05-01 00:00:00

abstract：:Compelling evidence has shown that in hippocampus tumor necrosis factor alpha (TNF-alpha) at pathological concentration inhibits long-term potentiation (LTP), a synaptic model of learning and memory. In the present work we investigated the role of TNF-alpha in LTP of C-fiber evoked field potentials in spinal dorsal ho...

journal_title：Neuropharmacology

authors： Liu YL,Zhou LJ,Hu NW,Xu JT,Wu CY,Zhang T,Li YY,Liu XG

更新日期：2007-03-01 00:00:00

abstract：:ORL-1 agonists have been proposed as potential therapeutics for substance abuse based on their propensity to counter the effects of mu opioid agonists in several systems, and to inhibit mesolimbic dopamine release, while mostly being devoid of aversive properties. In support of this, ORL-1 agonists have been shown to ...

journal_title：Neuropharmacology

authors： Shoblock JR,Wichmann J,Maidment NT

更新日期：2005-09-01 00:00:00

abstract：:Anxiety disorders contribute to the pathophysiology of psychiatric diseases, including major depression, substance abuse, and schizophrenia. The hippocampus is important for anxiety modulation. However, the mechanisms that control the neuronal activity of the hippocampus in anxiety are still not clear. We found that E...

journal_title：Neuropharmacology

authors： Chen M,Shu S,Yan HH,Pei L,Wang ZF,Wan Q,Bi LL

更新日期：2017-05-15 00:00:00

abstract：:Centrally-administered opioid peptides produce elevations in levels of catecholamines in plasma in conscious rats. To investigate the opioid receptor involved in mediating this response, morphine (3.5-105 nmol), [D-Ala2-D-Leu5]enkephalin (DADL, 1.05-35 nmol) and U50, 488H (35-1160 nmol), relatively selective ligands f...

journal_title：Neuropharmacology

authors： Conway EL,Brown MJ,Dollery CT

更新日期：1984-11-01 00:00:00

abstract：:Central administration of corticotropin-like peptides generally blocks the analgesic action of opiate ligands, yet it is unclear whether this is due to an independent hyperalgesic action of corticotropin or to some other mechanism. Single cells in the ventromedial medulla of the anaesthetized rat were characterized as...

journal_title：Neuropharmacology

authors： Smock T

更新日期：1987-12-01 00:00:00

abstract：:Our understanding of the role GABA(C) receptors play in the central nervous system is limited due to a lack of specific ligands. Here we describe the pharmacological effects of (+/-)-cis-3- and (+/-)-trans-3-(aminocyclopentyl)methylphosphinic acids ((+/-)-cis- and (+/-)-trans-3-ACPMPA) as novel ligands for the GABA(C)...

journal_title：Neuropharmacology

authors： Chebib M,Hanrahan JR,Kumar RJ,Mewett KN,Morriss G,Wooller S,Johnston GA

更新日期：2007-03-01 00:00:00

abstract：:The cannabinoid receptor CB2 plays a significant role in the regulation of immune function whereas neuronal expression remains a subject of contention. Multiple studies have described CB2 in retina and a recent study showed that CB2 deletion altered retinal visual processing. We revisited CB2 expression using immunohi...

journal_title：Neuropharmacology

authors： Borowska-Fielding J,Murataeva N,Smith B,Szczesniak AM,Leishman E,Daily L,Toguri JT,Hillard CJ,Romero J,Bradshaw H,Kelly MEM,Straiker A

更新日期：2018-10-01 00:00:00

abstract：:Ginsenoside Rg1 (Rg1) is a major bioactive ingredient in Panax ginseng that has low toxicity and has been shown to have neuroprotective effects. The objectives of the present study were to explore the potential of the application of Rg1 for the treatment of Parkinson's disease (PD) and to determine whether its neuropr...

journal_title：Neuropharmacology

authors： Zhou T,Zu G,Zhang X,Wang X,Li S,Gong X,Liang Z,Zhao J

更新日期：2016-02-01 00:00:00

abstract：:Prenatal cocaine exposure has been reported to result in abnormal neurobehavioral development, both in animals and humans. In this study, outbred CD-1 mice were exposed in utero to cocaine hydrochloride administered daily as i.p. injections to dams from day 10 of gestation to day 16, at the dose 0, 5 or 50 mg/kg. Coca...

journal_title：Neuropharmacology

authors： Laviola G,Fiore M,Loggi G,Alleva E

更新日期：1994-06-01 00:00:00