Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: the role of NF-kappa B, JNK and p38 MAPK.

abstract：:Central sensitization represents a key mechanism mediating chronic pain, a major clinical problem lacking effective treatment options. LIM-domain kinases (LIMKs) selectively regulate several substrates, e.g. cofilin and cAMP response element-binding protein (CREB), that profoundly affect neural activities, such as syn...

journal_title：Neuropharmacology

authors： Yang X,He G,Zhang X,Chen L,Kong Y,Xie W,Jia Z,Liu WT,Zhou Z

更新日期：2017-10-01 00:00:00

abstract：:Adenosine A(2A) agonists are known to induce catalepsy and inhibit dopamine mediated motor hyperactivity. An antagonistic interaction between adenosine A(2A) and dopamine D(2) receptors is known to regulate GABA-mediated neurotransmission in striatopallidal neurons. Stimulation of adenosine A(2A) and dopamine D(2) rec...

journal_title：Neuropharmacology

authors： Khisti RT,Chopde CT,Abraham E

更新日期：2000-04-03 00:00:00

abstract：:The mechanisms underlying the neuroprotective effects of cannabidiol (CBD) were studied in vivo using a hypoxic-ischemic (HI) brain injury model in newborn pigs. One- to two-day-old piglets were exposed to HI for 30 min by interrupting carotid blood flow and reducing the fraction of inspired oxygen to 10%. Thirty minu...

journal_title：Neuropharmacology

authors： Pazos MR,Mohammed N,Lafuente H,Santos M,Martínez-Pinilla E,Moreno E,Valdizan E,Romero J,Pazos A,Franco R,Hillard CJ,Alvarez FJ,Martínez-Orgado J

更新日期：2013-08-01 00:00:00

abstract：:About 20-30% of patients with epilepsy continue to have seizures despite carefully monitored treatment with antiepileptic drugs. The mechanisms explaining why some patients' respond and others prove resistant to antiepileptic drugs are poorly understood. It has been proposed that pharmacoresistance is related to reduc...

journal_title：Neuropharmacology

authors： Jeub M,Beck H,Siep E,Rüschenschmidt C,Speckmann EJ,Ebert U,Potschka H,Freichel C,Reissmüller E,Löscher W

更新日期：2002-01-01 00:00:00

abstract：:The present study was designed to determine whether abnormalities in serotonin receptor binding co-exist with the presynaptic serotonergic deficits that have previously been identified in the genetically epilepsy-prone rat (GEPR) brain. In vitro binding of [3H]8-OH-DPAT (0.16-10.3 nM) to 5-HT1A receptor sites was foun...

journal_title：Neuropharmacology

authors： Statnick MA,Dailey JW,Jobe PC,Browning RA

更新日期：1996-01-01 00:00:00

abstract：:In this study, we investigated whether resveratrol could protect against ischemic injury by improving brain energy metabolism and alleviating oxidative stress. Male rats were divided into three groups: sham operation, ischemia treatment, and ischemia combined with resveratrol treatment (resveratrol-treated group, 30 m...

journal_title：Neuropharmacology

authors： Li H,Yan Z,Zhu J,Yang J,He J

更新日期：2011-02-01 00:00:00

abstract：:Maternal aggression is highly expressed during lactation and serves to protect the developing young from intruders that may injure the offspring. One neurochemical modulator of maternal aggression appears to be arginine vasopressin (AVP). Earlier research supports a role for AVP in maternal aggression in rats as treat...

journal_title：Neuropharmacology

authors： Nephew BC,Byrnes EM,Bridges RS

更新日期：2010-01-01 00:00:00

abstract：:Ionic currents from non-inactivating Shaker K(+)-channels were expressed in Xenopus oocytes and recorded with the cut-open oocyte voltage clamp technique. Kinetic properties of ionic currents were studied between 1.4 and 19 degrees C. The forward step of the last transition (...C --> O) of the activation pathway, just...

journal_title：Neuropharmacology

authors： Rodríguez BM,Bezanilla F

更新日期：1996-01-01 00:00:00

abstract：:Extensive evidence indicates that noradrenergic activation of the basolateral amygdala (BLA) is essential for mediating emotional arousal effects on memory consolidation in different target regions. However, the mechanism by which BLA activation regulates such information storage processes remains largely elusive. Her...

journal_title：Neuropharmacology

authors： Chen Y,Barsegyan A,Nadif Kasri N,Roozendaal B

更新日期：2018-10-01 00:00:00

abstract：:An important feature of cocaine addiction in humans is the emergence of negative affect (e.g., dysphoria, irritability, anhedonia), postulated to play a key role in craving and relapse. Indeed, the DSM-IV recognizes that social, occupational and/or recreational activities become reduced as a consequence of repeated dr...

journal_title：Neuropharmacology

authors： Carelli RM,West EA

更新日期：2014-01-01 00:00:00

abstract：:N-methyl-d-aspartate (NMDA) receptors composed of glycine-binding GluN1 and GluN3 subunits function as excitatory glycine receptors that respond to agonist application only with a very low efficacy. Binding of glycine to the high-affinity GluN3 subunits triggers channel opening, whereas glycine binding to the low-affi...

journal_title：Neuropharmacology

authors： Mesic I,Madry C,Geider K,Bernhard M,Betz H,Laube B

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Alcohol use disorder (AUD) develops after chronic and heavy use of alcohol. Insomnia, a hallmark of AUD, plays a crucial role in the development of AUD. However, the causal mechanisms are unknown. Since chronic alcohol reduces acetylated histones and disrupts the epigenome, we hypothesized that chronic alcoh...

journal_title：Neuropharmacology

authors： Sharma R,Sahota P,Thakkar MM

更新日期：2020-12-01 00:00:00

abstract：:The aim of this study was to determine the effects of sex, corticosterone and oestradiol-17 beta on the hypothermia and motor behavioural syndrome induced by the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the rat. The hypothermia, but not the behavioural syndrome induced by 8-OH-DPAT...

journal_title：Neuropharmacology

authors： Young AH,Dow RC,Goodwin GM,Fink G

更新日期：1993-07-01 00:00:00

abstract：:The risk of Alzheimer's disease (AD) is higher in patients with type 2 diabetes mellitus (T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain insulin resistance in these animals leads to the accumulation of amyloid beta (Aβ) and the reduction in GSK-3β phosphorylation, which promote...

journal_title：Neuropharmacology

authors： Kang S,Kim CH,Jung H,Kim E,Song HT,Lee JE

更新日期：2017-02-01 00:00:00

abstract：:In general, N-methyl-D-aspartate (NMDA) receptor antagonists inhibit learning and long term potentiation (LTP). However, it has been suggested that direct tonic, i.e. non-temporal, activation of NMDA receptors, in contrast to learning, may lead to an increase in synaptic "noise" and, in turn, to a loss of association ...

journal_title：Neuropharmacology

authors： Zajaczkowski W,Frankiewicz T,Parsons CG,Danysz W

更新日期：1997-07-01 00:00:00

abstract：:To study individual differences in nicotine preference and intake, male and female rats were given free access to a choice of oral nicotine (10 or 20 mg/L) or water for 24 h/day for periods of at least six weeks, starting at adolescence or adulthood. A total of 341 rats, were used in four different experiments; weight...

journal_title：Neuropharmacology

authors： Nesil T,Kanit L,Collins AC,Pogun S

更新日期：2011-07-01 00:00:00

abstract：:5-hydroxytryptamine 1 (5-HT1) receptor blockade in combination with serotonin reuptake inhibition may provide a more rapid elevation of synaptic 5-HT compared to serotonin reuptake alone, by blocking the inhibitory effect of 5-HT1 receptor activation on serotonin release. GSK588045 is a novel compound with antagonist ...

journal_title：Neuropharmacology

authors： Comley RA,van der Aart J,Gulyás B,Garnier M,Iavarone L,Halldin C,Rabiner EA

更新日期：2015-05-01 00:00:00

abstract：:The effect of acute exposure to alcohols on ion current mediated by recombinant 5-HT3RA receptors transiently expressed in human embryonic kidney 293 cells was investigated. Cells transfected with 5-HT3RA cDNA expressed receptors with pharmacological and functional properties similar to those of native 5-HT3 receptors...

journal_title：Neuropharmacology

authors： Lovinger DM,Zhou Q

更新日期：1994-12-01 00:00:00

abstract：:Current antipsychotic drugs (APDs) act on D2 receptors, and preclinical studies demonstrate that repeated D2 antagonist administration downregulates spontaneously active DA neurons by producing overexcitation-induced inactivation of firing (depolarization block). Animal models of schizophrenia based on the gestational...

journal_title：Neuropharmacology

authors： Sonnenschein SF,Grace AA

更新日期：2020-02-01 00:00:00

abstract：:In the cerebellum of juvenile mice or rats, endocannabinoids are shown to mediate depolarization-induced suppression of excitation (DSE) and retrograde suppression induced by activation of type 1 metabotropic glutamate receptor (mGluR1) at parallel fiber (PF) to Purkinje cell (PC) synapses. However, recent studies sho...

journal_title：Neuropharmacology

authors： Tanimura A,Kawata S,Hashimoto K,Kano M

更新日期：2009-08-01 00:00:00

abstract：:Because of the claim that ibogaine suppresses the symptoms of "narcotic withdrawal" in humans, the effect of ibogaine on naltrexone-precipitated withdrawal signs in morphine-dependent rats was assessed. Morphine was administered subcutaneously through implanted silicone reservoirs for 5 days. Ibogaine (20, 40 or 80 mg...

journal_title：Neuropharmacology

authors： Glick SD,Rossman K,Rao NC,Maisonneuve IM,Carlson JN

更新日期：1992-05-01 00:00:00

abstract：:Pretreatment of primary cultures of cerebellar granule cells with sodium nitroprusside (SNP) protected these neurons from delayed death induced by glutamate and N-methyl-D-aspartate (NMDA). This neuroprotective effect was not mimicked by S-nitroso-N-acetylpenicillamine (SNAP) which like SNP stimulates guanylate cyclas...

journal_title：Neuropharmacology

authors： Kiedrowski L,Manev H,Costa E,Wroblewski JT

更新日期：1991-11-01 00:00:00

abstract：:Due in part to their rich behavioral repertoire rats have been widely used in behavioral studies of drug abuse-related traits for decades. However, the mouse became the model of choice for researchers exploring the genetic underpinnings of addiction after the first mouse study was published demonstrating the capabilit...

journal_title：Neuropharmacology

authors： Parker CC,Chen H,Flagel SB,Geurts AM,Richards JB,Robinson TE,Solberg Woods LC,Palmer AA

更新日期：2014-01-01 00:00:00

abstract：:Vulnerability to the addictive effects of drugs of abuse varies among individuals, but the biological basis of these differences are poorly known. This work tries to increase this knowledge by comparing the brain proteome of animals with different rate of extinction of cocaine-seeking behaviour. To achieve this goal, ...

journal_title：Neuropharmacology

authors： del Castillo C,Morales L,Alguacil LF,Salas E,Garrido E,Alonso E,Pérez-García C

更新日期：2009-07-01 00:00:00

abstract：:PDE10A is a newly identified phosphodiesterase that is highly expressed by the medium spiny projection neurons of the striatum. In order to investigate the physiological role of PDE10A in the central nervous system, PDE10A knockout mice (PDE10A(-/-)) were characterized both behaviorally and neurochemically. PDE10A(-/-...

journal_title：Neuropharmacology

authors： Siuciak JA,McCarthy SA,Chapin DS,Fujiwara RA,James LC,Williams RD,Stock JL,McNeish JD,Strick CA,Menniti FS,Schmidt CJ

更新日期：2006-08-01 00:00:00

abstract：:GABAA and glycine receptors are close relatives in the "gene superfamily" of ligand-gated ion channels, but have distinctly different pharmacology. For example, barbiturates have two effects on GABAA receptors (GABAA-R): at low micromolar concentrations (2-5 microM), the anesthetic barbiturate methohexital potentiates...

journal_title：Neuropharmacology

authors： Koltchine VV,Ye Q,Finn SE,Harrison NL

更新日期：1996-01-01 00:00:00

abstract：:It has been shown that endogenous adenosine 5'-triphosphate (ATP) as well as its exogenously applied structural analogue, 2-methylthio ATP (2-MeSATP), facilitate the release of dopamine from axon terminals in the rat nucleus accumbens (NAc) by activating ATP-sensitive P2 receptors. In the present study, reversed micro...

journal_title：Neuropharmacology

authors： Krügel U,Kittner H,Franke H,Illes P

更新日期：2001-06-01 00:00:00

abstract：:The effect of sumatriptan, a selective 5-HT1D receptor agent, on extracellular levels of 5-HT in the frontal cortex of the guinea pig was measured by intracerebral dialysis. A constant infusion of sumatriptan (10(-8)-10(-7) M) dose-dependently reduced extracellular levels of 5-HT (e.g. 80 +/- 2% decrease from control ...

journal_title：Neuropharmacology

authors： Sleight AJ,Cervenka A,Peroutka SJ

更新日期：1990-06-01 00:00:00

abstract：:Tobacco use is prevalent in the adolescent population. It is a major concern because tobacco is highly addictive and has also been linked to illicit drug use. There is not much research, however, on the interaction between nicotine and other stimulant drugs in animal models of early adolescence. This study examined th...

journal_title：Neuropharmacology

authors： Collins SL,Izenwasser S

更新日期：2004-03-01 00:00:00

abstract：:Ginsenoside Rg1 (Rg1) acts as a neuroprotective agent against various insults, however, the underlying mechanism has not been fully elucidated yet. Here, we report that Rg1 protects primary rat cerebrocortical neurons against β-amyloid peptide₂₅₋₃₅ (Aβ₂₅₋₃₅) injury via estrogen receptor α (ERα) and glucocorticoid rece...

journal_title：Neuropharmacology

authors： Wu J,Pan Z,Wang Z,Zhu W,Shen Y,Cui R,Lin J,Yu H,Wang Q,Qian J,Yu Y,Zhu D,Lou Y

更新日期：2012-09-01 00:00:00