Neuroprotective effects of resveratrol on ischemic injury mediated by improving brain energy metabolism and alleviating oxidative stress in rats.

abstract：:The secreted glycoprotein Dickkopf-1 (Dkk1), an antagonist of the Wnt/β-catenin pathway, has been implicated in many neurodegenerative diseases. However, it is unknown whether Dkk1 is involved in the pathogenesis of Parkinson's disease (PD). In this study, we discovered that Dkk1 was induced in MPP(+)-treated PC12 cel...

journal_title：Neuropharmacology

authors： Dun Y,Yang Y,Xiong Z,Feng M,Zhang Y,Wang M,Xiang J,Li G,Ma R

更新日期：2013-04-01 00:00:00

abstract：RATIONALE:Diabetes mellitus (DM) is a major risk factor for Alzheimer's disease and vascular dementia. Few animal models exist that focus on the metabolic contributions to dementia onset and progression. Thus, there is strong scientific rationale to explore the effects of streptozotocin (STZ), a diabetogenic compound, ...

journal_title：Neuropharmacology

authors： Murtishaw AS,Heaney CF,Bolton MM,Belmonte KCD,Langhardt MA,Kinney JW

更新日期：2018-07-15 00:00:00

abstract：:The effect of acute exposure to alcohols on ion current mediated by recombinant 5-HT3RA receptors transiently expressed in human embryonic kidney 293 cells was investigated. Cells transfected with 5-HT3RA cDNA expressed receptors with pharmacological and functional properties similar to those of native 5-HT3 receptors...

journal_title：Neuropharmacology

authors： Lovinger DM,Zhou Q

更新日期：1994-12-01 00:00:00

abstract：:Cyclosporine, a calcineurin inhibitor, significantly enhances spontaneous acetylcholine release after a brief tetanus and potentiates the effect of phorbol 12,13-dibutyrate. Both actions are prevented by the protein kinase C inhibitor, bisindolylmaleimide iodide. Protein kinase C and calcineurin thus play important ro...

journal_title：Neuropharmacology

authors： Lin MJ,Lin-Shiau SY

更新日期：1999-01-01 00:00:00

abstract：:In rats with cannulae permanently implanted into the third cerebral ventricle, the effects of different pharmacological manipulations affecting dopaminergic mechanisms, were studied on behaviour and electrocorticographic (ECoG) activity, continuously quantified in its spectrum power. The intraventricular injection (0....

journal_title：Neuropharmacology

authors： Bagetta G,Corasaniti MT,Strongoli MC,Sakurada S,Nisticò G

更新日期：1987-08-01 00:00:00

abstract：:Changes in astroglial volume were studied after incubating primary cultures from the cerebral cortex of newborn rats for 5 hr in taurine, glutamate or gamma-aminobutyric acid (GABA), alone or together with monoamine receptor agonists. Control cell volume was 2.2 microliters/mg protein. In the presence of taurine or gl...

journal_title：Neuropharmacology

authors： Hansson E,Rönnbäck L

更新日期：1992-01-01 00:00:00

abstract：:The voltage-dependent calcium channels (VDCCs) involved in K(+)-induced transmitter release have been studied. A maximally effective concentration of the N-type VDCC inhibitor, omega-conotoxin GVIA (GVIA) blocked the release of 5-HT (30%), DA (30%) and ACh (60%) but not that of GABA or glutamate. The O, P and Q-type V...

journal_title：Neuropharmacology

authors： Harvey J,Wedley S,Findlay JD,Sidell MR,Pullar IA

更新日期：1996-04-01 00:00:00

abstract：:Glutamatergic neurotransmission in the CNS plays a predominant role in learning and memory. While NMDA receptors have been extensively studied, less is known about the involvement of group I metabotropic glutamate receptors in this area. The purpose of the present study was to evaluate the contribution of mGluR1 and m...

journal_title：Neuropharmacology

authors： Gravius A,Barberi C,Schäfer D,Schmidt WJ,Danysz W

更新日期：2006-12-01 00:00:00

abstract：:There is increasing evidence that oxidative stress is critically involved in the pathogenesis of Parkinson's disease (PD), suggesting that pharmacological targeting of the antioxidant machinery may have therapeutic value. Naringenin, a natural flavonoid compound, has been reported to possess neuroprotective effect aga...

journal_title：Neuropharmacology

authors： Lou H,Jing X,Wei X,Shi H,Ren D,Zhang X

更新日期：2014-04-01 00:00:00

abstract：:Cyclic nucleotide-gated (CNG) channels, which are directly activated by cAMP and cGMP, have long been known to play a key role in retinal and olfactory signal transduction. Emerging evidence indicates that CNG channels are also involved in signaling pathways important for pain processing. Here, we found that the expre...

journal_title：Neuropharmacology

authors： Kallenborn-Gerhardt W,Metzner K,Lu R,Petersen J,Kuth MS,Heine S,Drees O,Paul M,Becirovic E,Kennel L,Flauaus C,Gross T,Wack G,Hohmann SW,Nemirovski D,Del Turco D,Biel M,Geisslinger G,Michalakis S,Schmidtko A

更新日期：2020-07-01 00:00:00

abstract：:We report in this study a 2-aminoethoxydiphenyl borate (2-APB) activated Ca2+ pathway in NG115-401L (401L) neuronal cells bearing resemblance to hormonal and ryanodine receptor activated pathways. We observed that 2-APB, in contrast to much earlier work, did not inhibit store operated Ca2+ channel (SOC) function, but ...

journal_title：Neuropharmacology

authors： Bose DD,Thomas DW

更新日期：2006-04-01 00:00:00

abstract：:3,4-Methlylenedioxymethamphetamine (MDMA) administration (4 x 15 mg/kg) on a single day has been shown to cause path integration deficits in rats. While most animal experiments focus on single binge-type models of MDMA use, many MDMA users take the drug on a recurring basis. The purpose of this study was to compare th...

journal_title：Neuropharmacology

authors： Skelton MR,Able JA,Grace CE,Herring NR,Schaefer TL,Gudelsky GA,Vorhees CV,Williams MT

更新日期：2008-12-01 00:00:00

abstract：:BMS-763534 is a potent (CRF(1) IC(50) = 0.4 nM) and selective (>1000-fold selectivity vs. all other sites tested) CRF(1) receptor antagonist (pA2 = 9.47 vs. CRF(1)-mediated cAMP production in Y79 cells). BMS-763534 accelerated the dissociation of (125)I-o-CRF from rat frontal cortex membrane CRF(1) receptors consisten...

journal_title：Neuropharmacology

authors： Lodge NJ,Lelas S,Li YW,Molski T,Grace J,Sivarao DV,Post-Munson D,Healy F,Bronson JJ,Hartz R,Macor JE,Zaczek R

更新日期：2013-04-01 00:00:00

abstract：:Direct GABA agonists that suppress spikes induced by penicillin in cats failed to do so in rats. Phenytoin and large doses of THIP increased the rate of spiking activity of the penicillin focus. Only progabide caused marked, initial, short-lasting suppression and a modest reduction of frequency of spikes for 1 hr. Hom...

journal_title：Neuropharmacology

authors： Golden GT,Fariello RG

更新日期：1984-09-01 00:00:00

abstract：:Studies with heterologous expression systems have shown that the α4β2 nicotinic acetylcholine receptor (nAChR) subtype can exist in two stoichiometries (with two [(α4)2(β2)3] or three [(α4)3(β2)2] copies of the α subunit in the receptor pentamer) which have different pharmacological and functional properties and are d...

journal_title：Neuropharmacology

authors： Fasoli F,Moretti M,Zoli M,Pistillo F,Crespi A,Clementi F,Mc Clure-Begley T,Marks MJ,Gotti C

更新日期：2016-09-01 00:00:00

abstract：:The nucleus tractus solitarius (NTS) region in the rat has been shown to receive arginine vasopressin (AVP) and oxytocin (OT) neurophysin-containing neuronal projections from the suprachiasmatic (SNC) and paraventricular nucleus (PVN). Thus, vasopressin and oxytocin might have central influences on the circulation. Th...

journal_title：Neuropharmacology

authors： Matsuguchi H,Sharabi FM,Gordon FJ,Johnson AK,Schmid PG

更新日期：1982-07-01 00:00:00

abstract：:Amyloid-beta (Abeta) deposition is a defining feature of Alzheimer's disease (AD). The toxicity of Abeta aggregation is thought to contribute to clinical deficits including progressive memory loss and cognitive dysfunction. Therefore, Abeta peptide has become the focus of many therapeutic approaches for the treatment ...

journal_title：Neuropharmacology

authors： Dong J,Revilla-Sanchez R,Moss S,Haydon PG

更新日期：2010-09-01 00:00:00

abstract：:The effects of age on the responsiveness of the body of the urinary bladder and base of the bladder to alpha-adrenergic agonists were studied. Regions of the bladder were isolated from Fischer 344 rats, ages 7, 16, and 27 months. Maximum isotonic contractions elicited by potassium chloride (KCl) in both regions of the...

journal_title：Neuropharmacology

authors： Ordway GA,Kolta MG,Gerald MC,Wallace LJ

更新日期：1986-12-01 00:00:00

abstract：:Centrally-administered opioid peptides produce elevations in levels of catecholamines in plasma in conscious rats. To investigate the opioid receptor involved in mediating this response, morphine (3.5-105 nmol), [D-Ala2-D-Leu5]enkephalin (DADL, 1.05-35 nmol) and U50, 488H (35-1160 nmol), relatively selective ligands f...

journal_title：Neuropharmacology

authors： Conway EL,Brown MJ,Dollery CT

更新日期：1984-11-01 00:00:00

abstract：:The effects of Substance P (SP) and of a specific nonpeptide antagonist of the NK1 receptor (RP 67580) on preovulatory gonadotropin surges and on the in vitro GnRH induced LH surge were investigated in cycling female rats. A subcutaneous injection of SP (0.5 mg/kg body weight) at 12.00 h on the proestrous day signific...

journal_title：Neuropharmacology

authors： Duval P,Lenoir V,Garret C,Kerdelhue B

更新日期：1996-01-01 00:00:00

abstract：:The sedative effect of SCH 34826, an enkephalinase inhibitor, was evaluated by studying electroencephalographic (EEG) activity, behaviour and the sleep-waking cycle in the rat. The reference opioid, morphine, was used for comparison. After administration of morphine (10 mg/kg s.c.) the rats were motionless and stuporo...

journal_title：Neuropharmacology

authors： Trampus M,Conti A,Marzanatti M,Monopoli A,Ongini E

更新日期：1990-03-01 00:00:00

abstract：:The aim of this study was to investigate the pharmacological characteristics of the 5-hydroxytryptamine-(5-HT)-induced electrical response in cultured neuroblastoma N1E-115 cells of the mouse. In these cells 5-HT induces a transient membrane depolarization, which is associated with a transient inward current, that has...

journal_title：Neuropharmacology

authors： Neijt HC,te Duits IJ,Vijverberg HP

更新日期：1988-03-01 00:00:00

abstract：:NMDA receptor (NMDAR) dysfunction has emerged as a common theme in several major nervous system disorders, including ischemic brain injury, chronic neurodegenerative diseases, pain, depression and schizophrenia. Either hyperactivity or hypofunction of NMDARs could contribute to disease pathophysiology. It is likely th...

journal_title：Neuropharmacology

authors： Zhou Q,Sheng M

更新日期：2013-11-01 00:00:00

abstract：:The effects of haloperidol, chlorpromazine and clozapine on transmitter release have been studied by measuring the simultaneous release of dopamine and acetylcholine from tissue slices of nucleus accumbens and striatum in vitro following in vivo drug application, either a single dose or daily for periods of up to 25 d...

journal_title：Neuropharmacology

authors： de Belleroche JS,Neal MJ

更新日期：1982-06-01 00:00:00

abstract：:The hypothesis that aberrant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor activity contributes to epileptogenesis and neurodegeneration has prompted the search for AMPA receptor antagonists as potential therapeutics to treat these conditions. We describe the functional characterization of a...

journal_title：Neuropharmacology

authors： Lazzaro JT,Paternain AV,Lerma J,Chenard BL,Ewing FE,Huang J,Welch WM,Ganong AH,Menniti FS

更新日期：2002-02-01 00:00:00

abstract：:Addiction involves drug-induced neuroplasticity in the circuitry of motivated behavior, which includes the medial forebrain bundle and the lateral hypothalamic area. Emerging at the forefront of neuroplasticity regulation are specialized extracellular matrix (ECM) structures that form perineuronal nets (PNNs) around c...

journal_title：Neuropharmacology

authors： Blacktop JM,Todd RP,Sorg BA

更新日期：2017-05-15 00:00:00

abstract：:Memory reactivation has been shown to open a time window for memory modulation. The majority of the methodological or pharmacological approaches target disruption of reconsolidation to weaken aversive memories. However, methods to improve appetitive memory persistence through reconsolidation or to reverse drug-induced...

journal_title：Neuropharmacology

authors： Wang SH

更新日期：2018-10-01 00:00:00

abstract：:Exposure to abused drugs and stressful experience, two factors that promote the development of addiction, also modify synaptic function in the mesolimbic dopamine system. Here, we show that exposure to a novel environment produces functional synaptic adaptations in the nucleus accumbens (NAc) that mirror the effect of...

journal_title：Neuropharmacology

authors： Rothwell PE,Kourrich S,Thomas MJ

更新日期：2011-12-01 00:00:00

abstract：:The effects of the anxiolytic drug chlordiazepoxide (CDZ) on general activity and anxiety-related behaviour of male and female Swiss-Webster mice were investigated in the triple test, which combines the open field (OF), elevated-plus maze (EPM) and the light-dark box (LDB). Mice were injected with saline or CDZ (1.0, ...

journal_title：Neuropharmacology

authors： Hussin AT,Fraser LM,Ramos A,Brown RE

更新日期：2012-10-01 00:00:00

abstract：:Lithium has been reported to exert neuroprotective activity in several neuronal cell cultures and in vivo models against glutamate toxicity. Since this action was reported to be associated with alterations in the antiapoptotic Bcl-2 family proteins, the effect of chronic lithium diet on the ability of the parkinsonism...

journal_title：Neuropharmacology

authors： Youdim MB,Arraf Z

更新日期：2004-06-01 00:00:00