Abstract:
:NMDA receptor (NMDAR) dysfunction has emerged as a common theme in several major nervous system disorders, including ischemic brain injury, chronic neurodegenerative diseases, pain, depression and schizophrenia. Either hyperactivity or hypofunction of NMDARs could contribute to disease pathophysiology. It is likely that distinct subtypes of NMDARs (as defined by subunit composition and/or subsynaptic location) are differentially involved in central nervous system diseases. Here we focus on a few examples of nervous system diseases where the contribution of NMDARs is relatively well characterized and discuss the implications for potential treatment of these illnesses. This article is part of the Special Issue entitled 'Glutamate Receptor-Dependent Synaptic Plasticity'.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Zhou Q,Sheng Mdoi
10.1016/j.neuropharm.2013.03.030subject
Has Abstractpub_date
2013-11-01 00:00:00pages
69-75eissn
0028-3908issn
1873-7064pii
S0028-3908(13)00126-3journal_volume
74pub_type
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