当前位置： SCI文献检索 > NEUROPHARMACOLOGY期刊下所有文献 > Induction of Dickkopf-1 contributes to the neurotoxicity of MPP+ in PC12 cells via inhibition of the canonical Wnt signaling pathway.

Induction of Dickkopf-1 contributes to the neurotoxicity of MPP+ in PC12 cells via inhibition of the canonical Wnt signaling pathway.

Abstract：

:The secreted glycoprotein Dickkopf-1 (Dkk1), an antagonist of the Wnt/β-catenin pathway, has been implicated in many neurodegenerative diseases. However, it is unknown whether Dkk1 is involved in the pathogenesis of Parkinson's disease (PD). In this study, we discovered that Dkk1 was induced in MPP(+)-treated PC12 cells and the increase of Dkk1 preceded PC12 cell loss. RhDkk1 aggravated the neurotoxicity of MPP(+) in PC12 cells. Furthermore, the level of Dkk1 was correlated with the number of apoptotic PC12 cells. The apoptosis could be decreased by Dkk1-siRNA in MPP(+)-induced PC12 cells and Dkk1-siRNA regulated the expression of β-catenin and p-Ser9-GSK-3β in MPP(+)-induced PC12 cells. LiCl (an inhibitor of GSK-3β) also rescued the loss of PC12 cell viability and the apoptosis induced by MPP(+). These data suggest that the induction of Dkk1 contributes to the MPP(+)-induced neurotoxicity in PC12 cells via inhibition of the canonical Wnt pathway and Dkk1 antagonists which could rescue the Wnt pathway might be neuroprotective in PD.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Dun Y,Yang Y,Xiong Z,Feng M,Zhang Y,Wang M,Xiang J,Li G,Ma R

doi

10.1016/j.neuropharm.2012.10.031

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

168-75

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(12)00539-4

journal_volume

67

pub_type

杂志文章

相关文献

NEUROPHARMACOLOGY文献大全