Abstract：
:The effects of the anxiolytic drug chlordiazepoxide (CDZ) on general activity and anxiety-related behaviour of male and female Swiss-Webster mice were investigated in the triple test, which combines the open field (OF), elevated-plus maze (EPM) and the light-dark box (LDB). Mice were injected with saline or CDZ (1.0, 7.5 or 15.0 mg/kg) and their behaviour was observed for 15 min in the triple test on each of two days. On day 1, increasing doses of CDZ increased open arm exploration and total distance travelled, and decreased risk assessments in the EPM. In the LDB, CDZ increased time in the light compartment and number of transitions between compartments. In spite of habituation to the apparatus, CDZ increased the number of transitions in the LDB, increased percent time in the open arms and total distance travelled in the EPM on day 2. Thus, there was a significant effect of CDZ in the triple test on both days, even though there was habituation to the apparatus after day 1. These results show that the drug effect was independent of the day effect and that there was no one-trial tolerance effect in the triple test of anxiety.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Hussin AT,Fraser LM,Ramos A,Brown REdoi
10.1016/j.neuropharm.2012.06.033subject
Has Abstractpub_date
2012-10-01 00:00:00pages
883-9issue
5eissn
0028-3908issn
1873-7064pii
S0028-3908(12)00291-2journal_volume
63pub_type
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