Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist.

abstract：:The present study investigated the possibility of multiple 5-HT(1) autoreceptor subtypes in the rostral raphé nuclei. Slices (350 microm) of rat dorsal or median raphé nucleus (DRN/MRN) were taken from male Wistar rats and superfused with artificial cerebrospinal fluid at 32 degrees C. Fast cyclic voltammetry at carbo...

journal_title：Neuropharmacology

authors： Hopwood SE,Stamford JA

更新日期：2001-03-01 00:00:00

abstract：:Pediatric traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality in children. Experimental and clinical studies demonstrate that the developmental age, the type of injury (diffuse vs. focal) and sex may play important roles in the response of the developing brain to a traumatic injur...

journal_title：Neuropharmacology

authors： Huh JW,Raghupathi R

更新日期：2019-02-01 00:00:00

abstract：:In fixed tissue, neuronal NADPH-diaphorase staining results from nitric oxide synthase (NOS) activity. Neuronal NOS only synthesizes nitric oxide once activated by the binding of Ca2+/calmodulin. We show here that neuronal NADPH-diaphorase staining is also dependent on Ca2+/calmodulin, implying that only activated NOS...

journal_title：Neuropharmacology

authors： Morris BJ,Simpson CS,Mundell S,Maceachern K,Johnston HM,Nolan AM

更新日期：1997-11-01 00:00:00

abstract：:A cDNA encoding the human metabotropic glutamate receptor type 4 (hmGluR4) was isolated from human brain cDNA libraries by cross-hybridization with rat mGluR4 probes. The deduced amino acid sequence of human mGluR4 consists of 912 residues and shows a sequence identity of 96% to the amino acid sequence of rat mGluR4. ...

journal_title：Neuropharmacology

authors： Flor PJ,Lukic S,Rüegg D,Leonhardt T,Knöpfel T,Kuhn R

更新日期：1995-02-01 00:00:00

abstract：:Midbrain dopamine neurons play a key role in goal-directed behaviour as well as in some psychiatric disorders. Recent studies have provided electrophysiological, anatomical and biochemical evidence that the lateral habenula (LHb) exerts strong inhibitory control over midbrain dopamine neurons. However, the behavioural...

journal_title：Neuropharmacology

authors： Gifuni AJ,Jozaghi S,Gauthier-Lamer AC,Boye SM

更新日期：2012-11-01 00:00:00

abstract：:Dopamine (DA) is a major catecholamine neurotransmitter in the mammalian brain that controls neural circuits involved in the cognitive, emotional, and motor aspects of goal-directed behavior. Accordingly, perturbations in DA neurotransmission play a central role in several neuropsychiatric disorders. Somewhat surprisi...

journal_title：Neuropharmacology

authors： Covey DP,Mateo Y,Sulzer D,Cheer JF,Lovinger DM

更新日期：2017-09-15 00:00:00

abstract：:The group II metabotropic glutamate (mGlu) receptors comprised of the mGlu2 and mGlu3 receptor subtypes have gained recognition in recent years as potential targets for psychiatric disorders, including anxiety and schizophrenia. In addition to studies already indicating which subtype mediates the anxiolytic and anti-p...

journal_title：Neuropharmacology

authors： Sanger H,Hanna L,Colvin EM,Grubisha O,Ursu D,Heinz BA,Findlay JD,Vivier RG,Sher E,Lodge D,Monn JA,Broad LM

更新日期：2013-03-01 00:00:00

abstract：:Imaging studies of serotonin transporter binding or tryptophan retention in autistic patients suggest that the brain serotonin system is decreased. However, treatment with drugs which increase serotonin (5-HT) levels, specific serotonin reuptake inhibitors (SSRIs), commonly produce a worsening of the symptoms. In this...

journal_title：Neuropharmacology

authors： Azmitia EC,Singh JS,Whitaker-Azmitia PM

更新日期：2011-06-01 00:00:00

abstract：:Opiates addiction is characterized by its long-term persistence. In order to study the enduring changes in long-term memory in hippocampus, a pivotal region for this process, we used suppression subtractive hybridization to compare hippocampal gene expression in morphine and saline-treated rats. Animals were subjected...

journal_title：Neuropharmacology

authors： Marie-Claire C,Courtin C,Robert A,Gidrol X,Roques BP,Noble F

更新日期：2007-02-01 00:00:00

abstract：:It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast howe...

journal_title：Neuropharmacology

authors： Massey PV,Warburton EC,Wynick D,Brown MW,Bashir ZI

更新日期：2003-01-01 00:00:00

abstract：:Propofol has been shown to attenuate brain injury in experimental ischemia models, but few studies have focused on the direct effect of propofol on mitochondrial dysfunction. In this study, we observed the effects of propofol on multiple aspects of mitochondrial dysfunction by studying the mitochondria isolated from r...

journal_title：Neuropharmacology

authors： Li J,Yu W,Li XT,Qi SH,Li B

更新日期：2014-02-01 00:00:00

abstract：:To assess a possible role for phospholipase D (PLD) in PC12 cell signal transduction and differentiation, we have investigated the expression of PLD in PC12 cells and found that the differentiation factor, nerve growth factor (NGF) increased PLD1 protein expression and phorbol 12-myristate 13 acetate (PMA)-induced PLD...

journal_title：Neuropharmacology

authors： Min DS,Ahn BH,Rhie DJ,Yoon SH,Hahn SJ,Kim MS,Jo YH

更新日期：2001-09-01 00:00:00

abstract：:A new mGluR antagonist, MAP4 (the alpha-methyl derivative of L-AP4), was found to antagonize the synaptic depressant actions of L-AP4 at the lateral perforant path synapse, in rat hippocampal slices. ...

journal_title：Neuropharmacology

authors： Bushell TJ,Jane DE,Tse HW,Watkins JC,Davies CH,Garthwaite J,Collingridge GL

更新日期：1995-02-01 00:00:00

abstract：:The subtype-selectivity of racemic [(3)H]CP-101,606, a novel high-affinity NMDA receptor radioligand was determined using defined recombinant NMDA receptor subunits expressed in HEK 293 cells. [(3)H]CP-101,606 binds to adult rodent forebrain and NR1/NR2B receptors expressed in HEK 293 cells with K(D)=4.2 nM and 6.0 nM...

journal_title：Neuropharmacology

authors： Chazot PL,Lawrence S,Thompson CL

更新日期：2002-03-01 00:00:00

abstract：:The present study investigated the metabolism of serotonin (5-HT) in rats made hypertensive by treatment with DOCA/NaCl. 5-Hydroxytryptamine and its major metabolite, 5-hydroxyindoleacetic acid (5-HIAA) were significantly elevated in a number of regions of the brain in rats treated for 2 weeks with DOCA/NaCl. Elevatio...

journal_title：Neuropharmacology

authors： Dawson R Jr,Nagamhama S,Oparil S

更新日期：1988-04-01 00:00:00

abstract：:We have previously shown that animals acquired robust conditioned place preference (CPP) to either social interaction alone or cocaine alone. Recently it has been reported that drugs of abuse abnormally activated p38, a member of mitogen-activated protein kinase family, in the nucleus accumbens. In this study, we aime...

journal_title：Neuropharmacology

authors： Salti A,Kummer KK,Sadangi C,Dechant G,Saria A,El Rawas R

更新日期：2015-12-01 00:00:00

abstract：:Owing to a broad spectrum of functions performed by neuropeptides, this class of signaling molecules attracts an increasing interest. One of the key steps in the regulation of biological activity of neuropeptides is proteolytic conversion or degradation by proteinases that change or terminate biological activity of na...

journal_title：Neuropharmacology

authors： Hartman K,Mielczarek P,Smoluch M,Silberring J

更新日期：2020-09-15 00:00:00

abstract：:Several studies on humans and mice support oxytocin's role in improving social behaviour, but its use in pharmacotherapy presents some important limiting factors. To date, it is emerging a pharmacological potential for melanocortin 4 receptor (MC4R) agonism in social deficits treatment. Recently, we demonstrated that ...

journal_title：Neuropharmacology

authors： Mastinu A,Premoli M,Maccarinelli G,Grilli M,Memo M,Bonini SA

更新日期：2018-05-01 00:00:00

abstract：:Antidepressants up-regulate the cAMP response element binding protein (CREB) and the brain-derived neurotrophic factor (BDNF) in hippocampus and these effects contribute to the protection of hippocampal neurons from stressful stimuli such as high glucocorticoid levels. CREB can be activated by both protein kinase A an...

journal_title：Neuropharmacology

authors： Vinet J,Carra S,Blom JM,Brunello N,Barden N,Tascedda F

更新日期：2004-12-01 00:00:00

abstract：:Electrophysiological studies suggest that 5-HT autoreceptor desensitization may be responsible for the delayed clinical efficacy of some antidepressant drugs, such as selective 5-HT reuptake inhibitors (SSRI) and certain MAO inhibitors (MAOI). In the present study we have used in vivo microdialysis to test this hypoth...

journal_title：Neuropharmacology

authors： Hjorth S,Auerbach SB

更新日期：1994-03-01 00:00:00

abstract：:Due to the claim that lithium (Li+) reduces morphine self-administration in dependent rats, the effects of acute and chronic Li+ treatments on naloxone-precipitated withdrawal syndrome and physical dependence development to morphine in mice chronically treated with morphine, were evaluated. Morphine dependency was ind...

journal_title：Neuropharmacology

authors： Dehpour AR,Farsam H,Azizabadi-Farahani M

更新日期：1995-01-01 00:00:00

abstract：:Nimodipine is a 1,4-dihydropyridine (DHP) calcium channel blocker which is used in the treatment of neurological deficits associated with subarachnoid hemorrhage. Small angle x-ray diffraction, differential scanning calorimetry, and equilibrium and kinetic binding techniques were used to study the interaction of nimod...

journal_title：Neuropharmacology

authors： Herbette LG,Mason PE,Sweeney KR,Trumbore MW,Mason RP

更新日期：1994-02-01 00:00:00

abstract：:Clinical studies have reported that the nicotinic receptor agonist varenicline improves balance and coordination in patients with several types of ataxia, but confirmation in an animal model has not been demonstrated. This study investigated whether varenicline and nicotine could attenuate the ataxia induced in rats f...

journal_title：Neuropharmacology

authors： Wecker L,Engberg ME,Philpot RM,Lambert CS,Kang CW,Antilla JC,Bickford PC,Hudson CE,Zesiewicz TA,Rowell PP

更新日期：2013-10-01 00:00:00

abstract：:Radioligand binding studies were performed in membranes of human cerebellum using [125I][Tyr3]octreotide also known as [125I]204-090, [125I]LTT-SRIF-28 ([Leu8, D-Trp22, 125I-Tyr25]SRIF-28) and [125I]CGP 23996 ([125I]c[Asu-Lys-Asn-Phe-Trp-Lys-Thr-Tyr-Thr-Ser]) to characterize the nature of cerebellar somatostatin recep...

journal_title：Neuropharmacology

authors： Piwko C,Thoss VS,Probst A,Hoyer D

更新日期：1996-06-01 00:00:00

abstract：:Animal models of inflammatory pain are characterized by the release of inflammatory mediators such as cytokines and neurotrophic factors, and enhanced analgesic sensitivity to opioids. In this study, we examine the mechanisms underlying this effect, in particular the roles of cholecystokinin (CCK) and nerve growth fac...

journal_title：Neuropharmacology

authors： Xanthos DN,Kumar N,Theodorsson E,Coderre TJ

更新日期：2009-03-01 00:00:00

abstract：:A micropipette-system was used to investigate intracranial self-injection of morphine in the rat. The system consisted of a glass micropipette (tip dia 5 microns) connected by flexible tubing and a swivel to a pressure source. Using nose-poking through a hole in one wall of the cage as the operant, rats self-injected ...

journal_title：Neuropharmacology

authors： Welzl H,Kuhn G,Huston JP

更新日期：1989-10-01 00:00:00

abstract：:Stimulation of cannabinoid CB1 receptors or inhibition of nitric oxide synthase (NOS) in the dorsolateral periaqueductal gray (dlPAG) decreases anxiety-like behavior. Moreover, activation of CB1 receptors attenuates flight responses induced by nitric oxide (NO) donors in the dlPAG, suggesting that endocannabinoids and...

journal_title：Neuropharmacology

authors： Lisboa SF,Magesto AC,Aguiar JC,Resstel LB,Guimarães FS

更新日期：2013-12-01 00:00:00

abstract：:Maternal sleep deprivation (MSD) has been suggested to be associated with increased frequency of neurodevelopmental disorders in offspring in both humans and animal models. However, the underlying cellular and molecular mechanism is still unclear. We have recently reported that MSD at different stages of pregnancy imp...

journal_title：Neuropharmacology

authors： Yu Y,Huang Z,Dai C,Du Y,Han H,Wang YT,Dong Z

更新日期：2018-05-01 00:00:00

abstract：:The stable transcription factor ΔFosB is induced in the nucleus accumbens (NAc) by chronic exposure to several drugs of abuse, and transgenic expression of ΔFosB in the striatum enhances the rewarding properties of morphine and cocaine. However, the mechanistic basis for these observations is incompletely understood. ...

journal_title：Neuropharmacology

authors： Sim-Selley LJ,Cassidy MP,Sparta A,Zachariou V,Nestler EJ,Selley DE

更新日期：2011-12-01 00:00:00

abstract：:A condition of excess activity in the hippocampal formation is observed in the aging brain and in conditions that confer additional risk during aging for Alzheimer's disease. Compounds that act as positive allosteric modulators at GABA(A) α5 receptors might be useful in targeting this condition because GABA(A) α5 rece...

journal_title：Neuropharmacology

authors： Koh MT,Rosenzweig-Lipson S,Gallagher M

更新日期：2013-01-01 00:00:00