Multiple 5-HT(1) autoreceptor subtypes govern serotonin release in dorsal and median raphé nuclei.

abstract：:Clinically effective antidepressants are thought to exert their therapeutic effects by facilitating central monoamine neurotransmission. However, recent data showing that neurokinin-1 receptor (NK1R) antagonists have antidepressant properties in both animal and clinical studies raise the possibility that classical ant...

journal_title：Neuropharmacology

authors： Sartori SB,Burnet PWJ,Sharp T,Singewald N

更新日期：2004-06-01 00:00:00

abstract：:In the present studies, an attempt was made to elucidate the role of endogenous opioid inputs to the depressor region of the caudal ventrolateral medulla in the tonic regulation of arterial pressure and to examine the subtype(s) of receptor underlying any observed effects by use of receptor-specific antagonists. The d...

journal_title：Neuropharmacology

authors： Drolet G,Morilak DA,Chalmers J

更新日期：1991-04-01 00:00:00

abstract：:Pediatric traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality in children. Experimental and clinical studies demonstrate that the developmental age, the type of injury (diffuse vs. focal) and sex may play important roles in the response of the developing brain to a traumatic injur...

journal_title：Neuropharmacology

authors： Huh JW,Raghupathi R

更新日期：2019-02-01 00:00:00

abstract：:This paper evaluates the involvement of hippocampal ATP-sensitive potassium channels (K(ATP)) in learning and memory. After confirming expression of the Kir6.2 subunit in the CA3 region of C57BL/6J mice, we performed intra-hippocampal pharmacological injections of specific openers and blockers of K(ATP) channels. The ...

journal_title：Neuropharmacology

authors： Betourne A,Bertholet AM,Labroue E,Halley H,Sun HS,Lorsignol A,Feng ZP,French RJ,Penicaud L,Lassalle JM,Frances B

更新日期：2009-03-01 00:00:00

abstract：:Seldom does a single individual have such a profound effect on the development of a scientific discipline as Erminio Costa had on neuropharmacology. During nearly sixty years of research, Costa and his collaborators helped established many of the basic principles of the pharmacodynamic actions of psychotherapeutics. H...

journal_title：Neuropharmacology

authors： Enna SJ

更新日期：2011-06-01 00:00:00

abstract：:Receptor-mediated signal transduction is thought to play an important role in neuronal differentiation and the modification of synaptic connections during brain development. The intracellular signalling molecule phospholipase C-beta1 (PLC-beta1), which is activated via specific neurotransmitter receptors, has recently...

journal_title：Neuropharmacology

authors： Hannan AJ,Kind PC,Blakemore C

更新日期：1998-04-01 00:00:00

abstract：:The metabotropic glutamate receptor 2 (mGlu2) plays an important role in the presynaptic control of glutamate release and several mGlu2 positive allosteric modulators (PAMs) have been under assessment for their potential as antipsychotics. The binding mode of mGlu2 PAMs is better characterized in functional terms whil...

journal_title：Neuropharmacology

authors： Lundström L,Bissantz C,Beck J,Dellenbach M,Woltering TJ,Wichmann J,Gatti S

更新日期：2017-03-15 00:00:00

abstract：:Cannabidiol (CBD), a non-euphorigenic compound derived from Cannabis, shows promise for improving recovery following cerebral ischemia and has recently been shown effective for the treatment of childhood seizures caused by Dravet and Lennox-Gastaut syndromes. Given evidence for activity to mitigate effects of CNS insu...

journal_title：Neuropharmacology

authors： Alalawi A,Dodu JC,Woolley-Roberts M,Brodie J,Di Marzo V,Soderstrom K

更新日期：2019-11-01 00:00:00

abstract：:Glutamic acid is the major excitatory amino acid of the central nervous system which interacts with two receptor families, the ionotropic and metabotropic glutamate receptors. The metabotropic glutamate receptors (mGluRs) are coupled to G proteins and can be divided into three subgroups based on their sequence homolog...

journal_title：Neuropharmacology

authors： Emile L,Mercken L,Apiou F,Pradier L,Bock MD,Menager J,Clot J,Doble A,Blanchard JC

更新日期：1996-05-01 00:00:00

abstract：:Tobacco use is prevalent in the adolescent population. It is a major concern because tobacco is highly addictive and has also been linked to illicit drug use. There is not much research, however, on the interaction between nicotine and other stimulant drugs in animal models of early adolescence. This study examined th...

journal_title：Neuropharmacology

authors： Collins SL,Izenwasser S

更新日期：2004-03-01 00:00:00

abstract：:Methamphetamine toxicity is associated with cell death and loss of dopamine neuron terminals in the striatum similar to what is found in some neurodegenerative diseases. Conversely, the endocannabinoid system (ECS) has been suggested to be neuroprotective in the brain, and new pharmacological tools have been developed...

journal_title：Neuropharmacology

authors： Nader J,Rapino C,Gennequin B,Chavant F,Francheteau M,Makriyannis A,Duranti A,Maccarrone M,Solinas M,Thiriet N

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:After neonatal ventral hippocampal lesions (NVHLs), adult rats exhibit evidence of neural processing deficits relevant to schizophrenia, including reduced prepulse inhibition (PPI) of acoustic startle and impaired sensory processing. In intact rats, the regulation of PPI by the ventral hippocampus (VH) is me...

journal_title：Neuropharmacology

authors： Swerdlow NR,Powell SB,Breier MR,Hines SR,Light GA

更新日期：2013-12-01 00:00:00

abstract：:γ-Aminobutyric acid type A receptors that contain the δ subunit (δGABAA receptors) are expressed in multiple types of neurons throughout the central nervous system, where they generate a tonic conductance that shapes neuronal excitability and synaptic plasticity. These receptors regulate a variety of important behavio...

journal_title：Neuropharmacology

authors： Whissell PD,Lecker I,Wang DS,Yu J,Orser BA

更新日期：2015-01-01 00:00:00

abstract：:Methylazoxymethanol (MAM)-treated pregnant rat at gestation day (GD) 17 has been shown to be a valuable developmental animal model for schizophrenia. Yet, this model remains to be established in mice. In the present study, we examined behavioral, cytoarchitectural, and neurochemical changes in the offspring of MAM-tre...

journal_title：Neuropharmacology

authors： Takahashi K,Nakagawasai O,Sakuma W,Nemoto W,Odaira T,Lin JR,Onogi H,Srivastava LK,Tan-No K

更新日期：2019-05-15 00:00:00

abstract：:Stimulation of cannabinoid CB1 receptors or inhibition of nitric oxide synthase (NOS) in the dorsolateral periaqueductal gray (dlPAG) decreases anxiety-like behavior. Moreover, activation of CB1 receptors attenuates flight responses induced by nitric oxide (NO) donors in the dlPAG, suggesting that endocannabinoids and...

journal_title：Neuropharmacology

authors： Lisboa SF,Magesto AC,Aguiar JC,Resstel LB,Guimarães FS

更新日期：2013-12-01 00:00:00

abstract：:Animal models of alcohol drinking and dependence are a critical resource for understanding the neurobiological mechanisms and development of more effective treatments for alcohol use disorder (AUD). Because most rat strains do not voluntarily consume large enough quantities of alcohol to adequately model heavy drinkin...

journal_title：Neuropharmacology

authors： Glover EJ,Khan F,Clayton-Stiglbauer K,Chandler LJ

更新日期：2021-02-15 00:00:00

abstract：:Schizophrenia is associated with increased oxidative stress, although the source of this redox disequilibrium requires further study. Altered tryptophan metabolism has been described in schizophrenia, possibly linked to inflammation and glutamate-directed excitotoxicity. Social isolation rearing (SIR) in rats induces ...

journal_title：Neuropharmacology

authors： Möller M,Du Preez JL,Emsley R,Harvey BH

更新日期：2012-06-01 00:00:00

abstract：:Valid animal models of psychopathology need to include behavioural readouts informed by human findings. In the probabilistic reversal learning (PRL) task, human subjects are confronted with serial reversal of the contingency between two operant stimuli and reward/punishment and, superimposed on this, a low probability...

journal_title：Neuropharmacology

authors： Ineichen C,Sigrist H,Spinelli S,Lesch KP,Sautter E,Seifritz E,Pryce CR

更新日期：2012-11-01 00:00:00

abstract：:Changes in astroglial volume were studied after incubating primary cultures from the cerebral cortex of newborn rats for 5 hr in taurine, glutamate or gamma-aminobutyric acid (GABA), alone or together with monoamine receptor agonists. Control cell volume was 2.2 microliters/mg protein. In the presence of taurine or gl...

journal_title：Neuropharmacology

authors： Hansson E,Rönnbäck L

更新日期：1992-01-01 00:00:00

abstract：:The effects of the novel antidepressant tianeptine on behaviours induced by the serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) and the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) were investigated. Tianeptine (10 mg/kg, i.p.) significantly attenuated wet dog shakes (WDS) induced by 5-HTP...

journal_title：Neuropharmacology

authors： Datla KP,Curzon G

更新日期：1993-09-01 00:00:00

abstract：:Histidine injected intraperitoneally into rats in doses from 400 to 800 mg/kg induced a dose-dependent bizarre behaviour. The behaviour after histidine was similar to that observed after L-DOPA and peripheral decarboxylase inhibition. The bizarre behaviour was antagonized by chloropyramine, ketotifen, clemastine and p...

journal_title：Neuropharmacology

authors： Pilc A,Rogóz Z,Skuza G

更新日期：1982-08-01 00:00:00

abstract：:N-Ethyl-maleimide (NEM, 2.5 x 10(-5) M) inhibited the compound action potential of the phrenic nerve and increased the spontaneous release of transmitter from the nerve terminals, recorded as miniature endplate potentials. The first effect was the cause of a blockade of the phrenic nerve diaphragm preparation, during ...

journal_title：Neuropharmacology

authors： Røed A

更新日期：1989-08-01 00:00:00

abstract：:The effects of Substance P (SP) and of a specific nonpeptide antagonist of the NK1 receptor (RP 67580) on preovulatory gonadotropin surges and on the in vitro GnRH induced LH surge were investigated in cycling female rats. A subcutaneous injection of SP (0.5 mg/kg body weight) at 12.00 h on the proestrous day signific...

journal_title：Neuropharmacology

authors： Duval P,Lenoir V,Garret C,Kerdelhue B

更新日期：1996-01-01 00:00:00

abstract：:The preparation of an isolated hemisected spinal cord preparation, maintained in vitro, from mature (180-300 g body weight) rats is described. Sacral and coccygeal segments (S2-Co1) gave consistent ventral root reflexes (DR-VRP) from electrical stimulation of dorsal roots. The mean latency and amplitude of the fastest...

journal_title：Neuropharmacology

authors： Long SK,Evans RH,Cull L,Krijzer F,Bevan P

更新日期：1988-05-01 00:00:00

abstract：:Brain inosine and hypoxanthine were measured in mice at intervals following the intraperitoneal injection of pentylenetetrazol (PTZ), 100 mg/kg. These purines increased only after myoclonic jerks appeared and were maximal at the time of tonic hindlimb extension. Phenytoin and phenobarbital, which prevent tonic hindlim...

journal_title：Neuropharmacology

authors： Lewin E,Bleck V

更新日期：1983-05-01 00:00:00

abstract：:The tryptophan metabolite kynurenic acid (KYNA) is an endogenous antagonist of the α7 nicotinic acetylcholine receptor (α7nAChR) and, at higher concentrations, inhibits ionotropic glutamate receptors. Increases in KYNA levels are seen in brain and cerebrospinal fluid in individuals with schizophrenia (SZ) and may be c...

journal_title：Neuropharmacology

authors： Beggiato S,Tanganelli S,Fuxe K,Antonelli T,Schwarcz R,Ferraro L

更新日期：2014-07-01 00:00:00

abstract：:Cannabidiol (CBD), the main non-psychotomimetic component of marihuana, exhibits anxiolytic-like properties in many behavioural tests, although its potential for treating major depression has been poorly explored. Moreover, the mechanism of action of CBD remains unclear. Herein, we have evaluated the effects of CBD fo...

journal_title：Neuropharmacology

authors： Linge R,Jiménez-Sánchez L,Campa L,Pilar-Cuéllar F,Vidal R,Pazos A,Adell A,Díaz Á

更新日期：2016-04-01 00:00:00

abstract：:There is considerable interest in histamine H3 receptors as emerging pharmaceutical targets recently. Diabetic rats display increased pain responses following the injection of formalin into the paw suggesting the presence of hyperalgesia. In this study, the efficacy of systemic administration of selective H3 receptor ...

journal_title：Neuropharmacology

authors： Hasanein P

更新日期：2011-05-01 00:00:00

abstract：:The homotrimeric P2X3 receptor, one of the seven members of the ATP-gated P2X receptor family, plays a crucial role in sensory neurotransmission. P2X3 receptor antagonists have been identified as promising drugs to treat chronic cough and are suggested to offer pain relief in chronic pain such as neuropathic pain. Her...

journal_title：Neuropharmacology

authors： Obrecht AS,Urban N,Schaefer M,Röse A,Kless A,Meents JE,Lampert A,Abdelrahman A,Müller CE,Schmalzing G,Hausmann R

更新日期：2019-11-01 00:00:00

abstract：:Application of capsaicin (CAP), bradykinin (BK) or nicotine (NIC) to intraluminally perfused rat tracheas induced an increase in calcitonin gene-related peptide (CGRP) levels in the perfusates. Depletion of sensory afferent CGRP with systemic CAP pretreatment resulted in a significant reduction of CGRP release evoked ...

journal_title：Neuropharmacology

authors： Hua XY,Jinno S,Back SM,Tam EK,Yaksh TL

更新日期：1994-10-01 00:00:00