Histidine-induced bizarre behaviour in rats: the possible involvement of central cholinergic system.

abstract：:Orexin contributes to the expression of the cardiovascular and behavioural response of some forms of stress, including novelty stress. Thus, Almorexant, a dual receptor antagonist that blocks the two known orexin receptors, Ox1R and Ox2R, reduces these responses. However, it is not known if the reduction results from ...

journal_title：Neuropharmacology

authors： Beig MI,Dampney BW,Carrive P

更新日期：2015-02-01 00:00:00

abstract：:Mefloquine continues to be a key drug used for malaria chemoprophylaxis and treatment, despite reports of adverse events like depression and anxiety. It is unknown how mefloquine acts within the central nervous system to cause depression and anxiety or why some individuals are more vulnerable. We show that intraperito...

journal_title：Neuropharmacology

authors： Heshmati M,Golden SA,Pfau ML,Christoffel DJ,Seeley EL,Cahill ME,Khibnik LA,Russo SJ

更新日期：2016-02-01 00:00:00

abstract：:Time-effects of morphine, methadone, meperidine and pentazocine upon locomotor activity were investigated in naive and in post-dependent rats. Dependence was induced by daily injection of 20 mg/kg (i.p.) of morphine for 30 days. Tests were run starting from 1 month after withdrawal from morphine. Morphine produced a g...

journal_title：Neuropharmacology

authors： Bartoletti M,Gaiardi M,Gubellini C,Bacchi A,Babbini M

更新日期：1985-09-01 00:00:00

abstract：:The effect of injection of inhibitors of GABA-transaminase into the nucleus tractus solitarius (NTS) on arterial pressure was examined in anesthetized rats. Two typical GABA-transaminase inhibitors, gamma-vinylGABA (GVG) and aminooxyacetic acid (AOAA), increased arterial pressure when injected into the NTS, a response...

journal_title：Neuropharmacology

authors： Tsukamoto K,Sved AF

更新日期：1993-06-01 00:00:00

abstract：:Alpidem is a new anxiolytic of imidazopyridine structure which has a high affinity for the omega 1 (BZ1) modulatory site of the GABAA receptor. The present study investigated whether tolerance and physical dependence develop after repeated treatment with alpidem, as is observed with benzodiazepines. Mice were given al...

journal_title：Neuropharmacology

authors： Perrault G,Morel E,Sanger DJ,Zivkovic B

更新日期：1993-09-01 00:00:00

abstract：:Nicotine stimulates the secretion of catecholamines from sympathetic nerve endings and adrenal medulla by acting on peripheral nicotinic cholinergic receptors. Nicotine is also a potent stimulant in the central nervous system but the significance of nicotinic receptors in brain in mediating cardiovascular and sympatho...

journal_title：Neuropharmacology

authors： Kiritsy-Roy JA,Mousa SA,Appel NM,Van Loon GR

更新日期：1990-06-01 00:00:00

abstract：:The effects of prostaglandin (PG) E(1) on NO neurotoxicity were examined using rat cultured spinal neurons. Rat cultured spinal neurons exposed to the NO donor, 2,2'-(hydroxynitrosohydrazono) bis-ethanamine (NOC18), showed neurotoxic effects that were accompanied by apoptotic nuclear change, free radical generation, a...

journal_title：Neuropharmacology

authors： Kikuchi S,Shinpo K,Niino M,Tsuji S,Iwabuchi K,Onoé K,Tashiro K

更新日期：2002-04-01 00:00:00

abstract：:Antipsychotic drug treatment increases neurotensin (NT) neurotransmission, and the exogenous administration of NT produces antipsychotic-like effects in rodents. In order to investigate whether "endogenous" NT may act as a natural occurring antipsychotic or may mediate antipsychotic drug activity, the effects of the s...

journal_title：Neuropharmacology

authors： Casti P,Marchese G,Casu G,Ruiu S,Pani L

更新日期：2004-07-01 00:00:00

abstract：:We used rats with a sciatic nerve chronic constrictive injury (CCI) and combined behavioural, molecular and morphological approaches to assess the involvement of mGlu5 receptors in neuropathic pain-associated hyperalgesia and spinal cord neuron apoptosis. Mechanical and thermal hyperalgesia developed 2-3 days after su...

journal_title：Neuropharmacology

authors： de Novellis V,Siniscalco D,Galderisi U,Fuccio C,Nolano M,Santoro L,Cascino A,Roth KA,Rossi F,Maione S

更新日期：2004-03-01 00:00:00

abstract：:In nonhuman primates, anxiety levels are typically assessed by observing social hierarchies or behavior in an intruder task. As measures of anxiety might influence performance on a particular cognitive task, it is important to analyze these measures in the same room as used for the cognitive task. As we use a playroom...

journal_title：Neuropharmacology

authors： Haley GE,McGuire A,Berteau-Pavy D,Weiss A,Patel R,Messaoudi I,Urbanski HF,Raber J

更新日期：2012-01-01 00:00:00

abstract：:Substance P, administered intrathecally in the lumbar area of paraplegic rats activated the electromyogram (EMG) of the hindlimbs. This effect was markedly enhanced by previous denervation by 5,7-dihydroxytryptamine. Stimulation of the motoneurons by substance P was followed by a blunted response to the excitatory sub...

journal_title：Neuropharmacology

authors： Tremblay LE,Maheux R,Bédard PJ

更新日期：1986-04-01 00:00:00

abstract：:The alpha7 and alpha4beta2 nicotinic acetylcholine receptor (nAchR) subtypes have been shown to be involved in memory. It is also known that losses of frontal cortical nAchRs are correlated to declining memory function in Alzheimer's disease, but the subtype-specific role of frontal cortical nAchRs in memory has not b...

journal_title：Neuropharmacology

authors： Chan WK,Wong PT,Sheu FS

更新日期：2007-06-01 00:00:00

abstract：:Seldom does a single individual have such a profound effect on the development of a scientific discipline as Erminio Costa had on neuropharmacology. During nearly sixty years of research, Costa and his collaborators helped established many of the basic principles of the pharmacodynamic actions of psychotherapeutics. H...

journal_title：Neuropharmacology

authors： Enna SJ

更新日期：2011-06-01 00:00:00

abstract：:Nitronyl nitroxides (NN) effectively decompose free radicals (. As brain endothelium, forming the blood-brain barrier (BBB), is both the main source and the target of reactive species during cerebral oxidative stress, we studied the effect of NN on brain endothelial cells injured by the mediator of oxidative stress H(...

journal_title：Neuropharmacology

authors： Blasig IE,Mertsch K,Haseloff RF

更新日期：2002-11-01 00:00:00

abstract：:Previous research shows Ouabain (OUA) to bind Na, K-ATPase, thereby triggering a number of signaling pathways, including the transcription factors NFᴋB and CREB. These transcription factors play a key role in the regulation of BDNF and WNT-β-catenin signaling cascades, which are involved in neuroprotection and memory ...

journal_title：Neuropharmacology

authors： Orellana AM,Leite JA,Kinoshita PF,Vasconcelos AR,Andreotti DZ,de Sá Lima L,Xavier GF,Kawamoto EM,Scavone C

更新日期：2018-09-15 00:00:00

abstract：:This review will provide an overview of the non-drug based approaches that have been demonstrated to enhance cognitive function of the compromised brain, primarily focussed on the two most widely adopted paradigms of environmental enrichment and enhanced physical exercise. Environmental enrichment involves the generat...

journal_title：Neuropharmacology

authors： Pang TY,Hannan AJ

更新日期：2013-01-01 00:00:00

abstract：:Depolarizations provoked by acetylcholine (ACh) and three dicholines, succinylcholine (SCh), glutarylcholine (GCh) and azelainylcholine (AzCh) were measured in normal and 3-7 days denervated muscles of adult, and in normal muscles of 0-27 days old mice and rats. Soleus and flexor digitorum superficialis muscles were m...

journal_title：Neuropharmacology

authors： Lorković H

更新日期：1989-04-01 00:00:00

abstract：:The risk of Alzheimer's disease (AD) is higher in patients with type 2 diabetes mellitus (T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain insulin resistance in these animals leads to the accumulation of amyloid beta (Aβ) and the reduction in GSK-3β phosphorylation, which promote...

journal_title：Neuropharmacology

authors： Kang S,Kim CH,Jung H,Kim E,Song HT,Lee JE

更新日期：2017-02-01 00:00:00

abstract：:BMS-763534 is a potent (CRF(1) IC(50) = 0.4 nM) and selective (>1000-fold selectivity vs. all other sites tested) CRF(1) receptor antagonist (pA2 = 9.47 vs. CRF(1)-mediated cAMP production in Y79 cells). BMS-763534 accelerated the dissociation of (125)I-o-CRF from rat frontal cortex membrane CRF(1) receptors consisten...

journal_title：Neuropharmacology

authors： Lodge NJ,Lelas S,Li YW,Molski T,Grace J,Sivarao DV,Post-Munson D,Healy F,Bronson JJ,Hartz R,Macor JE,Zaczek R

更新日期：2013-04-01 00:00:00

abstract：:Spinal metabotropic serotonin receptors encode transient experiences into long-lasting changes in motor behavior (i.e. motor plasticity). While interactions between serotonin receptor subtypes are known to regulate plasticity, the significance of molecular divergence in downstream G protein coupled receptor signaling ...

journal_title：Neuropharmacology

authors： Fields DP,Mitchell GS

更新日期：2017-02-01 00:00:00

abstract：:Alcohol damages the developing brain and can lead to fetal alcohol syndrome. One of alcohol's most important neuropathologic effects is neuronal death. As neurons mature, they become less vulnerable to alcohol-induced death because they acquire a protective signaling pathway, mediated by nitric oxide (NO). This pathwa...

journal_title：Neuropharmacology

authors： Bonthius DJ,Luong T,Bonthius NE,Hostager BS,Karacay B

更新日期：2009-03-01 00:00:00

abstract：:The voltage-dependent calcium channels (VDCCs) involved in K(+)-induced transmitter release have been studied. A maximally effective concentration of the N-type VDCC inhibitor, omega-conotoxin GVIA (GVIA) blocked the release of 5-HT (30%), DA (30%) and ACh (60%) but not that of GABA or glutamate. The O, P and Q-type V...

journal_title：Neuropharmacology

authors： Harvey J,Wedley S,Findlay JD,Sidell MR,Pullar IA

更新日期：1996-04-01 00:00:00

abstract：:Mechanisms underlying the neuroprotective properties of the weak MAO-A inhibitor moclobemide are not understood. Increasing evidence suggests that a moderate increase in intracellular free protons may contribute to neuroprotective properties due to a proton-mediated decrease in neuronal activity. Therefore, we studied...

journal_title：Neuropharmacology

authors： Bonnet U,Leniger T,Wiemann M

更新日期：2000-08-23 00:00:00

abstract：:Peptides derived from prodynorphin, dynorphin A and B, (Leu)-enkephalin and (Leu)enkephalyl-Arg, as well as substance P, were measured in substantia nigra, striatum and globus pallidus, after subacute (5 doses at 6 hr intervals) treatment of rats with a number of dopamine receptor agonists and antagonists. Drugs selec...

journal_title：Neuropharmacology

authors： Nylander I,Terenius LH

更新日期：1987-09-01 00:00:00

abstract：:Muscarinic acetylcholine receptors (mAChRs) are G proteincoupled receptors (GPCRs) that mediate the metabotropic actions of acetylcholine (ACh). There are five subtypes of mAChR, M1 - M5, which are expressed throughout the central nervous system (CNS) on numerous cell types and represent promising treatment targets fo...

journal_title：Neuropharmacology

authors： Lebois EP,Thorn C,Edgerton JR,Popiolek M,Xi S

更新日期：2018-07-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in the nervous system and are implicated in many normal and pathological processes. The structural determinants of allostery in nAChRs are not well understood. One class of nAChR allosteric modulators, including the small molecule morantel (Mor...

journal_title：Neuropharmacology

authors： Short CA,Cao AT,Wingfield MA,Doers ME,Jobe EM,Wang N,Levandoski MM

更新日期：2015-04-01 00:00:00

abstract：:Tobacco addiction is highly co-morbid with a variety of mental health conditions, including schizophrenia, mood and anxiety disorders. Nicotine, the primary psychoactive compound in tobacco-related products is known to functionally modulate brain circuits that are disturbed in these disorders. Nicotine can potently re...

journal_title：Neuropharmacology

authors： Laviolette SR

更新日期：2021-02-15 00:00:00

abstract：:The demonstrated functional interaction of metabotropic glutamate 5 (mGlu₅) receptors with N-methyl-d-aspartate (NMDA) receptors has prompted speculation that their activation may offer a potential treatment for aspects of schizophrenia. Development of selective mGlu₅ agonists has been difficult, but several different...

journal_title：Neuropharmacology

authors： Gilmour G,Broad LM,Wafford KA,Britton T,Colvin EM,Fivush A,Gastambide F,Getman B,Heinz BA,McCarthy AP,Prieto L,Shanks E,Smith JW,Taboada L,Edgar DM,Tricklebank MD

更新日期：2013-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra, leading to motor symptoms. Despite the remarkable improvements in the management of PD in recent decades, many patients remain significantly disabled. Metformin is a primary me...

journal_title：Neuropharmacology

authors： Ryu YK,Go J,Park HY,Choi YK,Seo YJ,Choi JH,Rhee M,Lee TG,Lee CH,Kim KS

更新日期：2020-09-15 00:00:00

abstract：:Postictal refractoriness may be taken as an expression of lasting activity of inhibitory systems arresting seizures. We tested drugs interfering with GABAergic inhibitory system in pairs of cortical epileptic afterdischarges induced with 1-min interval in rats. Under control conditions the second stimulation failed to...

journal_title：Neuropharmacology

authors： Mareš P,Kubová H

更新日期：2015-01-01 00:00:00