Abstract：
:Nitronyl nitroxides (NN) effectively decompose free radicals (. As brain endothelium, forming the blood-brain barrier (BBB), is both the main source and the target of reactive species during cerebral oxidative stress, we studied the effect of NN on brain endothelial cells injured by the mediator of oxidative stress H(2)O(2) (. H(2)O(2) caused hydroxyl radical generation, lipid peroxidation, membrane dysfunction, membrane leak and cell death, concentration dependently. Due to 0.5 mM H(2)O(2), oxy-radical-induced membrane phospholipid peroxidation (malondialdehyde) increased to 0.61+/-0.04 nmol/mg protein vs control (0.32+/-0.03, p<0.05), cells lost cytosolic proteins into the medium and viability decreased to 28+/-2% of control (p<0.05). Permeability through the endothelial monolayer (measure for the tightness of the BBB) rose to 250+/-40% after 0.15 mM H(2)O(2) (p<0.001). Addition of 10 microM of the NN 5,5-dimethyl-2,4-diphenyl-4-methoxy-2-imidazoline-3-oxide-1-oxyl (NN-2), 1 mM phenylbutyl nitrone (PBN), or 10 microM of the lazaroid U83836E improved cell viability during incubation with 0.5 mM H(2)O(2) to 57+/-1%, 49+/-2%, and 42+/-3% (p<0.05, vs drug-free H(2)O(2) group). The permeability enhancement by 0.15 mM H(2)O(2) was reduced to 171+/-21%, 170+/-25%, and 118+/-32% (p<0.05 vs drug-free H(2)O(2) group). Generally, the assumption is supported that during cerebral oxidative stress the protection should also be directed to the cells of the BBB, which can be provided by antioxidative approaches. NN represent a new group of antioxdatively acting cytoprotectiva improving the survival and function of the endothelium against oxidative stress.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Blasig IE,Mertsch K,Haseloff RFdoi
10.1016/s0028-3908(02)00180-6subject
Has Abstractpub_date
2002-11-01 00:00:00pages
1006-14issue
6eissn
0028-3908issn
1873-7064pii
S0028390802001806journal_volume
43pub_type
杂志文章abstract：:Serotonin (5-HT)1A and σ1 receptors have been implicated in psychiatric disorders. We previously found that combined 5-HT reuptake inhibition and σ1 receptor activation has a synergistic effect on prefrontal dopaminergic transmission in adrenalectomized/castrated mice lacking circulating steroid hormones. In the prese...
journal_title：Neuropharmacology
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pub_type： 杂志文章,评审
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更新日期：2017-09-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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更新日期：2002-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-08-01 00:00:00
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更新日期：1994-02-01 00:00:00
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doi：10.1016/j.neuropharm.2018.12.013
更新日期：2019-04-01 00:00:00
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journal_title：Neuropharmacology
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pub_type： 杂志文章,评审
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更新日期：2018-07-15 00:00:00
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pub_type： 杂志文章
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更新日期：2003-04-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2012.04.005
更新日期：2012-09-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
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更新日期：2017-09-15 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2013-10-01 00:00:00
abstract：:Compound FLZ (cFLZ) is a synthetic novel derivative of natural squamosamide. Previous pharmacological study found that cFLZ improved the abnormal behavior and the decrease of dopamine content in striatum in 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) model mice. 1-Methyl 4-phenylpyridinium (MPP+) is the activ...
journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2006.08.020
更新日期：2007-02-01 00:00:00
