Hypothesis: cannabinoid therapy for the treatment of gliomas?

Abstract:

:Gliomas, in particular glioblastoma multiforme or grade IV astrocytoma, are the most frequent class of malignant primary brain tumours and one of the most aggressive forms of cancer. Current therapeutic strategies for the treatment of glioblastoma multiforme are usually ineffective or just palliative. During the last few years, several studies have shown that cannabinoids-the active components of the plant Cannabis sativa and their derivatives--slow the growth of different types of tumours, including gliomas, in laboratory animals. Cannabinoids induce apoptosis of glioma cells in culture via sustained ceramide accumulation, extracellular signal-regulated kinase activation and Akt inhibition. In addition, cannabinoid treatment inhibits angiogenesis of gliomas in vivo. Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death. These and other findings reviewed here might set the basis for a potential use of cannabinoids in the management of gliomas.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Velasco G,Galve-Roperh I,Sánchez C,Blázquez C,Guzmán M

doi

10.1016/j.neuropharm.2004.04.016

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

315-23

issue

3

eissn

0028-3908

issn

1873-7064

pii

S0028390804001182

journal_volume

47

pub_type

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