Abstract:
:Amyotrophic Lateral Sclerosis (ALS) mostly affects motor neurons, but non-motor neural and cognitive alterations have been reported in ALS mouse models and patients. Here, we evaluated if time-dependent biphasic changes in synaptic transmission and plasticity occur in hippocampal synapses of ALS SOD1G93A mice. Recordings were performed in hippocampal slices of SOD1G93A and age-matched WT mice, in the pre-symptomatic and symptomatic stages. We found an enhancement of pre-synaptic function and increased adenosine A2A receptor levels in the hippocampus of pre-symptomatic mice. In contrast, in symptomatic mice, there was an impairment of long-term potentiation (LTP) and a decrease in NMDA receptor-mediated synaptic currents, with A2AR levels also being increased. Chronic treatment with the A2AR antagonist KW-6002, rescued LTP and A2AR values. Altogether, these findings suggest an increase in synaptic function during the pre-symptomatic stage, followed by a decrease in synaptic plasticity in the symptomatic stage, which involves over-activation of A2AR from early disease stages.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Rei N,Rombo DM,Ferreira MF,Baqi Y,Müller CE,Ribeiro JA,Sebastião AM,Vaz SHdoi
10.1016/j.neuropharm.2020.108106subject
Has Abstractpub_date
2020-07-01 00:00:00pages
108106eissn
0028-3908issn
1873-7064pii
S0028-3908(20)30174-Xjournal_volume
171pub_type
杂志文章abstract::1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), or 0.9% saline, was administered to a group of common marmosets initially treated with the toxin 12-18 months previously. Initial treatment had consisted of a cumulative dose of 6-22 mg/kg (i.p.) which caused marked parkinsonism. Subsequently, the animals gradually ...
journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/0028-3908(89)90122-6
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/0028-3908(82)90105-8
更新日期:1982-10-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neuropharmacology
pub_type: 杂志文章
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journal_title:Neuropharmacology
pub_type: 杂志文章
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.neuropharm.2019.05.009
更新日期:2020-02-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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更新日期:2006-09-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.neuropharm.2008.06.035
更新日期:2008-11-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:1989-12-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.neuropharm.2017.03.028
更新日期:2017-08-01 00:00:00
abstract::Phylogenetic research can help to elucidate the structure of the GABA/benzodiazepine receptor complex. In this study the evolution of the beta-carboline binding site was traced to see whether it paralleled that of the benzodiazepine binding site. The ratio of [3H]ethyl-beta-carboline-3-carboxylate (beta-CCE) to [3H]fl...
journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:1988-02-01 00:00:00