Abstract:
:This work reports the effect of chemokine fractalkine/CX3CL1, an endogenous small peptide highly expressed in the central nervous system, on evoked synaptic responses investigated in mouse CA1 stratum radiatum using an electrophysiological approach. We report that in acute mouse hippocampal slices, superfusion of CX3CL1 resulted in a reversible depression of the field excitatory postsynaptic potential (fEPSP) which developed within few seconds, increased for up to 10 min of application and disappeared within 30 min after the end of CX3CL1 treatment. We also show that CX3CL1-induced synaptic depression is (i) dose-dependent with IC50 and nH values of 0.7 nM and 1, respectively, (ii) not associated with a change in paired-pulse facilitation, (iii) mediated through CX3CL1 receptor (CX3CR1), being absent in CX3CR1-/- mice and inhibited in wild-type mice by a specific blocking antibody, and (iv) occluded by the induction of homosynaptic long-term depression (LTD). We conclude that CX3CL1 is a potent neuromodulator of the evoked excitatory synaptic transmission, sharing common mechanisms with LTD.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Bertollini C,Ragozzino D,Gross C,Limatola C,Eusebi Fdoi
10.1016/j.neuropharm.2006.05.027subject
Has Abstractpub_date
2006-09-01 00:00:00pages
816-21issue
4eissn
0028-3908issn
1873-7064pii
S0028-3908(06)00158-4journal_volume
51pub_type
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