Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain.

abstract：:Amyotrophic Lateral Sclerosis (ALS) mostly affects motor neurons, but non-motor neural and cognitive alterations have been reported in ALS mouse models and patients. Here, we evaluated if time-dependent biphasic changes in synaptic transmission and plasticity occur in hippocampal synapses of ALS SOD1G93A mice. Recordi...

journal_title：Neuropharmacology

authors： Rei N,Rombo DM,Ferreira MF,Baqi Y,Müller CE,Ribeiro JA,Sebastião AM,Vaz SH

更新日期：2020-07-01 00:00:00

abstract：:G protein-coupled receptor 35 (GPR35) is an orphan G protein-coupled receptor (GPCR) that can be activated by kynurenic acid at high micromolar concentrations. A previously unappreciated mechanism of action of GPR35 has emerged as a Gαi/o-coupled inhibitor of synaptic transmission, a finding that has significant impli...

journal_title：Neuropharmacology

authors： Mackenzie AE,Milligan G

更新日期：2017-02-01 00:00:00

abstract：:The relevance and property of studies related to stress effects on immune function are undisputable. All studies conducted on stress-immune relationships, however, provide from physical and/or psychological stressors. Indeed, as far as it is of our knowledge brain-innate immune responses were not analyzed after anxiog...

journal_title：Neuropharmacology

authors： Stankevicius D,Rodrigues-Costa EC,Camilo Flório J,Palermo-Neto J

更新日期：2008-02-01 00:00:00

abstract：:The present study investigated the effects of WB4101, a selective alpha 1-adrenoceptor blocking agent, and idazoxan, a selective alpha 2-adrenoceptor blocking agent, on antinociception and sedation in the rat mediated by adrenoceptors. Selective alpha 1-adrenoceptor agonists, e.g. ST587 and methoxamine induced antinoc...

journal_title：Neuropharmacology

authors： Hayes AG,Skingle M,Tyers MB

更新日期：1986-04-01 00:00:00

abstract：:In this study, we analysed the implication of superoxide (O2-.) and nitric oxide (NO.) free radicals and their resulting product peroxynitrite (ONOO-) in the neuronal death induced by the activation of the glutamatergic receptor of the N-methyl-D-aspartate (NMDA) subtype using cultured cerebellar granule cells. The NO...

journal_title：Neuropharmacology

authors： Lafon-Cazal M,Culcasi M,Gaven F,Pietri S,Bockaert J

更新日期：1993-11-01 00:00:00

abstract：:The locomotor activity of female rats was recorded during 10-min sessions in a circular open-field apparatus after the administration of vehicle or drug. Dose-response curves were obtained for seven neuroleptic drugs both alone (spontaneous activity) and in combination with 1.0 mg/kg of d-amphetamine. Haloperidol, pim...

journal_title：Neuropharmacology

authors： Schaefer GJ,Michael RP

更新日期：1984-08-01 00:00:00

abstract：:The antagonist effects of the 4-carboxyphenylglycines: (S)-4-carboxy-3hydroxyphenylglycine (4C3HPG), (S)-4-carboxyphenylglycine (4CPG) and (+)-alpha-methyl-4-carboxyphenylglycine (M4CPG) were compared on functional responses of human metabotropic glutamate receptor (mGluR) subtypes mGluR1 alpha and mGluR5a. These rece...

journal_title：Neuropharmacology

authors： Kingston AE,Burnett JP,Mayne NG,Lodge D

更新日期：1995-08-01 00:00:00

abstract：:Midazolam, which induces anaesthesia in humans at intravenous doses of 0.3 mg/kg, did not anaesthetize cats at doses of 20 mg/kg. Nevertheless, intravenous doses as small as 0.3 mg/kg enhanced spinal primary afferent depolarization and presynaptic inhibition of spinal monosynaptic reflexes, and both intravenous and mi...

journal_title：Neuropharmacology

authors： Leah JD,Malik R,Curtis DR

更新日期：1983-12-01 00:00:00

abstract：:Prenatal exposure to the CB1 receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone) mesylate (WIN) at a daily dose of 0.5 mg/kg, and Delta9-tetrahydrocannabinol (Delta9-THC) at a daily dose of 5 mg/kg, reduced dialysate glutamate levels in ...

journal_title：Neuropharmacology

authors： Castaldo P,Magi S,Gaetani S,Cassano T,Ferraro L,Antonelli T,Amoroso S,Cuomo V

更新日期：2007-09-01 00:00:00

abstract：:The impairment of social behaviors induced by social defeat stress exposure as juveniles is resistant to some antidepressants and an antipsychotic, although the underlying mechanisms and/or therapeutic target are not yet clear. In this study, we investigated the involvement of the glutamatergic neuronal system in the ...

journal_title：Neuropharmacology

authors： Hasegawa S,Yoshimi A,Mouri A,Uchida Y,Hida H,Mishina M,Yamada K,Ozaki N,Nabeshima T,Noda Y

更新日期：2019-04-01 00:00:00

abstract：:The effects of Substance P (SP) and of a specific nonpeptide antagonist of the NK1 receptor (RP 67580) on preovulatory gonadotropin surges and on the in vitro GnRH induced LH surge were investigated in cycling female rats. A subcutaneous injection of SP (0.5 mg/kg body weight) at 12.00 h on the proestrous day signific...

journal_title：Neuropharmacology

authors： Duval P,Lenoir V,Garret C,Kerdelhue B

更新日期：1996-01-01 00:00:00

abstract：:Marijuana use in adolescence, but not adulthood, may permanently impair cognitive functioning and increase the risk of developing schizophrenia. Cortical oscillations are patterns of neural network activity implicated in cognitive processing, and are abnormal in patients with schizophrenia. We have recently reported t...

journal_title：Neuropharmacology

authors： Raver SM,Keller A

更新日期：2014-11-01 00:00:00

abstract：:5-HT(7) receptor mRNA and protein are localised in the dorsal raphe nucleus (DRN) on non-serotonergic neurones. The effect of 5-HT(7) receptor antagonism on 5-HT efflux was measured from guinea-pig DRN slices, using the technique of fast cyclic voltammetry. The 5-HT(7) receptor antagonist, SB-269970-A, significantly i...

journal_title：Neuropharmacology

authors： Roberts C,Thomas DR,Bate ST,Kew JN

更新日期：2004-06-01 00:00:00

abstract：:Protease activity correlates with depressive or suicidal behaviors, with calpain activation being especially implicated in depression-like behaviors. However, the role of calpain in depression-like behaviors is currently unknown. In this study, the lipopolysaccharide (LPS) - and chronic unpredictable mild stress (CUMS...

journal_title：Neuropharmacology

authors： Song Z,Shen F,Zhang Z,Wu S,Zhu G

更新日期：2020-09-01 00:00:00

abstract：:Chronic treatment with imipramine and reserpine increased fluoride-stimulated activity of adenylate cyclase in homogenates of cerebral cortex and "limbic" forebrain of the rat. Concomitant treatment with lithium counteracted this effect, while lithium alone had no effect on the activity of adenylate cyclase. ...

journal_title：Neuropharmacology

authors： Andersen PH,Klysner R,Geisler A

更新日期：1984-04-01 00:00:00

abstract：:The weaver defect results in a loss of baclofen- and adenosine-gated K+ conductance in the hippocampus of adult homozygous (wv/wv) mice. In addition, suppression of hippocampal epileptiform activity by baclofen is impaired (Jarolimek, W., Bäurle, J., Misgeld, U., 1998. Pore mutation in a G protein-gated inwardly recti...

journal_title：Neuropharmacology

authors： Jarolimek W,Bäurle J,Misgeld U

更新日期：2000-01-04 00:00:00

abstract：:Rivastigmine, a cholinesterase inhibitor, is successfully used for the symptomatic therapy of Alzheimer's disease (AD) in the clinic. The drug has a very low potential for drug-drug interactions, as has been demonstrated within large clinical trials. Memantine, recently approved by the FDA for the treatment of moderat...

journal_title：Neuropharmacology

authors： Enz A,Gentsch C

更新日期：2004-09-01 00:00:00

abstract：:A single oral administration of allylnitrile, crotononitrile or 2-pentenenitrile in rats induced behavioral abnormalities, such as head-twitching, head weaving, hindlimb abduction, backward pedaling and pivoting. The head-twitching, which was most consistently observed, was suppressed by serotonin (5-HT) antagonists, ...

journal_title：Neuropharmacology

authors： Tanii H,Hayashi M,Hashimoto K

更新日期：1991-08-01 00:00:00

abstract：:The binding of three, structurally distinct, 5-hydroxytryptamine3 (5-HT3) receptor radioligands was characterized in rat cerebral cortex, rabbit ileum myenteric plexus and NG-108-15 neuroblastoma cells. The density of sites labeled by the three ligands in rat cortex or in rabbit ileum was markedly different. [3H]Quipa...

journal_title：Neuropharmacology

authors： Wong EH,Bonhaus DW,Lee JA,Wu I,Loury DN,Eglen RM

更新日期：1993-09-01 00:00:00

abstract：:The modulatory effects exerted by the glucocorticoid hydrocortisone (HC) on the nicotinic acetylcholine receptor (AChR) were studied in mutants of the alpha subunit M4 transmembrane region. Based on the photoaffinity labeling of alpha M4 412 with the steroid promegestone this position was mutated to different residues...

journal_title：Neuropharmacology

authors： Garbus I,Roccamo AM,Barrantes FJ

更新日期：2002-07-01 00:00:00

abstract：:The risk of Alzheimer's disease (AD) is higher in patients with type 2 diabetes mellitus (T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain insulin resistance in these animals leads to the accumulation of amyloid beta (Aβ) and the reduction in GSK-3β phosphorylation, which promote...

journal_title：Neuropharmacology

authors： Kang S,Kim CH,Jung H,Kim E,Song HT,Lee JE

更新日期：2017-02-01 00:00:00

abstract：:There is strong evidence that blocking CB1 receptors may reduce alcohol intake in alcohol-dependent individuals. However, there is still limited evidence that CB1 receptor antagonists may also be beneficial in the attenuation of alcohol withdrawal syndrome, even though alcohol withdrawal appears to be milder in CB1 re...

journal_title：Neuropharmacology

authors： Rubio M,Fernández-Ruiz J,de Miguel R,Maestro B,Michael Walker J,Ramos JA

更新日期：2008-05-01 00:00:00

abstract：:As a preliminary to positron emission tomography (PET) studies of excitatory amino acid neurotransmission, N-methyl-D-aspartate (NMDA)-sensitive glutamate receptors of mice and rats were labelled in vivo with [3H]fluorothienylcyclohexylpiperidine [corrected] (FTCP), which binds to the phencyclidine site of the NMDA re...

journal_title：Neuropharmacology

authors： Ferrarese C,Guidotti A,Costa E,Miletich RS,Rice KC,de Costa BR,Fulham MJ,Di Chiro G

更新日期：1991-08-01 00:00:00

abstract：:Compound FLZ (cFLZ) is a synthetic novel derivative of natural squamosamide. Previous pharmacological study found that cFLZ improved the abnormal behavior and the decrease of dopamine content in striatum in 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) model mice. 1-Methyl 4-phenylpyridinium (MPP+) is the activ...

journal_title：Neuropharmacology

authors： Zhang D,Zhang JJ,Liu GT

更新日期：2007-02-01 00:00:00

abstract：:Intrauterine inflammation is a major risk for offspring neurodevelopmental brain damage and may result in cognitive limitations and poor cognitive and perceptual outcomes. Pro-inflammatory cytokines, stimulated during inflammatory response, have a pleotrophic effect on neurons and glia cells. They act in a dose-depend...

journal_title：Neuropharmacology

authors： Golan HM,Lev V,Hallak M,Sorokin Y,Huleihel M

更新日期：2005-05-01 00:00:00

abstract：:Sensory gating can be assessed in rodents and humans using an auditory conditioning (C)-test (T) paradigm, with schizophrenic patients exhibiting a loss of gating. Dysregulation of the endocannabinoid system has been proposed to be involved in the pathogenesis of schizophrenia. We studied auditory gating and the effec...

journal_title：Neuropharmacology

authors： Dissanayake DW,Zachariou M,Marsden CA,Mason R

更新日期：2008-12-01 00:00:00

abstract：:We investigated the role of nitric oxide (NO) in learning and memory formation in a radial maze test, by using the NO synthase (NOS) inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), and an NO precursor, L-arginine. Rats were trained on a working and reference memory task in an eight ar...

journal_title：Neuropharmacology

authors： Zou LB,Yamada K,Tanaka T,Kameyama T,Nabeshima T

更新日期：1998-01-01 00:00:00

abstract：:Here, we define a protophenotype as an endophenotype that has been conserved during evolution. Social feeding in Caenorhabditis elegans may be an example of a protophenotype related to asociality in schizophrenia. It is regulated by the highly conserved neuropeptide Y receptor, NPR-1, and we speculated that social fee...

journal_title：Neuropharmacology

authors： Dwyer DS,Awatramani P,Thakur R,Seeni R,Aamodt EJ

更新日期：2015-05-01 00:00:00

abstract：:Hippocampal volume reductions and functional impairments are reliable findings in posttraumatic stress disorder (PTSD) imaging studies. However, it is not clear if and how hippocampal dysfunction contributes to the etiology and maintenance of PTSD. Individuals with PTSD are often described as showing fear responses to...

journal_title：Neuropharmacology

authors： Acheson DT,Gresack JE,Risbrough VB

更新日期：2012-02-01 00:00:00

abstract：:The effect of U-50,488H, a selective kappa opioid receptor agonist on the intake of food in food-deprived and non-deprived spontaneously hypertensive and normotensive Wistar-Kyoto rats was determined. In food deprived Wistar-Kyoto rats, intraperitoneal administration of U-50,488H, produced a bell-shaped curve on the i...

journal_title：Neuropharmacology

authors： Bhargava HN,Ramarao P,Richter CM,Bieniarz AA

更新日期：1989-01-01 00:00:00