Antagonism of alpha-adrenoceptor agonist-induced antinociception in the rat.

abstract：:Urocortin 3 (Ucn3) is an anorexigenic neuropeptide with high affinity for the type 2 corticotropin-releasing factor receptor (CRF₂-R). How the expression of hypothalamic Ucn3 is regulated by fasting and refeeding in genetically obese (fa/fa) Zucker rats is not known. Obese Zucker rats develop early hyperphagia associa...

journal_title：Neuropharmacology

authors： Poulin AM,Lenglos C,Mitra A,Timofeeva E

更新日期：2012-07-01 00:00:00

abstract：:Amphetamine has been shown to either potentiate or protect against MPTP neurotoxicity. The time course of changes in dopamine and its metabolites was examined after MPTP, amphetamine, or MPTP plus amphetamine administration. Results suggest that under conditions of granular depletion and release of dopamine by 10 mg/k...

journal_title：Neuropharmacology

authors： Sershen H,Mason MF,Reith ME,Hashim A,Lajtha A

更新日期：1986-08-01 00:00:00

abstract：:In this study, the role of CB₂r on aversive memory consolidation was further evaluated. Mice lacking CB₂r (CB2KO) and their corresponding littermates (WT) were exposed to the step-down inhibitory avoidance test (SDIA). MAP2, NF200 and synaptophysin (SYN)-immunoreactive fibers were studied in the hippocampus (HIP) of b...

journal_title：Neuropharmacology

authors： García-Gutiérrez MS,Ortega-Álvaro A,Busquets-García A,Pérez-Ortiz JM,Caltana L,Ricatti MJ,Brusco A,Maldonado R,Manzanares J

更新日期：2013-10-01 00:00:00

abstract：:Behavioral sensitization, or augmented locomotor response to successive drug exposures, results from neuroadaptive changes contributing to addiction. Both the medial prefrontal cortex (mPFC) and ventral tegmental area (VTA) influence behavioral sensitization and display increased immediate-early gene and BDNF expressi...

journal_title：Neuropharmacology

authors： Fanous S,Lacagnina MJ,Nikulina EM,Hammer RP Jr

更新日期：2011-09-01 00:00:00

abstract：:Systemic treatment with cholecystokinin octapeptide (CCK-8, 2.5-10 micrograms/kg, s.c.), a non-selective CCK agonist, decreased the exploratory activity of mice in an elevated plus-maze. At higher doses (5-10 micrograms/kg) CCK-8 reduced the frequency of rearing, but only 10 micrograms/kg of CCK-8 significantly inhibi...

journal_title：Neuropharmacology

authors： Vasar E,Lang A,Harro J,Bourin M,Bradwejn J

更新日期：1994-06-01 00:00:00

abstract：:The role of monamine oxidase (MAO), type A and B, on the deamination of dopamine in the striatum, nucleus accumbens and frontal cortex of the rat was studied. Levels of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) tissue were quantified by means of high pressure liquid chromatography wi...

journal_title：Neuropharmacology

authors： Garrett MC,Soares-da-Silva P

更新日期：1990-10-01 00:00:00

abstract：:Protease activity correlates with depressive or suicidal behaviors, with calpain activation being especially implicated in depression-like behaviors. However, the role of calpain in depression-like behaviors is currently unknown. In this study, the lipopolysaccharide (LPS) - and chronic unpredictable mild stress (CUMS...

journal_title：Neuropharmacology

authors： Song Z,Shen F,Zhang Z,Wu S,Zhu G

更新日期：2020-09-01 00:00:00

abstract：:Despite evidence from psychiatry and psychology clinics pointing to altered cognition and decision making following the consumption of cannabis, the effects of cannabis derivatives are still under dispute and the mechanisms of cannabinoid effects on cognition are not known. In this study, we used effort-based and dela...

journal_title：Neuropharmacology

authors： Fatahi Z,Reisi Z,Rainer G,Haghparast A,Khani A

更新日期：2018-05-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), or 0.9% saline, was administered to a group of common marmosets initially treated with the toxin 12-18 months previously. Initial treatment had consisted of a cumulative dose of 6-22 mg/kg (i.p.) which caused marked parkinsonism. Subsequently, the animals gradually ...

journal_title：Neuropharmacology

authors： Ueki A,Chong PN,Albanese A,Rose S,Chivers JK,Jenner P,Marsden CD

更新日期：1989-10-01 00:00:00

abstract：:The GABAA receptor/chloride ionophore (GABAR) is allosterically modulated by several classes of anticonvulsant agents, including benzodiazepines and barbiturates, and some alkyl-substituted butyrolactones. To test the hypothesis that the anticonvulsant butyrolactones act at a distinct positive-modulatory site on the G...

journal_title：Neuropharmacology

authors： Mathews GC,Bolos-Sy AM,Covey DF,Rothman SM,Ferrendelli JA

更新日期：1996-02-01 00:00:00

abstract：:The sleeping time induced by thiopentone in rats was markedly prolonged by the (-)-isomer of propranolol while the (+)-isomer was virtually without effect. Since the two isomers are equipotent in their membrane-stabilizing effects but the (-)-isomer is about seven to ten times more potent than the (+)-isomer in beta-b...

journal_title：Neuropharmacology

authors： Mason ST,Angel A

更新日期：1983-09-01 00:00:00

abstract：:The effect of the D1 dopamine receptor antagonist SCH 23390 on sleep patterns was studied in rats by means of the electroencephalographic (EEG) technique. Haloperidol, an established D2 antagonist neuroleptic, was used for comparison. Over a very small dose range (0.003-0.03 mg/kg, subcutaneously), SCH 23390 significa...

journal_title：Neuropharmacology

authors： Trampus M,Ongini E

更新日期：1990-10-01 00:00:00

abstract：:The role of orexin receptors in the nucleus accumbens shell in rat turning behaviour of rats was studied. Unilateral injection of neither the orexin 1 and 2 receptor agonist orexin A (2 microg) nor the orexin 1 receptor antagonist SB 334867 (20 ng) into the nucleus accumbens shell elicited turning behaviour. Unilatera...

journal_title：Neuropharmacology

authors： Kotani A,Ikeda H,Koshikawa N,Cools AR

更新日期：2008-03-01 00:00:00

abstract：:The pharmacotherapy for the treatment of pain is an active area of investigation. There are effective drugs to treat this problem, but there is also a need to find alternative treatments free of undesirable side effects. In the present work the capacity of a series of flavonoids to bind to the μ opioid receptor was ev...

journal_title：Neuropharmacology

authors： Higgs J,Wasowski C,Loscalzo LM,Marder M

更新日期：2013-09-01 00:00:00

abstract：:In the present study we examined the effect of MPEP [2-methyl-6-(phenylethynyl)-pyridine] a potent, selective and systemically active metabotropic glutamate receptor (mGluR) type I (subtype mGluR5) antagonist on conditioned morphine reward in mice. In an unbiased version of conditioned place preference (CPP) paradigm,...

journal_title：Neuropharmacology

authors： Popik P,Wróbel M

更新日期：2002-12-01 00:00:00

abstract：:The effects of various benzodiazepine receptor ligands on the GABA autoreceptor have been studied in slices of cerebral cortex of the rat. The GABAA receptor agonist muscimol inhibited the K+-stimulated release of [3H]GABA with a pIC25 of 7.65 +/- 0.11. This effect was antagonised by the GABAA receptor antagonist bicu...

journal_title：Neuropharmacology

authors： Ennis C,Minchin MC

更新日期：1988-10-01 00:00:00

abstract：:The bed nucleus of the stria terminalis (BNST) is a group of inter-connected subnuclei that play critical roles in stress-reward interactions. An interesting feature of this brain region is the massive noradrenergic input that it receives. Important roles for norepinephrine in this region have been documented in a num...

journal_title：Neuropharmacology

authors： Flavin SA,Winder DG

更新日期：2013-07-01 00:00:00

abstract：:Epidemiological studies have reported that cigarette smoking may protect from neurodegenerative diseases such as Parkinson's disease. These protective effects are thought to be mediated by nicotine. Recent data showed that nicotine significantly decreases respiratory control ratio (RCR) and superoxide anion generation...

journal_title：Neuropharmacology

authors： Cormier A,Morin C,Zini R,Tillement JP,Lagrue G

更新日期：2003-04-01 00:00:00

abstract：:This paper evaluates the involvement of hippocampal ATP-sensitive potassium channels (K(ATP)) in learning and memory. After confirming expression of the Kir6.2 subunit in the CA3 region of C57BL/6J mice, we performed intra-hippocampal pharmacological injections of specific openers and blockers of K(ATP) channels. The ...

journal_title：Neuropharmacology

authors： Betourne A,Bertholet AM,Labroue E,Halley H,Sun HS,Lorsignol A,Feng ZP,French RJ,Penicaud L,Lassalle JM,Frances B

更新日期：2009-03-01 00:00:00

abstract：:We generated transgenic (Thy1alpha6) mice in which the GABA(A) receptor alpha6 subunit, whose expression is usually confined to granule cells of cerebellum and cochlear nuclei, is ectopically expressed under the control of the pan-neuronal Thy-1.2 promoter. Strong Thy1alpha6 subunit expression occurs, for example, in ...

journal_title：Neuropharmacology

authors： Wisden W,Cope D,Klausberger T,Hauer B,Sinkkonen ST,Tretter V,Lujan R,Jones A,Korpi ER,Mody I,Sieghart W,Somogyi P

更新日期：2002-09-01 00:00:00

abstract：:5-HT(7) receptor mRNA and protein are localised in the dorsal raphe nucleus (DRN) on non-serotonergic neurones. The effect of 5-HT(7) receptor antagonism on 5-HT efflux was measured from guinea-pig DRN slices, using the technique of fast cyclic voltammetry. The 5-HT(7) receptor antagonist, SB-269970-A, significantly i...

journal_title：Neuropharmacology

authors： Roberts C,Thomas DR,Bate ST,Kew JN

更新日期：2004-06-01 00:00:00

abstract：:Nicotine elicits several behavioural effects on mood as well as on stress and anxiety processes. Recently, it was found that the higher order components of the sensory cortex, such as the secondary auditory cortex Te2, are essential for the long-term storage of remote fear memories. Therefore, in the present study, we...

journal_title：Neuropharmacology

authors： Cambiaghi M,Grosso A,Renna A,Concina G,Sacchetti B

更新日期：2015-12-01 00:00:00

abstract：:This study examined the role of cannabinoid CB1 receptors (CB1r) in aggressive behavior. Social encounters took place in grouped and isolated mice lacking CB1r (CB1KO) and in wild-type (WT) littermates. Cognitive impulsivity was evaluated in the delayed reinforcement task (DRT). Gene expression analyses of monoaminoox...

journal_title：Neuropharmacology

authors： Rodriguez-Arias M,Navarrete F,Daza-Losada M,Navarro D,Aguilar MA,Berbel P,Miñarro J,Manzanares J

更新日期：2013-12-01 00:00:00

abstract：:The nucleus tractus solitarius (NTS) region in the rat has been shown to receive arginine vasopressin (AVP) and oxytocin (OT) neurophysin-containing neuronal projections from the suprachiasmatic (SNC) and paraventricular nucleus (PVN). Thus, vasopressin and oxytocin might have central influences on the circulation. Th...

journal_title：Neuropharmacology

authors： Matsuguchi H,Sharabi FM,Gordon FJ,Johnson AK,Schmid PG

更新日期：1982-07-01 00:00:00

abstract：:Administration of serotonin-enhancing drugs induces a distinctive behavioral syndrome in rodents. We previously reported that mice with a targeted disruption of the serotonin transporter (SERT) display some of these behaviors spontaneously, in the absence of drug. In the current studies, we assessed the drug-induced s...

journal_title：Neuropharmacology

authors： Fox MA,Jensen CL,Gallagher PS,Murphy DL

更新日期：2007-10-01 00:00:00

abstract：:Chronic administration of desipramine resulted in a significant decrease in the degree of stimulation of production of cyclic AMP by noradrenaline, isoproterenol and forskolin in slices of the cerebral cortex of the rat. In preparations of membranes from similarly treated animals, GppNHp- and forskolin-stimulated aden...

journal_title：Neuropharmacology

authors： Newman ME,Lipot M,Lerer B

更新日期：1987-08-01 00:00:00

abstract：:The central nucleus of the amygdala (CeA) is a component of the limbic fear-anxiety circuit, and has also been implicated in regulation of the hypothalamic-pituitary-adrenal (HPA) stress axis. The CeA receives dense noradrenergic innervation, and is rich in expression of alpha(1)-adrenergic receptors. We hypothesized ...

journal_title：Neuropharmacology

authors： Cecchi M,Khoshbouei H,Morilak DA

更新日期：2002-12-01 00:00:00

abstract：:Treatment-related sexual dysfunction is a common side effect of antidepressants and contributes to patient non-compliance or treatment cessation. However, the multimodal antidepressant, vortioxetine, demonstrates low sexual side effects in depressed patients. To investigate the mechanisms involved, sexual behavior was...

journal_title：Neuropharmacology

authors： Li Y,Pehrson AL,Oosting RS,Gulinello M,Olivier B,Sanchez C

更新日期：2017-07-15 00:00:00

abstract：:Methamphetamine is a neurotoxic drug of abuse known to cause cell death both in vitro and in vivo. Nevertheless, the molecular and cellular mechanisms involved in this process remain to be clarified. Herein, we show that methamphetamine-induced apoptosis is associated with early (2 h) overexpression of bax, decreases ...

journal_title：Neuropharmacology

authors： Deng X,Cai NS,McCoy MT,Chen W,Trush MA,Cadet JL

更新日期：2002-05-01 00:00:00

abstract：:Identification of synthetic agonists and antagonists at orphan receptors represents an important step for understanding their physiological function and therapeutic potential. Accordingly, we have recently described a non-peptide agonist at the opioid receptor like (ORL1) receptor (1S,3aS)-8-(2,3,3a,4,5,6-hexahydro-1H...

journal_title：Neuropharmacology

authors： Higgins GA,Grottick AJ,Ballard TM,Richards JG,Messer J,Takeshima H,Pauly-Evers M,Jenck F,Adam G,Wichmann J

更新日期：2001-07-01 00:00:00