GABAergic modulation of 5-HT7 receptor-mediated effects on 5-HT efflux in the guinea-pig dorsal raphe nucleus.

abstract：:Previous reports have shown that activation of N-methyl-D-aspartate (NMDA) receptors potentiates responses to activation of the group I metabotropic glutamate receptor mGluR5 by reversing PKC-mediated desensitization of this receptor. NMDA-induced reversal of mGluR5 desensitization is dependent on activation of protei...

journal_title：Neuropharmacology

authors： Alagarsamy S,Saugstad J,Warren L,Mansuy IM,Gereau RW 4th,Conn PJ

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Recombinant tissue plasminogen activator (rtPA) is widely used for patients with thromboembolic disease, and increasing evidence indicates that it can directly induce neurotoxicity independent of its thrombolysis property. Here, we aimed to confirm the long-term effect of rtPA on animal's behavior, and inves...

journal_title：Neuropharmacology

authors： Dong MX,Li CM,Shen P,Hu QC,Wei YD,Ren YF,Yu J,Gui SW,Liu YY,Pan JX,Xie P

更新日期：2018-01-01 00:00:00

abstract：:Nitric oxide modulates pain development. However, there is no evidence on the effect of nitroxyl (HNO/NO⁻) in nociception. Therefore, we addressed whether nitroxyl inhibits inflammatory hyperalgesia and its mechanism using the nitroxyl donor Angeli's salt (AS; Na₂N₂O₃). Mechanical hyperalgesia was evaluated using a mo...

journal_title：Neuropharmacology

authors： Zarpelon AC,Souza GR,Cunha TM,Schivo IR,Marchesi M,Casagrande R,Pinge-Filho P,Cunha FQ,Ferreira SH,Miranda KM,Verri WA Jr

更新日期：2013-08-01 00:00:00

abstract：:Symptomatic temporal lobe epilepsy typically develops in three phases: brain damage --> epileptogenesis --> spontaneous seizures (epilepsy). The challenge is to prevent epileptogenesis after injury. We hypothesized that alleviation of damage by caspase inhibitors will reduce epileptogenesis or at least have disease-mo...

journal_title：Neuropharmacology

authors： Narkilahti S,Nissinen J,Pitkänen A

更新日期：2003-06-01 00:00:00

abstract：:The effect of long term treatment with two tricyclic antidepressants on the sensitivity of 5-HT1B presynaptic heteroreceptors inhibiting acetylcholine (ACh) release was investigated. Groups of male rats received during 14 days either saline, citalopram (20 mg/kg), a serotonin (5-HT) uptake blocker, or tianeptine (2 x ...

journal_title：Neuropharmacology

authors： Bolaños-Jiménez F,Manhães de Castro R,Fillion G

更新日期：1994-01-01 00:00:00

abstract：:A subgroup of anticonvulsant and neuroleptic drugs acts through the potentiation of GABA pathways. The regulatory role of GABA in neuronal circuit formation is related to its depolarizing action that supports activity-dependent synaptogenesis. We hypothesized that elevated levels of GABA in the immature brain modify s...

journal_title：Neuropharmacology

authors： Melamed O,Levav-Rabkin T,Zukerman C,Clarke G,Cryan JF,Dinan TG,Grossman Y,Golan HM

更新日期：2014-04-01 00:00:00

abstract：:Recently we reported that fluoxetine (10 mg/kg) improves functional recovery by attenuating blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). Here we investigated whether a low-dose of fluoxetine (1 mg/kg) and vitamin C (100 mg/kg), separately not possessing any protective effect, prevents BS...

journal_title：Neuropharmacology

authors： Lee JY,Choi HY,Yune TY

更新日期：2016-10-01 00:00:00

abstract：:The mechanisms underlying lateralization and progression of motor symptoms from unilateral to bilateral in Parkinson's disease (PD) remain to be elucidated. In addition, the molecular mechanisms involved in levodopa-induced dyskinesias (LIDs) depending on lateralization and disease progression from unilaterally to bil...

journal_title：Neuropharmacology

authors： Marin C,Bonastre M,Mengod G,Cortés R,Rodríguez-Oroz MC

更新日期：2015-10-01 00:00:00

abstract：:Increasingly in the realm of neurological disorders, particularly those involving neurodegeneration, mitochondrial dysfunction is emerging at the core of their pathogenic processes. Most of these diseases still lack effective treatment and are hampered by a shortfall in the development of novel medicines. Clearly new ...

journal_title：Neuropharmacology

authors： Chan F,Lax NZ,Davies CH,Turnbull DM,Cunningham MO

更新日期：2016-03-01 00:00:00

abstract：:This study was undertaken to determine whether 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)(2)D(3)], an active metabolite of vitamin D, protects dopaminergic neurons against the neurotoxic effects of glutamate and dopaminergic toxins using rat mesecephalic culture. Brief glutamate exposure elicited cytotoxicity in ...

journal_title：Neuropharmacology

authors： Ibi M,Sawada H,Nakanishi M,Kume T,Katsuki H,Kaneko S,Shimohama S,Akaike A

更新日期：2001-05-01 00:00:00

abstract：:The techniques of co-immunoprecipitation and immunocytochemical co-labelling are classically used to identify protein-protein interactions. We have used an antibody to the rat small conductance calcium-activated potassium channel subtype 1 (rSK1) to immunoprecipitate proteins from rat brain. A 35 kDa protein was recog...

journal_title：Neuropharmacology

authors： Fletcher S,Bowden SE,Marrion NV

更新日期：2003-05-01 00:00:00

abstract：:Administration of 0.13% lead acetate solution as drinking fluid to breeding mice was without significant effect on the numbers of live or dead births or on weight of pups at 1 day. The appearance of fur was delayed and the body weights at 21 days and 31-38 weeks were smaller than in controls. On weaning, the treated o...

journal_title：Neuropharmacology

authors： Donald JM,Cutler MG,Moore MR,Bradley M

更新日期：1986-02-01 00:00:00

abstract：:Orexin-A, -B play a crucial role in arousal and feeding by activating two G-protein-coupled receptors: orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R). Orexins, along with orexin receptors, are expressed in retinal neurons, and they have been shown to differentially modulate excitatory AMPA receptors of amacrine...

journal_title：Neuropharmacology

authors： Zhang G,Wu XH,Xu GZ,Weng SJ,Yang XL,Zhong YM

更新日期：2018-05-01 00:00:00

abstract：:The function of 5-HT1A autoreceptors was examined by measuring the ability of the 5-HT1A receptor agonist 8-OH-DPAT to reduce 5-HT release in the striatum using in vivo microdialysis. 8-OH-DPAT reduced the release of 5-HT in the striatum. Chronic treatment with 8-OH-DPAT (1.0 mg/kg s.c.) for 7 days, but not 1 day, att...

journal_title：Neuropharmacology

authors： Kreiss DS,Lucki I

更新日期：1992-10-01 00:00:00

abstract：:Chronic nicotine administration in animals, and smoking in humans, causes up-regulation of α4β2* neuronal nicotinic receptors (nAChRs), which has been hypothesized to contribute to the addictive actions of nicotine. We used a rat model to test whether such up-regulatory effects differ in adolescents versus adults, and...

journal_title：Neuropharmacology

authors： Hoegberg BG,Lomazzo E,Lee NH,Perry DC

更新日期：2015-12-01 00:00:00

abstract：:The effects of the anxiolytic drug chlordiazepoxide (CDZ) on general activity and anxiety-related behaviour of male and female Swiss-Webster mice were investigated in the triple test, which combines the open field (OF), elevated-plus maze (EPM) and the light-dark box (LDB). Mice were injected with saline or CDZ (1.0, ...

journal_title：Neuropharmacology

authors： Hussin AT,Fraser LM,Ramos A,Brown RE

更新日期：2012-10-01 00:00:00

abstract：:Central administration of corticotropin-like peptides generally blocks the analgesic action of opiate ligands, yet it is unclear whether this is due to an independent hyperalgesic action of corticotropin or to some other mechanism. Single cells in the ventromedial medulla of the anaesthetized rat were characterized as...

journal_title：Neuropharmacology

authors： Smock T

更新日期：1987-12-01 00:00:00

abstract：:Chronic administration of desipramine resulted in a significant decrease in the degree of stimulation of production of cyclic AMP by noradrenaline, isoproterenol and forskolin in slices of the cerebral cortex of the rat. In preparations of membranes from similarly treated animals, GppNHp- and forskolin-stimulated aden...

journal_title：Neuropharmacology

authors： Newman ME,Lipot M,Lerer B

更新日期：1987-08-01 00:00:00

abstract：:Anxiety disorders contribute to the pathophysiology of psychiatric diseases, including major depression, substance abuse, and schizophrenia. The hippocampus is important for anxiety modulation. However, the mechanisms that control the neuronal activity of the hippocampus in anxiety are still not clear. We found that E...

journal_title：Neuropharmacology

authors： Chen M,Shu S,Yan HH,Pei L,Wang ZF,Wan Q,Bi LL

更新日期：2017-05-15 00:00:00

abstract：:Diazepam binding inhibitor (DBI) acts in brain by binding to GABAA/benzodiazepine receptors (GBR) and to mitochondrial benzodiazepine receptors (MBR). Because DBI acting at MBR, has been shown to be an effector of ACTH-induced steroidogenesis and stress is known to change the level of GBR and MBR, the model of acute n...

journal_title：Neuropharmacology

authors： Ferrarese C,Mennini T,Pecora N,Pierpaoli C,Frigo M,Marzorati C,Gobbi M,Bizzi A,Codegoni A,Garattini S

更新日期：1991-12-01 00:00:00

abstract：:The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in the cerebellum was blocked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for...

journal_title：Neuropharmacology

authors： Batchelor AM,Knöpfel T,Gasparini F,Garthwaite J

更新日期：1997-03-01 00:00:00

abstract：:Cannabidiol (CBD), the main non-psychotomimetic component of marihuana, exhibits anxiolytic-like properties in many behavioural tests, although its potential for treating major depression has been poorly explored. Moreover, the mechanism of action of CBD remains unclear. Herein, we have evaluated the effects of CBD fo...

journal_title：Neuropharmacology

authors： Linge R,Jiménez-Sánchez L,Campa L,Pilar-Cuéllar F,Vidal R,Pazos A,Adell A,Díaz Á

更新日期：2016-04-01 00:00:00

abstract：:Adenosine 5'-triphosphate-sensitive potassium channel (KATP channel) activator, minoxidil sulfate (MS), can selectively increase the permeability of the blood-tumor barrier (BTB); however, the mechanism by which this occurs is still under investigation. Using a rat brain glioma (C6) model, we first examined the expres...

journal_title：Neuropharmacology

authors： Gu YT,Xue YX,Wang YF,Wang JH,Chen X,ShangGuan QR,Lian Y,Zhong L,Meng YN

更新日期：2013-12-01 00:00:00

abstract：:Hypoxic-ischemic encephalopathy (HI) accounts for the majority of developmental, motor and cognitive deficits in children, leading to life-long neurological impairments. Since the plasmamembrane sodium/calcium exchanger (NCX) plays a fundamental role in maintaining ionic homeostasis during adult brain ischemia, in the...

journal_title：Neuropharmacology

authors： Cerullo P,Brancaccio P,Anzilotti S,Vinciguerra A,Cuomo O,Fiorino F,Severino B,Di Vaio P,Di Renzo G,Annunziato L,Pignataro G

更新日期：2018-06-01 00:00:00

abstract：:D-Tubocurarine is a potent competitive antagonist of two members of the ligand-gated ion channel family, the muscle-type nicotinic acetylcholine receptor (AChR) and serotonin type-3 receptor (5HT3R). We have used a series of analogs of D-tubocurarine to determine the effects of methylation, stereoisomerization and hal...

journal_title：Neuropharmacology

authors： Yan D,Pedersen SE,White MM

更新日期：1998-01-01 00:00:00

abstract：:The rat hemisected spinal cord preparation was used to assess the role of different adrenoceptor subtypes on the modulation of nociceptive reflexes. These were elicited by trains of high intensity electrical stimuli delivered to a lumbar dorsal root. Responses were recorded from the corresponding ventral root in AC- a...

journal_title：Neuropharmacology

authors： Hedo G,Lopez-Garcia JA

更新日期：2001-12-01 00:00:00

abstract：:Hippocampal Long-Term Potentiation (LTP) is facilitated by BDNF, through the activation of tropomyosin-related kinase B (TrkB) receptors. However, an influence of BDNF upon Long-Term Depression (LTD) was also shown. The present work aimed to further evaluate the effect of BDNF and TrkB receptors upon CA1 hippocampal L...

journal_title：Neuropharmacology

authors： Rodrigues TM,Jerónimo-Santos A,Sebastião AM,Diógenes MJ

更新日期：2014-04-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced in the lateral hypothalamus and zona incerta that increases food intake. The neuronal pathways and behavioral mechanisms mediating the orexigenic effects of MCH are poorly understood, as is the extent to which MCH-mediated feeding outcomes are ...

journal_title：Neuropharmacology

authors： Terrill SJ,Subramanian KS,Lan R,Liu CM,Cortella AM,Noble EE,Kanoski SE

更新日期：2020-11-01 00:00:00

abstract：:The contribution of metabotropic glutamate receptors (mGluRs) to the modulation of nociception by the periaqueductal gray (PAG) matter was investigated in mice. Intra-PAG microinjection of (IS,3R)-ACPD, an agonist of groups I and II mGluRs, as well as (S)-3,5-DHPG, a selective agonist of group I mGluRs, increased the ...

journal_title：Neuropharmacology

authors： Maione S,Marabese I,Leyva J,Palazzo E,de Novellis V,Rossi F

更新日期：1998-12-01 00:00:00

abstract：:The effect of clonidine (0.1 mg/kg, i.p.), as a three-injection course, on behaviour in the forced swimming test was studied in rats injected intracerebroventricularly (i.c.v.) with 150 micrograms 5,7-dihydroxy-tryptamine (5,7-DHT) to destroy serotonin (5-HT) neurones or treated with 100 mg/kg (i.p.) (+/-)-sulpiride o...

journal_title：Neuropharmacology

authors： Cervo L,Rossi C,Samanin R

更新日期：1992-04-01 00:00:00