Neuronal oscillations: A physiological correlate for targeting mitochondrial dysfunction in neurodegenerative diseases?

abstract：:The surface expression and metabolic turnover time of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors are important factors in determining the involvement of these proteins in synaptic function. We used the membrane-impermeant chemical crosslinking reagent BS3 and subsequent immunoblot analysis t...

journal_title：Neuropharmacology

authors： Archibald K,Perry MJ,Molnár E,Henley JM

更新日期：1998-10-01 00:00:00

abstract：:A pharmacological study using monkeys, in which parkinsonism was induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was undertaken to elucidate the mechanism underlying urinary bladder dysfunctions in Parkinson's disease. Under ketamine anesthesia, cystometrograms showed that, in MPTP-treated monkeys, a c...

journal_title：Neuropharmacology

authors： Yoshimura N,Mizuta E,Kuno S,Sasa M,Yoshida O

更新日期：1993-04-01 00:00:00

abstract：:An earlier finding that three systems were responsible for the uptake of gamma-aminobutyric acid by synaptosomes was corroborated. In addition, the existence of three uptake systems for RS-nipecotic acid and beta-alanine was demonstrated. We have called these systems high affinity, medium affinity and low affinity upt...

journal_title：Neuropharmacology

authors： Sidhu HS,Wood JD

更新日期：1986-05-01 00:00:00

abstract：:24S-hydroxycholesterol (24S-HC) is a brain-derived product of lipid metabolism present in the systemic circulation, where its level can change significantly in response to physiological and pathophysiological conditions. Here, using electrophysiological and optical approaches, we have found a high sensitivity to 24S-H...

journal_title：Neuropharmacology

authors： Kasimov MR,Fatkhrakhmanova MR,Mukhutdinova KA,Petrov AM

更新日期：2017-05-01 00:00:00

abstract：:The effects of Substance P (SP) and of a specific nonpeptide antagonist of the NK1 receptor (RP 67580) on preovulatory gonadotropin surges and on the in vitro GnRH induced LH surge were investigated in cycling female rats. A subcutaneous injection of SP (0.5 mg/kg body weight) at 12.00 h on the proestrous day signific...

journal_title：Neuropharmacology

authors： Duval P,Lenoir V,Garret C,Kerdelhue B

更新日期：1996-01-01 00:00:00

abstract：:Putative kappa binding was investigated in homogenates of the brain of the rat using [3H]ethylketocylazocine and [3H]diprenorphine under conditions where mu and delta sites were blocked. Under blocked conditions, the binding of [3H]ethylketocyclazocine labelled a single site, as defined by kinetic and equilibrium anal...

journal_title：Neuropharmacology

authors： Weyhenmeyer JA,Mack KJ

更新日期：1985-02-01 00:00:00

abstract：:Alcohol produces many subjective and objective effects in man including pleasure, sedation, anxiolysis, plus impaired eye movements and memory. In human volunteers we have used a newly available GABA-A/benzodiazepine receptor inverse agonist that is selective for the alpha5 subtype (a5IA) to evaluate the role of this ...

journal_title：Neuropharmacology

authors： Nutt DJ,Besson M,Wilson SJ,Dawson GR,Lingford-Hughes AR

更新日期：2007-12-01 00:00:00

abstract：:Phosphodiesterase 2 (PDE2) plays an important role in treatment of stress-related depression through regulation of antioxidant defense and neuroprotective mechanisms. However, the causal relationship between PDE2 and the prevalence of depression and anxiety upon exposure to oxidative stress has not been investigated. ...

journal_title：Neuropharmacology

authors： Huang X,Xiaokaiti Y,Yang J,Pan J,Li Z,Luria V,Li Y,Song G,Zhu X,Zhang HT,O'Donnell JM,Xu Y

更新日期：2018-12-01 00:00:00

abstract：:Estradiol (E(2)) and progesterone (P(4)) have classical, steroid receptor-mediated actions in the ventral medial hypothalamus to initiate lordosis of female rodents. P(4) and the P(4) metabolite and neurosteroid, 5 alpha-pregnan-3 alpha-ol-20-one (3 alpha,5 alpha-THP), have non-classical actions in the midbrain ventra...

journal_title：Neuropharmacology

authors： Frye CA,Walf AA

更新日期：2010-01-01 00:00:00

abstract：:The ability of GABAA and GABAB receptors in the shell of the nucleus accumbens to modulate distinct types of turning behaviour was investigated in freely moving rats, using the unilateral injection technique. The GABAA receptor agonist muscimol and the GABAA receptor antagonist bicuculline did not produce turning beha...

journal_title：Neuropharmacology

authors： Akiyama G,Ikeda H,Matsuzaki S,Sato M,Moribe S,Koshikawa N,Cools AR

更新日期：2004-06-01 00:00:00

abstract：:Neural uptake of glutamate is executed by the structurally related members of the SLC1A family of solute transporters: GLAST/EAAT1, GLT-1/EAAT2, EAAC1/EAAT3, EAAT4, ASCT2. These plasma membrane proteins ensure supply of glutamate, aspartate and some neutral amino acids, including glutamine and cysteine, for synthetic,...

journal_title：Neuropharmacology

authors： Gegelashvili G,Bjerrum OJ

更新日期：2019-12-15 00:00:00

abstract：:Presynaptic nicotinic acetylcholine receptors on striatal nerve terminals modulate the release of dopamine. Using rat striatal synaptosomes loaded with [3H]dopamine, we have characterized the action of the selective nicotinic agonist, (+/-)anatoxin-a, with respect to [3H]dopamine release, in order to explore the mecha...

journal_title：Neuropharmacology

authors： Soliakov L,Gallagher T,Wonnacott S

更新日期：1995-11-01 00:00:00

abstract：:Understanding the natural history of and factors associated with pharmacoresistant epilepsy provides the foundation for formulating mechanistic hypotheses that can be evaluated to drive the development of novel treatments. This article reviews the modern definition of drug-resistant epilepsy, its prevalence and incide...

journal_title：Neuropharmacology

authors： Janmohamed M,Brodie MJ,Kwan P

更新日期：2020-05-15 00:00:00

abstract：:Opioid drugs such as heroin interact directly with opioid receptors whilst other addictive drugs, including marijuana, alcohol and nicotine indirectly activate endogenous opioid systems to contribute to their rewarding properties. The opioid system therefore plays a key role in addiction neurobiology and continues to ...

journal_title：Neuropharmacology

authors： Kieffer BL,Evans CJ

更新日期：2009-01-01 00:00:00

abstract：:A new in vivo pharmacological method for the quantitative evaluation of alpha 1-adrenoceptor agonists and antagonists has been developed. It consists of recording the myoclonic twitch activity (MTA) of the suprahyoideal muscle of rats anesthetized with urethane. In these animals, the isomers of amphetamine elicited my...

journal_title：Neuropharmacology

authors： Menon MK,Kodama CK,Kling AS,Fitten J

更新日期：1986-05-01 00:00:00

abstract：:Dopamine (DA) is a classical neurotransmitter modulating various brain functions by acting on its specific receptors. In addition, DA is a reactive molecule that has been implicated in neurodegeneration, especially in Parkinson's disease. Here we show that DA inhibited cell growth of dopamine transporter transfected c...

journal_title：Neuropharmacology

authors： Woldman I,Reither H,Kattinger A,Hornykiewicz O,Pifl C

更新日期：2005-03-01 00:00:00

abstract：:The so-called generalized polarization (GP) of the fluorescent probe Laurdan and the steady-state fluorescence anisotropy of the probe diphenylhexatriene (DPH) and its phenylpropionic derivative (PA-DPH) were used to study the effects of several organochlorine insecticides of the chlorophenylethane, chlorinated cycloh...

journal_title：Neuropharmacology

authors： Massol RH,Antollini SS,Barrantes FJ

更新日期：2000-04-03 00:00:00

abstract：:GABA(B) receptors inhibit and dopamine D1 receptors stimulate the release of GABA from striatal terminals in the pars reticulata of the substantia nigra. Here we have studied the interaction between both classes of receptors by exploring the effect of GABA(B) receptors upon the stimulation of depolarization-induced [(...

journal_title：Neuropharmacology

authors： Nava-Asbell C,Paz-Bermudez F,Erlij D,Aceves J,Florán B

更新日期：2007-10-01 00:00:00

abstract：:Cocaine administration can be both rewarding and aversive. While much effort has gone to investigating the rewarding effect, the mechanisms underlying cocaine-induced aversion remain murky. There is increasing evidence that the lateral habenula (LHb), a small epithalamic structure, plays a critical role in the aversiv...

journal_title：Neuropharmacology

authors： Zuo W,Chen L,Wang L,Ye JH

更新日期：2013-07-01 00:00:00

abstract：:The N-methyl-d-aspartate (NMDA) receptor is a key target of ethanol action in the central nervous system. Alcohol inhibition of NMDA receptor function involves small clusters of residues in the third and fourth membrane-associated (M) domains. Previous results from this laboratory have shown that two adjacent position...

journal_title：Neuropharmacology

authors： Ren H,Zhao Y,Wu M,Dwyer DS,Peoples RW

更新日期：2017-03-01 00:00:00

abstract：:Deficits in social memory, cognition, and aberrant responses to stimulants are common among persons affected by schizophrenia and other conditions with a presumed developmental etiology. We previously found that expression changes in the adenosine metabolizing enzyme adenosine kinase (ADK) in the adult brain are assoc...

journal_title：Neuropharmacology

authors： Osborne DM,Sandau US,Jones AT,Vander Velden JW,Weingarten AM,Etesami N,Huo Y,Shen HY,Boison D

更新日期：2018-10-01 00:00:00

abstract：:Reserpine (5 mg/kg s.c.) was given to rats kept under a reversed light-dark cycle and 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) determined in frontal cortex tissue and dialysate at various times after drug treatment. The decline and return of spontaneous locomotor activity was also measured. ...

journal_title：Neuropharmacology

authors： Heslop KE,Curzon G

更新日期：1994-03-01 00:00:00

abstract：:There is increasing evidence that oxidative stress is critically involved in the pathogenesis of Parkinson's disease (PD), suggesting that pharmacological targeting of the antioxidant machinery may have therapeutic value. Naringenin, a natural flavonoid compound, has been reported to possess neuroprotective effect aga...

journal_title：Neuropharmacology

authors： Lou H,Jing X,Wei X,Shi H,Ren D,Zhang X

更新日期：2014-04-01 00:00:00

abstract：:The effects of nefiracetam on GABA-induced chloride currents were studied with rat dorsal root ganglion neurons in primary culture using the whole-cell patch-clamp technique. The dose-response curve for GABA-induced currents was shifted by 16 microM to lower concentrations by 10 microM nefiracetam while the maximal re...

journal_title：Neuropharmacology

authors： Huang CS,Ma JY,Marszalec W,Narahashi T

更新日期：1996-01-01 00:00:00

abstract：:Mice were found to exhibit a marked suppression of motor activity when placed into the same experimental chamber in which they had previously received electrical shocks. This suppression was found to be a stable response when mice, 6-8 weeks of age, received shocks of frequencies of 1/10 or 1/30 Hz, and their motility...

journal_title：Neuropharmacology

authors： Kameyama T,Nagasaka M

更新日期：1982-12-01 00:00:00

abstract：:Under conditions in which NG-nitro-L-arginine (NOArg) treatment prevents morphine tolerance, NOArg induces a slow progressive inhibition of nitric oxide synthase (NOS), starting at approx. 20% after a single treatment and increasing to approx. 65% after 10 days. Studies designed to examine potential changes in NOS lev...

journal_title：Neuropharmacology

authors： Babey AM,Kolesnikov Y,Cheng J,Inturrisi CE,Trifilletti RR,Pasternak GW

更新日期：1994-11-01 00:00:00

abstract：:Inhibition in the brain is dominated by the neurotransmitter gamma-aminobutyric acid (GABA); operating through GABA(A) receptors. This form of neural inhibition was presumed to be mediated by synaptic receptors, however recent evidence has highlighted a previously unappreciated role for extrasynaptic GABA(A) receptors...

journal_title：Neuropharmacology

authors： Wafford KA,van Niel MB,Ma QP,Horridge E,Herd MB,Peden DR,Belelli D,Lambert JJ

更新日期：2009-01-01 00:00:00

abstract：:High-frequency stimulation of afferents to the supraoptic nucleus (SON) results in a robust increase in the frequency and amplitude of pharmacologically isolated, tetrodotoxin-resistant, miniature excitatory postsynaptic currents (mEPSCs) lasting for 5-20 min. This increase in mEPSC frequency, termed short-term potent...

journal_title：Neuropharmacology

authors： Kombian SB,Hirasawa M,Matowe WC,Pittman QJ

更新日期：2001-10-01 00:00:00

abstract：:Depression is a leading cause of mortality and morbidity. Selective serotonin reuptake inhibitors, such as fluoxetine, are the most commonly prescribed antidepressant medication. SSRIs produce their therapeutic effects by elevating extracellular concentrations of serotonin. Although this elevation occurs rapidly, ther...

journal_title：Neuropharmacology

authors： Van Dyke AM,Francis TC,Chen H,Bailey AM,Thompson SM

更新日期：2019-05-15 00:00:00

abstract：:Group II metabotropic glutamate (mGlu) receptor agonists were efficacious in randomized clinical research trials for schizophrenia and generalized anxiety disorder. The regional quantification of mGlu(2) and mGlu(3) receptors remains unknown. A selective and structurally novel mGlu(2/3) receptor agonist, 2-amino-4-flu...

journal_title：Neuropharmacology

authors： Wright RA,Johnson BG,Zhang C,Salhoff C,Kingston AE,Calligaro DO,Monn JA,Schoepp DD,Marek GJ

更新日期：2013-03-01 00:00:00