Abstract：
:Putative kappa binding was investigated in homogenates of the brain of the rat using [3H]ethylketocylazocine and [3H]diprenorphine under conditions where mu and delta sites were blocked. Under blocked conditions, the binding of [3H]ethylketocyclazocine labelled a single site, as defined by kinetic and equilibrium analysis, which showed high affinity for dynorphin 1-17, U50,488H, and benzomorphan compounds. However, blocked binding of [3H]diprenorphine showed a biphasic dissociation curve, and did not show high affinity for the specific kappa agonists dynorphin 1-17 or U50,488H. It is proposed that blocked [3H]ethylketocyclazocine is the more appropriate paradigm to study putative kappa binding, while blocked [3H]diprenorphine may label additional non-mu/non-delta sites.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Weyhenmeyer JA,Mack KJdoi
10.1016/0028-3908(85)90169-8subject
Has Abstractpub_date
1985-02-01 00:00:00pages
111-5issue
2eissn
0028-3908issn
1873-7064journal_volume
24pub_type
杂志文章abstract：:Etomidate and propofol have clearly distinguishable effects on the central nervous system. However, studies in knock-in mice provided evidence that these agents produce anesthesia via largely overlapping molecular targets, namely GABA(A) receptors containing beta3 subunits. Here the authors address the question as to ...
journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
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journal_title：Neuropharmacology
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pub_type： 杂志文章
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更新日期：1994-03-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2000-10-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2016.06.016
更新日期：2016-10-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.neuropharm.2014.09.022
更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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更新日期：2020-01-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2005-11-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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