Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1.

abstract：:The monosynaptic reflex (MSR), recorded in vitro from the neonatal rat spinal cord, was depressed by 5-hydroxytryptamine (5-HT) and 5-HT receptor agonists. The results, together with our previous findings, indicate an apparent rank order of potency: 5-carboxamidotryptamine (5-CT) > sumatriptan > methysergide > 5-HT > ...

journal_title：Neuropharmacology

authors： Crick H,Manuel NA,Wallis DI

更新日期：1994-07-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis is activated by a wide range of stimuli, including drugs. Here we report that in male rats, a dose of sodium butyrate (NaBu) that is typically used to inhibit histone deacetylation (1200 mg/kg) increased the peripheral levels of HPA hormones and glucose. In a further exper...

journal_title：Neuropharmacology

authors： Gagliano H,Delgado-Morales R,Sanz-Garcia A,Armario A

更新日期：2014-04-01 00:00:00

abstract：:In genetically obese (ob/ob) mice the development of obesity was correlated with the binding of [3H] (+)-amphetamine to the hypothalamus. In 39-day-old ob/ob mice, which had obtained a body weight greater than 150% of their lean littermates, hypothalamic [3H] (+)-amphetamine binding had increased by approximately 60% ...

journal_title：Neuropharmacology

authors： Hauger R,Hulihan-Giblin B,Paul SM

更新日期：1986-03-01 00:00:00

abstract：:Dopamine neurons in the ventral tegmental area (VTA) play a very important role in a variety of physiological as well as addictive behaviors. However, a clear understanding of the cellular mechanisms underlying these behaviors is still missing. Within the VTA, recent studies have shown that forms of synaptic plasticit...

journal_title：Neuropharmacology

authors： Bonci A,Borgland S

更新日期：2009-01-01 00:00:00

abstract：:Alcohol use disorder (AUD) is a serious public health problem that results in tremendous social, legal and medical costs to society. Unlike other addictive drugs, there is no specific molecular target for ethanol (EtOH). Here, we report a novel molecular target that mediates EtOH effects at concentrations below those ...

journal_title：Neuropharmacology

authors： Gao F,Chen D,Ma X,Sudweeks S,Yorgason JT,Gao M,Turner D,Eaton JB,McIntosh JM,Lukas RJ,Whiteaker P,Chang Y,Steffensen SC,Wu J

更新日期：2019-05-01 00:00:00

abstract：:The role in ligand recognition and receptor activation of two adjacent charged residues (lysine 195 and aspartate 196) in the first extracellular loop of the human VPAC(1) receptor was investigated in stably transfected CHO cells expressing the wild type or point mutated receptors.Replacement of lysine 195 by glutamin...

journal_title：Neuropharmacology

authors： Langer I,Vertongen P,Perret J,Waelbroeck M,Robberecht P

更新日期：2003-01-01 00:00:00

abstract：:To identify the enzymes involved in the induction of N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) at CA1 synapses of two-week-old rats we have tested various kinase inhibitors. Surprisingly, given the large body of evidence supporting a role for calcium/calmodulin-dependent protein kinas...

journal_title：Neuropharmacology

authors： Wikström MA,Matthews P,Roberts D,Collingridge GL,Bortolotto ZA

更新日期：2003-11-01 00:00:00

abstract：:Serotonin2C (5-HT2C) receptors may influence motivation and reward through effects on the mesocorticolimbic dopamine (DA) system. Previous work from this laboratory indicated that 5-HT2C receptor stimulation does not induce place conditioning when animals are tested in a drug-free state, but does result in decreased l...

journal_title：Neuropharmacology

authors： Mosher TM,Smith JG,Greenshaw AJ

更新日期：2006-09-01 00:00:00

abstract：:Glutamate receptors play an essential role in fear-related learning and memory. The present study was designed to assess the role of the group I metabotropic glutamate receptor (mGluR) subtype 5 in the acquisition and retrieval of conditioned fear in rats. The selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyr...

journal_title：Neuropharmacology

authors： Schulz B,Fendt M,Gasparini F,Lingenhöhl K,Kuhn R,Koch M

更新日期：2001-07-01 00:00:00

abstract：:Ifenprodil, which is clinically used as a cerebral vasodilator, inhibited rat brain type A (MAO-A) and type B (MAO-B) monoamine oxidase activity. It did not, however, affect rat lung semicarbazide-sensitive amine oxidase. The degree of inhibition of either form of MAO was not changed by 30 min preincubation of the enz...

journal_title：Neuropharmacology

authors： Arai Y,Nakazato K,Kinemuchi H,Tadano T,Satoh N,Oyama K,Kisara K

更新日期：1991-07-01 00:00:00

abstract：:Cannabidiol (CBD), a non-euphorigenic compound derived from Cannabis, shows promise for improving recovery following cerebral ischemia and has recently been shown effective for the treatment of childhood seizures caused by Dravet and Lennox-Gastaut syndromes. Given evidence for activity to mitigate effects of CNS insu...

journal_title：Neuropharmacology

authors： Alalawi A,Dodu JC,Woolley-Roberts M,Brodie J,Di Marzo V,Soderstrom K

更新日期：2019-11-01 00:00:00

abstract：:The bed nucleus of the stria terminalis (BNST) is a forebrain structure implicated in physiological and behavioral responses to emotional stress. However, the local neurochemical mechanisms mediating the BNST control of stress responses are not fully known. Here, we investigated the involvement of BNST cholinergic neu...

journal_title：Neuropharmacology

authors： Gouveia MK,Miguel TT,Busnardo C,Scopinho AA,Corrêa FM,Nunes-de-Souza RL,Crestani CC

更新日期：2016-02-01 00:00:00

abstract：:NMDA receptors have been known to play a central role in long-term potentiation at glutamatergic synapses in principal cells for thirty years. In contrast, their roles in the development and activity-dependent plasticity of synapses in inhibitory circuits have only recently begun to be understood. Progress has, to a g...

journal_title：Neuropharmacology

authors： Moreau AW,Kullmann DM

更新日期：2013-11-01 00:00:00

abstract：:Mefloquine continues to be a key drug used for malaria chemoprophylaxis and treatment, despite reports of adverse events like depression and anxiety. It is unknown how mefloquine acts within the central nervous system to cause depression and anxiety or why some individuals are more vulnerable. We show that intraperito...

journal_title：Neuropharmacology

authors： Heshmati M,Golden SA,Pfau ML,Christoffel DJ,Seeley EL,Cahill ME,Khibnik LA,Russo SJ

更新日期：2016-02-01 00:00:00

abstract：:Group II metabotropic glutamate (mGlu) receptor agonists were efficacious in randomized clinical research trials for schizophrenia and generalized anxiety disorder. The regional quantification of mGlu(2) and mGlu(3) receptors remains unknown. A selective and structurally novel mGlu(2/3) receptor agonist, 2-amino-4-flu...

journal_title：Neuropharmacology

authors： Wright RA,Johnson BG,Zhang C,Salhoff C,Kingston AE,Calligaro DO,Monn JA,Schoepp DD,Marek GJ

更新日期：2013-03-01 00:00:00

abstract：:Flavopiridol was developed as a drug for cancer therapy due to its ability to inhibit cell cycle progression by targeting cyclin-dependent kinases (CDKs). In this study, we show that flavopiridol may also have a neuroprotective action. We show that at therapeutic dosage (or at micromolar range), flavopiridol almost co...

journal_title：Neuropharmacology

authors： Jorda EG,Verdaguer E,Canudas AM,Jiménez A,Bruna A,Caelles C,Bravo R,Escubedo E,Pubill D,Camarasa J,Pallàs M,Camins A

更新日期：2003-10-01 00:00:00

abstract：:Recent evidence suggests an early involvement of dopaminergic (DA) processes and terminals in Parkinson's disease (PD). The arborization of neurons depends on the actin cytoskeleton, which in turn is regulated by small GTPases of the Rho family, encompassing Rho, Rac and Cdc42 subfamilies. Indeed, some reports point t...

journal_title：Neuropharmacology

authors： Musilli M,Ciotti MT,Pieri M,Martino A,Borrelli S,Dinallo V,Diana G

更新日期：2016-10-01 00:00:00

abstract：:The GABA(B) receptor has been shown to consist of a heterodimer of two related 7-transmembrane receptors GABAB-R1 and GABA(B)-R2. These receptors share close homology to the Ca2+-sensing receptor and also to the metabotropic glutamate receptors, which have also been shown to respond to extracellular calcium. We show h...

journal_title：Neuropharmacology

authors： Wise A,Green A,Main MJ,Wilson R,Fraser N,Marshall FH

更新日期：1999-11-01 00:00:00

abstract：:Slow excitatory postsynaptic currents (EPSCs) mediated by metabotropic glutamate receptors (mGlu receptors) have been reported in several neuronal subtypes, but their presence in hippocampal pyramidal neurons remains elusive. Here we find that in CA1 pyramidal neurons a slow EPSC is induced by repetitive stimulation w...

journal_title：Neuropharmacology

authors： Sheng N,Yang J,Silm K,Edwards RH,Nicoll RA

更新日期：2017-03-15 00:00:00

abstract：:Prenatal cocaine exposure has been reported to result in abnormal neurobehavioral development, both in animals and humans. In this study, outbred CD-1 mice were exposed in utero to cocaine hydrochloride administered daily as i.p. injections to dams from day 10 of gestation to day 16, at the dose 0, 5 or 50 mg/kg. Coca...

journal_title：Neuropharmacology

authors： Laviola G,Fiore M,Loggi G,Alleva E

更新日期：1994-06-01 00:00:00

abstract：:Acromelic acid, a kainate derivative of natural origin, markedly increased intracellular Ca2+ concentration ([Ca2+]i) in cultured rat spinal neurons in a concentration dependent manner; the half effective concentration (EC50) was 1.3 microM. Acromelic acid was more potent in increasing [Ca2+]i than any other glutamate...

journal_title：Neuropharmacology

authors： Ogata T,Nakamura Y,Tsuji K,Shibata T,Kataoka K,Ishida M,Shinozaki H

更新日期：1994-09-01 00:00:00

abstract：:This study was undertaken to determine whether 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)(2)D(3)], an active metabolite of vitamin D, protects dopaminergic neurons against the neurotoxic effects of glutamate and dopaminergic toxins using rat mesecephalic culture. Brief glutamate exposure elicited cytotoxicity in ...

journal_title：Neuropharmacology

authors： Ibi M,Sawada H,Nakanishi M,Kume T,Katsuki H,Kaneko S,Shimohama S,Akaike A

更新日期：2001-05-01 00:00:00

abstract：:The nucleus tractus solitarius (NTS) region in the rat has been shown to receive arginine vasopressin (AVP) and oxytocin (OT) neurophysin-containing neuronal projections from the suprachiasmatic (SNC) and paraventricular nucleus (PVN). Thus, vasopressin and oxytocin might have central influences on the circulation. Th...

journal_title：Neuropharmacology

authors： Matsuguchi H,Sharabi FM,Gordon FJ,Johnson AK,Schmid PG

更新日期：1982-07-01 00:00:00

abstract：:Ketoprofen is a non-steroidal antiinflammatory drug (NSAID) which provides effective analgesia in situations of pain provoked by tissue inflammation. However, the location of its analgesic effects, (peripheral tissues versus central nervous system), have not been clearly identified and separated. In the present study ...

journal_title：Neuropharmacology

authors： Herrero JF,Parrado A,Cervero F

更新日期：1997-10-01 00:00:00

abstract：:Glutamatergic neurotransmission in the CNS plays a predominant role in learning and memory. While NMDA receptors have been extensively studied, less is known about the involvement of group I metabotropic glutamate receptors in this area. The purpose of the present study was to evaluate the contribution of mGluR1 and m...

journal_title：Neuropharmacology

authors： Gravius A,Barberi C,Schäfer D,Schmidt WJ,Danysz W

更新日期：2006-12-01 00:00:00

abstract：:Methylphenidate (MPD), or Ritalin, is a psychostimulant that is prescribed for an extended period of time to children and adolescents with attention deficit hyperactivity disorder. Adolescence is a time of critical brain maturation and development, and the drug exposure during this time could lead to lasting changes i...

journal_title：Neuropharmacology

authors： Lee MJ,Yang PB,Wilcox VT,Burau KD,Swann AC,Dafny N

更新日期：2009-09-01 00:00:00

abstract：:The effects of the chronic administration of antidepressants on threshold electroconvulsive (ECS) seizures were evaluated in rats. Initially, tonic-clonic seizures were induced in 90% of the animals. Of those animals responding with tonic-clonic seizures, 42% had hindlimb extension (extensors); the remainder showed on...

journal_title：Neuropharmacology

authors： Peterson SL,Trzeciakowski JP,St Mary JS

更新日期：1985-10-01 00:00:00

abstract：:The cyclic octapeptide, CYN-154806, inhibited specific [(125)I]-[Tyr(11)]-SRIF binding to CHO-K1 cell membranes expressing human recombinant somatostatin (SRIF) sst(2) receptors (pIC(50) 8. 58) or rat sst(2(a)) and rat sst(2(b)) receptors (pIC(50) 8.35 and 8. 10, respectively). The affinity of CYN-154806 at other huma...

journal_title：Neuropharmacology

authors： Feniuk W,Jarvie E,Luo J,Humphrey PP

更新日期：2000-06-08 00:00:00

abstract：:The effects of microiontophoretically-applied and pneumatically-applied morphine on the spontaneous discharge of Purkinje cells in the cerebellum of the anesthetized cat were examined. Microiontophoretic application of morphine produced both inhibitory and excitatory responses of the Purkinje cells. Pneumatic applicat...

journal_title：Neuropharmacology

authors： Taguchi K,Suzuki Y

更新日期：1989-03-01 00:00:00

abstract：:The effects of the anxiolytic benzodiazepine flurazepam and the anxiogenic beta-carboline N-methyl-beta-carboline-3-carboxylate (FG 7142) were measured in unanaesthetised rats. Changes in motor activity, using a Doppler-shift microwave device, and in the extracellular concentration of ascorbate in the striatum and nuc...

journal_title：Neuropharmacology

authors： Brose N,O'Neill RD,Boutelle MG,Fillenz M

更新日期：1989-05-01 00:00:00