Abstract:
:Glutamate receptors play an essential role in fear-related learning and memory. The present study was designed to assess the role of the group I metabotropic glutamate receptor (mGluR) subtype 5 in the acquisition and retrieval of conditioned fear in rats. The selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) was applied systemically (0.0, 0.3, 3.0, 30.0 mg/kg per os) 60 min before the acquisition training and before the expression of conditioned fear, respectively, in the fear-potentiated startle paradigm. MPEP dose-dependently blocked the acquisition of fear. This effect was not due to state-dependent learning. MPEP also prevented the expression of fear at a dose of 30.0 mg/kg. As a positive control for these effects, we showed that the benzodiazepine anxiolytic compound diazepam (1.25 mg/kg intraperitoneally) also blocked acquisition and expression of fear potentiated startle. MPEP did not affect the baseline startle magnitude, short-term habituation of startle, sensitisation of startle by footshocks or prepulse inhibition of startle. These data indicate a crucial role for mGluR5 in the regulation of fear conditioning. In the highest dose MPEP might exert anxiolytic properties.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Schulz B,Fendt M,Gasparini F,Lingenhöhl K,Kuhn R,Koch Mdoi
10.1016/s0028-3908(01)00036-3subject
Has Abstractpub_date
2001-07-01 00:00:00pages
1-7issue
1eissn
0028-3908issn
1873-7064pii
S0028390801000363journal_volume
41pub_type
杂志文章abstract::Dopamine (DA) neurotransmission, particularly the ventral tegmental area-nucleus accumbens (VTA-NAcc) projection, underlies reward and aversion processing, and deficient DA function could underlie motivational impairments in psychiatric disorders. 6-hydroxydopamine (6-OHDA) injection is an established method for chron...
journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neuropharmacology
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pub_type: 杂志文章
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更新日期:2007-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.neuropharm.2016.09.010
更新日期:2016-12-01 00:00:00
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更新日期:2015-06-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-02-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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journal_title:Neuropharmacology
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更新日期:2005-12-01 00:00:00