Abstract：
:The anticonvulsant action and the long-term effects on learning, memory and behavior of the new generation antiepileptic drug gabapentin (GBP) were investigated in immature animals. Kainic acid (KA) was administered to rats on postnatal day (P) 35. Animals were treated with GBP or saline from P36 to P75 and spontaneous seizure frequency was monitored. After tapering the drug, the rats were tested in the water maze and open field test. Brains were then analyzed for histological lesions. Animals treated with GBP following KA-induced status epilepticus had a reduced incidence of spontaneous recurrent seizures, a better pathology score, and less aggressiveness compared to saline-treated controls. Effectiveness of GBP on seizure threshold was tested using flurothyl inhalation in 10 separate age groups of animals ranging from the newborn period to adulthood. Furthermore, GBP plasma concentration peaks were determined in all age groups. At all ages, GBP pre-treated animals demonstrated a higher seizure threshold. Plasma GBP concentrations did not significantly change with age. These data suggest that acute administration of a single therapeutic dose of GBP increases the seizure threshold at all ages studied, while chronic treatment following the status reduces spontaneous seizure frequency and cell damage and has no long-term adverse consequences on cognitive processes during development.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Cilio MR,Bolanos AR,Liu Z,Schmid R,Yang Y,Stafstrom CE,Mikati MA,Holmes GLdoi
10.1016/s0028-3908(00)00103-9subject
Has Abstractpub_date
2001-01-01 00:00:00pages
139-47issue
1eissn
0028-3908issn
1873-7064pii
S0028390800001039journal_volume
40pub_type
杂志文章abstract：:Histidine injected intraperitoneally into rats in doses from 400 to 800 mg/kg induced a dose-dependent bizarre behaviour. The behaviour after histidine was similar to that observed after L-DOPA and peripheral decarboxylase inhibition. The bizarre behaviour was antagonized by chloropyramine, ketotifen, clemastine and p...
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,随机对照试验
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abstract：:Nicotine improves endotoxic manifestations of hypotension and cardiac autonomic dysfunction in rats. Here, we test the hypothesis that brainstem antiinflammatory pathways of α7/α4β2 nicotinic acetylcholine receptors (nAChRs) modulate endotoxic cardiovascular derangements. Pharmacologic and molecular studies were perfo...
journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2009-03-01 00:00:00
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更新日期：1993-07-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
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pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2020-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
