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Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models.

Abstract：

:The protopine isolated from a Chinese herb Dactylicapnos scandens Hutch was identified as an inhibitor of both serotonin transporter and noradrenaline transporter in vitro assays. 5-hydroxy-DL-tryptophan(5-HTP)-induced head twitch response (HTR) and tail suspension test were adopted to study whether protopine has anti-depression effect in mice using reference antidepressant fluoxetine and desipramine as positive controls. In HTR test, protopine at doses of 5, 10, 20 mg/kg dose dependently increase the number of 5-HTP-induced HTR. Protopine at doses of 3.75 mg/kg, 7.5 mg/kg and 30 mg/kg also produces a dose-dependent reduction in immobility in the tail suspension test. The present results open up new possibilities for the use of protopine in the treatment of mood disorders, such as mild and moderate states of depression.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Xu LF,Chu WJ,Qing XY,Li S,Wang XS,Qing GW,Fei J,Guo LH

doi

10.1016/j.neuropharm.2006.01.003

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

934-40

issue

8

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(06)00011-6

journal_volume

50

pub_type

杂志文章

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