In vivo striatal binding of the D1 antagonist SCH 23390 is not modified by changes in dopaminergic transmission.

abstract：:Protein phosphorylation, controlled by the coordinated actions of phosphatases and kinases, is an important regulatory mechanism in synaptic transmission and other neurophysiological processes. Ionotropic glutamate receptors are known targets of phosphorylation on serine, threonine and tyrosine residues, with function...

journal_title：Neuropharmacology

authors： Orlando LR,Dunah AW,Standaert DG,Young AB

更新日期：2002-08-01 00:00:00

abstract：:The effects of prostaglandin (PG) E(1) on NO neurotoxicity were examined using rat cultured spinal neurons. Rat cultured spinal neurons exposed to the NO donor, 2,2'-(hydroxynitrosohydrazono) bis-ethanamine (NOC18), showed neurotoxic effects that were accompanied by apoptotic nuclear change, free radical generation, a...

journal_title：Neuropharmacology

authors： Kikuchi S,Shinpo K,Niino M,Tsuji S,Iwabuchi K,Onoé K,Tashiro K

更新日期：2002-04-01 00:00:00

abstract：:Under conditions in which NG-nitro-L-arginine (NOArg) treatment prevents morphine tolerance, NOArg induces a slow progressive inhibition of nitric oxide synthase (NOS), starting at approx. 20% after a single treatment and increasing to approx. 65% after 10 days. Studies designed to examine potential changes in NOS lev...

journal_title：Neuropharmacology

authors： Babey AM,Kolesnikov Y,Cheng J,Inturrisi CE,Trifilletti RR,Pasternak GW

更新日期：1994-11-01 00:00:00

abstract：:Dieting induces depression and anxiety among other emotional symptoms. Animal models indicate that repeated access to palatable foods such as sugar induces depression and anxiety-like behavior when the food is no longer available. However, the neurobiological mechanisms of how dietary restriction influences mood have ...

journal_title：Neuropharmacology

authors： Kim S,Shou J,Abera S,Ziff EB

更新日期：2018-03-01 00:00:00

abstract：:Adenosine A2a receptors (A2aRs) are highly and selectively expressed in D2-medium spiny neurons (D2-MSNs) that also express a high level of dopamine D2 receptors (D2Rs). However, it was not established how A2aR activity affects D2-MSN excitability, let alone the ion channels involved. We have performed two sets of exp...

journal_title：Neuropharmacology

authors： Wang Q,Zhou FM

更新日期：2019-04-01 00:00:00

abstract：:The central amygdala (CeA) is a critical regulator of emotional behavior that has been implicated in psychiatric illnesses, including anxiety disorders and addiction. The CeA corticotropin releasing factor receptor 1 (CRF1) system has been implicated in alcohol use disorder (AUD) and mood disorders, and has been shown...

journal_title：Neuropharmacology

authors： Agoglia AE,Tella J,Herman MA

更新日期：2020-12-01 00:00:00

abstract：:The NMDA receptor is a major target of alcohol action in the CNS, and recent behavioral and cellular studies have pointed to the importance of the GluN2B subunit in alcohol action. We and others have previously characterized four amino acid positions in the third and fourth membrane-associated (M) domains of the NMDA ...

journal_title：Neuropharmacology

authors： Zhao Y,Ren H,Dwyer DS,Peoples RW

更新日期：2015-10-01 00:00:00

abstract：:Phenytoin (DPH) is a clinically useful sodium (Na) channel blocker with efficacy against partial and generalized seizures. We have developed a novel hydantoin compound (HA) using comparative molecular field analysis (CoMFA) and evaluated its effects on hNa(v)1.2 channels. Both DPH and HA demonstrated affinity for rest...

journal_title：Neuropharmacology

authors： Lenkowski PW,Batts TW,Smith MD,Ko SH,Jones PJ,Taylor CH,McCusker AK,Davis GC,Hartmann HA,White HS,Brown ML,Patel MK

更新日期：2007-03-01 00:00:00

abstract：:It has been hypothesized that Acetyl-L-Carnitine (ALC) contributes to mitochondrial ATP production through maintenance of key mitochondrial proteins and protects mitochondria against oxidative stress. We have investigated the role of ALC on the expression of two forms of synaptic plasticity in the striatum: (i) the ph...

journal_title：Neuropharmacology

authors： Bagetta V,Barone I,Ghiglieri V,Di Filippo M,Sgobio C,Bernardi G,Calabresi P,Picconi B

更新日期：2008-08-01 00:00:00

abstract：:The contribution of metabotropic glutamate receptors (mGluRs) to the modulation of nociception by the periaqueductal gray (PAG) matter was investigated in mice. Intra-PAG microinjection of (IS,3R)-ACPD, an agonist of groups I and II mGluRs, as well as (S)-3,5-DHPG, a selective agonist of group I mGluRs, increased the ...

journal_title：Neuropharmacology

authors： Maione S,Marabese I,Leyva J,Palazzo E,de Novellis V,Rossi F

更新日期：1998-12-01 00:00:00

abstract：:Marijuana smoking is recognised to impair human cognition and learning, but the mechanisms by which this occurs are not well characterised. This article focuses exclusively on the hippocampus to review the effects of cannabinoids on hippocampal function and evaluate the evidence that hippocampal cannabinoid receptors ...

journal_title：Neuropharmacology

authors： Davies SN,Pertwee RG,Riedel G

更新日期：2002-06-01 00:00:00

abstract：:Grip strength deficit is a measure of pain-induced functional disability in rheumatic disease. We tested whether this parameter and tactile allodynia, the standard pain measure in preclinical studies, show parallels in their response to analgesics and basic mechanisms. Mice with periarticular injections of complete Fr...

journal_title：Neuropharmacology

authors： Montilla-García Á,Tejada MÁ,Perazzoli G,Entrena JM,Portillo-Salido E,Fernández-Segura E,Cañizares FJ,Cobos EJ

更新日期：2017-10-01 00:00:00

abstract：:Both short-term (48 h) exposure to the neuroactive steroid 3alpha,5alpha[beta]-THP and its withdrawal increase expression of the benzodiazepine (BDZ)-insensitive GABAA receptor (GABAR) alpha4 subunit in hippocampus. This increase in alpha4 subunit expression was associated with a relative insensitivity of CA1 hippocam...

journal_title：Neuropharmacology

authors： Smith SS,Gong QH

更新日期：2004-07-01 00:00:00

abstract：:Changes in brain reward and control systems of frontal cortical areas including the orbitofrontal cortex (OFC) are associated with alcohol use disorders (AUD). The OFC is extensively innervated by monoamines, and drugs that target monoamine receptors have been used to treat a number of neuropsychiatric diseases, inclu...

journal_title：Neuropharmacology

authors： Nimitvilai S,Lopez MF,Woodward JJ

更新日期：2018-07-15 00:00:00

abstract：:Extrapyramidal syndromes (EPS) caused by antipsychotic therapy are currently treated with anticholinergics that lack selectivity for the five muscarinic receptor subtypes. Since these receptors are heterogeneously expressed among the different classes of striatal neurons and their afferents, it can be expected that th...

journal_title：Neuropharmacology

authors： Erosa-Rivero HB,Bata-García JL,Alvarez-Cervera FJ,Heredia-López FJ,Góngora-Alfaro JL

更新日期：2014-06-01 00:00:00

abstract：:Glibenclamide (GBC), a sulfonylurea receptor 1 blocker, emerges recently as a promising neuron protectant in various neurological disorders. This study aimed to determine whether GBC improves survival and neurological outcome of status epilepticus (SE). Male Sprague-Dawley rats successfully undergoing SE for 2.5 h (n ...

journal_title：Neuropharmacology

authors： Lin Z,Huang H,Gu Y,Huang K,Hu Y,Ji Z,Wu Y,Wang S,Yang T,Pan S

更新日期：2017-07-15 00:00:00

abstract：:Muscarinic acetylcholine receptors (mAChRs) are G proteincoupled receptors (GPCRs) that mediate the metabotropic actions of acetylcholine (ACh). There are five subtypes of mAChR, M1 - M5, which are expressed throughout the central nervous system (CNS) on numerous cell types and represent promising treatment targets fo...

journal_title：Neuropharmacology

authors： Lebois EP,Thorn C,Edgerton JR,Popiolek M,Xi S

更新日期：2018-07-01 00:00:00

abstract：:Marijuana use in adolescence, but not adulthood, may permanently impair cognitive functioning and increase the risk of developing schizophrenia. Cortical oscillations are patterns of neural network activity implicated in cognitive processing, and are abnormal in patients with schizophrenia. We have recently reported t...

journal_title：Neuropharmacology

authors： Raver SM,Keller A

更新日期：2014-11-01 00:00:00

abstract：:In three experiments, rats were injected once daily with 5.0 mg/kg apomorphine or vehicle and tested for locomotor activity for 10-14 days. In each experiment, apomorphine produced behavioral sensitization, characterized by a progressively greater increase in locomotor activity with each succeeding injection. On day 1...

journal_title：Neuropharmacology

authors： Rowlett JK,Mattingly BA,Bardo MT

更新日期：1991-02-01 00:00:00

abstract：:The hippocampal slice is a popular model system in which to study the cellular properties of long-term potentiation (LTP). Synaptogenesis induced by exposure to ice-cold artificial cerebrospinal fluid (ACSF), however, raises the concern that morphological correlates of LTP might be obscured, especially in mature slice...

journal_title：Neuropharmacology

authors： Bourne JN,Kirov SA,Sorra KE,Harris KM

更新日期：2007-01-01 00:00:00

abstract：:The aim of this study was to investigate the facilitatory effects of subanalgesic or low doses of different drugs (acetylsalicylic acid, ibuprofen and morphine) on the antinociceptive responses induced by the endogenous opioid peptides, enkephalins, protected from their catabolism by the dual enkephalin-degrading enzy...

journal_title：Neuropharmacology

authors： Nieto MM,Wilson J,Walker J,Benavides J,Fournié-Zaluski MC,Roques BP,Noble F

更新日期：2001-09-01 00:00:00

abstract：:Alpha2-adrenergic drugs modulate cortical arousal and EEG. However, the role of individual alpha2-adrenoceptor (alpha(2)-AR) subtypes in these functions is not clear. We investigated the role of alpha(2C)-ARs in the modulation of baseline cortical EEG activity and EEG responses to the alpha(2)-AR selective agonist, de...

journal_title：Neuropharmacology

authors： Puoliväli J,Björklund M,Holmberg M,Ihalainen JA,Scheinin M,Tanila H

更新日期：2002-12-01 00:00:00

abstract：:Symptomatic temporal lobe epilepsy typically develops in three phases: brain damage --> epileptogenesis --> spontaneous seizures (epilepsy). The challenge is to prevent epileptogenesis after injury. We hypothesized that alleviation of damage by caspase inhibitors will reduce epileptogenesis or at least have disease-mo...

journal_title：Neuropharmacology

authors： Narkilahti S,Nissinen J,Pitkänen A

更新日期：2003-06-01 00:00:00

abstract：:The binding of three, structurally distinct, 5-hydroxytryptamine3 (5-HT3) receptor radioligands was characterized in rat cerebral cortex, rabbit ileum myenteric plexus and NG-108-15 neuroblastoma cells. The density of sites labeled by the three ligands in rat cortex or in rabbit ileum was markedly different. [3H]Quipa...

journal_title：Neuropharmacology

authors： Wong EH,Bonhaus DW,Lee JA,Wu I,Loury DN,Eglen RM

更新日期：1993-09-01 00:00:00

abstract：:We describe a touchscreen method that satisfies a proposed 'wish-list' of desirables for a cognitive testing method for assessing rodent models of schizophrenia. A number of tests relevant to schizophrenia research are described which are currently being developed and validated using this method. These tests can be us...

journal_title：Neuropharmacology

authors： Bussey TJ,Holmes A,Lyon L,Mar AC,McAllister KA,Nithianantharajah J,Oomen CA,Saksida LM

更新日期：2012-03-01 00:00:00

abstract：:Increasing evidence suggests that oxidative stress may be implicated in the degeneration of dopaminergic neurons in Parkinson's disease (PD), and anti-oxidation have been shown to be effective to PD treatment. Myricetin has been reported to have the biological functions of anti-oxidation, anti-apoptosis, anti-inflamma...

journal_title：Neuropharmacology

authors： Zhang K,Ma Z,Wang J,Xie A,Xie J

更新日期：2011-07-01 00:00:00

abstract：:G protein-coupled receptor 35 (GPR35) is an orphan G protein-coupled receptor (GPCR) that can be activated by kynurenic acid at high micromolar concentrations. A previously unappreciated mechanism of action of GPR35 has emerged as a Gαi/o-coupled inhibitor of synaptic transmission, a finding that has significant impli...

journal_title：Neuropharmacology

authors： Mackenzie AE,Milligan G

更新日期：2017-02-01 00:00:00

abstract：:In the prostatic portion of rat vas deferens, the non-selective adenosine receptor agonist NECA (0.1-30 microM), but not the A(2A) agonist CGS 21680 (0.001-10 microM), caused a facilitation of electrically evoked noradrenaline release (up to 43 +/- 4%), when inhibitory adenosine A(1) receptors were blocked. NECA-elici...

journal_title：Neuropharmacology

authors： Queiroz G,Quintas C,Talaia C,Gonçalves J

更新日期：2004-08-01 00:00:00

abstract：:Neurones isolated from the CA1 region of rat hippocampal slices by the "vibrodissociation" method were voltage-clamped in the whole-cell configuration. The currents through N-methyl-D-aspartate (NMDA) channels were recorded in response to the rapid application (solution exchange time <30 msec) of 100 microM aspartate ...

journal_title：Neuropharmacology

authors： Sobolevsky A,Koshelev S,Khodorov BI

更新日期：1997-03-01 00:00:00

abstract：:In PC12 cells, isosorbide dinitrate (ISDN) and S-nitrosol-acetyl-penicillamine (SNAP), both nitric oxide (NO) generators, attenuated K+ (56 mM)-stimulated release of dopamine. The attenuation was not observed with isosorbide, an ISDN analog lacking NO generating capacity. In this model, A23187 (Ca2+ ionophore), Bay K8...

journal_title：Neuropharmacology

authors： Sun P,Kanthasamy A,Yim GK,Isom GE

更新日期：1995-02-01 00:00:00