Sucrose withdrawal induces depression and anxiety-like behavior by Kir2.1 upregulation in the nucleus accumbens.

abstract：:Antidepressants such as Selective Serotonin Reuptake Inhibitors (SSRI) act as indirect agonists of serotonin (5-HT) receptors. Although these drugs produce a rapid blockade of serotonin transporters (SERTs) in vitro, several weeks of treatment are necessary to observe clinical benefits. This paradox has not been solve...

journal_title：Neuropharmacology

authors： Deltheil T,Guiard BP,Cerdan J,David DJ,Tanaka KF,Repérant C,Guilloux JP,Coudoré F,Hen R,Gardier AM

更新日期：2008-11-01 00:00:00

abstract：:Intraventricular administration of substance P (SP), of the heptapeptide SP5-11 and of DiMe-C7, a stable analogue of SP5-11 induced locomotor activation in rats and in mice. The activating effect of substance P was longer-lasting in mice than in rats, whereas the effect of the two heptapeptides appears to be more mark...

journal_title：Neuropharmacology

authors： Naranjo JR,Del Rio J

更新日期：1984-10-01 00:00:00

abstract：:Limited information exists on the link between purinergic class P2X7 receptors (P2X7Rs) and calcium ion channels in epilepsy; no data has been reported regarding the interaction between P2X7Rs and T-type calcium ion channels in epilepsy. Thus, this study is an evaluation of the role that T-type calcium ion channels pl...

journal_title：Neuropharmacology

authors： Arslan G,Avci B,Kocacan SE,Rzayev E,Ayyildiz M,Agar E

更新日期：2019-05-01 00:00:00

abstract：:Dural plasma extravasation produced by electrical stimulation of the trigeminal ganglion was measured in rats and the concomitant expression of c-fos mRNA produced in the trigeminal nucleus caudalis (NtV) was measured using in situ hybridization techniques. The non-peptide NK1 receptor selective antagonist CP-99,994 (...

journal_title：Neuropharmacology

authors： Shepheard SL,Williamson DJ,Williams J,Hill RG,Hargreaves RJ

更新日期：1995-03-01 00:00:00

abstract：:To compare the actions of prototypic drugs which are selective for phencyclidine and sigma receptors, the electrophysiological effects of phencyclidine (PCP),3-[3-hydroxyphenyl]-N-(1-propyl)piperidine [+)3-PPP), and 1,3-di(2-tolyl)guanidine (DTG) on CA1 hippocampal pyramidal neurons were examined. A wide range of conc...

journal_title：Neuropharmacology

authors： Malouf AT,Swearengen E,Chavkin C

更新日期：1988-11-01 00:00:00

abstract：:It has been reported that application of 1S,3R-1-aminocyclopentane 1,3-dicarboxylic acid (ACPD) in vitro triggers a slow-onset potentiation in the hippocampal CA1 region. This study examined the effect of ACPD in the CA1 of freely moving rats. No effect on fEPSP baseline recordings occurred at 40 and 400 microM/5 micr...

journal_title：Neuropharmacology

authors： Manahan-Vaughan D,Reymann KG

更新日期：1995-08-01 00:00:00

abstract：:The group III metabotropic glutamate (mGlu) receptors mGlu7 and mGlu8 are receiving increased attention as potential novel therapeutic targets for anxiety disorders. The effects mediated by these receptors appear to result from a complex interplay of facilitatory and inhibitory actions at different brain sites in the ...

journal_title：Neuropharmacology

authors： Dobi A,Sartori SB,Busti D,Van der Putten H,Singewald N,Shigemoto R,Ferraguti F

更新日期：2013-03-01 00:00:00

abstract：:Transgenic mice that accumulate Aβ peptides in the CNS are commonly used to interrogate functional consequences of Alzheimer's disease-associated amyloidopathy. In addition to changes to synaptic function, there is also growing evidence that changes to intrinsic excitability of neurones can arise in these models of am...

journal_title：Neuropharmacology

authors： Kerrigan TL,Brown JT,Randall AD

更新日期：2014-04-01 00:00:00

abstract：:E2020 is a piperidine cholinesterase inhibitor (ChEI) which is structurally distinct from other compounds presently under study for treatment of Alzheimer's disease. We studied the effect of this compound on acetylcholine (ACh), norepinephrine (NE), dopamine (DA) and serotonin (5-HT; 5-hydroxytryptamine) by means of t...

journal_title：Neuropharmacology

authors： Giacobini E,Zhu X D,Williams E,Sherman KA

更新日期：1996-02-01 00:00:00

abstract：:Akt is a serine/threonine kinase, which is dramatically reduced in the prefrontal cortex (PFC) of patients with schizophrenia, and a deficiency in Akt1 results in PFC function abnormalities. Although the importance of Akt in dopamine (DA) transmission is well established, how impaired Akt signaling affects the DA modu...

journal_title：Neuropharmacology

authors： Li YC,Yang SS,Gao WJ

更新日期：2016-09-01 00:00:00

abstract：:Systemic administration of thiazolidinediones reduces peripheral inflammation in vivo, presumably by acting at peroxisome proliferator-activated receptor gamma (PPARgamma) in peripheral tissues. Based on a rapidly growing body of literature indicating the CNS as a functional target of PPARgamma actions, we postulated ...

journal_title：Neuropharmacology

authors： Morgenweck J,Abdel-Aleem OS,McNamara KC,Donahue RR,Badr MZ,Taylor BK

更新日期：2010-02-01 00:00:00

abstract：:In this study we investigate the presence, modulation and biological function of P2 receptors and extracellular ATP in cultured cerebellar granule neurons. As we demonstrate by RT-PCR and western blotting, both P2X and P2Y receptor subtypes are expressed and furthermore regulated as a function of neuronal maturation. ...

journal_title：Neuropharmacology

authors： Amadio S,D'Ambrosi N,Cavaliere F,Murra B,Sancesario G,Bernardi G,Burnstock G,Volonté C

更新日期：2002-03-01 00:00:00

abstract：:In recent years, neuroscientists have produced profound conceptual and mechanistic advances on the neurocircuitry of reward and substance use disorders. Here, we will provide a brief review of intracranial drug self-administration and optogenetic self-stimulation studies that identified brain regions and neurotransmit...

journal_title：Neuropharmacology

authors： Ikemoto S,Bonci A

更新日期：2014-01-01 00:00:00

abstract：:Desensitization of the nicotinic acetylcholine receptor (nAChR) containing the β2 subunit is a potentially critical mechanism underlying the body weight (BW) reducing effects of nicotine. The purpose of this study was a) to determine the α subunit(s) that partners with the β2 subunit to form the nAChR subtype that end...

journal_title：Neuropharmacology

authors： Dezfuli G,Olson TT,Martin LM,Keum Y,Siegars BA,Desai A,Uitz M,Sahibzada N,Gillis RA,Kellar KJ

更新日期：2020-04-01 00:00:00

abstract：:Conantokin-G (Con-G), a gamma-carboxylglutamate (Gla) containing peptide derived from the venom of the marine cone snail Conus geographus, acts as a selective and potent inhibitor of N-methyl-D-aspartate (NMDA) receptors. Here, the effect of Con-G on recombinant NMDA receptors carrying point mutations within the glyci...

journal_title：Neuropharmacology

authors： Wittekindt B,Malany S,Schemm R,Otvos L,Maccecchini ML,Laube B,Betz H

更新日期：2001-11-01 00:00:00

abstract：:The effects of various benzodiazepine receptor ligands on the GABA autoreceptor have been studied in slices of cerebral cortex of the rat. The GABAA receptor agonist muscimol inhibited the K+-stimulated release of [3H]GABA with a pIC25 of 7.65 +/- 0.11. This effect was antagonised by the GABAA receptor antagonist bicu...

journal_title：Neuropharmacology

authors： Ennis C,Minchin MC

更新日期：1988-10-01 00:00:00

abstract：:Maternal aggression is highly expressed during lactation and serves to protect the developing young from intruders that may injure the offspring. One neurochemical modulator of maternal aggression appears to be arginine vasopressin (AVP). Earlier research supports a role for AVP in maternal aggression in rats as treat...

journal_title：Neuropharmacology

authors： Nephew BC,Byrnes EM,Bridges RS

更新日期：2010-01-01 00:00:00

abstract：:The present study investigated the effects of WB4101, a selective alpha 1-adrenoceptor blocking agent, and idazoxan, a selective alpha 2-adrenoceptor blocking agent, on antinociception and sedation in the rat mediated by adrenoceptors. Selective alpha 1-adrenoceptor agonists, e.g. ST587 and methoxamine induced antinoc...

journal_title：Neuropharmacology

authors： Hayes AG,Skingle M,Tyers MB

更新日期：1986-04-01 00:00:00

abstract：:We investigated the role of nitric oxide (NO) in learning and memory formation in a radial maze test, by using the NO synthase (NOS) inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), and an NO precursor, L-arginine. Rats were trained on a working and reference memory task in an eight ar...

journal_title：Neuropharmacology

authors： Zou LB,Yamada K,Tanaka T,Kameyama T,Nabeshima T

更新日期：1998-01-01 00:00:00

abstract：:We describe a touchscreen method that satisfies a proposed 'wish-list' of desirables for a cognitive testing method for assessing rodent models of schizophrenia. A number of tests relevant to schizophrenia research are described which are currently being developed and validated using this method. These tests can be us...

journal_title：Neuropharmacology

authors： Bussey TJ,Holmes A,Lyon L,Mar AC,McAllister KA,Nithianantharajah J,Oomen CA,Saksida LM

更新日期：2012-03-01 00:00:00

abstract：:The modulatory effects exerted by the glucocorticoid hydrocortisone (HC) on the nicotinic acetylcholine receptor (AChR) were studied in mutants of the alpha subunit M4 transmembrane region. Based on the photoaffinity labeling of alpha M4 412 with the steroid promegestone this position was mutated to different residues...

journal_title：Neuropharmacology

authors： Garbus I,Roccamo AM,Barrantes FJ

更新日期：2002-07-01 00:00:00

abstract：:Acetylcholine-induced currents were measured in partially depolarized mouse soleus muscles, denervated for 3-6 days by using a point voltage clamp. When 0.25 microM d-tubocurarine (d-Tc) was used, the weak currents provoked by 0.1 microM ACh, at a holding potential of -20 mV, were barely affected, while the large curr...

journal_title：Neuropharmacology

authors： Lorković H

更新日期：1990-06-01 00:00:00

abstract：:Long-term memory formation is known to be critically dependent upon de novo gene expression in the brain. As a consequence, pharmacological enhancement of the transcriptional processes mediating long-term memory formation provides a potential therapeutic strategy for cognitive disorders involving aberrant neuroplastic...

journal_title：Neuropharmacology

authors： Fass DM,Reis SA,Ghosh B,Hennig KM,Joseph NF,Zhao WN,Nieland TJ,Guan JS,Kuhnle CE,Tang W,Barker DD,Mazitschek R,Schreiber SL,Tsai LH,Haggarty SJ

更新日期：2013-01-01 00:00:00

abstract：:We studied the neuroprotective effect of lubeluzole, a NOS (nitric oxide synthase) pathway modulator, on the development of ischemic damage within the first six hours after a photochemically induced neocortical infarct in rats using diffusion-weighted MRI and Apparent Diffusion Coefficient (ADC) maps. A unilateral pho...

journal_title：Neuropharmacology

authors： De Ryck M,Verhoye M,Van der Linden AM

更新日期：2000-02-14 00:00:00

abstract：:In the present study, the effects of bilateral injections of the GABAergic receptor agents into the dorsal hippocampal CA1 regions (intra-CA1) on morphine-induced amnesia were examined in morphine sensitized-mice. Pre-training subcutaneous (s.c.) administration of morphine (5 mg/kg) suppressed the learning of a one-tr...

journal_title：Neuropharmacology

authors： Zarrindast MR,Hoghooghi V,Rezayof A

更新日期：2008-03-01 00:00:00

abstract：:Glutamate receptors play an essential role in fear-related learning and memory. The present study was designed to assess the role of the group I metabotropic glutamate receptor (mGluR) subtype 5 in the acquisition and retrieval of conditioned fear in rats. The selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyr...

journal_title：Neuropharmacology

authors： Schulz B,Fendt M,Gasparini F,Lingenhöhl K,Kuhn R,Koch M

更新日期：2001-07-01 00:00:00

abstract：:Long-term L-DOPA treatment for Parkinson's disease (PD) is limited by motor complications, particularly L-DOPA-induced dyskinesia (LID). A therapy with the ability to ameliorate LID without reducing anti-parkinsonian benefit would be of great value. We assessed the ability of TC-8831, an agonist at nicotinic acetylcho...

journal_title：Neuropharmacology

authors： Johnston TH,Huot P,Fox SH,Koprich JB,Szeliga KT,James JW,Graef JD,Letchworth SR,Jordan KG,Hill MP,Brotchie JM

更新日期：2013-10-01 00:00:00

abstract：:Benzodiazepines (BZDs) are widely used in the treatment of a variety of neurological and psychiatric conditions including anxiety, insomnia and epilepsy. BZDs are thought to act predominantly by affecting the gating of GABAA receptor channels, resulting in enhanced GABA-mediated currents in neurons. However, mutations...

journal_title：Neuropharmacology

authors： Lévi S,Le Roux N,Eugène E,Poncer JC

更新日期：2015-01-01 00:00:00

abstract：:Conantokin-G (con-G), conantokin-T (con-T), a truncated conantokin-R (con-R[1-17]), that functions the same as wild-type con-R, and variant sequences of con-T, were chemically synthesized and employed to investigate their selectivities as antagonists of glutamate/glycine-evoked ion currents in human embryonic kidney-2...

journal_title：Neuropharmacology

authors： Sheng Z,Dai Q,Prorok M,Castellino FJ

更新日期：2007-07-01 00:00:00

abstract：:The effects of guanosine-5'-triphosphate (GTP), sodium chloride and manganese chloride on the binding of buprenorphine to opiate receptors present in rat brain has been studied. Manganese chloride significantly decreased the affinity of binding of both [3H] buprenorphine and unlabelled buprenorphine to morphine and en...

journal_title：Neuropharmacology

authors： Villiger JW

更新日期：1984-03-01 00:00:00