Abstract:
:In PC12 cells, isosorbide dinitrate (ISDN) and S-nitrosol-acetyl-penicillamine (SNAP), both nitric oxide (NO) generators, attenuated K+ (56 mM)-stimulated release of dopamine. The attenuation was not observed with isosorbide, an ISDN analog lacking NO generating capacity. In this model, A23187 (Ca2+ ionophore), Bay K8644 (Ca2+ slow channel agonist) and veratridine (Na+ channel agonist) stimulated dopamine release. Treatment with ISDN enhanced Bay K8644 and veratridine-evoked dopamine release, while ISDN had no significant effect on the A23187 response. Incubation with 8-bromo-cGMP (membrane permeable cGMP analog) had no effect on basal or stimulated dopamine release in these cells, suggesting NO's response was not mediated by cGMP. In additional studies, K+ (56 mM), Bay K8644 and veratridine elevated cytosolic free calcium levels ([Ca2+]i). ISDN reduced K(+)-stimulated increase in [Ca2+]i, but enhanced the increases of [Ca2+]i induced by Bay K8644 or veratridine. These results suggest NO interacts with K(+)-induced membrane depolarization (possibly by inhibiting membrane conductance to K+) to attenuate Ca2+ influx and Ca(2+)-mediated dopamine secretion stimulated by K+.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Sun P,Kanthasamy A,Yim GK,Isom GEdoi
10.1016/0028-3908(94)00151-hsubject
Has Abstractpub_date
1995-02-01 00:00:00pages
205-10issue
2eissn
0028-3908issn
1873-7064pii
002839089400151Hjournal_volume
34pub_type
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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pub_type: 杂志文章,评审
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journal_title:Neuropharmacology
pub_type: 杂志文章
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journal_title:Neuropharmacology
pub_type: 杂志文章
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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