The endogenous cannabinoid system and the treatment of marijuana dependence.

abstract：:Aberrant increases in NMDA receptor (NMDAR) signaling contributes to central nervous system sensitization and chronic pain by activating neuronal nitric oxide synthase (nNOS) and generating nitric oxide (NO). Because the scaffolding protein postsynaptic density 95kDA (PSD95) tethers nNOS to NMDARs, the PSD95-nNOS comp...

journal_title：Neuropharmacology

authors： Lee WH,Xu Z,Ashpole NM,Hudmon A,Kulkarni PM,Thakur GA,Lai YY,Hohmann AG

更新日期：2015-10-01 00:00:00

abstract：:Excitatory neurotransmission mediated by N-methyl-d-aspartate receptors (NMDARs) is fundamental to learning and memory and, when impaired, causes certain neurological disorders. NMDARs are heterotetrameric complexes composed of two GluN1 [NR1] and two GluN2(A-D) [NR2(A-D)] subunits. The GluN2 subunit is responsible fo...

journal_title：Neuropharmacology

authors： Punnakkal P,Jendritza P,Köhr G

更新日期：2012-04-01 00:00:00

abstract：:The involvement of metabotropic glutamate receptor group II (mGluRII) in the induction of long-term depression (LTD) was investigated in the medial perforant path of the rat dentate gyrus, a region with a very high density of mGluRII. Perfusion of either of two potent mGluRII agonists, (2S,1R,2R,3R)-2-(2S, 1'R, 2'R, 3...

journal_title：Neuropharmacology

authors： Huang L,Killbride J,Rowan MJ,Anwyl R

更新日期：1999-01-01 00:00:00

abstract：:Addiction involves drug-induced neuroplasticity in the circuitry of motivated behavior, which includes the medial forebrain bundle and the lateral hypothalamic area. Emerging at the forefront of neuroplasticity regulation are specialized extracellular matrix (ECM) structures that form perineuronal nets (PNNs) around c...

journal_title：Neuropharmacology

authors： Blacktop JM,Todd RP,Sorg BA

更新日期：2017-05-15 00:00:00

abstract：:In isolation-reared mice, social encounter stimulation induces locomotor hyperactivity and activation of the dorsal raphe nucleus (DRN), suggesting that dysregulation of dorsal raphe function may be involved in abnormal behaviors. In this study, we examined the involvement of dorsal raphe GABAergic dysregulation in th...

journal_title：Neuropharmacology

authors： Araki R,Hiraki Y,Nishida S,Kuramoto N,Matsumoto K,Yabe T

更新日期：2016-02-01 00:00:00

abstract：:3,4-methylenedioxypyrovalerone (MDPV) is a synthetic cathinone with cocaine-like properties. In a previous work, we exposed adolescent mice to MDPV, finding sensitization to cocaine effects, and a higher vulnerability to cocaine abuse in adulthood. Here we sought to determine if such MDPV schedule induces additional b...

journal_title：Neuropharmacology

authors： Duart-Castells L,López-Arnau R,Buenrostro-Jáuregui M,Muñoz-Villegas P,Valverde O,Camarasa J,Pubill D,Escubedo E

更新日期：2019-01-01 00:00:00

abstract：:Heterogeneous binding interactions of cerebellar GABA(A) receptors were investigated with GABA agonists and neurosteroids. GABA(A) receptors of rat cerebellum were labelled with [(3)H]ethynylbicycloorthobenzoate (EBOB), a convulsant radioligand. Saturation analysis revealed a homogenous, nanomolar population of [(3)H]...

journal_title：Neuropharmacology

authors： Maksay G,Bíró T

更新日期：2005-09-01 00:00:00

abstract：:Tetraethylammonium (TEA) (2.6 x 10(-3) M) potentiated the twitches of the indirectly- or directly-stimulated phrenic nerve diaphragm of the rat at 37 degrees C by prolonging the action potential of the sarcolemma, due to an inhibition of the repolarizing K+ current. With indirect stimulation, TEA caused a use-dependen...

journal_title：Neuropharmacology

authors： Røed A

更新日期：1989-06-01 00:00:00

abstract：:Hypoxic-ischemic encephalopathy (HI) accounts for the majority of developmental, motor and cognitive deficits in children, leading to life-long neurological impairments. Since the plasmamembrane sodium/calcium exchanger (NCX) plays a fundamental role in maintaining ionic homeostasis during adult brain ischemia, in the...

journal_title：Neuropharmacology

authors： Cerullo P,Brancaccio P,Anzilotti S,Vinciguerra A,Cuomo O,Fiorino F,Severino B,Di Vaio P,Di Renzo G,Annunziato L,Pignataro G

更新日期：2018-06-01 00:00:00

abstract：:Pain is among the most common symptoms in cancer and approximately 90% of patients experience end-stage cancer pain. The management of cancer pain is challenging due to the significant side effects associated with opioids, and novel therapeutic approaches are needed. MMG22 is a bivalent ligand containing MOR agonist a...

journal_title：Neuropharmacology

authors： Shueb SS,Erb SJ,Lunzer MM,Speltz R,Harding-Rose C,Akgün E,Simone DA,Portoghese PS

更新日期：2019-12-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors (nAChR) have been suggested to play a role in a variety of modulatory and regulatory processes, including neuroprotection. Here we have characterized the neuroprotective effects of nicotine against an excitotoxic insult in primary hippocampal cultures. Exposure of hippocampal...

journal_title：Neuropharmacology

authors： Dajas-Bailador FA,Lima PA,Wonnacott S

更新日期：2000-10-01 00:00:00

abstract：:The kinetics of synaptic currents is largely determined by the postsynaptic receptor gating and the concentration time course of synaptic neurotransmitter. While the analysis of current responses to rapid agonist application provides the means to study the ligand-gated receptor gating, no direct tools are available to...

journal_title：Neuropharmacology

authors： Mozrzymas JW

更新日期：2004-12-01 00:00:00

abstract：:Glutamic acid is the major excitatory amino acid of the central nervous system which interacts with two receptor families, the ionotropic and metabotropic glutamate receptors. The metabotropic glutamate receptors (mGluRs) are coupled to G proteins and can be divided into three subgroups based on their sequence homolog...

journal_title：Neuropharmacology

authors： Emile L,Mercken L,Apiou F,Pradier L,Bock MD,Menager J,Clot J,Doble A,Blanchard JC

更新日期：1996-05-01 00:00:00

abstract：:The stable transcription factor ΔFosB is induced in the nucleus accumbens (NAc) by chronic exposure to several drugs of abuse, and transgenic expression of ΔFosB in the striatum enhances the rewarding properties of morphine and cocaine. However, the mechanistic basis for these observations is incompletely understood. ...

journal_title：Neuropharmacology

authors： Sim-Selley LJ,Cassidy MP,Sparta A,Zachariou V,Nestler EJ,Selley DE

更新日期：2011-12-01 00:00:00

abstract：:Orexin-A, -B play a crucial role in arousal and feeding by activating two G-protein-coupled receptors: orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R). Orexins, along with orexin receptors, are expressed in retinal neurons, and they have been shown to differentially modulate excitatory AMPA receptors of amacrine...

journal_title：Neuropharmacology

authors： Zhang G,Wu XH,Xu GZ,Weng SJ,Yang XL,Zhong YM

更新日期：2018-05-01 00:00:00

abstract：:The potential contributions of dysregulation of the brain's histaminergic modulatory system to neuropsychiatric disease, and the potential of histamine-targeting medications as therapeutic agents, are gradually coming into focus. The H3R receptor, which is expressed primarily in the central nervous system, is a promis...

journal_title：Neuropharmacology

authors： Rapanelli M,Pittenger C

更新日期：2016-07-01 00:00:00

abstract：:The role of dopamine in spinal motor transmission was investigated using spinal reflexes in acutely spinalized rats. Intravenous administration of a relatively high dose of the dopamine receptor agonist apomorphine-HCl (3 mg/kg) or the D2 receptor agonist bromocriptine mesylate (1 mg/kg) reduced the amplitude of the m...

journal_title：Neuropharmacology

authors： Kamijo N,Nagao T,Ono H

更新日期：1993-08-01 00:00:00

abstract：:Tobacco smoking is a preventable cause of morbidity and mortality throughout the world. Very high rates of tobacco smoking are seen in patients with schizophrenia. Importantly, smokers with schizophrenia generally have higher nicotine dependence scores, experience more severe withdrawal symptoms upon smoking cessation...

journal_title：Neuropharmacology

authors： D'Souza MS,Markou A

更新日期：2012-03-01 00:00:00

abstract：:Conantokin-G (Con-G), a gamma-carboxylglutamate (Gla) containing peptide derived from the venom of the marine cone snail Conus geographus, acts as a selective and potent inhibitor of N-methyl-D-aspartate (NMDA) receptors. Here, the effect of Con-G on recombinant NMDA receptors carrying point mutations within the glyci...

journal_title：Neuropharmacology

authors： Wittekindt B,Malany S,Schemm R,Otvos L,Maccecchini ML,Laube B,Betz H

更新日期：2001-11-01 00:00:00

abstract：:Long-term L-DOPA treatment for Parkinson's disease (PD) is limited by motor complications, particularly L-DOPA-induced dyskinesia (LID). A therapy with the ability to ameliorate LID without reducing anti-parkinsonian benefit would be of great value. We assessed the ability of TC-8831, an agonist at nicotinic acetylcho...

journal_title：Neuropharmacology

authors： Johnston TH,Huot P,Fox SH,Koprich JB,Szeliga KT,James JW,Graef JD,Letchworth SR,Jordan KG,Hill MP,Brotchie JM

更新日期：2013-10-01 00:00:00

abstract：:The study investigated the interaction between phencyclidine (PCP) and morphine in affecting the levels of met-enkephalin, dopamine, DOPAC and HVA in mice. Morphine 5 mg/kg alone and PCP 10 mg/kg alone failed to change the levels of met-enkephalin in the midbrain and striatum. However, PCP in combination with morphine...

journal_title：Neuropharmacology

authors： Nabeshima T,Hiramatsu M,Furukawa H,Kameyama T

更新日期：1985-08-01 00:00:00

abstract：:A challenge for theories of general anesthesia is the existence of compounds predicted to be anesthetics but which, instead, do not produce anesthesia and often elicit other behavioral effects such as convulsions. This study focused on flurothyl (bis[2,2, 2-trifluoroethyl] ether), a potent volatile convulsant, and its...

journal_title：Neuropharmacology

authors： Krasowski MD

更新日期：2000-04-27 00:00:00

abstract：:Marijuana use in adolescence, but not adulthood, may permanently impair cognitive functioning and increase the risk of developing schizophrenia. Cortical oscillations are patterns of neural network activity implicated in cognitive processing, and are abnormal in patients with schizophrenia. We have recently reported t...

journal_title：Neuropharmacology

authors： Raver SM,Keller A

更新日期：2014-11-01 00:00:00

abstract：:Recent experimental evidence indicates that in the neocortex, the manner in which each synapse releases neurotransmitter in response to trains of presynaptic action potentials is potentially unique. These unique transmission characteristics arise because of a large heterogeneity in various synaptic properties that det...

journal_title：Neuropharmacology

authors： Markram H,Pikus D,Gupta A,Tsodyks M

更新日期：1998-04-01 00:00:00

abstract：:Animal models of alcohol drinking and dependence are a critical resource for understanding the neurobiological mechanisms and development of more effective treatments for alcohol use disorder (AUD). Because most rat strains do not voluntarily consume large enough quantities of alcohol to adequately model heavy drinkin...

journal_title：Neuropharmacology

authors： Glover EJ,Khan F,Clayton-Stiglbauer K,Chandler LJ

更新日期：2021-02-15 00:00:00

abstract：:The alpha7 and alpha4beta2 nicotinic acetylcholine receptor (nAchR) subtypes have been shown to be involved in memory. It is also known that losses of frontal cortical nAchRs are correlated to declining memory function in Alzheimer's disease, but the subtype-specific role of frontal cortical nAchRs in memory has not b...

journal_title：Neuropharmacology

authors： Chan WK,Wong PT,Sheu FS

更新日期：2007-06-01 00:00:00

abstract：:The effects of the dopamine antagonists haloperidol and sultopride were investigated on the twitch response, evoked by 0.1 Hz stimulation of guinea-pig isolated ileal longitudinal muscle, and on the inhibition of the twitch response induced by 10 Hz stimulation (post-tetanic twitch inhibition) and by application of op...

journal_title：Neuropharmacology

authors： Ozaki M,Miyamoto Y,Kishioka S,Masuda Y,Yamamoto H

更新日期：1995-05-01 00:00:00

abstract：:Though amyloid precursor protein (APP) can potentially be cleaved to generate the pathological amyloid β peptide (Aβ), APP itself plays an important role in regulating neuronal activity. APP deficiency causes functional impairment in cholinergic synaptic transmission and cognitive performance. However, the mechanisms ...

journal_title：Neuropharmacology

authors： Cai ZL,Zhang JJ,Chen M,Wang JZ,Xiao P,Yang L,Long C

更新日期：2016-11-01 00:00:00

abstract：:Recent evidence suggests an early involvement of dopaminergic (DA) processes and terminals in Parkinson's disease (PD). The arborization of neurons depends on the actin cytoskeleton, which in turn is regulated by small GTPases of the Rho family, encompassing Rho, Rac and Cdc42 subfamilies. Indeed, some reports point t...

journal_title：Neuropharmacology

authors： Musilli M,Ciotti MT,Pieri M,Martino A,Borrelli S,Dinallo V,Diana G

更新日期：2016-10-01 00:00:00

abstract：:In Huntington's disease (HD), dysfunctional affective processes emerge as key symptoms of disturbances. In human HD and transgenic rat models of the disease, the amygdala was previously shown to have a reduced volume and to carry a high load of mutant huntingtin (mHTT) aggregates. In search of the pathophysiology of a...

journal_title：Neuropharmacology

authors： Lamirault C,Yu-Taeger L,Doyère V,Riess O,Nguyen HP,El Massioui N

更新日期：2017-09-01 00:00:00