Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons.

abstract：:Conantokin-G (Con-G), a gamma-carboxylglutamate (Gla) containing peptide derived from the venom of the marine cone snail Conus geographus, acts as a selective and potent inhibitor of N-methyl-D-aspartate (NMDA) receptors. Here, the effect of Con-G on recombinant NMDA receptors carrying point mutations within the glyci...

journal_title：Neuropharmacology

authors： Wittekindt B,Malany S,Schemm R,Otvos L,Maccecchini ML,Laube B,Betz H

更新日期：2001-11-01 00:00:00

abstract：:The possible synergism between caffeine and muscarinic antagonists to inhibit haloperidol-induced catalepsy was investigated with the bar test in rats. Pretreatment with low doses of caffeine (1-3 mg/kg), a non-selective adenosine antagonist, dose dependently reduced the intensity and increased the onset latency of ca...

journal_title：Neuropharmacology

authors： Moo-Puc RE,Góngora-Alfaro JL,Alvarez-Cervera FJ,Pineda JC,Arankowsky-Sandoval G,Heredia-López F

更新日期：2003-09-01 00:00:00

abstract：:We present an overview of our studies on the differential role of serotonergic projections from the median raphe nucleus (MRN) and dorsal raphe nucleus (DRN) in behavioural animal models with relevance to schizophrenia. Stereotaxic microinjection of the serotonin neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) into the M...

journal_title：Neuropharmacology

authors： Adams W,Kusljic S,van den Buuse M

更新日期：2008-11-01 00:00:00

abstract：:Basal ganglia, an ensemble of interconnected subcortical nuclei, are involved in adaptive motor planning and procedural learning. Striatum, the primary input nucleus of basal ganglia, extracts the pertinent cortical and thalamic information from background noise in relation with the environmental stimuli and motivatio...

journal_title：Neuropharmacology

authors： Fino E,Venance L

更新日期：2011-04-01 00:00:00

abstract：:Spinal metabotropic serotonin receptors encode transient experiences into long-lasting changes in motor behavior (i.e. motor plasticity). While interactions between serotonin receptor subtypes are known to regulate plasticity, the significance of molecular divergence in downstream G protein coupled receptor signaling ...

journal_title：Neuropharmacology

authors： Fields DP,Mitchell GS

更新日期：2017-02-01 00:00:00

abstract：:The elevation of extracellular 5-HT after systemic administration of 5-HT reuptake inhibiting drugs is strongly potentiated by agents capable of blocking 5-HT1A autoreceptors in the midbrain raphe. The present in vivo microdialysis study was aimed at assessing the relative importance of 5-HT reuptake inhibition versus...

journal_title：Neuropharmacology

authors： Hjorth S,Westlin D,Bengtsson HJ

更新日期：1997-04-01 00:00:00

abstract：:The present study was designed to examine the possible involvement of both an anti-serotonin action and a catecholamine-stimulating action in the mechanism of the inhibition of the muricide in rats with lesions of the midbrain raphe. Serotonin antagonists, such as cyproheptadine (10 mg/kg), cinanserin (10 mg/kg) and p...

journal_title：Neuropharmacology

authors： Yamamoto T,Ohno M,Takao K,Ueki S

更新日期：1988-02-01 00:00:00

abstract：:Rats were trained to recognize a discriminative stimulus (DS) elicited by the dopamine D(2)/D(3) receptor agonist, PD128,907 (0.16 mg/kg, i.p.), which suppressed frontocortical release of dopamine (DA) but not 5-HT. The selective 5-HT1A receptor agonists, 8-OH-DPAT and flesinoxan, dose-dependently generalized to PD128...

journal_title：Neuropharmacology

authors： Dekeyne A,Rivet JM,Gobert A,Millan MJ

更新日期：2001-06-01 00:00:00

abstract：:In this study, we investigated whether resveratrol could protect against ischemic injury by improving brain energy metabolism and alleviating oxidative stress. Male rats were divided into three groups: sham operation, ischemia treatment, and ischemia combined with resveratrol treatment (resveratrol-treated group, 30 m...

journal_title：Neuropharmacology

authors： Li H,Yan Z,Zhu J,Yang J,He J

更新日期：2011-02-01 00:00:00

abstract：:Hypotheses are scaffoldings erected in front of a building and then dismantled when the building is finished. They are indispensable for the workman; but you mustn't mistake the scaffolding for the building. Johann Wolfgang von Goethe. The neurogenesis hypothesis of affective disorders - in its simplest form - postula...

journal_title：Neuropharmacology

authors： Petrik D,Lagace DC,Eisch AJ

更新日期：2012-01-01 00:00:00

abstract：:The role of orexin receptors in the nucleus accumbens shell in rat turning behaviour of rats was studied. Unilateral injection of neither the orexin 1 and 2 receptor agonist orexin A (2 microg) nor the orexin 1 receptor antagonist SB 334867 (20 ng) into the nucleus accumbens shell elicited turning behaviour. Unilatera...

journal_title：Neuropharmacology

authors： Kotani A,Ikeda H,Koshikawa N,Cools AR

更新日期：2008-03-01 00:00:00

abstract：:The Mouse Defense Test Battery (MDTB) has been designed to investigate defensive responses of Swiss-Webster mice confronted with a natural predator, a rat. These behaviors include flight, avoidance, defensive threat/attack responses, and risk assessment activities. Previous studies with the MDTB have suggested that th...

journal_title：Neuropharmacology

authors： Griebel G,Blanchard DC,Jung A,Lee JC,Masuda CK,Blanchard RJ

更新日期：1995-12-01 00:00:00

abstract：:Improgan is a chemical congener of the H2 antagonist cimetidine which shows the profile of a highly effective analgesic when administered directly into the CNS. Although the improgan receptor is unknown, improgan activates analgesic pathways which are independent of opioids, but may utilize cannabinoid mechanisms. To ...

journal_title：Neuropharmacology

authors： Hough LB,de Esch IJ,Janssen E,Phillips J,Svokos K,Kern B,Trachler J,Abood ME,Leurs R,Nalwalk JW

更新日期：2006-09-01 00:00:00

abstract：:Using knockout (KO) mice lacking the histamine (HA)-synthesizing enzyme (histidine decarboxylase, HDC), we have previously shown the importance of histaminergic neurons in maintaining wakefulness (W) under behavioral challenges. Since the central actions of HA are mediated by several receptor subtypes, it remains to b...

journal_title：Neuropharmacology

authors： Parmentier R,Zhao Y,Perier M,Akaoka H,Lintunen M,Hou Y,Panula P,Watanabe T,Franco P,Lin JS

更新日期：2016-07-01 00:00:00

abstract：:There is poor experimental evidence concerning the effects of anesthetic doses of the non-competitive NMDA receptor antagonist ketamine on rodents' memory abilities. The present study was designed to investigate a) the long-term consequences of anesthetic ketamine on rats' non-spatial and spatial recognition memory; b...

journal_title：Neuropharmacology

authors： Pitsikas N,Boultadakis A

更新日期：2009-07-01 00:00:00

abstract：:Different neurotransmitter systems are involved in behavioural and molecular responses to morphine. The brain stress system is activated by acute administration of drugs of abuse, being CRF the main neuropeptide of this circuitry. In this study we have studied the role of CRF1R in the rewarding effects of morphine usi...

journal_title：Neuropharmacology

authors： Lasheras MC,Laorden ML,Milanés MV,Núñez C

更新日期：2015-08-01 00:00:00

abstract：:This study utilised the selective 5-ht(5A) receptor antagonist, SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), to investigate 5-ht5A receptor function in guinea pig brain. SB-699551-A competitively antagonised 5-HT-stimulate...

journal_title：Neuropharmacology

authors： Thomas DR,Soffin EM,Roberts C,Kew JN,de la Flor RM,Dawson LA,Fry VA,Coggon SA,Faedo S,Hayes PD,Corbett DF,Davies CH,Hagan JJ

更新日期：2006-09-01 00:00:00

abstract：:Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor (GPCR) expressed in several mammalian brain areas and activated by "trace amines" (TAs). TAs role is unknown; however, discovery of their receptors provided an opportunity to investigate their functions. In vivo evidence has indicated an inhibit...

journal_title：Neuropharmacology

authors： Leo D,Mus L,Espinoza S,Hoener MC,Sotnikova TD,Gainetdinov RR

更新日期：2014-06-01 00:00:00

abstract：:Opiates addiction is characterized by its long-term persistence. In order to study the enduring changes in long-term memory in hippocampus, a pivotal region for this process, we used suppression subtractive hybridization to compare hippocampal gene expression in morphine and saline-treated rats. Animals were subjected...

journal_title：Neuropharmacology

authors： Marie-Claire C,Courtin C,Robert A,Gidrol X,Roques BP,Noble F

更新日期：2007-02-01 00:00:00

abstract：:In rats with partial, unilateral lesions of the dopaminergic nigrostriatal pathway, synthesis of dopamine (DA) per surviving neurone was assessed by measuring the ratio of DOPA accumulated after inhibition of aromatic amino acid decarboxylase to dopamine (DOPA/DA ratio). Release of DA per surviving neurone was assesse...

journal_title：Neuropharmacology

authors： Hefti F,Enz A,Melamed E

更新日期：1985-01-01 00:00:00

abstract：:A subgroup of anticonvulsant and neuroleptic drugs acts through the potentiation of GABA pathways. The regulatory role of GABA in neuronal circuit formation is related to its depolarizing action that supports activity-dependent synaptogenesis. We hypothesized that elevated levels of GABA in the immature brain modify s...

journal_title：Neuropharmacology

authors： Melamed O,Levav-Rabkin T,Zukerman C,Clarke G,Cryan JF,Dinan TG,Grossman Y,Golan HM

更新日期：2014-04-01 00:00:00

abstract：:Electrophysiology, immunostaining and time lapse imaging techniques were employed to study the mechanism of long-term depression (LTD) induced by DHPG, a specific group I metabotropic glutamate receptor (mGluR) agonist. Experiments were performed in primary hippocampal culture or in the CA1 area of acute rat hippocamp...

journal_title：Neuropharmacology

authors： Xiao MY,Zhou Q,Nicoll RA

更新日期：2001-11-01 00:00:00

abstract：:The dorsal striatum plays a key role in motor control and cognitive processes. Proper functioning of the striatum relies on the fine dynamic balance between the direct pathway projection medium spiny neurons (MSNs) that express D1 dopamine receptor (D1 MSNs) and indirect pathway projection MSNs that express D2 dopamin...

journal_title：Neuropharmacology

authors： Zhao B,Zhu J,Dai D,Xing J,He J,Fu Z,Zhang L,Li Z,Wang W

更新日期：2016-08-01 00:00:00

abstract：:Phenytoin (DPH) is a clinically useful sodium (Na) channel blocker with efficacy against partial and generalized seizures. We have developed a novel hydantoin compound (HA) using comparative molecular field analysis (CoMFA) and evaluated its effects on hNa(v)1.2 channels. Both DPH and HA demonstrated affinity for rest...

journal_title：Neuropharmacology

authors： Lenkowski PW,Batts TW,Smith MD,Ko SH,Jones PJ,Taylor CH,McCusker AK,Davis GC,Hartmann HA,White HS,Brown ML,Patel MK

更新日期：2007-03-01 00:00:00

abstract：:The neuronal nicotinic acetylcholine receptor alpha7 (nAChR alpha7) may be involved in cognitive deficits in Schizophrenia and Alzheimer's disease. A fast pharmacological characterization of homomeric alpha7 receptors is mostly hampered by their low functional expression levels in heterologous expression systems. In t...

journal_title：Neuropharmacology

authors： Feuerbach D,Lingenhöhl K,Dobbins P,Mosbacher J,Corbett N,Nozulak J,Hoyer D

更新日期：2005-02-01 00:00:00

abstract：:Time-effects of morphine, methadone, meperidine and pentazocine upon locomotor activity were investigated in naive and in post-dependent rats. Dependence was induced by daily injection of 20 mg/kg (i.p.) of morphine for 30 days. Tests were run starting from 1 month after withdrawal from morphine. Morphine produced a g...

journal_title：Neuropharmacology

authors： Bartoletti M,Gaiardi M,Gubellini C,Bacchi A,Babbini M

更新日期：1985-09-01 00:00:00

abstract：:Trace amines are biological compounds that are still awaiting identification of their role in neuronal function. Using intracellular electrophysiological recordings, we investigated the depressant action of two trace amines (beta-phenylethylamine and tyramine) on the firing activity of dopaminergic neurons of the subs...

journal_title：Neuropharmacology

authors： Geracitano R,Federici M,Prisco S,Bernardi G,Mercuri NB

更新日期：2004-05-01 00:00:00

abstract：:Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortunately, the developmental parameters of susceptibility to general...

journal_title：Neuropharmacology

authors： Landin JD,Palac M,Carter JM,Dzumaga Y,Santerre-Anderson JL,Fernandez GM,Savage LM,Varlinskaya EI,Spear LP,Moore SD,Swartzwelder HS,Fleming RL,Werner DF

更新日期：2019-05-15 00:00:00

abstract：:Methylphenidate (MPH, Ritalin©) is widely used in the treatment of Attention Deficit Hyperactivity Disorder and recently as a drug of abuse. Although the effect of MPH has been studied in brain regions such as striatum and prefrontal cortex (PFC), the hippocampus has received relatively little attention. It is known t...

journal_title：Neuropharmacology

authors： Rozas C,Carvallo C,Contreras D,Carreño M,Ugarte G,Delgado R,Zeise ML,Morales B

更新日期：2015-12-01 00:00:00

abstract：:Following its binding to somatodendritic receptors, the neuropeptide neurotensin (NT) internalizes via a clathrin-mediated process. In the present study, we investigated whether NT also internalizes presynaptically using synaptosomes from rat neostriatum, a region in which NT1 receptors are virtually all presynaptic. ...

journal_title：Neuropharmacology

authors： Nguyen HM,Cahill CM,McPherson PS,Beaudet A

更新日期：2002-06-01 00:00:00