Abstract：
:The present study was designed to examine the possible involvement of both an anti-serotonin action and a catecholamine-stimulating action in the mechanism of the inhibition of the muricide in rats with lesions of the midbrain raphe. Serotonin antagonists, such as cyproheptadine (10 mg/kg), cinanserin (10 mg/kg) and pirenperone (1 mg/kg), given alone showed little suppression of muricide in rats with raphe lesions, although the first two drugs were inhibitory at very large doses. Methamphetamine showed no inhibition of muricide at 0.32 mg/kg (i.p.), but exerted a marked inhibition of muricide when combined with the above serotonin antagonists. In addition, the dose-response curve for cyproheptadine and cinanserin was shifted markedly to the left when combined with L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) (100 mg/kg i.p.), but not with lisuride (0.32 mg/kg i.p.). Similarly, pirenperone produced a marked inhibition of muricide at doses of 0.32-1.8 mg/kg (i.p.) when combined with L-threo-DOPS, but not when combined with lisuride. These results suggest that the combination of an anti-serotonin action with noradrenergic activation is important for inhibiting muricide, at least in rats with raphe lesions. A similar mechanism also seems to be valid for the anti-muricidal effect of antidepressant drugs.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Yamamoto T,Ohno M,Takao K,Ueki Sdoi
10.1016/0028-3908(88)90160-8subject
Has Abstractpub_date
1988-02-01 00:00:00pages
123-7issue
2eissn
0028-3908issn
1873-7064journal_volume
27pub_type
杂志文章abstract：:N-Ethyl-maleimide (NEM, 2.5 x 10(-5) M) inhibited the compound action potential of the phrenic nerve and increased the spontaneous release of transmitter from the nerve terminals, recorded as miniature endplate potentials. The first effect was the cause of a blockade of the phrenic nerve diaphragm preparation, during ...
journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Neuropharmacology
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