LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice.

abstract：:Long-term potentiation (LTP) resembles memory in that it is initially unstable and then, over about 30 min, becomes increasingly resistant to disruption. Here we present an hypothesis to account for this initial consolidation effect and consider implications that follow from it. Anatomical studies indicate that LTP is...

journal_title：Neuropharmacology

authors： Lynch G,Rex CS,Gall CM

更新日期：2007-01-01 00:00:00

abstract：:Neonatal administration of monosodium glutamate (MSG) destroyed perikarya in the arcuate nucleus and median eminence, including those that contain met-enkephalin and beta-endorphin and it increased the density of opiate receptors in the midbrain. Treatment with glutamate decreased the analgesic response on the jump te...

journal_title：Neuropharmacology

authors： Badillo-Martinez D,Kirchgessner AL,Butler PD,Bodnar RJ

更新日期：1984-10-01 00:00:00

abstract：:The present experiments investigated the ability of LY392098, a novel positive allosteric modulator of AMPA receptors, to potentiate AMPA receptor-mediated currents of neurons in the prefrontal cortex (PFC). Co-application of LY392098 (0.03-10 microM) with AMPA (5 microM) enhanced current through AMPA receptor/channel...

journal_title：Neuropharmacology

authors： Baumbarger P,Muhlhauser M,Yang CR,Nisenbaum ES

更新日期：2001-06-01 00:00:00

abstract：:A striking observation among veterans returning from the recent conflicts in Iraq and Afghanistan has been the co-occurrence of blast-related mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). PTSD and mTBI might coexist due to additive effects of independent psychological and physical traum...

journal_title：Neuropharmacology

authors： Perez-Garcia G,Gama Sosa MA,De Gasperi R,Tschiffely AE,McCarron RM,Hof PR,Gandy S,Ahlers ST,Elder GA

更新日期：2019-02-01 00:00:00

abstract：:The stable transcription factor ΔFosB is induced in the nucleus accumbens (NAc) by chronic exposure to several drugs of abuse, and transgenic expression of ΔFosB in the striatum enhances the rewarding properties of morphine and cocaine. However, the mechanistic basis for these observations is incompletely understood. ...

journal_title：Neuropharmacology

authors： Sim-Selley LJ,Cassidy MP,Sparta A,Zachariou V,Nestler EJ,Selley DE

更新日期：2011-12-01 00:00:00

abstract：:Physical exercise has become a potentially beneficial therapy for reducing neurodegeneration symptoms in Alzheimer's disease. Previous studies have shown that cognitive deterioration, anxiety and the startle response observed in 7-month-old 3xTg-AD mice were ameliorated after 6 months of free access to a running wheel...

journal_title：Neuropharmacology

authors： Revilla S,Suñol C,García-Mesa Y,Giménez-Llort L,Sanfeliu C,Cristòfol R

更新日期：2014-06-01 00:00:00

abstract：:Of the five excitatory amino acid transporters (EAATs) identified, two genes are expressed by neurons (EAAT3 and EAAT4) and give rise to transporters confined to neuronal cell bodies and dendrites. At an ultrastructural level, EAAT3 and EAAT4 proteins are clustered at the edges of postsynaptic densities of excitatory ...

journal_title：Neuropharmacology

authors： Meera P,Dodson PD,Karakossian MH,Otis TS

更新日期：2005-11-01 00:00:00

abstract：:Several lines of evidence suggest a tight functional coupling between N-methyl-D-aspartate (NMDA) and phencyclidine (PCP) receptors. The effects of PCP receptor agonists (PCP, dexoxadrol, ketamine and MK-801) and NMDA receptor antagonists, cis-4-phosphonomethyl-2-piperidine carboxylic acid (CGS-19755) and 3-(2-carboxy...

journal_title：Neuropharmacology

authors： Rao TS,Kim HS,Lehmann J,Martin LL,Wood PL

更新日期：1990-03-01 00:00:00

abstract：:The effects of the glycine derivative, CP 1552-S (2-N-pentylaminoacetamide hydrochloride) were evaluated for potential anticonvulsant activity in rats which were cortically- or amygdaloid-kindled. Large doses (300-600 mg/kg, i.p.) of CP 1552 given 30 min before stimulation resulted in significant reductions in duratio...

journal_title：Neuropharmacology

authors： Albertson TE,Stark LG,Joy RM

更新日期：1984-08-01 00:00:00

abstract：:The cyclic octapeptide, CYN-154806, inhibited specific [(125)I]-[Tyr(11)]-SRIF binding to CHO-K1 cell membranes expressing human recombinant somatostatin (SRIF) sst(2) receptors (pIC(50) 8. 58) or rat sst(2(a)) and rat sst(2(b)) receptors (pIC(50) 8.35 and 8. 10, respectively). The affinity of CYN-154806 at other huma...

journal_title：Neuropharmacology

authors： Feniuk W,Jarvie E,Luo J,Humphrey PP

更新日期：2000-06-08 00:00:00

abstract：:The Erwinia ligand-gated ion channel (ELIC) is a bacterial homologue of vertebrate Cys-loop ligand-gated ion channels. It is activated by GABA, and this property, combined with its structural similarity to GABA(A) and other Cys-loop receptors, makes it potentially an excellent model to probe their structure and functi...

journal_title：Neuropharmacology

authors： Thompson AJ,Alqazzaz M,Ulens C,Lummis SC

更新日期：2012-09-01 00:00:00

abstract：:Intraventricular administration of substance P (SP), of the heptapeptide SP5-11 and of DiMe-C7, a stable analogue of SP5-11 induced locomotor activation in rats and in mice. The activating effect of substance P was longer-lasting in mice than in rats, whereas the effect of the two heptapeptides appears to be more mark...

journal_title：Neuropharmacology

authors： Naranjo JR,Del Rio J

更新日期：1984-10-01 00:00:00

abstract：:Alcohol damages the developing brain and can lead to fetal alcohol syndrome. One of alcohol's most important neuropathologic effects is neuronal death. As neurons mature, they become less vulnerable to alcohol-induced death because they acquire a protective signaling pathway, mediated by nitric oxide (NO). This pathwa...

journal_title：Neuropharmacology

authors： Bonthius DJ,Luong T,Bonthius NE,Hostager BS,Karacay B

更新日期：2009-03-01 00:00:00

abstract：:Recently it has been reported that "I(f) channel blockers", which block the hyperpolarization-activated inward current (I(f)) in heart sino atrial node cells, also block the hyperpolarization-activated inward current (I(h)) in other tissues. Here we compared the effects of one of these agents, ZD7288 [4-(N-ethyl-N-phe...

journal_title：Neuropharmacology

authors： Satoh TO,Yamada M

更新日期：2000-04-27 00:00:00

abstract：:Following intraperitoneal administration, the selective cAMP phosphodiesterase (PDE) inhibitors rolipram, ICI 63 197 and Ro 20-1724 were investigated in mice in comparison with imipramine for their effectiveness in two classical test models for prediction of clinical antidepressant activity: antagonism of reserpine-in...

journal_title：Neuropharmacology

authors： Wachtel H

更新日期：1983-03-01 00:00:00

abstract：:Systemic administration of thiazolidinediones reduces peripheral inflammation in vivo, presumably by acting at peroxisome proliferator-activated receptor gamma (PPARgamma) in peripheral tissues. Based on a rapidly growing body of literature indicating the CNS as a functional target of PPARgamma actions, we postulated ...

journal_title：Neuropharmacology

authors： Morgenweck J,Abdel-Aleem OS,McNamara KC,Donahue RR,Badr MZ,Taylor BK

更新日期：2010-02-01 00:00:00

abstract：:Stroke is one of the leading causes of death and serious disability in Westernized societies. The risk of stroke approximately doubles with each decade after the age of 55. Therefore, even though the incidence of stroke is declining, mostly because of the efforts to lower blood pressure and reduce smoking, the overall...

journal_title：Neuropharmacology

authors： Darsalia V,Klein T,Nyström T,Patrone C

更新日期：2018-07-01 00:00:00

abstract：:Depression is a polygenic and highly complex psychiatric disorder that is currently a major burden on society. Depression is highly heterogeneous in presentation and frequently exhibits high comorbidity with other psychiatric and somatic disorders. Commonly used treatments, such as selective serotonin reuptake inhibit...

journal_title：Neuropharmacology

authors： Samuels BA,Leonardo ED,Gadient R,Williams A,Zhou J,David DJ,Gardier AM,Wong EH,Hen R

更新日期：2011-09-01 00:00:00

abstract：:Striking circadian changes in behavioral sensitivity to haloperidol were found by measurements of cataleptic responses in rats trained in a controlled lighting cycle (lights on, 7:00 a.m.--7:00 p.m.). Thus, catalepsy was maximal at about 4:00 p.m. and minimal at about 4:00 a.m., virtually the opposite of the circadian...

journal_title：Neuropharmacology

authors： Campbell A,Herschel M,Sommer B,Madsen JR,Cohen BM,Baldessarini RJ

更新日期：1982-07-01 00:00:00

abstract：:The influence of the subunit composition of human GABA(A) receptors upon the GABA-modulatory properties of 5alpha-pregnan-3alpha-ol-20-one (5alpha,3alpha) has been examined using the Xenopus laevis oocyte expression system and the two electrode voltage-clamp technique. Steroid potency (EC(50)) is modestly influenced b...

journal_title：Neuropharmacology

authors： Belelli D,Casula A,Ling A,Lambert JJ

更新日期：2002-09-01 00:00:00

abstract：:Orexin-A, -B play a crucial role in arousal and feeding by activating two G-protein-coupled receptors: orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R). Orexins, along with orexin receptors, are expressed in retinal neurons, and they have been shown to differentially modulate excitatory AMPA receptors of amacrine...

journal_title：Neuropharmacology

authors： Zhang G,Wu XH,Xu GZ,Weng SJ,Yang XL,Zhong YM

更新日期：2018-05-01 00:00:00

abstract：:Long-term alcohol use causes widespread changes in gene expression in the human brain. Aberrant gene expression changes likely contribute to the progression from occasional alcohol use to alcohol use disorder (including alcohol dependence). Transcriptome studies have identified individual gene candidates that are link...

journal_title：Neuropharmacology

authors： Warden AS,Mayfield RD

更新日期：2017-08-01 00:00:00

abstract：:We have used patch-clamp recording from cultured neurones, immunohistochemistry and gene deletion techniques to characterize the P2X receptors present in mouse otic ganglion neurones, and demonstrated the presence of similar receptors in rat neurones. All neurones from wild-type (WT) mice responded to ATP (EC(50) 109 ...

journal_title：Neuropharmacology

authors： Ma B,Ruan HZ,Cockayne DA,Ford AP,Burnstock G,Dunn PM

更新日期：2004-06-01 00:00:00

abstract：:The aim of the present study was to investigate if different levels of circulating corticosterone (CORT) modulate the effect of nicotine on prepulse inhibition (PPI), a measure of sensorimotor gating that is disrupted in schizophrenia and other mental illnesses. Four groups of mice were investigated: sham-operated, ad...

journal_title：Neuropharmacology

authors： Ingram N,Martin S,Wang JH,van der Laan S,Loiacono R,van den Buuse M

更新日期：2005-01-01 00:00:00

abstract：:Metabotropic glutamate (mGlu) receptors are implicated in many neurological and psychiatric diseases and are the targets of therapeutic agents currently in clinical development. Their activation has diverse effects in the central nervous system (CNS) that includes an involvement in synaptic plasticity. We previously r...

journal_title：Neuropharmacology

authors： Lodge D,Tidball P,Mercier MS,Lucas SJ,Hanna L,Ceolin L,Kritikos M,Fitzjohn SM,Sherwood JL,Bannister N,Volianskis A,Jane DE,Bortolotto ZA,Collingridge GL

更新日期：2013-11-01 00:00:00

abstract：:Maternal behavior and anxiety are potently modulated by the brain corticotropin-releasing factor (CRF) system postpartum. Downregulation of CRF in limbic brain regions is essential for appropriate maternal behavior and an adaptive anxiety response. Here, we focus our attention on arguably the most important brain regi...

journal_title：Neuropharmacology

authors： Klampfl SM,Schramm MM,Gaßner BM,Hübner K,Seasholtz AF,Brunton PJ,Bayerl DS,Bosch OJ

更新日期：2018-05-01 00:00:00

abstract：:The effect of chronic (4 weeks) treatment of rats with the antidepressant drugs desipramine, maprotiline, chlorimipramine, zimelidine or iprindol on the sensitivity of presynaptic alpha 2- and postsynaptic beta-adrenoceptors in neocortical slices was investigated. Acute (1 day) treatment with the antidepressants did n...

journal_title：Neuropharmacology

authors： Schoffelmeer AN,Hoorneman EM,Sminia P,Mulder AH

更新日期：1984-02-01 00:00:00

abstract：:The ventromedial nucleus of the hypothalamus (VMH) plays an important role in feeding and energy homeostasis. Electroconvulsive seizure (ECS) therapy is highly effective in the treatment of several psychiatric diseases, including depression, but may also have beneficial effects in other neurological diseases. Although...

journal_title：Neuropharmacology

authors： Segi-Nishida E,Sukeno M,Imoto Y,Kira T,Sakaida M,Tsuchiya S,Sugimoto Y,Okuno Y

更新日期：2013-08-01 00:00:00

abstract：:The mechanisms underlying lateralization and progression of motor symptoms from unilateral to bilateral in Parkinson's disease (PD) remain to be elucidated. In addition, the molecular mechanisms involved in levodopa-induced dyskinesias (LIDs) depending on lateralization and disease progression from unilaterally to bil...

journal_title：Neuropharmacology

authors： Marin C,Bonastre M,Mengod G,Cortés R,Rodríguez-Oroz MC

更新日期：2015-10-01 00:00:00

abstract：:Previous research shows Ouabain (OUA) to bind Na, K-ATPase, thereby triggering a number of signaling pathways, including the transcription factors NFᴋB and CREB. These transcription factors play a key role in the regulation of BDNF and WNT-β-catenin signaling cascades, which are involved in neuroprotection and memory ...

journal_title：Neuropharmacology

authors： Orellana AM,Leite JA,Kinoshita PF,Vasconcelos AR,Andreotti DZ,de Sá Lima L,Xavier GF,Kawamoto EM,Scavone C

更新日期：2018-09-15 00:00:00