当前位置： SCI文献检索 > NEUROPHARMACOLOGY期刊下所有文献 > Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors.

Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors.

Abstract：

:Metabotropic glutamate (mGlu) receptors are implicated in many neurological and psychiatric diseases and are the targets of therapeutic agents currently in clinical development. Their activation has diverse effects in the central nervous system (CNS) that includes an involvement in synaptic plasticity. We previously reported that the brief exposure of hippocampal slices to dihydroxyphenylglycine (DHPG) can result in a long-term depression (LTD) of excitatory synaptic transmission. Surprisingly, this LTD could be fully reversed by mGlu receptor antagonists in a manner that was itself fully reversible upon washout of the antagonist. Here, 15 years after the discovery of DHPG-LTD and its reversible reversibility, we summarise these initial findings. We then present new data on DHPG-LTD, which demonstrates that evoked epileptiform activity triggered by activation of group I mGlu receptors can also be reversibly reversed by mGlu receptor antagonists. Furthermore, we show that the phenomenon of reversible reversibility is not specific to group I mGlu receptors. We report that activation of group II mGlu receptors in the temporo-ammonic pathway (TAP) and mossy fibre pathway within the hippocampus and in the cortical input to neurons of the lateral amygdala induces an LTD that is reversed by LY341495, a group II mGlu receptor antagonist. We also show that activation of group III mGlu8 receptors induces an LTD at lateral perforant path inputs to the dentate gyrus and that this LTD is reversed by MDCPG, an mGlu8 receptor antagonist. In conclusion, we have shown that activation of representative members of each of the three groups of mGlu receptors can induce forms of LTD than can be reversed by antagonists, and that in each case washout of the antagonist is associated with the re-establishment of the LTD. This article is part of the Special Issue entitled 'Glutamate Receptor-Dependent Synaptic Plasticity'.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Lodge D,Tidball P,Mercier MS,Lucas SJ,Hanna L,Ceolin L,Kritikos M,Fitzjohn SM,Sherwood JL,Bannister N,Volianskis A,Jane DE,Bortolotto ZA,Collingridge GL

doi

10.1016/j.neuropharm.2013.03.011

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

135-46

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(13)00107-X

journal_volume

pub_type

杂志文章

在线工具

Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors.