Interplay between PACAP and NO in mouse ileum.

abstract：:Identification of synthetic agonists and antagonists at orphan receptors represents an important step for understanding their physiological function and therapeutic potential. Accordingly, we have recently described a non-peptide agonist at the opioid receptor like (ORL1) receptor (1S,3aS)-8-(2,3,3a,4,5,6-hexahydro-1H...

journal_title：Neuropharmacology

authors： Higgins GA,Grottick AJ,Ballard TM,Richards JG,Messer J,Takeshima H,Pauly-Evers M,Jenck F,Adam G,Wichmann J

更新日期：2001-07-01 00:00:00

abstract：:The effects of phospholipase A2, cyclooxygenase-1, cyclooxygenase-2, and 5-lipoxygenase inhibitors on acute opiate withdrawal induced by selective mu, kappa and delta receptor agonists was investigated in vitro. After a 4 min in vitro exposure to D-Ala2-N-methyl-Phe-Gly5-ol)enkephalin (DAMGO; a highly selective mu ago...

journal_title：Neuropharmacology

authors： Capasso A

更新日期：1999-06-01 00:00:00

abstract：:Behavioral sensitization, or augmented locomotor response to successive drug exposures, results from neuroadaptive changes contributing to addiction. Both the medial prefrontal cortex (mPFC) and ventral tegmental area (VTA) influence behavioral sensitization and display increased immediate-early gene and BDNF expressi...

journal_title：Neuropharmacology

authors： Fanous S,Lacagnina MJ,Nikulina EM,Hammer RP Jr

更新日期：2011-09-01 00:00:00

abstract：:Maternal behavior and anxiety are potently modulated by the brain corticotropin-releasing factor (CRF) system postpartum. Downregulation of CRF in limbic brain regions is essential for appropriate maternal behavior and an adaptive anxiety response. Here, we focus our attention on arguably the most important brain regi...

journal_title：Neuropharmacology

authors： Klampfl SM,Schramm MM,Gaßner BM,Hübner K,Seasholtz AF,Brunton PJ,Bayerl DS,Bosch OJ

更新日期：2018-05-01 00:00:00

abstract：:In the present study, the effects of bilateral injections of the GABAergic receptor agents into the dorsal hippocampal CA1 regions (intra-CA1) on morphine-induced amnesia were examined in morphine sensitized-mice. Pre-training subcutaneous (s.c.) administration of morphine (5 mg/kg) suppressed the learning of a one-tr...

journal_title：Neuropharmacology

authors： Zarrindast MR,Hoghooghi V,Rezayof A

更新日期：2008-03-01 00:00:00

abstract：:A unique type of limbic seizures, maximal dentate activation, was used to examine the effects of cholinergic and adrenergic agents on the processes involved in epileptogenesis. The time to onset of maximal dentate activation was used to monitor the initiation of seizures while the duration of maximal dentate activatio...

journal_title：Neuropharmacology

authors： Stringer JL,Lothman EW

更新日期：1991-01-01 00:00:00

abstract：:Orexin contributes to the expression of the cardiovascular and behavioural response of some forms of stress, including novelty stress. Thus, Almorexant, a dual receptor antagonist that blocks the two known orexin receptors, Ox1R and Ox2R, reduces these responses. However, it is not known if the reduction results from ...

journal_title：Neuropharmacology

authors： Beig MI,Dampney BW,Carrive P

更新日期：2015-02-01 00:00:00

abstract：:A condition of excess activity in the hippocampal formation is observed in the aging brain and in conditions that confer additional risk during aging for Alzheimer's disease. Compounds that act as positive allosteric modulators at GABA(A) α5 receptors might be useful in targeting this condition because GABA(A) α5 rece...

journal_title：Neuropharmacology

authors： Koh MT,Rosenzweig-Lipson S,Gallagher M

更新日期：2013-01-01 00:00:00

abstract：:Peptides derived from prodynorphin, dynorphin A and B, (Leu)-enkephalin and (Leu)enkephalyl-Arg, as well as substance P, were measured in substantia nigra, striatum and globus pallidus, after subacute (5 doses at 6 hr intervals) treatment of rats with a number of dopamine receptor agonists and antagonists. Drugs selec...

journal_title：Neuropharmacology

authors： Nylander I,Terenius LH

更新日期：1987-09-01 00:00:00

abstract：:The analgesic fentanyl, having a predominantly mu-opioid agonist activity, when injected into the supraoptic or paraventricular nucleus of the hypothalamus in a water-loaded and ethanol-anesthetized rat, induced a potent antidiuretic effect in a time- and dose-dependent manner. The outflow of urine decreased to a mini...

journal_title：Neuropharmacology

authors： Tsushima H,Mori M,Matsuda T

更新日期：1990-08-01 00:00:00

abstract：:An earlier finding that three systems were responsible for the uptake of gamma-aminobutyric acid by synaptosomes was corroborated. In addition, the existence of three uptake systems for RS-nipecotic acid and beta-alanine was demonstrated. We have called these systems high affinity, medium affinity and low affinity upt...

journal_title：Neuropharmacology

authors： Sidhu HS,Wood JD

更新日期：1986-05-01 00:00:00

abstract：:In Huntington's disease (HD), dysfunctional affective processes emerge as key symptoms of disturbances. In human HD and transgenic rat models of the disease, the amygdala was previously shown to have a reduced volume and to carry a high load of mutant huntingtin (mHTT) aggregates. In search of the pathophysiology of a...

journal_title：Neuropharmacology

authors： Lamirault C,Yu-Taeger L,Doyère V,Riess O,Nguyen HP,El Massioui N

更新日期：2017-09-01 00:00:00

abstract：:The pharmacotherapy for the treatment of pain is an active area of investigation. There are effective drugs to treat this problem, but there is also a need to find alternative treatments free of undesirable side effects. In the present work the capacity of a series of flavonoids to bind to the μ opioid receptor was ev...

journal_title：Neuropharmacology

authors： Higgs J,Wasowski C,Loscalzo LM,Marder M

更新日期：2013-09-01 00:00:00

abstract：:The effects of the glycine derivative, CP 1552-S (2-N-pentylaminoacetamide hydrochloride) were evaluated for potential anticonvulsant activity in rats which were cortically- or amygdaloid-kindled. Large doses (300-600 mg/kg, i.p.) of CP 1552 given 30 min before stimulation resulted in significant reductions in duratio...

journal_title：Neuropharmacology

authors： Albertson TE,Stark LG,Joy RM

更新日期：1984-08-01 00:00:00

abstract：:The effect of an acute intraperitoneal (i.p.) injection of acetaldehyde, 20 mg/kg or 100 mg/kg, on the microdialysate content of both amino acids and monoamines was studies in the nucleus accumbens (NA) by a microdialysis technique. Acetaldehyde, ACH, which was detectable at levels of 50-130 mumol/g brain tissue 10 mi...

journal_title：Neuropharmacology

authors： Ward RJ,Colantuoni C,Dahchour A,Quertemont E,De Witte P

更新日期：1997-02-01 00:00:00

abstract：:Momordica charantia (MC) is a medicinal plant for stroke treatment in Traditional Chinese Medicine, but its active compounds and molecular targets are unknown yet. M. charantia polysaccharide (MCP) is one of the important bioactive components in MC. In the present study, we tested the hypothesis that MCP has neuroprot...

journal_title：Neuropharmacology

authors： Gong J,Sun F,Li Y,Zhou X,Duan Z,Duan F,Zhao L,Chen H,Qi S,Shen J

更新日期：2015-04-01 00:00:00

abstract：:Alternative splicing of the dopamine D2 receptor gene produces two distinct isoforms referred to as D2long (D2L) and D2short (D2S). In mesencephalic dopamine neurons, inhibition of the firing rate through activation of somatodendritic D2 receptors and blockade of neurotransmitter release through stimulation of termina...

journal_title：Neuropharmacology

authors： Jomphe C,Tiberi M,Trudeau LE

更新日期：2006-04-01 00:00:00

abstract：:Over the last decade, robust human genetic findings have been instrumental in elucidating the heritable basis of nicotine addiction (NA). They highlight coding and synonymous polymorphisms in a cluster on chromosome 15, encompassing the CHRNA5, CHRNA3 and CHRNB4 genes, coding for three subunits of the nicotinic acetyl...

journal_title：Neuropharmacology

authors： Icick R,Forget B,Cloëz-Tayarani I,Pons S,Maskos U,Besson M

更新日期：2020-10-15 00:00:00

abstract：:This review will provide an overview of the non-drug based approaches that have been demonstrated to enhance cognitive function of the compromised brain, primarily focussed on the two most widely adopted paradigms of environmental enrichment and enhanced physical exercise. Environmental enrichment involves the generat...

journal_title：Neuropharmacology

authors： Pang TY,Hannan AJ

更新日期：2013-01-01 00:00:00

abstract：:Neonatal maternal deprivation permanently modifies the hypothalamo-pituitary-adrenal (HPA) axis and other neurobiological and behavioural parameters in rats. The HPA axis plays a central role in the control of feeding, and participates in the anorexigenic action of dexfenfluramine and restraint stress, and in the orex...

journal_title：Neuropharmacology

authors： Penke Z,Fernette B,Nyakas C,Max JP,Burlet A

更新日期：2002-03-01 00:00:00

abstract：:The functional expression of H4 receptors (H4R) within neurons of the central nervous system has been recently reported, but their role is poorly understood. The present study aims to elucidate the role of neuronal H4R by providing the first description of the behavioural phenotype of H4R-deficient (H4R knockout, H4R-...

journal_title：Neuropharmacology

authors： Sanna MD,Ghelardini C,Thurmond RL,Masini E,Galeotti N

更新日期：2017-03-01 00:00:00

abstract：:The effects of short- and long-term exposure of cells to elevated cyclic adenosine monophosphate (c-AMP), using dibutyryl-c-AMP, 8-bromo-c-AMP, cholera toxin or forskolin, or cyclic guanosine monophosphate (c-GMP), using dibutyryl-c-GMP or 8-bromo-c-GMP, on the activity and expression of the noradrenaline transporter ...

journal_title：Neuropharmacology

authors： Bryan-Lluka LJ,Paczkowski FA,Bönisch H

更新日期：2001-03-01 00:00:00

abstract：:In this study we investigate the presence, modulation and biological function of P2 receptors and extracellular ATP in cultured cerebellar granule neurons. As we demonstrate by RT-PCR and western blotting, both P2X and P2Y receptor subtypes are expressed and furthermore regulated as a function of neuronal maturation. ...

journal_title：Neuropharmacology

authors： Amadio S,D'Ambrosi N,Cavaliere F,Murra B,Sancesario G,Bernardi G,Burnstock G,Volonté C

更新日期：2002-03-01 00:00:00

abstract：:The bed nucleus of the stria terminalis (BNST) is a group of inter-connected subnuclei that play critical roles in stress-reward interactions. An interesting feature of this brain region is the massive noradrenergic input that it receives. Important roles for norepinephrine in this region have been documented in a num...

journal_title：Neuropharmacology

authors： Flavin SA,Winder DG

更新日期：2013-07-01 00:00:00

abstract：:It has been hypothesized that Acetyl-L-Carnitine (ALC) contributes to mitochondrial ATP production through maintenance of key mitochondrial proteins and protects mitochondria against oxidative stress. We have investigated the role of ALC on the expression of two forms of synaptic plasticity in the striatum: (i) the ph...

journal_title：Neuropharmacology

authors： Bagetta V,Barone I,Ghiglieri V,Di Filippo M,Sgobio C,Bernardi G,Calabresi P,Picconi B

更新日期：2008-08-01 00:00:00

abstract：:A large body of evidence indicates that ligand-gated channels may open spontaneously, exhibiting a basal activity in the absence of the neurotransmitter. In the present work, we were interested in studying the Ca(2+)-induced modulation of the basal channel activity of unliganded human L248Talpha7 receptors expressed i...

journal_title：Neuropharmacology

authors： Tonini R,Renzi M,Eusebi F

更新日期：2004-04-01 00:00:00

abstract：:We have used patch-clamp recording from cultured neurones, immunohistochemistry and gene deletion techniques to characterize the P2X receptors present in mouse otic ganglion neurones, and demonstrated the presence of similar receptors in rat neurones. All neurones from wild-type (WT) mice responded to ATP (EC(50) 109 ...

journal_title：Neuropharmacology

authors： Ma B,Ruan HZ,Cockayne DA,Ford AP,Burnstock G,Dunn PM

更新日期：2004-06-01 00:00:00

abstract：:Neurogenesis requires the balance between the proliferation of newly formed progenitor cells and subsequent death of surplus cells. RT-PCR and immunocytochemistry demonstrated the presence of P2X7 receptor mRNA and immunoreactivity in cultured neural progenitor cells (NPCs) prepared from the adult mouse subventricular...

journal_title：Neuropharmacology

authors： Messemer N,Kunert C,Grohmann M,Sobottka H,Nieber K,Zimmermann H,Franke H,Nörenberg W,Straub I,Schaefer M,Riedel T,Illes P,Rubini P

更新日期：2013-10-01 00:00:00

abstract：:The ability of specific dopamine (DA) receptor agonists and antagonists to modify the release and metabolism of DA in the ventrolateral striatum of awake rats was assessed using in vivo microdialysis. The specific DA D2 receptor antagonist, raclopride (0.1, 0.5 and 2.0 mg/kg, i.p.), dose-dependently increased release ...

journal_title：Neuropharmacology

authors： See RE,Sorg BA,Chapman MA,Kalivas PW

更新日期：1991-12-01 00:00:00

abstract：:In the solitary tract nucleus, neuronal responsiveness to synaptic input from peripheral afferent fibres has been found to decrease as the frequency of that input is increased. The present study investigated the possibility that glycine and gamma-aminobutyric acid (GABA) are (1) involved in this phenomenon of "frequen...

journal_title：Neuropharmacology

authors： Feldman PD,Felder RB

更新日期：1991-03-01 00:00:00