Histamine-induced rise in core temperature of chloral-anaesthetized rats: mediation by H2-receptors located in the preopticus area of hypothalamus.

abstract：:Administration of stimulant and non-stimulant drugs that inhibit monoamine reuptake is known to improve cognitive and behavioral symptoms of attention deficit hyperactivity disorder (ADHD). Although this may reflect acute actions of these drugs, clinical observations suggest that prolonged treatment with these agents ...

journal_title：Neuropharmacology

authors： Seu E,Jentsch JD

更新日期：2009-12-01 00:00:00

abstract：:Somatostatin-14 (SRIF) is a potent anticonvulsant in rodent models of limbic seizures in which the hippocampus is its major site of action. However, the distribution of hippocampal sst receptors and their role in the anticonvulsant effects of SRIF remain controversial. Moreover, striking differences have been describe...

journal_title：Neuropharmacology

authors： Aourz N,De Bundel D,Stragier B,Clinckers R,Portelli J,Michotte Y,Smolders I

更新日期：2011-12-01 00:00:00

abstract：:Parkinson's disease (PD) shows a complex etiology, where both genetic and environmental factors contribute to initiation and advance of pathology. Mitochondrial dysfunction and mutation of genes implicated in mitochondria quality control are recognized contributors to etiopathology and progression of PD. Here we repor...

journal_title：Neuropharmacology

authors： Moisoi N,Fedele V,Edwards J,Martins LM

更新日期：2014-02-01 00:00:00

abstract：:The psychostimulant drug amphetamine increases extracellular monamines in the brain acting on neurotransmitter transporters, especially the dopamine transporter. Mediated by this plasmalemmal pump, amphetamine does not only induce release but also charge transfer which might be involved in the release mechanism. To st...

journal_title：Neuropharmacology

authors： Pifl C,Rebernik P,Kattinger A,Reither H

更新日期：2004-02-01 00:00:00

abstract：:The group III metabotropic glutamate (mGlu) receptors mGlu7 and mGlu8 are receiving increased attention as potential novel therapeutic targets for anxiety disorders. The effects mediated by these receptors appear to result from a complex interplay of facilitatory and inhibitory actions at different brain sites in the ...

journal_title：Neuropharmacology

authors： Dobi A,Sartori SB,Busti D,Van der Putten H,Singewald N,Shigemoto R,Ferraguti F

更新日期：2013-03-01 00:00:00

abstract：:The effects of prostaglandin (PG) E(1) on NO neurotoxicity were examined using rat cultured spinal neurons. Rat cultured spinal neurons exposed to the NO donor, 2,2'-(hydroxynitrosohydrazono) bis-ethanamine (NOC18), showed neurotoxic effects that were accompanied by apoptotic nuclear change, free radical generation, a...

journal_title：Neuropharmacology

authors： Kikuchi S,Shinpo K,Niino M,Tsuji S,Iwabuchi K,Onoé K,Tashiro K

更新日期：2002-04-01 00:00:00

abstract：:Dieting induces depression and anxiety among other emotional symptoms. Animal models indicate that repeated access to palatable foods such as sugar induces depression and anxiety-like behavior when the food is no longer available. However, the neurobiological mechanisms of how dietary restriction influences mood have ...

journal_title：Neuropharmacology

authors： Kim S,Shou J,Abera S,Ziff EB

更新日期：2018-03-01 00:00:00

abstract：:Glutamate may be a key transmitter in the emetic reflex arc. The present investigation focussed on the involvement of the NMDA subtype of glutamate receptors in cisplatin-induced emesis. Ferrets were injected with cisplatin (10 mg/kg i.v.) and either of the non-competitive NMDA receptor antagonists dextromethorphan or...

journal_title：Neuropharmacology

authors： Lehmann A,Kärrberg L

更新日期：1996-04-01 00:00:00

abstract：:Differences in overall cocaine intake can directly affect neuroadaptations, and this relationship can make it difficult to interpret neurobiological changes seen in drug-choice studies, since drug intake varies between subjects. Herein, a choice procedure that controls for cocaine intake was utilized to explore if neu...

journal_title：Neuropharmacology

authors： Chow JJ,Hofford RS,Beckmann JS

更新日期：2021-02-15 00:00:00

abstract：:The ability of the enantiomers of the atypical dopamine receptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) to counteract gamma-butyrolactone-induced hyperprolactinemia was compared in male and female rats. Following gamma-butyrolactone (GBL) pretreatment serum prolactin concentrations were higher in fem...

journal_title：Neuropharmacology

authors： Carlsson M,Eriksson E,Nilsson C,Carlsson A

更新日期：1986-08-01 00:00:00

abstract：:Whole-cell patch clamp recording and immunohistochemistry were used to investigate the expression of P2X receptors on rat parasympathetic ganglion neurons of the otic, sphenopalatine, submandibular, intracardiac and paratracheal ganglia. Neurons from all five ganglia responded to ATP with a rapidly activating, sustain...

journal_title：Neuropharmacology

authors： Ma B,Ruan HZ,Burnstock G,Dunn PM

更新日期：2005-04-01 00:00:00

abstract：:Ketogenesis is a metabolic process wherein ketone bodies are produced from the breakdown of fatty acids. In humans, fatty acid catabolism results in the production of acetyl-CoA which can then be used to synthesize three ketone bodies: acetoacetate, acetone, and β-hydroxybutyrate. Ketogenesis occurs at a higher rate i...

journal_title：Neuropharmacology

authors： Pflanz NC,Daszkowski AW,James KA,Mihic SJ

更新日期：2019-04-01 00:00:00

abstract：:The effects of short- and long-term exposure of cells to elevated cyclic adenosine monophosphate (c-AMP), using dibutyryl-c-AMP, 8-bromo-c-AMP, cholera toxin or forskolin, or cyclic guanosine monophosphate (c-GMP), using dibutyryl-c-GMP or 8-bromo-c-GMP, on the activity and expression of the noradrenaline transporter ...

journal_title：Neuropharmacology

authors： Bryan-Lluka LJ,Paczkowski FA,Bönisch H

更新日期：2001-03-01 00:00:00

abstract：:Diazepam binding inhibitor (DBI) is a neuromodulatory peptide for gamma-aminobutyric acid (GABA) neurotransmission. Levels of DBI in cerebrospinal fluid (CSF) were found to be elevated in depressed patients, when compared to age- and sex-matched normal controls. Levels of the peptide, corticotropin-releasing hormone (...

journal_title：Neuropharmacology

authors： Roy A

更新日期：1991-12-01 00:00:00

abstract：:Administration of serotonin-enhancing drugs induces a distinctive behavioral syndrome in rodents. We previously reported that mice with a targeted disruption of the serotonin transporter (SERT) display some of these behaviors spontaneously, in the absence of drug. In the current studies, we assessed the drug-induced s...

journal_title：Neuropharmacology

authors： Fox MA,Jensen CL,Gallagher PS,Murphy DL

更新日期：2007-10-01 00:00:00

abstract：:The intravenous administration of L-5-hydroxytryptophan (5-HTP), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), p-chloroamphetamine (PCA), LSD and methysergide to acute spinal rats, transected at C1, stimulated the flexor reflexes induced by electrical stimulation applied to the skin of the toe. The enhancement produced...

journal_title：Neuropharmacology

authors： Ono H,Miyamoto M,Kobayashi M,Fukuda H

更新日期：1987-09-01 00:00:00

abstract：:Exogenous brain-derived neurotrophic factor (BDNF) can regulate behavioral sensitization and conditioned place preference (CPP) when animals are exposed to repeated cocaine administration. However, it is unclear whether BDNF signaling through the TrkB receptor can mediate these behavioral responses when animals are gi...

journal_title：Neuropharmacology

authors： Crooks KR,Kleven DT,Rodriguiz RM,Wetsel WC,McNamara JO

更新日期：2010-06-01 00:00:00

abstract：:Traumatic injuries to peripheral nerves are frequent, however, specific pharmacological treatments are currently lacking. Curcumin has antioxidant, anti-inflammatory and neuroprotective properties but high oral doses are required for therapeutic use, particularly due to its low bioavailability. The aim of the present ...

journal_title：Neuropharmacology

authors： Caillaud M,Chantemargue B,Richard L,Vignaud L,Favreau F,Faye PA,Vignoles P,Sturtz F,Trouillas P,Vallat JM,Desmoulière A,Billet F

更新日期：2018-09-01 00:00:00

abstract：:Tobacco use is prevalent in the adolescent population. It is a major concern because tobacco is highly addictive and has also been linked to illicit drug use. There is not much research, however, on the interaction between nicotine and other stimulant drugs in animal models of early adolescence. This study examined th...

journal_title：Neuropharmacology

authors： Collins SL,Izenwasser S

更新日期：2004-03-01 00:00:00

abstract：:Intensive computerized auditory training results in improved cognition for schizophrenia patients, but participants show variation in their cognitive gains and the biological factors that affect the response to training are unknown. Single nucleotide polymorphisms (SNPs) in the catechol-O-methyltransferase (COMT) gene...

journal_title：Neuropharmacology

authors： Panizzutti R,Hamilton SP,Vinogradov S

更新日期：2013-01-01 00:00:00

abstract：:Rats were pretreated twice daily for six consecutive days with either saline or 1.0, 5.0, or 10.0 mg/kg (+)-amphetamine. On the following day, single-unit recording techniques were used to identify serotonin-containing neurons in the dorsal raphe nucleus (DRN). Pretreatment with amphetamine did not alter the mean spon...

journal_title：Neuropharmacology

authors： Heidenreich BA,Basse-Tomusk AE,Rebec GV

更新日期：1987-07-01 00:00:00

abstract：:Up to 80% of cancer patients are affected by the cancer anorexia-cachexia syndrome (CACS), which leads to excessive body weight loss, reduced treatment success and increased lethality. The area postrema/nucleus of the solitary tract (AP/NTS) region emerged as a central nervous key structure in this multi-factorial pro...

journal_title：Neuropharmacology

authors： Navarro I Batista K,Schraner M,Riediger T

更新日期：2020-12-01 00:00:00

abstract：:T-type (Cav3) calcium channels play important roles in neuronal excitability, both in normal and pathological activities of the brain. In particular, they contribute to hyper-excitability disorders such as epilepsy. Here we have characterized the anticonvulsant properties of TTA-A2, a selective T-type channel blocker,...

journal_title：Neuropharmacology

authors： Sakkaki S,Gangarossa G,Lerat B,Françon D,Forichon L,Chemin J,Valjent E,Lerner-Natoli M,Lory P

更新日期：2016-02-01 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA) receptors are important CNS target sites of alcohols, but the site and mechanism of action of alcohols on NMDA receptors remains unclear. In CHO-K1 cells transfected with NR1/NR2B NMDA receptor subunits, ethanol inhibited NMDA-activated current with an IC(50) of 138 mM. Truncation of the in...

journal_title：Neuropharmacology

authors： Peoples RW,Stewart RR

更新日期：2000-07-24 00:00:00

abstract：:Reductions in the capacity of the human choline transporter (SLC5A7, CHT) have been hypothesized to diminish cortical cholinergic neurotransmission, leading to risk for cognitive and mood disorders. To determine the acetylcholine (ACh) release capacity of cortical cholinergic projections in a mouse model of cholinergi...

journal_title：Neuropharmacology

authors： Paolone G,Mallory CS,Cherian AK,Miller TR,Blakely RD,Sarter M

更新日期：2013-12-01 00:00:00

abstract：:Dopamine (DA) is a major catecholamine neurotransmitter in the mammalian brain that controls neural circuits involved in the cognitive, emotional, and motor aspects of goal-directed behavior. Accordingly, perturbations in DA neurotransmission play a central role in several neuropsychiatric disorders. Somewhat surprisi...

journal_title：Neuropharmacology

authors： Covey DP,Mateo Y,Sulzer D,Cheer JF,Lovinger DM

更新日期：2017-09-15 00:00:00

abstract：:The Forkhead Box G1 (FOXG1) gene encodes a transcription factor with an essential role in mammalian telencephalon development. FOXG1-related disorders, caused by deletions, intragenic mutations or duplications, are usually associated with severe intellectual disability, autistic features, and, in 87% of subjects, epil...

journal_title：Neuropharmacology

authors： Testa G,Mainardi M,Olimpico F,Pancrazi L,Cattaneo A,Caleo M,Costa M

更新日期：2019-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia, clinically characterized by loss of memory and progressive deficits in different cognitive domains. An emerging disease-modifying approach to face the multifactorial nature of AD may be represented by the development of Multi-Target Directed Ligands (MTDLs...

journal_title：Neuropharmacology

authors： Minarini A,Milelli A,Tumiatti V,Rosini M,Simoni E,Bolognesi ML,Andrisano V,Bartolini M,Motori E,Angeloni C,Hrelia S

更新日期：2012-02-01 00:00:00

abstract：:The current study describes the neuroprotective effects of an endogenous diketopiperazine, cyclo-glycyl-proline (cyclic GP), in rats with hypoxic-ischemic brain injury and the pre-clinical development of an analogue, cyclo-L-glycyl-L-2-allylproline (NNZ 2591), modified for improved bioavailability. The compounds were ...

journal_title：Neuropharmacology

authors： Guan J,Mathai S,Harris P,Wen JY,Zhang R,Brimble M,Gluckman P

更新日期：2007-11-01 00:00:00

abstract：:Purine nucleotides, such as ATP and ADP, activate ionotropic P2X and metabotropic P2Y receptors to regulate neurotransmitter release in the peripheral as well as central nervous system. Here we report another type of ATP-induced presynaptic modulation of glutamate release in rat medullary dorsal horn neurons. Glutamat...

journal_title：Neuropharmacology

authors： Choi IS,Cho JH,Lee MG,Jang IS

更新日期：2015-06-01 00:00:00