当前位置： SCI文献检索 > NEUROPHARMACOLOGY期刊下所有文献 > Rat hippocampal somatostatin sst3 and sst4 receptors mediate anticonvulsive effects in vivo: indications of functional interactions with sst2 receptors.

Rat hippocampal somatostatin sst3 and sst4 receptors mediate anticonvulsive effects in vivo: indications of functional interactions with sst2 receptors.

Abstract：

:Somatostatin-14 (SRIF) is a potent anticonvulsant in rodent models of limbic seizures in which the hippocampus is its major site of action. However, the distribution of hippocampal sst receptors and their role in the anticonvulsant effects of SRIF remain controversial. Moreover, striking differences have been described between mice and rats. In rats, sst(2) but not sst(1) receptors play a critical role in the anticonvulsant effects of SRIF. At present, the role of rat sst(3) and sst(4) receptors in these anticonvulsive effects remains unknown. Here we demonstrate in vivo anticonvulsive actions of rat hippocampal sst(3) and sst(4) receptors. Using microdialysis and telemetry-based electroencephalographic recordings we show that intrahippocampal administration of the sst(2) agonist L-779,976 (500 nM), the sst(3) agonist L-796,778 (100 nM) or the sst(4) agonist L-803,087 (100 nM) protects rats against focal pilocarpine-induced seizures. SRIF (1 μM)-, sst(3)- and sst(4)-mediated anticonvulsive actions are reversed by the selective sst(2) receptor antagonist cyanamid 154806 (100 nM). Moreover, the selective sst(3) antagonist SST3-ODN-8 (100 nM) blocks the sst(4)-mediated anticonvulsant effect. Sst(3) antagonism does not reverse the sst(2)- or SRIF-mediated anticonvulsant effects. Our findings provide the first in vivo evidence for potent anticonvulsive properties of sst(3) and sst(4) receptors in the rat hippocampus. Nevertheless, selective sst(2) receptor antagonism prevented these sst(3)- or sst(4) receptor-mediated anticonvulsant effects, suggesting a functional cooperation with rat hippocampal sst(2) receptors.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Aourz N,De Bundel D,Stragier B,Clinckers R,Portelli J,Michotte Y,Smolders I

doi

10.1016/j.neuropharm.2011.08.003

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1327-33

issue

8

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(11)00334-0

journal_volume

61

pub_type

杂志文章

相关文献

NEUROPHARMACOLOGY文献大全
  • Modulation of the GABAA-like autoreceptor by barbiturates but not by steroids.

    abstract：:In slices of cerebral cortex from rat preloaded with [3H]GABA, muscimol produced a concentration-related inhibition of K(+)-evoked release of tritium with a pIC25 value of 7.80 +/- 0.39. Dimethylbarbituric acid (10 and 100 microM) and pentobarbitone (100 microM) significantly increased this value to 8.31 +/- 0.09, 9.9...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(93)90156-w

    authors： Ennis C,Minchin MC

    更新日期：1993-04-01 00:00:00

  • Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept

    abstract：:(+)-2-Methyl-4-carboxyphenylglycine (LY367385), a potent and selective antagonist of mGlu1a metabotropic glutamate receptors, was neuroprotective in the following in vitro and in vivo models of excitotoxic death: (i) mixed cultures of murine cortical cells transiently exposed to N-methyl-D-aspartate (NMDA); (ii) rats ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(98)00159-2

    authors： Bruno V,Battaglia G,Kingston A,O'Neill MJ,Catania MV,Di Grezia R,Nicoletti F

    更新日期：1999-02-01 00:00:00

  • The kynurenine pathway and parasitic infections that affect CNS function.

    abstract：:The kynurenine pathway of tryptophan metabolism has been implicated in brain function, immunoregulation, anti-microbial mechanisms and pregnancy. Some of these actions are due to depletion of tryptophan and others to the formation of biologically active metabolites. This review focuses on the roles of the kynurenine p...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2016.02.029

    authors： Hunt NH,Too LK,Khaw LT,Guo J,Hee L,Mitchell AJ,Grau GE,Ball HJ

    更新日期：2017-01-01 00:00:00

  • Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons.

    abstract：:Of the five excitatory amino acid transporters (EAATs) identified, two genes are expressed by neurons (EAAT3 and EAAT4) and give rise to transporters confined to neuronal cell bodies and dendrites. At an ultrastructural level, EAAT3 and EAAT4 proteins are clustered at the edges of postsynaptic densities of excitatory ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2005.08.015

    authors： Meera P,Dodson PD,Karakossian MH,Otis TS

    更新日期：2005-11-01 00:00:00

  • Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models.

    abstract：:Agonists and positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (nAChRs) are currently being considered as novel therapeutic approaches for managing cognitive deficits in schizophrenia and Alzheimer's disease. Though α7 agonists were recently found to possess antinociceptive and anti-inflamm...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2012.08.022

    authors： Freitas K,Ghosh S,Ivy Carroll F,Lichtman AH,Imad Damaj M

    更新日期：2013-02-01 00:00:00

  • Transgenerational attenuation of opioid self-administration as a consequence of adolescent morphine exposure.

    abstract：:The United States is in the midst of an opiate epidemic, with abuse of prescription and illegal opioids increasing steadily over the past decade. While it is clear that there is a genetic component to opioid addiction, there is a significant portion of heritability that cannot be explained by genetics alone. The curre...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.10.006

    authors： Vassoler FM,Oliver DJ,Wyse C,Blau A,Shtutman M,Turner JR,Byrnes EM

    更新日期：2017-02-01 00:00:00

  • Modulation of neurotransmitter release by P2X and P2Y receptors in the rat spinal cord.

    abstract：:In this study, the P2 receptor-mediated modulation of [3H]glutamate and [3H]noradrenaline release were examined in rat spinal cord slices. Adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP), and 2-methylthioadenosine 5'-diphosphate (2-MeSADP) decreased the electrical stimulation-evoked [3H]glutamate efflu...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2007.10.013

    authors： Heinrich A,Kittel A,Csölle C,Sylvester Vizi E,Sperlágh B

    更新日期：2008-02-01 00:00:00

  • Noradrenergic control of the bed nucleus of the stria terminalis in stress and reward.

    abstract：:The bed nucleus of the stria terminalis (BNST) is a group of inter-connected subnuclei that play critical roles in stress-reward interactions. An interesting feature of this brain region is the massive noradrenergic input that it receives. Important roles for norepinephrine in this region have been documented in a num...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2013.02.013

    authors： Flavin SA,Winder DG

    更新日期：2013-07-01 00:00:00

  • Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain.

    abstract：:Clinically effective antidepressants are thought to exert their therapeutic effects by facilitating central monoamine neurotransmission. However, recent data showing that neurokinin-1 receptor (NK1R) antagonists have antidepressant properties in both animal and clinical studies raise the possibility that classical ant...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2004.02.013

    authors： Sartori SB,Burnet PWJ,Sharp T,Singewald N

    更新日期：2004-06-01 00:00:00

  • An increase in tryptophan in brain may be a general mechanism for the effect of stress on sensitivity to pain.

    abstract：:The role of the stress-induced increase in the uptake of tryptophan in brain in opioid-induced analgesia was investigated by modifying the uptake of amino acid in brain with injections of competing amino acids. Blockade of analgesia by valine (200 mg/kg, i.p.) alone, and by valine and tyrosine (100 mg/kg, i.p.), but n...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(85)90185-6

    authors： Kelly SJ,Franklin KB

    更新日期：1985-11-01 00:00:00

  • Safinamide inhibits in vivo glutamate release in a rat model of Parkinson's disease.

    abstract：:To investigate whether the reversible MAO-B inhibitor and sodium channel blocker safinamide impairs glutamate release under parkinsonian conditions in vivo, and this effect is dependent on MAO-B inhibition, safinamide (and rasagiline as a comparator) were administered to 6-hydroxydopamine hemilesioned rats, a model of...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2020.108006

    authors： Pisanò CA,Brugnoli A,Novello S,Caccia C,Keywood C,Melloni E,Vailati S,Padoani G,Morari M

    更新日期：2020-05-01 00:00:00

  • Nigrostriatal dopamine actions on the D2 receptors mediate methamphetamine effects on the striatonigral substance P system.

    abstract：:Multiple administrations of methamphetamine to rats produced elevated concentrations of substance P-like immunoreactivity within the substantia nigra, an effect which is believed to be mediated by increases in dopaminergic activity induced by methamphetamine. The results reported here demonstrate that the effect of me...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(86)90139-5

    authors： Sonsalla PK,Gibb JW,Hanson GR

    更新日期：1986-11-01 00:00:00

  • On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats.

    abstract：:The mechanisms underlying 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonergic (5-HT) toxicity remain unclear. It has been suggested that MDMA depletes 5-HT by increasing brain tyrosine levels, which via non-enzymatic hydroxylation leads to DA-derived free radical formation. Because this hypothesis assumes th...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2008.01.007

    authors： Goñi-Allo B,Puerta E,Mathúna BO,Hervias I,Lasheras B,de la Torre R,Aguirre N

    更新日期：2008-04-01 00:00:00

  • Ectopic expression of the GABA(A) receptor alpha6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition.

    abstract：:We generated transgenic (Thy1alpha6) mice in which the GABA(A) receptor alpha6 subunit, whose expression is usually confined to granule cells of cerebellum and cochlear nuclei, is ectopically expressed under the control of the pan-neuronal Thy-1.2 promoter. Strong Thy1alpha6 subunit expression occurs, for example, in ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(02)00151-x

    authors： Wisden W,Cope D,Klausberger T,Hauer B,Sinkkonen ST,Tretter V,Lujan R,Jones A,Korpi ER,Mody I,Sieghart W,Somogyi P

    更新日期：2002-09-01 00:00:00

  • Glutamate transport system as a key constituent of glutamosome: Molecular pathology and pharmacological modulation in chronic pain.

    abstract：:Neural uptake of glutamate is executed by the structurally related members of the SLC1A family of solute transporters: GLAST/EAAT1, GLT-1/EAAT2, EAAC1/EAAT3, EAAT4, ASCT2. These plasma membrane proteins ensure supply of glutamate, aspartate and some neutral amino acids, including glutamine and cysteine, for synthetic,...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2019.04.029

    authors： Gegelashvili G,Bjerrum OJ

    更新日期：2019-12-15 00:00:00

  • Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors.

    abstract：:Electrophysiology, immunostaining and time lapse imaging techniques were employed to study the mechanism of long-term depression (LTD) induced by DHPG, a specific group I metabotropic glutamate receptor (mGluR) agonist. Experiments were performed in primary hippocampal culture or in the CA1 area of acute rat hippocamp...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(01)00134-4

    authors： Xiao MY,Zhou Q,Nicoll RA

    更新日期：2001-11-01 00:00:00

  • Mefloquine in the nucleus accumbens promotes social avoidance and anxiety-like behavior in mice.

    abstract：:Mefloquine continues to be a key drug used for malaria chemoprophylaxis and treatment, despite reports of adverse events like depression and anxiety. It is unknown how mefloquine acts within the central nervous system to cause depression and anxiety or why some individuals are more vulnerable. We show that intraperito...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2015.10.013

    authors： Heshmati M,Golden SA,Pfau ML,Christoffel DJ,Seeley EL,Cahill ME,Khibnik LA,Russo SJ

    更新日期：2016-02-01 00:00:00

  • Depletion of nucleus accumbens dopamine leads to impaired reward and aversion processing in mice: Relevance to motivation pathologies.

    abstract：:Dopamine (DA) neurotransmission, particularly the ventral tegmental area-nucleus accumbens (VTA-NAcc) projection, underlies reward and aversion processing, and deficient DA function could underlie motivational impairments in psychiatric disorders. 6-hydroxydopamine (6-OHDA) injection is an established method for chron...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.03.048

    authors： Bergamini G,Sigrist H,Ferger B,Singewald N,Seifritz E,Pryce CR

    更新日期：2016-10-01 00:00:00

  • Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: relevance to antidepressant action.

    abstract：:GABA(B) receptor antagonists have been shown to have antidepressant-like properties in animal models and thus, could represent a novel approach for the treatment of depression. The neurobiological mechanisms underlying these effects are currently unknown. Adult hippocampal neurogenesis (the birth of new neurons) is th...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2012.06.066

    authors： Felice D,O'Leary OF,Pizzo RC,Cryan JF

    更新日期：2012-12-01 00:00:00

  • Chronic nicotine differentially alters cocaine-induced locomotor activity in adolescent vs. adult male and female rats.

    abstract：:Tobacco use is prevalent in the adolescent population. It is a major concern because tobacco is highly addictive and has also been linked to illicit drug use. There is not much research, however, on the interaction between nicotine and other stimulant drugs in animal models of early adolescence. This study examined th...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2003.09.024

    authors： Collins SL,Izenwasser S

    更新日期：2004-03-01 00:00:00

  • Primary brain tumors, neural stem cell, and brain tumor cancer cells: where is the link?

    abstract：:The discovery of brain tumor-derived cells (BTSC) with the properties of stem cells has led to the formulation of the hypothesis that neural stem cells could be the cell of origin of primary brain tumors (PBT). In this review we present the most common molecular changes in PBT, define the criteria of identification of...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2009.12.019

    authors： Germano I,Swiss V,Casaccia P

    更新日期：2010-05-01 00:00:00

  • Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.

    abstract：:Long-term memory formation is known to be critically dependent upon de novo gene expression in the brain. As a consequence, pharmacological enhancement of the transcriptional processes mediating long-term memory formation provides a potential therapeutic strategy for cognitive disorders involving aberrant neuroplastic...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2012.06.043

    authors： Fass DM,Reis SA,Ghosh B,Hennig KM,Joseph NF,Zhao WN,Nieland TJ,Guan JS,Kuhnle CE,Tang W,Barker DD,Mazitschek R,Schreiber SL,Tsai LH,Haggarty SJ

    更新日期：2013-01-01 00:00:00

  • Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats.

    abstract：:Many studies have described potent effects of BDNF, 17β-estradiol or androgen on hippocampal synapses and their plasticity. Far less information is available about the interactions between 17β-estradiol and BDNF in hippocampus, or interactions between androgen and BDNF in hippocampus. Here we review the regulation of ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2013.04.029

    authors： Scharfman HE,MacLusky NJ

    更新日期：2014-01-01 00:00:00

  • Interferon modifies morphine withdrawal phenomena in rodents.

    abstract：:Interferon injection in morphine dependent rats prior to naloxone treatment eliminates 7 behavioral sings of the abstinence (withdrawal) phenomenon. When a single injection of interferon was given prior to chronic morphine treatment it reduces opiate addiction liability. ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(83)90157-0

    authors： Dafny N

    更新日期：1983-05-01 00:00:00

  • Central serotonin(2B) receptor blockade inhibits cocaine-induced hyperlocomotion independently of changes of subcortical dopamine outflow.

    abstract：:The central serotonin2B receptor (5-HT2BR) is currently considered as an interesting pharmacological target for improved treatment of drug addiction. In the present study, we assessed the effect of two selective 5-HT2BR antagonists, RS 127445 and LY 266097, on cocaine-induced hyperlocomotion and dopamine (DA) outflow ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2015.06.012

    authors： Devroye C,Cathala A,Di Marco B,Caraci F,Drago F,Piazza PV,Spampinato U

    更新日期：2015-10-01 00:00:00

  • The roles of nerve growth factor and cholecystokinin in the enhancement of morphine analgesia in a rodent model of central nervous system inflammation.

    abstract：:Animal models of inflammatory pain are characterized by the release of inflammatory mediators such as cytokines and neurotrophic factors, and enhanced analgesic sensitivity to opioids. In this study, we examine the mechanisms underlying this effect, in particular the roles of cholecystokinin (CCK) and nerve growth fac...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2008.12.002

    authors： Xanthos DN,Kumar N,Theodorsson E,Coderre TJ

    更新日期：2009-03-01 00:00:00

  • An estrogenic effect of 5alpha-androstane-3beta, 17beta-diol on the behavioral response to stress and on CRH regulation.

    abstract：:The gender difference in behavioral and hormonal response to stress is well known, but the underlying mechanism remains elusive. Arginine-vasopressin (AVP) and corticotrophin-releasing hormone (CRH) are two major regulatory peptides in the brain involved in stress regulation. Their response to stress has been shown to...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2008.03.016

    authors： Huang Q,Zhu H,Fischer DF,Zhou JN

    更新日期：2008-06-01 00:00:00

  • Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation.

    abstract：:Nerve growth factor (NGF) holds a pivotal role in brain development and maintenance, been also involved in the pathophysiology of neurodegenerative diseases. Here, we provide evidence that a novel C17-spiroepoxy steroid derivative, BNN27, specifically interacts with and activates the TrkA receptor of NGF, inducing pho...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.09.007

    authors： Pediaditakis I,Efstathopoulos P,Prousis KC,Zervou M,Arévalo JC,Alexaki VI,Nikoletopoulou V,Karagianni E,Potamitis C,Tavernarakis N,Chavakis T,Margioris AN,Venihaki M,Calogeropoulou T,Charalampopoulos I,Gravanis A

    更新日期：2016-12-01 00:00:00

  • Dynamism of GABA(A) receptor activation shapes the "personality" of inhibitory synapses.

    abstract：:The kinetics of synaptic currents is largely determined by the postsynaptic receptor gating and the concentration time course of synaptic neurotransmitter. While the analysis of current responses to rapid agonist application provides the means to study the ligand-gated receptor gating, no direct tools are available to...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2004.07.003

    authors： Mozrzymas JW

    更新日期：2004-12-01 00:00:00

  • Attenuation of withdrawal-induced hyperactivity of locus coeruleus neurones by inhibitors of nitric oxide synthase in morphine-dependent rats.

    abstract：:Electrophysiological, biochemical, and behavioural studies have suggested that opiate withdrawal is mediated, at least in part, by a hyperactivity of locus coeruleus (LC) neurones. The aim of this study was to evaluate, using single-unit extracellular recordings, the role of NO in the opiate withdrawal-induced hyperac...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(98)00063-x

    authors： Pineda J,Torrecilla M,Martín-Ruiz R,Ugedo L

    更新日期：1998-06-01 00:00:00