当前位置： SCI文献检索 > NEUROPHARMACOLOGY期刊下所有文献 > Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation.

Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation.

Abstract：

:Nerve growth factor (NGF) holds a pivotal role in brain development and maintenance, been also involved in the pathophysiology of neurodegenerative diseases. Here, we provide evidence that a novel C17-spiroepoxy steroid derivative, BNN27, specifically interacts with and activates the TrkA receptor of NGF, inducing phosphorylation of TrkA tyrosine residues and down-stream neuronal survival-related kinase signaling. Additionally, BNN27 potentiates the efficacy of low levels of NGF, by facilitating its binding to the TrkA receptors and differentially inducing fast return of internalized TrkA receptors into neuronal cell membranes. Furthermore, BNN27 synergizes with NGF in promoting axonal outgrowth, effectively rescues from apoptosis NGF-dependent and TrkA positive sympathetic and sensory neurons, in vitro, ex vivo and in vivo in NGF null mice. Interestingly, BNN27 does not possess the hyperalgesic properties of NGF. BNN27 represents a lead molecule for the development of neuroprotective TrkA receptor agonists, with potential therapeutic applications in neurodegenerative diseases and in brain trauma.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Pediaditakis I,Efstathopoulos P,Prousis KC,Zervou M,Arévalo JC,Alexaki VI,Nikoletopoulou V,Karagianni E,Potamitis C,Tavernarakis N,Chavakis T,Margioris AN,Venihaki M,Calogeropoulou T,Charalampopoulos I,Gravanis A

doi

10.1016/j.neuropharm.2016.09.007

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

266-282

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(16)30383-5

journal_volume

111

pub_type

杂志文章

相关文献

NEUROPHARMACOLOGY文献大全
  • Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice.

    abstract：:The aim of the present study was to investigate if different levels of circulating corticosterone (CORT) modulate the effect of nicotine on prepulse inhibition (PPI), a measure of sensorimotor gating that is disrupted in schizophrenia and other mental illnesses. Four groups of mice were investigated: sham-operated, ad...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2004.08.015

    authors： Ingram N,Martin S,Wang JH,van der Laan S,Loiacono R,van den Buuse M

    更新日期：2005-01-01 00:00:00

  • Brainstem cholinergic pathways diminish cardiovascular and neuroinflammatory actions of endotoxemia in rats: Role of NFκB/α7/α4β2AChRs signaling.

    abstract：:Nicotine improves endotoxic manifestations of hypotension and cardiac autonomic dysfunction in rats. Here, we test the hypothesis that brainstem antiinflammatory pathways of α7/α4β2 nicotinic acetylcholine receptors (nAChRs) modulate endotoxic cardiovascular derangements. Pharmacologic and molecular studies were perfo...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2019.107683

    authors： Sallam MY,El-Gowilly SM,Fouda MA,Abd-Alhaseeb MM,El-Mas MM

    更新日期：2019-10-01 00:00:00

  • Acetaldehyde-induced changes in monoamine and amino acid extracellular microdialysate content of the nucleus accumbens.

    abstract：:The effect of an acute intraperitoneal (i.p.) injection of acetaldehyde, 20 mg/kg or 100 mg/kg, on the microdialysate content of both amino acids and monoamines was studies in the nucleus accumbens (NA) by a microdialysis technique. Acetaldehyde, ACH, which was detectable at levels of 50-130 mumol/g brain tissue 10 mi...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(97)00007-5

    authors： Ward RJ,Colantuoni C,Dahchour A,Quertemont E,De Witte P

    更新日期：1997-02-01 00:00:00

  • Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1.

    abstract：:Cyclic nucleotide-gated (CNG) channels, which are directly activated by cAMP and cGMP, have long been known to play a key role in retinal and olfactory signal transduction. Emerging evidence indicates that CNG channels are also involved in signaling pathways important for pain processing. Here, we found that the expre...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2020.108087

    authors： Kallenborn-Gerhardt W,Metzner K,Lu R,Petersen J,Kuth MS,Heine S,Drees O,Paul M,Becirovic E,Kennel L,Flauaus C,Gross T,Wack G,Hohmann SW,Nemirovski D,Del Turco D,Biel M,Geisslinger G,Michalakis S,Schmidtko A

    更新日期：2020-07-01 00:00:00

  • Dopamine D3 receptor-modulated neuroprotective effects of lisuride.

    abstract：:Dopamine (DA) contributes to the regulation of voluntary movement, and a deficiency in DAergic neurons leads to movement disorders. The objective of this study was to examine the neuroprotective effect of DA D2-like receptor agonist, lisuride, and the role of DA receptors in this protection. Treatment with lisuride al...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2017.01.022

    authors： Kim M,Lee S,Cho J,Kim G,Won C

    更新日期：2017-05-01 00:00:00

  • Dysregulation and restoration of homeostatic network plasticity in fragile X syndrome mice.

    abstract：:Chronic activity perturbations in neurons induce homeostatic plasticity through modulation of synaptic strength or other intrinsic properties to maintain the correct physiological range of excitability. Although similar plasticity can also occur at the population level, what molecular mechanisms are involved remain un...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2018.06.011

    authors： Jewett KA,Lee KY,Eagleman DE,Soriano S,Tsai NP

    更新日期：2018-08-01 00:00:00

  • Modular chemical probes for visualizing and tracking endogenous ion channels.

    abstract：:Fluorescently labeled, small molecule ligands designed for the labeling and tracking of neuronal receptors have become an increasingly popular tool in neurobiology. The small size of these probes allows for subcellular imaging of proteins in their native state with minimal perturbation of the system. Several factors s...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2015.03.033

    authors： McCarron ST,Chambers JJ

    更新日期：2015-11-01 00:00:00

  • Drug interactions on spontaneous locomotor activity in rats. Neuroleptics and amphetamine-induced hyperactivity.

    abstract：:The locomotor activity of female rats was recorded during 10-min sessions in a circular open-field apparatus after the administration of vehicle or drug. Dose-response curves were obtained for seven neuroleptic drugs both alone (spontaneous activity) and in combination with 1.0 mg/kg of d-amphetamine. Haloperidol, pim...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(84)90004-2

    authors： Schaefer GJ,Michael RP

    更新日期：1984-08-01 00:00:00

  • Glycinergic synaptic currents in the deep cerebellar nuclei.

    abstract：:Despite evidence of local glycinergic circuits in the mature cerebellar nuclei the result of their activation remains unknown. Here, using whole cell recordings in rat cerebellar slices we demonstrated that after postnatal day 17 (>P17) glycinergic IPSCs can be readily evoked in large deep cerebellar nuclear neurons (...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2007.12.005

    authors： Pedroarena CM,Kamphausen S

    更新日期：2008-04-01 00:00:00

  • Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons.

    abstract：:Painful nerve injury disrupts Ca2+ signaling in primary sensory neurons by elevating plasma membrane Ca2+-ATPase (PMCA) function and depressing sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) function, which decreases endoplasmic reticulum (ER) Ca2+ stores and stimulates store-operated Ca2+ entry (SOCE). The extracell...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2017.02.019

    authors： Guo Y,Zhang Z,Wu HE,Luo ZD,Hogan QH,Pan B

    更新日期：2017-05-01 00:00:00

  • Chronic exposure to anabolic androgenic steroids alters activity and synaptic function in neuroendocrine control regions of the female mouse.

    abstract：:Disruption of reproductive function is a hallmark of abuse of anabolic androgenic steroids (AAS) in female subjects. To understand the central actions of AAS, patch clamp recordings were made in estrous, diestrous and AAS-treated mice from gonadotropin releasing hormone (GnRH) neurons, neurons in the medial preoptic a...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.05.008

    authors： Penatti CA,Oberlander JG,Davis MC,Porter DM,Henderson LP

    更新日期：2011-09-01 00:00:00

  • Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats.

    abstract：:Tau hyperphosphorylation and memory deficit are characteristic alterations of Alzheimer's disease (AD), and glycogen synthase kinase-3 (GSK-3) plays a crucial role in these AD-like changes. We have reported that activation of GSK-3 through ventricular injection of wortmannin and GF-109203X (WT/GFX, 100 microM each) in...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2007.02.008

    authors： Peng JH,Zhang CE,Wei W,Hong XP,Pan XP,Wang JZ

    更新日期：2007-06-01 00:00:00

  • LY392098, a novel AMPA receptor potentiator: electrophysiological studies in prefrontal cortical neurons.

    abstract：:The present experiments investigated the ability of LY392098, a novel positive allosteric modulator of AMPA receptors, to potentiate AMPA receptor-mediated currents of neurons in the prefrontal cortex (PFC). Co-application of LY392098 (0.03-10 microM) with AMPA (5 microM) enhanced current through AMPA receptor/channel...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(00)00195-7

    authors： Baumbarger P,Muhlhauser M,Yang CR,Nisenbaum ES

    更新日期：2001-06-01 00:00:00

  • Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis.

    abstract：:Flavopiridol was developed as a drug for cancer therapy due to its ability to inhibit cell cycle progression by targeting cyclin-dependent kinases (CDKs). In this study, we show that flavopiridol may also have a neuroprotective action. We show that at therapeutic dosage (or at micromolar range), flavopiridol almost co...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(03)00204-1

    authors： Jorda EG,Verdaguer E,Canudas AM,Jiménez A,Bruna A,Caelles C,Bravo R,Escubedo E,Pubill D,Camarasa J,Pallàs M,Camins A

    更新日期：2003-10-01 00:00:00

  • Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor.

    abstract：:Because of the claim that ibogaine suppresses the symptoms of "narcotic withdrawal" in humans, the effect of ibogaine on naltrexone-precipitated withdrawal signs in morphine-dependent rats was assessed. Morphine was administered subcutaneously through implanted silicone reservoirs for 5 days. Ibogaine (20, 40 or 80 mg...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(92)90089-8

    authors： Glick SD,Rossman K,Rao NC,Maisonneuve IM,Carlson JN

    更新日期：1992-05-01 00:00:00

  • Abnormalities in 5-HT1A and 5-HT1B receptor binding in severe-seizure genetically epilepsy-prone rats (GEPR-9s).

    abstract：:The present study was designed to determine whether abnormalities in serotonin receptor binding co-exist with the presynaptic serotonergic deficits that have previously been identified in the genetically epilepsy-prone rat (GEPR) brain. In vitro binding of [3H]8-OH-DPAT (0.16-10.3 nM) to 5-HT1A receptor sites was foun...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(95)00141-7

    authors： Statnick MA,Dailey JW,Jobe PC,Browning RA

    更新日期：1996-01-01 00:00:00

  • Excitatory drive onto dopaminergic neurons in the rostral linear nucleus is enhanced by norepinephrine in an α1 adrenergic receptor-dependent manner.

    abstract：:Dopaminergic innervation of the extended amygdala regulates anxiety-like behavior and stress responsivity. A portion of this dopamine input arises from dopamine neurons located in the ventral lateral periaqueductal gray (vlPAG) and rostral (RLi) and caudal linear nuclei of the raphe (CLi). These neurons receive substa...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2014.07.001

    authors： Williams MA,Li C,Kash TL,Matthews RT,Winder DG

    更新日期：2014-11-01 00:00:00

  • In vivo study of NMDA-sensitive glutamate receptor by fluorothienylcyclohexylpiperidine [correction of fluorothienylcycloexylpiperidine], a possible ligand for positron emission tomography.

    abstract：:As a preliminary to positron emission tomography (PET) studies of excitatory amino acid neurotransmission, N-methyl-D-aspartate (NMDA)-sensitive glutamate receptors of mice and rats were labelled in vivo with [3H]fluorothienylcyclohexylpiperidine [corrected] (FTCP), which binds to the phencyclidine site of the NMDA re...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(91)90125-u

    authors： Ferrarese C,Guidotti A,Costa E,Miletich RS,Rice KC,de Costa BR,Fulham MJ,Di Chiro G

    更新日期：1991-08-01 00:00:00

  • Anti-inflammatory properties of cholinergic up-regulation: A new role for acetylcholinesterase inhibitors.

    abstract：:We investigated the anti-inflammatory effects of acetylcholinesterase inhibitors (AChEI) at the cellular and molecular levels. AChEI suppressed lymphocyte proliferation and pro-inflammatory cytokine production, as well as extracellular esterase activity. Anti-inflammatory activity was mediated by the alpha7 nicotinic ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2005.10.013

    authors： Nizri E,Hamra-Amitay Y,Sicsic C,Lavon I,Brenner T

    更新日期：2006-04-01 00:00:00

  • Differential effects of the new antipsychotic risperidone on sleep and wakefulness in the rat.

    abstract：:The effects of risperidone, a new antipsychotic with potent 5-hydroxytryptamine2 (5-HT2) and dopamine-D2 (DA-D2) antagonistic properties, were studied on sleep-wakefulness patterns in rats. Administration of low doses (0.01-0.16 mg/kg i.p.) resulted in a significant increase of deep slow wave sleep (SWS2) and a decrea...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(89)90023-3

    authors： Dugovic C,Wauquier A,Janssen PA

    更新日期：1989-12-01 00:00:00

  • cAMP-producing chemogenetic and adenosine A2a receptor activation inhibits the inwardly rectifying potassium current in striatal projection neurons.

    abstract：:Adenosine A2a receptors (A2aRs) are highly and selectively expressed in D2-medium spiny neurons (D2-MSNs) that also express a high level of dopamine D2 receptors (D2Rs). However, it was not established how A2aR activity affects D2-MSN excitability, let alone the ion channels involved. We have performed two sets of exp...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2019.01.014

    authors： Wang Q,Zhou FM

    更新日期：2019-04-01 00:00:00

  • Blockade of apomorphine-induced yawning in rats by the dopamine autoreceptor antagonist (+)-AJ 76.

    abstract：:The effects of the putative, selective dopamine autoreceptor antagonist (+)-AJ 76 on yawning, penile grooming and mouth movements induced by small doses of apomorphine in male rats were examined. Yawning induced by 0.05mg/kg apomorphine was dose dependently blocked by (+)-AJ-76, significant decreases being observed at...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(89)90021-x

    authors： Dourish CT,Herbert EN,Iversen SD

    更新日期：1989-12-01 00:00:00

  • Safinamide inhibits in vivo glutamate release in a rat model of Parkinson's disease.

    abstract：:To investigate whether the reversible MAO-B inhibitor and sodium channel blocker safinamide impairs glutamate release under parkinsonian conditions in vivo, and this effect is dependent on MAO-B inhibition, safinamide (and rasagiline as a comparator) were administered to 6-hydroxydopamine hemilesioned rats, a model of...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2020.108006

    authors： Pisanò CA,Brugnoli A,Novello S,Caccia C,Keywood C,Melloni E,Vailati S,Padoani G,Morari M

    更新日期：2020-05-01 00:00:00

  • TC-8831, a nicotinic acetylcholine receptor agonist, reduces L-DOPA-induced dyskinesia in the MPTP macaque.

    abstract：:Long-term L-DOPA treatment for Parkinson's disease (PD) is limited by motor complications, particularly L-DOPA-induced dyskinesia (LID). A therapy with the ability to ameliorate LID without reducing anti-parkinsonian benefit would be of great value. We assessed the ability of TC-8831, an agonist at nicotinic acetylcho...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2013.06.005

    authors： Johnston TH,Huot P,Fox SH,Koprich JB,Szeliga KT,James JW,Graef JD,Letchworth SR,Jordan KG,Hill MP,Brotchie JM

    更新日期：2013-10-01 00:00:00

  • Synergistic effect of 5-HT1A and σ1 receptor activation on prefrontal dopaminergic transmission under circulating steroid deficiency.

    abstract：:Serotonin (5-HT)1A and σ1 receptors have been implicated in psychiatric disorders. We previously found that combined 5-HT reuptake inhibition and σ1 receptor activation has a synergistic effect on prefrontal dopaminergic transmission in adrenalectomized/castrated mice lacking circulating steroid hormones. In the prese...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2013.06.026

    authors： Hiramatsu N,Ago Y,Hasebe S,Nishimura A,Mori K,Takuma K,Matsuda T

    更新日期：2013-12-01 00:00:00

  • Characterisation of mGluRs which modulate nociception in the PAG of the mouse.

    abstract：:The contribution of metabotropic glutamate receptors (mGluRs) to the modulation of nociception by the periaqueductal gray (PAG) matter was investigated in mice. Intra-PAG microinjection of (IS,3R)-ACPD, an agonist of groups I and II mGluRs, as well as (S)-3,5-DHPG, a selective agonist of group I mGluRs, increased the ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(98)00126-9

    authors： Maione S,Marabese I,Leyva J,Palazzo E,de Novellis V,Rossi F

    更新日期：1998-12-01 00:00:00

  • Role of sensory deficits in motor impairments after injury to primary motor cortex.

    abstract：:After a focal ischemic lesion in the hand representation of the primary motor cortex in squirrel monkeys, manual skill was mildly and transiently impaired on a reach-and-retrieval task. Performance was significantly poorer during weeks 1 and 3 post-lesion, but was normal by week 4. An unusual behavioral event was also...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(99)00254-3

    authors： Nudo RJ,Friel KM,Delia SW

    更新日期：2000-03-03 00:00:00

  • Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia.

    abstract：:Clinical studies have reported that the nicotinic receptor agonist varenicline improves balance and coordination in patients with several types of ataxia, but confirmation in an animal model has not been demonstrated. This study investigated whether varenicline and nicotine could attenuate the ataxia induced in rats f...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2013.05.016

    authors： Wecker L,Engberg ME,Philpot RM,Lambert CS,Kang CW,Antilla JC,Bickford PC,Hudson CE,Zesiewicz TA,Rowell PP

    更新日期：2013-10-01 00:00:00

  • A mutation in the GABAA receptor alpha 1 subunit linked to human epilepsy affects channel gating properties.

    abstract：:A genetic component is associated with the development of many forms of epilepsy. Recently, mutations in the GABAA receptor have been linked to several inherited epilepsies. One of these mutations is a non-conservative change of alanine to aspartate in the third transmembrane domain of the alpha1 subunit. To determine...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2003.11.015

    authors： Fisher JL

    更新日期：2004-04-01 00:00:00

  • The role of cytokines and prostaglandin-E(2) in thymulin induced hyperalgesia.

    abstract：:We have recently reported that intraperitoneal (i.p.) injection of thymulin at low doses (50 ng) resulted in thermal and mechanical hyperalgesia and upregulation of the level of interleukin-1beta in the liver. In this study, we demonstrate that such injections of thymulin result in a significant elevation in the level...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(99)00247-6

    authors： Safieh-Garabedian B,Dardenne M,Kanaan SA,Atweh SF,Jabbur SJ,Saadé NE

    更新日期：2000-07-10 00:00:00