Abstract：
:Mefloquine continues to be a key drug used for malaria chemoprophylaxis and treatment, despite reports of adverse events like depression and anxiety. It is unknown how mefloquine acts within the central nervous system to cause depression and anxiety or why some individuals are more vulnerable. We show that intraperitoneal injection of mefloquine in mice, when coupled to subthreshold social defeat stress, is sufficient to produce depression-like social avoidance behavior. Direct infusion of mefloquine into the nucleus accumbens (NAc), a key brain reward region, increased stress-induced social avoidance and anxiety behavior. In contrast, infusion into the ventral hippocampus had no effect. Whole cell recordings from NAc medium spiny neurons indicated that mefloquine application increases the frequency of spontaneous excitatory postsynaptic currents, a synaptic adaptation that we have previously shown to be associated with increased susceptibility to social defeat stress. Together, these data demonstrate a role for the NAc in mefloquine-induced depression and anxiety-like behaviors.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Heshmati M,Golden SA,Pfau ML,Christoffel DJ,Seeley EL,Cahill ME,Khibnik LA,Russo SJdoi
10.1016/j.neuropharm.2015.10.013subject
Has Abstractpub_date
2016-02-01 00:00:00pages
351-7eissn
0028-3908issn
1873-7064pii
S0028-3908(15)30136-2journal_volume
101pub_type
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
