当前位置： SCI文献检索 > NEUROPHARMACOLOGY期刊下所有文献 > Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain.

Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain.

Abstract：

:Physical exercise has become a potentially beneficial therapy for reducing neurodegeneration symptoms in Alzheimer's disease. Previous studies have shown that cognitive deterioration, anxiety and the startle response observed in 7-month-old 3xTg-AD mice were ameliorated after 6 months of free access to a running wheel. Also, alterations in synaptic response to paired-pulse stimulation were improved. The present study further investigated some molecular mechanisms underlying the beneficial effects of 6 months of voluntary exercise on synaptic plasticity in 7-month-old 3xTg-AD mice. Changes in binding parameters of [(3)H]-flunitrazepam to GABAA receptor and of [(3)H]-MK-801 to NMDA receptor in cerebral cortex of 3xTgAD mice were restored by voluntary exercise. In addition, reduced expression levels of NMDA receptor NR2B subunit were reestablished. The synaptic proteins synaptophysin and PSD-95 and the neuroprotective proteins GDNF and SIRT1 were downregulated in 3xTgAD mice and were recovered by exercise treatment. Overall, in this paper we highlight the fact that different interrelated mechanisms are involved in the beneficial effects of exercise on synaptic plasticity alterations in the 3xTg-AD mouse model.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Revilla S,Suñol C,García-Mesa Y,Giménez-Llort L,Sanfeliu C,Cristòfol R

doi

10.1016/j.neuropharm.2014.01.037

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

55-63

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(14)00044-6

journal_volume

81

pub_type

杂志文章

相关文献

NEUROPHARMACOLOGY文献大全
  • Brainstem prolactin-releasing peptide contributes to cancer anorexia-cachexia syndrome in rats.

    abstract：:Up to 80% of cancer patients are affected by the cancer anorexia-cachexia syndrome (CACS), which leads to excessive body weight loss, reduced treatment success and increased lethality. The area postrema/nucleus of the solitary tract (AP/NTS) region emerged as a central nervous key structure in this multi-factorial pro...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2020.108289

    authors： Navarro I Batista K,Schraner M,Riediger T

    更新日期：2020-12-01 00:00:00

  • Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor.

    abstract：:Because of the claim that ibogaine suppresses the symptoms of "narcotic withdrawal" in humans, the effect of ibogaine on naltrexone-precipitated withdrawal signs in morphine-dependent rats was assessed. Morphine was administered subcutaneously through implanted silicone reservoirs for 5 days. Ibogaine (20, 40 or 80 mg...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(92)90089-8

    authors： Glick SD,Rossman K,Rao NC,Maisonneuve IM,Carlson JN

    更新日期：1992-05-01 00:00:00

  • Individual differences in oral nicotine intake in rats.

    abstract：:To study individual differences in nicotine preference and intake, male and female rats were given free access to a choice of oral nicotine (10 or 20 mg/L) or water for 24 h/day for periods of at least six weeks, starting at adolescence or adulthood. A total of 341 rats, were used in four different experiments; weight...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.03.027

    authors： Nesil T,Kanit L,Collins AC,Pogun S

    更新日期：2011-07-01 00:00:00

  • Naloxone antagonizes the hyperdipsic effect of sulpiride in a salt-preference test in male and female rats.

    abstract：:The consumption of saline and water in a two-bottle test of salt-preference was measured after the administration of sulpiride, a dopamine receptor antagonist and of naloxone, an antagonist at opiate receptors. The two drugs were injected alone, or in combination. Three concentrations of saline (0.125, 0.6 and 1.7% Na...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(86)90090-0

    authors： Gilbert DB,Cooper SJ

    更新日期：1986-07-01 00:00:00

  • Endogenous gamma-aminobutyric acid (GABA)(A) receptor active neurosteroids and the sedative/hypnotic action of gamma-hydroxybutyric acid (GHB): a study in GHB-S (sensitive) and GHB-R (resistant) rat lines.

    abstract：:In the rat brain, gamma-hydroxybutyric-acid (GHB) increases the concentrations of 3alpha-hydroxy,5alpha-pregnan-20-one (allopregnanolone, 3alpha,5alpha-THP) and 3alpha,21-dihydroxy,5alpha-pregnan-20-one (allotetrahydrodeoxycorticosterone/3alpha,5alphaTHDOC), two neurosteroids acting as positive allosteric modulators o...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2005.01.026

    authors： Barbaccia ML,Carai MA,Colombo G,Lobina C,Purdy RH,Gessa GL

    更新日期：2005-07-01 00:00:00

  • Effects of cations on high-affinity binding of 3H-ADTN to dopaminergic sites in calf caudate tissue.

    abstract：:Effects of cations on binding of 0.1-10 nM 3H-ADTN to calf caudate membranes included decreased apparent Bmax by [Na+] greater than or equal to 100 mM, little effect on Kd or on affinity of other dopamine (DA) agonists (DA and apomorphine), decreased slopes of inhibition curves produced by agonists, but increased affi...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(87)90159-6

    authors： Lamont JS,Kula NS,Baldessarini RJ

    更新日期：1987-06-01 00:00:00

  • A pharmacological study of dopaminergic receptors in planaria.

    abstract：:The dopaminergic receptors of planaria have been studied with pharmacological and biochemical criteria. Dopamine D1 selective agonists (CY 208243 (10 micrograms/ml) and SKF 38393 (10 micrograms/ml] induced in planaria typical screw-like hyperkinesias, that were inhibited by a D1 antagonist (SCH 23390 (10 micrograms/ml...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(89)90013-0

    authors： Venturini G,Stocchi F,Margotta V,Ruggieri S,Bravi D,Bellantuono P,Palladini G

    更新日期：1989-12-01 00:00:00

  • Activation of mGluR1 contributes to neuronal hyperexcitability in the rat anterior cingulate cortex via inhibition of HCN channels.

    abstract：:Neuronal hyperexcitability in the anterior cingulate cortex (ACC) is considered as one of the most important pathological changes responsible for the chronification of neuropathic pain. However, the underlying mechanisms remain elusive. In the present study, we investigated the possible mechanisms using a rat model of...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.01.036

    authors： Gao SH,Wen HZ,Shen LL,Zhao YD,Ruan HZ

    更新日期：2016-06-01 00:00:00

  • Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurones in vivo.

    abstract：:Using the technique of microelectrophoresis on spinal neurones in pentobarbitone-anaesthetized rats, (1S,3R)-1-aminocyclo-pentane-1,3-dicarboxylate (1S,3R-ACPD) reversibly and dose-dependently enhanced responses to alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA), kainate, N-methyl-D-aspartate (NMDA) and L...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(95)00046-9

    authors： Bond A,Lodge D

    更新日期：1995-08-01 00:00:00

  • Serotonin modulation of cell excitability and of [3H]GABA and [3H]D-aspartate efflux in primary cultures of rat cortical neurons.

    abstract：:The effects of 5-hydroxytryptamine (5-HT) on neuronal excitability, evaluated as depolarization-induced firing rate, and on amino acid release, measured as electrically-evoked [(3)H]GABA and [(3)H]d-aspartate efflux, were investigated in rat primary cortical neuronal cultures. 5-HT displayed a concentration-dependent,...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2006.10.017

    authors： Bianchi C,Marani L,Marino S,Barbieri M,Nazzaro C,Beani L,Siniscalchi A

    更新日期：2007-03-01 00:00:00

  • Lysine 195 and aspartate 196 in the first extracellular loop of the VPAC1 receptor are essential for high affinity binding of agonists but not of antagonists.

    abstract：:The role in ligand recognition and receptor activation of two adjacent charged residues (lysine 195 and aspartate 196) in the first extracellular loop of the human VPAC(1) receptor was investigated in stably transfected CHO cells expressing the wild type or point mutated receptors.Replacement of lysine 195 by glutamin...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(02)00233-2

    authors： Langer I,Vertongen P,Perret J,Waelbroeck M,Robberecht P

    更新日期：2003-01-01 00:00:00

  • Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain.

    abstract：:Central sensitization represents a key mechanism mediating chronic pain, a major clinical problem lacking effective treatment options. LIM-domain kinases (LIMKs) selectively regulate several substrates, e.g. cofilin and cAMP response element-binding protein (CREB), that profoundly affect neural activities, such as syn...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2017.06.031

    authors： Yang X,He G,Zhang X,Chen L,Kong Y,Xie W,Jia Z,Liu WT,Zhou Z

    更新日期：2017-10-01 00:00:00

  • Coupling to protein kinases A and C of adenosine A2B receptors involved in the facilitation of noradrenaline release in the prostatic portion of rat vas deferens.

    abstract：:In the prostatic portion of rat vas deferens, the non-selective adenosine receptor agonist NECA (0.1-30 microM), but not the A(2A) agonist CGS 21680 (0.001-10 microM), caused a facilitation of electrically evoked noradrenaline release (up to 43 +/- 4%), when inhibitory adenosine A(1) receptors were blocked. NECA-elici...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2004.03.015

    authors： Queiroz G,Quintas C,Talaia C,Gonçalves J

    更新日期：2004-08-01 00:00:00

  • Effect of trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidin) cyclohexyl]-benzeneacetamide (U-50,488H), a kappa opioid receptor agonist, on intake of food in food-deprived and non-deprived spontaneously hypertensive and normotensive Wistar-Kyoto rats.

    abstract：:The effect of U-50,488H, a selective kappa opioid receptor agonist on the intake of food in food-deprived and non-deprived spontaneously hypertensive and normotensive Wistar-Kyoto rats was determined. In food deprived Wistar-Kyoto rats, intraperitoneal administration of U-50,488H, produced a bell-shaped curve on the i...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(89)90069-5

    authors： Bhargava HN,Ramarao P,Richter CM,Bieniarz AA

    更新日期：1989-01-01 00:00:00

  • Antagonist discrimination of two muscarinic responses elicited by applied agonists and orthodromic stimuli in superior cervical ganglion of rabbit.

    abstract：:Pirenzepine and gallamine selectively and differentially antagonized two muscarinic responses, in the superior cervical ganglion of the rabbit, whether elicited by the muscarinic agonist methacholine or by orthodromic stimulation. Methacholine elicited a biphasic ganglionic response, consisting of hyperpolarizing and ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(87)90001-3

    authors： Yarosh CA,Ashe JH

    更新日期：1987-11-01 00:00:00

  • P2X7 receptors at adult neural progenitor cells of the mouse subventricular zone.

    abstract：:Neurogenesis requires the balance between the proliferation of newly formed progenitor cells and subsequent death of surplus cells. RT-PCR and immunocytochemistry demonstrated the presence of P2X7 receptor mRNA and immunoreactivity in cultured neural progenitor cells (NPCs) prepared from the adult mouse subventricular...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2013.05.017

    authors： Messemer N,Kunert C,Grohmann M,Sobottka H,Nieber K,Zimmermann H,Franke H,Nörenberg W,Straub I,Schaefer M,Riedel T,Illes P,Rubini P

    更新日期：2013-10-01 00:00:00

  • Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior.

    abstract：:Phosphodiesterase 2 (PDE2) plays an important role in treatment of stress-related depression through regulation of antioxidant defense and neuroprotective mechanisms. However, the causal relationship between PDE2 and the prevalence of depression and anxiety upon exposure to oxidative stress has not been investigated. ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2018.09.039

    authors： Huang X,Xiaokaiti Y,Yang J,Pan J,Li Z,Luria V,Li Y,Song G,Zhu X,Zhang HT,O'Donnell JM,Xu Y

    更新日期：2018-12-01 00:00:00

  • Ethanol protects cultured neurons against amyloid-β and α-synuclein-induced synapse damage.

    abstract：:The loss of synapses and a corresponding reduction in synaptic proteins are histopathological features of Alzheimer's disease that correlate strongly with dementia. Here we report that stable Aβ oligomers secreted by 7PA2 cells reduced the amount of synaptophysin, a protein used as an indicator of synapse density, in ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.08.030

    authors： Bate C,Williams A

    更新日期：2011-12-01 00:00:00

  • Activation of mGluRII induces LTD via activation of protein kinase A and protein kinase C in the dentate gyrus of the hippocampus in vitro.

    abstract：:The involvement of metabotropic glutamate receptor group II (mGluRII) in the induction of long-term depression (LTD) was investigated in the medial perforant path of the rat dentate gyrus, a region with a very high density of mGluRII. Perfusion of either of two potent mGluRII agonists, (2S,1R,2R,3R)-2-(2S, 1'R, 2'R, 3...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(98)00168-3

    authors： Huang L,Killbride J,Rowan MJ,Anwyl R

    更新日期：1999-01-01 00:00:00

  • Effects of risperidone on locomotor activity and spatial memory in rats with hippocampal damage.

    abstract：:Hippocampal damage produces spatial memory impairment and hyperactivity in animals, while reductions in hippocampal size have been associated with memory deficits in humans. There are no known treatments for the behavioral changes specifically related to reduced hippocampal size. The purpose of this study was to deter...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2006.07.014

    authors： Bardgett ME,Baum KT,O'Connell SM,Lee NM,Hon JC

    更新日期：2006-12-01 00:00:00

  • Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area.

    abstract：:Oxytocin (100 ng) injected unilaterally into the ventral subiculum of the hippocampus induces penile erection episodes, which started 30 min after treatment and were abolished by the prior injection of d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin (2 μg), an oxytocin receptor antagonist, into the ventral subiculum. Oxytocin-...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.03.026

    authors： Succu S,Sanna F,Argiolas A,Melis MR

    更新日期：2011-07-01 00:00:00

  • Effects of histamine H3 receptors on chemical hyperalgesia in diabetic rats.

    abstract：:There is considerable interest in histamine H3 receptors as emerging pharmaceutical targets recently. Diabetic rats display increased pain responses following the injection of formalin into the paw suggesting the presence of hyperalgesia. In this study, the efficacy of systemic administration of selective H3 receptor ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.01.004

    authors： Hasanein P

    更新日期：2011-05-01 00:00:00

  • The kynurenine pathway and parasitic infections that affect CNS function.

    abstract：:The kynurenine pathway of tryptophan metabolism has been implicated in brain function, immunoregulation, anti-microbial mechanisms and pregnancy. Some of these actions are due to depletion of tryptophan and others to the formation of biologically active metabolites. This review focuses on the roles of the kynurenine p...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2016.02.029

    authors： Hunt NH,Too LK,Khaw LT,Guo J,Hee L,Mitchell AJ,Grau GE,Ball HJ

    更新日期：2017-01-01 00:00:00

  • Neuroprotective effects of novel small peptides in vitro and after brain injury.

    abstract：:Thyrotropin-releasing hormone (TRH) and TRH analogues have been reported to be neuroprotective in experimental models of spinal cord injury and head injury. We have previously shown that a diketopiperazine structurally related to the TRH metabolite cyclo-his-pro reduces neuronal cell death in vitro and in vivo. Here w...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2005.04.001

    authors： Faden AI,Movsesyan VA,Knoblach SM,Ahmed F,Cernak I

    更新日期：2005-09-01 00:00:00

  • Stress-induced activation of the brainstem Bcl-xL gene expression in rats treated with fluoxetine: correlations with serotonin metabolism and depressive-like behavior.

    abstract：:Mechanisms underlying stress-induced depression and antidepressant drug action were shown to involve alterations in serotonergic (5-HT) neurotransmission and expression of genes coding for proteins associated with neurotrophic signaling pathways and cell-survival in the hippocampus and cortex. Expression of these gene...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.06.016

    authors： Shishkina GT,Kalinina TS,Berezova IV,Dygalo NN

    更新日期：2012-01-01 00:00:00

  • Selective activation of dopaminergic pathways in the mesocortex by compounds that act at the phencyclidine (PCP) binding site: tentative evidence for PCP recognition sites not coupled to N-methyl-D-aspartate (NMDA) receptors.

    abstract：:Several lines of evidence suggest a tight functional coupling between N-methyl-D-aspartate (NMDA) and phencyclidine (PCP) receptors. The effects of PCP receptor agonists (PCP, dexoxadrol, ketamine and MK-801) and NMDA receptor antagonists, cis-4-phosphonomethyl-2-piperidine carboxylic acid (CGS-19755) and 3-(2-carboxy...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(90)90005-c

    authors： Rao TS,Kim HS,Lehmann J,Martin LL,Wood PL

    更新日期：1990-03-01 00:00:00

  • Dynamism of GABA(A) receptor activation shapes the "personality" of inhibitory synapses.

    abstract：:The kinetics of synaptic currents is largely determined by the postsynaptic receptor gating and the concentration time course of synaptic neurotransmitter. While the analysis of current responses to rapid agonist application provides the means to study the ligand-gated receptor gating, no direct tools are available to...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2004.07.003

    authors： Mozrzymas JW

    更新日期：2004-12-01 00:00:00

  • A somatic marker theory of addiction.

    abstract：:Similar to patients with ventromedial prefrontal cortex (VMPC) lesions, substance abusers show altered decision-making, characterized by a tendency to choose the immediate reward, at the expense of negative future consequences. The somatic marker model proposes that decision-making depends on neural substrates that re...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2008.07.035

    authors： Verdejo-García A,Bechara A

    更新日期：2009-01-01 00:00:00

  • Spontaneous activity, singly bound states and the impact of alpha1Phe64 mutation on GABAAR gating in the novel kinetic model based on the single-channel recordings.

    abstract：:GABAA receptor is the primary mediator of inhibition in the adult mammalian brain. Our recent studies revealed that a classic gating scheme for GABAAR needed to be updated with an intermediate step (flipping) and that the α1Phe64 mutation at the GABA binding site affects this transition. However, description of flippi...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2017.11.030

    authors： Kisiel M,Jatczak M,Brodzki M,Mozrzymas JW

    更新日期：2018-03-15 00:00:00

  • The modulation of cortical acetylcholine release by GABA, GABA-like drugs and benzodiazepines in freely moving guinea-pigs.

    abstract：:In order to define the modulatory role played by gamma-aminobutyric acid (GABA) in corticopetal cholinergic projections, the effect of this amino acid and related drugs on gross behaviour, the EEG and the release of acetylcholine (ACh) from the cerebral cortex in freely moving guinea-pigs was studied. gamma Aminobutyr...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(85)90134-0

    authors： Tanganelli S,Bianchi C,Beani L

    更新日期：1985-04-01 00:00:00