Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor.


:Because of the claim that ibogaine suppresses the symptoms of "narcotic withdrawal" in humans, the effect of ibogaine on naltrexone-precipitated withdrawal signs in morphine-dependent rats was assessed. Morphine was administered subcutaneously through implanted silicone reservoirs for 5 days. Ibogaine (20, 40 or 80 mg/kg, i.p.) or saline was administered 30 min prior to challenge with naltrexone (1 mg/kg, i.p.) and withdrawal signs were counted for the following 2 hr. Ibogaine (40 and 80 mg/kg) significantly reduced the occurrence of four signs (wet-dog shakes, grooming, teeth chattering and diarrhea) during naltrexone-precipitated withdrawal; three other signs (weight loss, burying and flinching) were unaffected. Ibogaine induces head and body tremors lasting for 2-3 hr and the tremors might have interfered with the expression of opioid withdrawal. To examine this issue, another experiment was conducted in which ibogaine (40 mg/kg) or saline was administered 4 hr prior to challenge with naltrexone. Although there was a complete absence of tremors, ibogaine still significantly reduced the occurrence of the same four signs of withdrawal.






Glick SD,Rossman K,Rao NC,Maisonneuve IM,Carlson JN




Has Abstract


1992-05-01 00:00:00












  • Proteomic analysis of the nucleus accumbens of rats with different vulnerability to cocaine addiction.

    abstract::Vulnerability to the addictive effects of drugs of abuse varies among individuals, but the biological basis of these differences are poorly known. This work tries to increase this knowledge by comparing the brain proteome of animals with different rate of extinction of cocaine-seeking behaviour. To achieve this goal, ...


    pub_type: 杂志文章


    authors: del Castillo C,Morales L,Alguacil LF,Salas E,Garrido E,Alonso E,Pérez-García C

    更新日期:2009-07-01 00:00:00

  • Glutamate transport system as a key constituent of glutamosome: Molecular pathology and pharmacological modulation in chronic pain.

    abstract::Neural uptake of glutamate is executed by the structurally related members of the SLC1A family of solute transporters: GLAST/EAAT1, GLT-1/EAAT2, EAAC1/EAAT3, EAAT4, ASCT2. These plasma membrane proteins ensure supply of glutamate, aspartate and some neutral amino acids, including glutamine and cysteine, for synthetic,...


    pub_type: 杂志文章,评审


    authors: Gegelashvili G,Bjerrum OJ

    更新日期:2019-12-15 00:00:00

  • The endozepine ODN stimulates [3H]thymidine incorporation in cultured rat astrocytes.

    abstract::High concentrations of diazepam-binding inhibitor (DBI) mRNA have been detected in astrocytoma, suggesting that DBI-derived peptides may play a role in glial cell proliferation. In the present study, we have investigated the effect of a processing product of DBI, the octadecaneuropeptide ODN, on DNA synthesis in cultu...


    pub_type: 杂志文章


    authors: Gandolfo P,Patte C,Thoumas JL,Leprince J,Vaudry H,Tonon MC

    更新日期:1999-05-01 00:00:00

  • Neuron-specific chromatin remodeling: a missing link in epigenetic mechanisms underlying synaptic plasticity, memory, and intellectual disability disorders.

    abstract::Long-term memory formation requires the coordinated regulation of gene expression. Until recently nucleosome remodeling, one of the major epigenetic mechanisms for controlling gene expression, had been largely unexplored in the field of neuroscience. Nucleosome remodeling is carried out by chromatin remodeling complex...


    pub_type: 杂志文章,评审


    authors: Vogel-Ciernia A,Wood MA

    更新日期:2014-05-01 00:00:00

  • Ablation of μ opioid receptor-expressing GABA neurons in rostromedial tegmental nucleus increases ethanol consumption and regulates ethanol-related behaviors.

    abstract::There has been increasing interest in the rostromedial tegmental nucleus (RMTg), given its potential regulatory role in many aversion-related behaviors. The RMTg contains mostly GABAergic neurons, sends a dense inhibitory projection to dopamine neurons in the midbrain, and is rich with μ-opioid receptors (MOR). Like m...


    pub_type: 杂志文章


    authors: Fu R,Chen X,Zuo W,Li J,Kang S,Zhou LH,Siegel A,Bekker A,Ye JH

    更新日期:2016-08-01 00:00:00

  • Glucagon-like receptor 1 agonists and DPP-4 inhibitors: Anti-diabetic drugs with anti-stroke potential.

    abstract::Stroke is one of the leading causes of death and serious disability in Westernized societies. The risk of stroke approximately doubles with each decade after the age of 55. Therefore, even though the incidence of stroke is declining, mostly because of the efforts to lower blood pressure and reduce smoking, the overall...


    pub_type: 杂志文章,评审


    authors: Darsalia V,Klein T,Nyström T,Patrone C

    更新日期:2018-07-01 00:00:00

  • Brain noradrenaline and anaesthesia: further characterization of the beta-receptor.

    abstract::The sleeping time induced by thiopentone in rats was markedly prolonged by the (-)-isomer of propranolol while the (+)-isomer was virtually without effect. Since the two isomers are equipotent in their membrane-stabilizing effects but the (-)-isomer is about seven to ten times more potent than the (+)-isomer in beta-b...


    pub_type: 杂志文章


    authors: Mason ST,Angel A

    更新日期:1983-09-01 00:00:00

  • Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors.

    abstract::Methamphetamine toxicity is associated with cell death and loss of dopamine neuron terminals in the striatum similar to what is found in some neurodegenerative diseases. Conversely, the endocannabinoid system (ECS) has been suggested to be neuroprotective in the brain, and new pharmacological tools have been developed...


    pub_type: 杂志文章


    authors: Nader J,Rapino C,Gennequin B,Chavant F,Francheteau M,Makriyannis A,Duranti A,Maccarrone M,Solinas M,Thiriet N

    更新日期:2014-12-01 00:00:00

  • The endogenous cannabinoid system and the treatment of marijuana dependence.

    abstract::The active principle of marijuana, Delta9-tetrahydrocannabinol (Delta9-THC), exerts its pharmacological effects by binding to selective receptors present on the membranes of neurons and other cells. These cannabinoid receptors are normally engaged by a family of lipid mediators, called endocannabinoids, which are thou...


    pub_type: 杂志文章,评审


    authors: Piomelli D

    更新日期:2004-01-01 00:00:00

  • Further characterization of the binding of the adenosine receptor agonist [3H]CGS 21680 to rat brain using autoradiography.

    abstract::2-[p-(2-carboxyethyl)-phenylethylamino]-5'-N-ethylcarboxamidoadeno sine (CGS 21680) is considered a selective ligand for adenosine A2A receptors, which are known to be enriched in striatum and olfactory tubercle. We have investigated the characteristics of [3H]CGS 21680 binding in several brain regions using quantitat...


    pub_type: 杂志文章


    authors: Johansson B,Fredholm BB

    更新日期:1995-04-01 00:00:00

  • Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.

    abstract::Since its characterisation in 2001, the mGlu8-selective agonist DCPG has been widely used to explore the potential functional role of this group III mGlu receptor within the central nervous system. This research has implicated mGlu8 receptors in a number of disease states and conditions such as epilepsy and anxiety, s...


    pub_type: 杂志文章


    authors: Mercier MS,Lodge D,Fang G,Nicolas CS,Collett VJ,Jane DE,Collingridge GL,Bortolotto ZA

    更新日期:2013-04-01 00:00:00

  • Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs).

    abstract::Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid, is an inhibitor of gap junctional intercellular communication. Systemic administration of CBX was able to decrease the seizure severity score and to increase the latency time of seizure onset in genetically epilepsy prone rats (GEPRs). In particular, intr...


    pub_type: 杂志文章


    authors: Gareri P,Condorelli D,Belluardo N,Russo E,Loiacono A,Barresi V,Trovato-Salinaro A,Mirone MB,Ferreri Ibbadu G,De Sarro G

    更新日期:2004-12-01 00:00:00

  • Effects of bath-applied GABA on the firing pattern of cells in an in vitro preparation of mammalian cerebral cortex.

    abstract::The patterns of spontaneous firing recorded from 25 cells in slice preparations of rat cerebral cortex were characterised using inter-spike interval plots (ISI). Histograms of the ISI showed two peaks having modal values of 20 and 82ms, corresponding to episodes of high frequency bursts of action potentials, and a low...


    pub_type: 杂志文章


    authors: Bagust J,Nagi I,Kerkut GA

    更新日期:1985-06-01 00:00:00

  • Gene expression profiling in the human alcoholic brain.

    abstract::Long-term alcohol use causes widespread changes in gene expression in the human brain. Aberrant gene expression changes likely contribute to the progression from occasional alcohol use to alcohol use disorder (including alcohol dependence). Transcriptome studies have identified individual gene candidates that are link...


    pub_type: 杂志文章,评审


    authors: Warden AS,Mayfield RD

    更新日期:2017-08-01 00:00:00

  • Different densities of 5-HT3 receptors are labeled by [3H]quipazine, [3H]GR 65630 and [3H]granisetron.

    abstract::The binding of three, structurally distinct, 5-hydroxytryptamine3 (5-HT3) receptor radioligands was characterized in rat cerebral cortex, rabbit ileum myenteric plexus and NG-108-15 neuroblastoma cells. The density of sites labeled by the three ligands in rat cortex or in rabbit ileum was markedly different. [3H]Quipa...


    pub_type: 杂志文章


    authors: Wong EH,Bonhaus DW,Lee JA,Wu I,Loury DN,Eglen RM

    更新日期:1993-09-01 00:00:00

  • Nigrostriatal dopamine actions on the D2 receptors mediate methamphetamine effects on the striatonigral substance P system.

    abstract::Multiple administrations of methamphetamine to rats produced elevated concentrations of substance P-like immunoreactivity within the substantia nigra, an effect which is believed to be mediated by increases in dopaminergic activity induced by methamphetamine. The results reported here demonstrate that the effect of me...


    pub_type: 杂志文章


    authors: Sonsalla PK,Gibb JW,Hanson GR

    更新日期:1986-11-01 00:00:00

  • FK1706, a novel non-immunosuppressive immunophilin ligand, modifies the course of painful diabetic neuropathy.

    abstract::FK1706, a derivative of FK506, is a non-immunosuppressive immunophilin ligand with significant neurotrophic activity mediated via FKBP-52 and the RAS/RAF/MAPK signaling pathway. Here, we tested the effect of FK1706 on painful diabetic neuropathy in rat model of diabetes induced by streptozotocin (STZ). FK1706 ameliora...


    pub_type: 杂志文章


    authors: Yamazaki S,Yamaji T,Murai N,Yamamoto H,Price RD,Matsuoka N,Mutoh S

    更新日期:2008-12-01 00:00:00

  • In vivo assessment of release and metabolism of dopamine in the ventrolateral striatum of awake rats following administration of dopamine D1 and D2 receptor agonists and antagonists.

    abstract::The ability of specific dopamine (DA) receptor agonists and antagonists to modify the release and metabolism of DA in the ventrolateral striatum of awake rats was assessed using in vivo microdialysis. The specific DA D2 receptor antagonist, raclopride (0.1, 0.5 and 2.0 mg/kg, i.p.), dose-dependently increased release ...


    pub_type: 杂志文章


    authors: See RE,Sorg BA,Chapman MA,Kalivas PW

    更新日期:1991-12-01 00:00:00

  • Pannexin-1-mediated ATP release from area CA3 drives mGlu5-dependent neuronal oscillations.

    abstract::The activation of Group I metabotropic glutamate receptors (GI mGluRs) in the hippocampus results in the appearance of persistent bursts of synchronised neuronal activity. In response to other stimuli, such activity is known to cause the release of the purines ATP and its neuroactive metabolite, adenosine. We have thu...


    pub_type: 杂志文章


    authors: Lopatář J,Dale N,Frenguelli BG

    更新日期:2015-06-01 00:00:00

  • The effects of tetraethylammonium during twitch and tetanic stimulation of the phrenic nerve diaphragm preparation in the rat.

    abstract::Tetraethylammonium (TEA) (2.6 x 10(-3) M) potentiated the twitches of the indirectly- or directly-stimulated phrenic nerve diaphragm of the rat at 37 degrees C by prolonging the action potential of the sarcolemma, due to an inhibition of the repolarizing K+ current. With indirect stimulation, TEA caused a use-dependen...


    pub_type: 杂志文章


    authors: Røed A

    更新日期:1989-06-01 00:00:00

  • Biomarkers in translational research of Alzheimer's disease.

    abstract::The identification and characterization of amyloid-beta (Abeta) and tau as the main pathological substrates of Alzheimer's disease (AD) have driven many efforts in search for suitable biomarkers for AD. In the last decade, research in this area has focused on developing a better understanding of the principles that go...


    pub_type: 杂志文章,评审


    authors: Tarawneh R,Holtzman DM

    更新日期:2010-09-01 00:00:00

  • AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies.

    abstract::Mu-opioid and CB1-cannabinoid agonists produce analgesia; however, adverse effects limit use of drugs in both classes. Additive or synergistic effects resulting from concurrent administration of low doses of mu- and CB1-agonists may produce analgesia with fewer side effects. Synergism potentially results from interact...


    pub_type: 杂志文章


    authors: Seely KA,Brents LK,Franks LN,Rajasekaran M,Zimmerman SM,Fantegrossi WE,Prather PL

    更新日期:2012-10-01 00:00:00

  • Effects of cations on high-affinity binding of 3H-ADTN to dopaminergic sites in calf caudate tissue.

    abstract::Effects of cations on binding of 0.1-10 nM 3H-ADTN to calf caudate membranes included decreased apparent Bmax by [Na+] greater than or equal to 100 mM, little effect on Kd or on affinity of other dopamine (DA) agonists (DA and apomorphine), decreased slopes of inhibition curves produced by agonists, but increased affi...


    pub_type: 杂志文章


    authors: Lamont JS,Kula NS,Baldessarini RJ

    更新日期:1987-06-01 00:00:00

  • Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.

    abstract::Anandamide and 2-arachidonoyl glycerol, referred to as endocannabinoids (eCBs), are the endogenous agonists for the cannabinoid receptor type 1 (CB1). Several pieces of evidence support a role for eCBs in the attenuation of anxiety-related behaviours, although the precise mechanism has remained uncertain. The fatty ac...


    pub_type: 杂志文章


    authors: Moreira FA,Kaiser N,Monory K,Lutz B

    更新日期:2008-01-01 00:00:00

  • Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice.

    abstract::Mice that were rendered heterozygous for the γ2 subunit of GABAA receptors (γ2(+/-) mice) have been characterized extensively as a model for major depressive disorder. The phenotype of these mice includes behavior indicative of heightened anxiety, despair, and anhedonia, as well as defects in hippocampus-dependent pat...


    pub_type: 杂志文章


    authors: Ren Z,Sahir N,Murakami S,Luellen BA,Earnheart JC,Lal R,Kim JY,Song H,Luscher B

    更新日期:2015-01-01 00:00:00

  • Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154.

    abstract::Although selective activation of the M1 muscarinic acetylcholine receptor (mAChR) subtype has been shown to improve cognitive function in animal models of neuropsychiatric disorders, recent evidence suggests that enhancing M4 mAChR function can also improve memory performance. Positive allosteric modulators (PAMs) tar...


    pub_type: 杂志文章


    authors: Gould RW,Grannan MD,Gunter BW,Ball J,Bubser M,Bridges TM,Wess J,Wood MW,Brandon NJ,Duggan ME,Niswender CM,Lindsley CW,Conn PJ,Jones CK

    更新日期:2018-01-01 00:00:00

  • Vasopressin mediates enhanced offspring protection in multiparous rats.

    abstract::Maternal aggression is highly expressed during lactation and serves to protect the developing young from intruders that may injure the offspring. One neurochemical modulator of maternal aggression appears to be arginine vasopressin (AVP). Earlier research supports a role for AVP in maternal aggression in rats as treat...


    pub_type: 杂志文章


    authors: Nephew BC,Byrnes EM,Bridges RS

    更新日期:2010-01-01 00:00:00

  • Regulation of glutamate transporter 1 (GLT-1) gene expression by cocaine self-administration and withdrawal.

    abstract::Downregulation of the astroglial glutamate transporter GLT-1 is observed in the nucleus accumbens (NAc) following administration of multiple drugs of abuse. The decrease in GLT-1 protein expression following cocaine self-administration is dependent on both the amount of cocaine self-administered and the length of with...


    pub_type: 杂志文章


    authors: Kim R,Sepulveda-Orengo MT,Healey KL,Williams EA,Reissner KJ

    更新日期:2018-01-01 00:00:00

  • In vitro and in vivo effect of BU99006 (5-isothiocyanato-2-benzofuranyl-2-imidazoline) on I2 binding in relation to MAO: evidence for two distinct I2 binding sites.

    abstract::BU99006 is an irreversible I(2) ligand which selectively inactivates I(2) binding sites, making it an ideal tool with which to study I(2) site mechanism. We sought to determine the effects of BU99006 on I(2) binding in relation to monoamine oxidase (MAO), and the time course of these effects. In vitro, rat brain membr...


    pub_type: 杂志文章


    authors: Paterson LM,Tyacke RJ,Robinson ES,Nutt DJ,Hudson AL

    更新日期:2007-02-01 00:00:00

  • Basolateral amygdala noradrenergic activity is required for enhancement of object recognition memory by histone deacetylase inhibition in the anterior insular cortex.

    abstract::Extensive evidence indicates that noradrenergic activation of the basolateral amygdala (BLA) is essential for mediating emotional arousal effects on memory consolidation in different target regions. However, the mechanism by which BLA activation regulates such information storage processes remains largely elusive. Her...


    pub_type: 杂志文章


    authors: Chen Y,Barsegyan A,Nadif Kasri N,Roozendaal B

    更新日期:2018-10-01 00:00:00