Serotonin modulation of cell excitability and of [3H]GABA and [3H]D-aspartate efflux in primary cultures of rat cortical neurons.

abstract：:The effects of injection of the thyrotrophin-releasing hormone (TRH) analogue, orotyl-histidyl-proline amide (CG3509) into the accumbens and striatum, was studied on dopamine metabolism by means of in vivo voltammetry. Forty minutes after infusion of CG3509 (1-5 micrograms) into the n. accumbens there was a significan...

journal_title：Neuropharmacology

authors： Sharp T,Brazell MP,Bennett GW,Marsden CA

更新日期：1984-06-01 00:00:00

abstract：:Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states. However, THC has a significant side effect profile. We examined whether the profile of THC could be improved by co-administering it with the first-...

journal_title：Neuropharmacology

authors： Atwal N,Casey SL,Mitchell VA,Vaughan CW

更新日期：2019-01-01 00:00:00

abstract：:Mechanical hyperalgesia induced in rat paws by carrageenan (250microg) was modified by pre-treatment with three selective inhibitors of cyclo-oxygenase-2 (COX-2); celecoxib, rofecoxib and SC236. These inhibitors raised the nociceptive threshold above the normal, non-inflamed, level, inducing a state of hypoalgesia. Su...

journal_title：Neuropharmacology

authors： França DS,Ferreira-Alves DL,Duarte ID,Ribeiro MC,Rezende RM,Bakhle YS,Francischi JN

更新日期：2006-07-01 00:00:00

abstract：:We investigated the effects of salvinorin A on the basal and the 12 mM K(+)-evoked release of preloaded [(3)H]noradenaline ([(3)H]NA) and [(3)H]serotonin ([(3)H]5-HT) from mouse hippocampal nerve terminals (synaptosomes), as well as on the basal and 12mM K(+)-evoked release of preloaded [(3)H]dopamine ([(3)H]DA) from ...

journal_title：Neuropharmacology

authors： Grilli M,Neri E,Zappettini S,Massa F,Bisio A,Romussi G,Marchi M,Pittaluga A

更新日期：2009-10-01 00:00:00

abstract：:Prenatal hypoxia ischemia is a major cause of neurodevelopmental impairment in the newborn, associated with risk for motor, behavioral and cognitive impaired outcomes. We used an established mouse model of maternal hypoxia to examine the immediate molecular responses of signaling pathways associated with both cell dea...

journal_title：Neuropharmacology

authors： Golan MH,Mane R,Molczadzki G,Zuckerman M,Kaplan-Louson V,Huleihel M,Perez-Polo JR

更新日期：2009-10-01 00:00:00

abstract：:Stroke is one of the leading causes of death and serious disability in Westernized societies. The risk of stroke approximately doubles with each decade after the age of 55. Therefore, even though the incidence of stroke is declining, mostly because of the efforts to lower blood pressure and reduce smoking, the overall...

journal_title：Neuropharmacology

authors： Darsalia V,Klein T,Nyström T,Patrone C

更新日期：2018-07-01 00:00:00

abstract：:The effects of the glutamate receptor antagonist gamma-D-glutamylaminomethyl sulfonic acid (GAMS) on inward currents induced by bath application of kainic acid (KA) or alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) were studied with single-electrode voltage clamp methods in Xenopus oocytes injected 3...

journal_title：Neuropharmacology

authors： Zhou N,Hammerland LG,Parks TN

更新日期：1993-08-01 00:00:00

abstract：:The Forkhead Box G1 (FOXG1) gene encodes a transcription factor with an essential role in mammalian telencephalon development. FOXG1-related disorders, caused by deletions, intragenic mutations or duplications, are usually associated with severe intellectual disability, autistic features, and, in 87% of subjects, epil...

journal_title：Neuropharmacology

authors： Testa G,Mainardi M,Olimpico F,Pancrazi L,Cattaneo A,Caleo M,Costa M

更新日期：2019-04-01 00:00:00

abstract：:The effects of the putative, selective dopamine autoreceptor antagonist (+)-AJ 76 on yawning, penile grooming and mouth movements induced by small doses of apomorphine in male rats were examined. Yawning induced by 0.05mg/kg apomorphine was dose dependently blocked by (+)-AJ-76, significant decreases being observed at...

journal_title：Neuropharmacology

authors： Dourish CT,Herbert EN,Iversen SD

更新日期：1989-12-01 00:00:00

abstract：:Bradykinin interacts with the bradykinin B2 receptor on dorsal root ganglion (DRG) neurons, setting off a series of reactions inside the cells that ultimately make the vanilloid receptor 1 more sensitive to a normal stimulus by activating various enzymes coupled with second messenger signaling cascades. Zaltoprofen, a...

journal_title：Neuropharmacology

authors： Tang HB,Inoue A,Oshita K,Hirate K,Nakata Y

更新日期：2005-06-01 00:00:00

abstract：:The properties of central ATP-mediated synaptic currents were studied using whole-cell patch-clamp recording in rat medial habenula slices. Release was shown to be calcium dependent with a Hill coefficient of approximately 2. The voltage dependence of synaptic current amplitudes was approximately linear. Some reductio...

journal_title：Neuropharmacology

authors： Edwards FA,Robertson SJ,Gibb AJ

更新日期：1997-09-01 00:00:00

abstract：:This study was undertaken to determine whether 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)(2)D(3)], an active metabolite of vitamin D, protects dopaminergic neurons against the neurotoxic effects of glutamate and dopaminergic toxins using rat mesecephalic culture. Brief glutamate exposure elicited cytotoxicity in ...

journal_title：Neuropharmacology

authors： Ibi M,Sawada H,Nakanishi M,Kume T,Katsuki H,Kaneko S,Shimohama S,Akaike A

更新日期：2001-05-01 00:00:00

abstract：:Hormones may produce long-term effects on excitability by regulating K+ channel gene expression. Previous studies demonstrated that administration of dexamethasone, a glucocorticoid receptor agonist, to adrenalectomized rats, rapidly induces Kv1.5 K+ channel expression in the ventricle of the hear. Here, RNase protect...

journal_title：Neuropharmacology

authors： Levitan ES,Hershman KM,Sherman TG,Takimoto K

更新日期：1996-01-01 00:00:00

abstract：:Small doses of clonidine probably induce hypoactivity (a distinct form of sedation) by stimulating presynaptic alpha 2-adrenoceptors. This was attenuated by injection of 0.1-10 mg/kg of thyrotropin releasing hormone (TRH) or its biologically stable analogues, CG3509, CG3703 and RX77368, when these were given 10 min be...

journal_title：Neuropharmacology

authors： Heal DJ,Stoodley N,Elliott JM,Marsden CA,Bennett GW,Youdim MB

更新日期：1987-04-01 00:00:00

abstract：:The endocannabinoid (eCB) system is involved in the modulation of the reward system and participates in the reinforcing effects of different drugs of abuse, including alcohol. The most abundant receptor of the eCB system in the central nervous system is the CB1 receptor (CB1R), which is predominantly expressed in area...

journal_title：Neuropharmacology

authors： Frontera JL,Gonzalez Pini VM,Messore FL,Brusco A

更新日期：2018-07-15 00:00:00

abstract：:Intensive computerized auditory training results in improved cognition for schizophrenia patients, but participants show variation in their cognitive gains and the biological factors that affect the response to training are unknown. Single nucleotide polymorphisms (SNPs) in the catechol-O-methyltransferase (COMT) gene...

journal_title：Neuropharmacology

authors： Panizzutti R,Hamilton SP,Vinogradov S

更新日期：2013-01-01 00:00:00

abstract：:Rat hearts were labelled with [3H]norepinephrine in vivo. Slices of ventricles were prepared, preincubated in Krebs-HCO3 medium (KRB), and then incubated in a Na+-deficient, choline+-Krebs HCO3 (Ch+-Ca2+). The choline+-Krebs HCO3 medium induced a delayed neurosecretion which could be inhibited by either one of the blo...

journal_title：Neuropharmacology

authors： Bogdanski DF

更新日期：1985-01-01 00:00:00

abstract：:The effects of short- and long-term exposure of cells to elevated cyclic adenosine monophosphate (c-AMP), using dibutyryl-c-AMP, 8-bromo-c-AMP, cholera toxin or forskolin, or cyclic guanosine monophosphate (c-GMP), using dibutyryl-c-GMP or 8-bromo-c-GMP, on the activity and expression of the noradrenaline transporter ...

journal_title：Neuropharmacology

authors： Bryan-Lluka LJ,Paczkowski FA,Bönisch H

更新日期：2001-03-01 00:00:00

abstract：:Propofol has been shown to attenuate brain injury in experimental ischemia models, but few studies have focused on the direct effect of propofol on mitochondrial dysfunction. In this study, we observed the effects of propofol on multiple aspects of mitochondrial dysfunction by studying the mitochondria isolated from r...

journal_title：Neuropharmacology

authors： Li J,Yu W,Li XT,Qi SH,Li B

更新日期：2014-02-01 00:00:00

abstract：:Interferon injection in morphine dependent rats prior to naloxone treatment eliminates 7 behavioral sings of the abstinence (withdrawal) phenomenon. When a single injection of interferon was given prior to chronic morphine treatment it reduces opiate addiction liability. ...

journal_title：Neuropharmacology

authors： Dafny N

更新日期：1983-05-01 00:00:00

abstract：:The NMDA receptor is a major target of alcohol action in the CNS, and recent behavioral and cellular studies have pointed to the importance of the GluN2B subunit in alcohol action. We and others have previously characterized four amino acid positions in the third and fourth membrane-associated (M) domains of the NMDA ...

journal_title：Neuropharmacology

authors： Zhao Y,Ren H,Dwyer DS,Peoples RW

更新日期：2015-10-01 00:00:00

abstract：:Addiction is associated with changes in synaptic plasticity mediated, in part, by alterations in the trafficking and stabilization of AMPA receptors at synapses within the nucleus accumbens. Exposure to cocaine can lead to protein kinase C-mediated phosphorylation of GluA2 AMPA subunits and this phosphorylation event ...

journal_title：Neuropharmacology

authors： Briand LA,Deutschmann AU,Ellis AS,Fosnocht AQ

更新日期：2016-12-01 00:00:00

abstract：:The effect of long term treatment with two tricyclic antidepressants on the sensitivity of 5-HT1B presynaptic heteroreceptors inhibiting acetylcholine (ACh) release was investigated. Groups of male rats received during 14 days either saline, citalopram (20 mg/kg), a serotonin (5-HT) uptake blocker, or tianeptine (2 x ...

journal_title：Neuropharmacology

authors： Bolaños-Jiménez F,Manhães de Castro R,Fillion G

更新日期：1994-01-01 00:00:00

abstract：:The ability of drugs of abuse to increase mesolimbic levels of dopamine is a characteristic associated with their rewarding effects. Exactly how these effects are produced by different substances is not as well characterised. Our previous work in rats has demonstrated that accumbal glycine receptors (GlyRs) are involv...

journal_title：Neuropharmacology

authors： Jonsson S,Adermark L,Ericson M,Söderpalm B

更新日期：2014-07-01 00:00:00

abstract：:Behavioral and electrophysiological comparative analyses of the effects of 2-o-chlorobenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S) and diazepam on the CNS were performed with cats and monkeys. No essential difference between 45-0088-S and diazepam on the effects in the CNS was observed, alt...

journal_title：Neuropharmacology

authors： Yamamoto K,Sawada T,Utsumi S,Naito Y,Koshida H

更新日期：1982-05-01 00:00:00

abstract：:Anandamide and 2-arachidonoyl glycerol, referred to as endocannabinoids (eCBs), are the endogenous agonists for the cannabinoid receptor type 1 (CB1). Several pieces of evidence support a role for eCBs in the attenuation of anxiety-related behaviours, although the precise mechanism has remained uncertain. The fatty ac...

journal_title：Neuropharmacology

authors： Moreira FA,Kaiser N,Monory K,Lutz B

更新日期：2008-01-01 00:00:00

abstract：:There has been increasing interest in the rostromedial tegmental nucleus (RMTg), given its potential regulatory role in many aversion-related behaviors. The RMTg contains mostly GABAergic neurons, sends a dense inhibitory projection to dopamine neurons in the midbrain, and is rich with μ-opioid receptors (MOR). Like m...

journal_title：Neuropharmacology

authors： Fu R,Chen X,Zuo W,Li J,Kang S,Zhou LH,Siegel A,Bekker A,Ye JH

更新日期：2016-08-01 00:00:00

abstract：:The metabotropic glutamate receptor (mGluR) agonist ACPD exerts an unusual inhibitory effect on a population of neurons of the song-control nucleus HVc of the zebra finch via activation of the GIRK channel. We report in the present study the pharmacology of this response. ACPD directly hyperpolarized the neurons by a ...

journal_title：Neuropharmacology

authors： Dutar P,Vu HM,Perkel DJ

更新日期：1999-04-01 00:00:00

abstract：:Though amyloid precursor protein (APP) can potentially be cleaved to generate the pathological amyloid β peptide (Aβ), APP itself plays an important role in regulating neuronal activity. APP deficiency causes functional impairment in cholinergic synaptic transmission and cognitive performance. However, the mechanisms ...

journal_title：Neuropharmacology

authors： Cai ZL,Zhang JJ,Chen M,Wang JZ,Xiao P,Yang L,Long C

更新日期：2016-11-01 00:00:00

abstract：:In the present studies, an attempt was made to elucidate the role of endogenous opioid inputs to the depressor region of the caudal ventrolateral medulla in the tonic regulation of arterial pressure and to examine the subtype(s) of receptor underlying any observed effects by use of receptor-specific antagonists. The d...

journal_title：Neuropharmacology

authors： Drolet G,Morilak DA,Chalmers J

更新日期：1991-04-01 00:00:00