The TRH analogue CG3509 increases in vivo catechol/ascorbate oxidation in the N. accumbens but not in the striatum of the rat.

abstract：:In the rat brain, gamma-hydroxybutyric-acid (GHB) increases the concentrations of 3alpha-hydroxy,5alpha-pregnan-20-one (allopregnanolone, 3alpha,5alpha-THP) and 3alpha,21-dihydroxy,5alpha-pregnan-20-one (allotetrahydrodeoxycorticosterone/3alpha,5alphaTHDOC), two neurosteroids acting as positive allosteric modulators o...

journal_title：Neuropharmacology

authors： Barbaccia ML,Carai MA,Colombo G,Lobina C,Purdy RH,Gessa GL

更新日期：2005-07-01 00:00:00

abstract：:Efficient transcytosis across the blood-brain-barrier (BBB) is an important strategy for accessing drug targets within the central nervous system (CNS). Despite extensive research the number of studies reporting successful delivery of macromolecules or macromolecular complexes to the CNS has remained very low. In orde...

journal_title：Neuropharmacology

authors： Mäger I,Meyer AH,Li J,Lenter M,Hildebrandt T,Leparc G,Wood MJA

更新日期：2017-07-01 00:00:00

abstract：:The cannabinoid receptor CB2 plays a significant role in the regulation of immune function whereas neuronal expression remains a subject of contention. Multiple studies have described CB2 in retina and a recent study showed that CB2 deletion altered retinal visual processing. We revisited CB2 expression using immunohi...

journal_title：Neuropharmacology

authors： Borowska-Fielding J,Murataeva N,Smith B,Szczesniak AM,Leishman E,Daily L,Toguri JT,Hillard CJ,Romero J,Bradshaw H,Kelly MEM,Straiker A

更新日期：2018-10-01 00:00:00

abstract：:YM992, (S)-2-[[(7-fluoro-4-indanyl)oxy]methyl]morpholine monohydrochloride, exhibited the biochemical profile of a selective serotonin (5-HT) reuptake inhibitor (SSRI) with 5-HT2A receptor antagonistic activity. YM922 showed the same high affinity as fluoxetine against the 5-HT reuptake site (Ki = 21 nM) and a similar...

journal_title：Neuropharmacology

authors： Hatanaka K,Nomura T,Hidaka K,Takeuchi H,Yatsugi S,Fujii M,Yamaguchi T

更新日期：1996-01-01 00:00:00

abstract：:Acromelic acid, a kainate derivative of natural origin, markedly increased intracellular Ca2+ concentration ([Ca2+]i) in cultured rat spinal neurons in a concentration dependent manner; the half effective concentration (EC50) was 1.3 microM. Acromelic acid was more potent in increasing [Ca2+]i than any other glutamate...

journal_title：Neuropharmacology

authors： Ogata T,Nakamura Y,Tsuji K,Shibata T,Kataoka K,Ishida M,Shinozaki H

更新日期：1994-09-01 00:00:00

abstract：:The binding of three, structurally distinct, 5-hydroxytryptamine3 (5-HT3) receptor radioligands was characterized in rat cerebral cortex, rabbit ileum myenteric plexus and NG-108-15 neuroblastoma cells. The density of sites labeled by the three ligands in rat cortex or in rabbit ileum was markedly different. [3H]Quipa...

journal_title：Neuropharmacology

authors： Wong EH,Bonhaus DW,Lee JA,Wu I,Loury DN,Eglen RM

更新日期：1993-09-01 00:00:00

abstract：:The proconvulsant and anticonvulsant effects of acute and chronic exposure to cocaine were investigated in adult, male, CF-1 mice. The proconvulsant effects of cocaine in mice only manifested themselves after daily exposure to motor-stimulant doses. Although daily treatment decreased electroshock convulsion threshold,...

journal_title：Neuropharmacology

authors： Karler R,Petty C,Calder L,Turkanis SA

更新日期：1989-07-01 00:00:00

abstract：:Using the rat model of early life seizures (ELS), which has exaggerated mGluR mediated long-term depression of synaptic strength (mGluR-LTD) in adulthood, we probed the signaling cascades underlying mGluR-LTD induction. Several inhibitors completely blocked mGluR-LTD in control but not in ELS rats: the proteasome, the...

journal_title：Neuropharmacology

authors： Bernard PB,Castano AM,Bayer KU,Benke TA

更新日期：2014-09-01 00:00:00

abstract：:Sensory gating can be assessed in rodents and humans using an auditory conditioning (C)-test (T) paradigm, with schizophrenic patients exhibiting a loss of gating. Dysregulation of the endocannabinoid system has been proposed to be involved in the pathogenesis of schizophrenia. We studied auditory gating and the effec...

journal_title：Neuropharmacology

authors： Dissanayake DW,Zachariou M,Marsden CA,Mason R

更新日期：2008-12-01 00:00:00

abstract：:Some phytochemical-derived synthetic compounds have been shown to improve neurological disorders, especially in ischemic stroke. In this study, we identified a novel biscoumarin compound, known as COM 3, which had substantial antioxidant effects in neurons. Next, we found that COM 3 occupies a critical binding site be...

journal_title：Neuropharmacology

authors： Wang J,Zhang W,Lv C,Wang Y,Ma B,Zhang H,Fan Z,Li M,Li X

更新日期：2020-05-01 00:00:00

abstract：:In slices of the hypothalamus of the rat, prelabelled with [3H]5-hydroxytryptamine ([3H]5-HT), dihydroergocristine (DHEC) decreased in a concentration-dependent manner (0.01-1 microM) the release of [3H]transmitter elicited by stimulation. In the presence of phentolamine (1 microM), sulpiride (1 microM), atropine (1 m...

journal_title：Neuropharmacology

authors： Moret C,Briley M

更新日期：1986-02-01 00:00:00

abstract：:Inhibition of 5-HT(6) receptors has been shown to improve memory consolidation, thus we tested whether a novel tryptamine analog with high affinity for 5-HT(6) receptors, BGC20-761 (5-methoxy-2-phenyl-N,N-dimethyltryptamine, PMDT), can enhance long-term memory. BGC20-761 (10 mg/kg i.p.) alone had no effect on social r...

journal_title：Neuropharmacology

authors： Mitchell ES,Hoplight BJ,Lear SP,Neumaier JF

更新日期：2006-03-01 00:00:00

abstract：:The role of neurally born acetylcholine in the central modulation of cardiovascular short-term variability was assessed using a pharmacological probe physostigmine, a cholinesterase inhibitor that can act centrally also. Experiments were performed in instrumented conscious rats. Equidistant sampling at 20 Hz of systol...

journal_title：Neuropharmacology

authors： Milutinović S,Murphy D,Japundzić-Zigon N

更新日期：2006-06-01 00:00:00

abstract：:The kinetics of synaptic currents is largely determined by the postsynaptic receptor gating and the concentration time course of synaptic neurotransmitter. While the analysis of current responses to rapid agonist application provides the means to study the ligand-gated receptor gating, no direct tools are available to...

journal_title：Neuropharmacology

authors： Mozrzymas JW

更新日期：2004-12-01 00:00:00

abstract：:Over one hundred years ago, Sir Charles Sherrington described a population of spinal cord interneurons (INs) that connect multiple spinal cord segments and participate in complex or 'long' motor reflexes. These neurons were subsequently termed propriospinal neurons (PNs) and are known to play a crucial role in motor c...

journal_title：Neuropharmacology

authors： Flynn JR,Graham BA,Galea MP,Callister RJ

更新日期：2011-04-01 00:00:00

abstract：:Effects of alaproclate, an inhibitor of the uptake of serotonin, on muscarinic cholinergic responses in N1E-115 neuroblastoma cells were studied using intracellular recording techniques. Application of carbachol activates an inward calcium channel, through an action on muscarinic receptors. The influx of calcium activ...

journal_title：Neuropharmacology

authors： Hedlund B

更新日期：1987-10-01 00:00:00

abstract：:The effects of haloperidol, chlorpromazine and clozapine on transmitter release have been studied by measuring the simultaneous release of dopamine and acetylcholine from tissue slices of nucleus accumbens and striatum in vitro following in vivo drug application, either a single dose or daily for periods of up to 25 d...

journal_title：Neuropharmacology

authors： de Belleroche JS,Neal MJ

更新日期：1982-06-01 00:00:00

abstract：:Postsynaptic Density Protein-95 (PSD-95) is a major scaffolding protein in the excitatory synapses in the brain and a critical regulator of synaptic maturation for NMDA and AMPA receptors. PSD-95 deficiency has been linked to cognitive and learning deficits implicated in neurodevelopmental disorders such as autism and...

journal_title：Neuropharmacology

authors： McEachern EP,Coley AA,Yang SS,Gao WJ

更新日期：2020-11-15 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory deficits and cognitive decline. Amyloid-β (Aβ) deposition and cholinergic defect are widely thought to be the underlying mechanism of learning and memory impairment. Geniposide, which is the main active component of the tradit...

journal_title：Neuropharmacology

authors： Zhao C,Zhang H,Li H,Lv C,Liu X,Li Z,Xin W,Wang Y,Zhang W

更新日期：2017-04-01 00:00:00

abstract：:Cannabinoid CB(1) receptors mediate, in part, the neuroprotectant properties of endocannabinoids, and altered signalling via the CB(1) receptor may contribute to the pathogenesis of diabetic neuropathy. We investigated CB(1) receptor function in PC12 cells differentiated into a neuronal phenotype with nerve growth fac...

journal_title：Neuropharmacology

authors： Zhang F,Challapalli SC,Smith PJ

更新日期：2009-08-01 00:00:00

abstract：:In rats with cannulae permanently implanted into the third cerebral ventricle, the effects of different pharmacological manipulations affecting dopaminergic mechanisms, were studied on behaviour and electrocorticographic (ECoG) activity, continuously quantified in its spectrum power. The intraventricular injection (0....

journal_title：Neuropharmacology

authors： Bagetta G,Corasaniti MT,Strongoli MC,Sakurada S,Nisticò G

更新日期：1987-08-01 00:00:00

abstract：:Stimulus evoked neurotransmitter release requires that Na(+) channel-dependent nerve terminal depolarization be transduced into synaptic vesicle exocytosis. Inhaled anesthetics block presynaptic Na(+) channels and selectively inhibit glutamate over GABA release from isolated nerve terminals, indicating mechanistic dif...

journal_title：Neuropharmacology

authors： Westphalen RI,Kwak NB,Daniels K,Hemmings HC Jr

更新日期：2011-09-01 00:00:00

abstract：:Benzodiazepines (BZDs) and barbiturates exert their CNS actions by binding to GABA-A receptors (GABARs). The structural mechanisms by which these drugs allosterically modulate GABAR function, to either enhance or inhibit GABA-gated current, are poorly understood. Here, we used the substituted cysteine accessibility me...

journal_title：Neuropharmacology

authors： Sancar F,Czajkowski C

更新日期：2011-02-01 00:00:00

abstract：:Ginsenoside Rg1 (Rg1) is a major bioactive ingredient in Panax ginseng that has low toxicity and has been shown to have neuroprotective effects. The objectives of the present study were to explore the potential of the application of Rg1 for the treatment of Parkinson's disease (PD) and to determine whether its neuropr...

journal_title：Neuropharmacology

authors： Zhou T,Zu G,Zhang X,Wang X,Li S,Gong X,Liang Z,Zhao J

更新日期：2016-02-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptor antagonists have therapeutic potential in numerous CNS disorders ranging from acute neurodegeneration (e.g. stroke and trauma), chronic neurodegeneration (e.g. Parkinson's disease, Alzheimer's disease, Huntington's disease, ALS) to symptomatic treatment (e.g. epilepsy, Parkinson's ...

journal_title：Neuropharmacology

authors： Parsons CG,Danysz W,Quack G

更新日期：1999-06-01 00:00:00

abstract：:Regional differences are known in the serotonin-induced modulation of neuronal activity within the amygdala. This in vitro study in rats focuses on analyzing the ionic mechanism underlying serotonin-induced depolarization in the lateral amygdala. Serotonin depolarized membrane potential by 5 mV, which is underlain by ...

journal_title：Neuropharmacology

authors： Yamamoto R,Hatano N,Sugai T,Kato N

更新日期：2014-07-01 00:00:00

abstract：:Absence epilepsy is generated by the cortico-thalamo-cortical network, which undergoes a finely tuned regulation by metabotropic glutamate (mGlu) receptors. We have shown previously that potentiation of mGlu1 receptors reduces spontaneous occurring spike and wave discharges (SWDs) in the WAG/Rij rat model of absence e...

journal_title：Neuropharmacology

authors： D'Amore V,Santolini I,van Rijn CM,Biagioni F,Molinaro G,Prete A,Conn PJ,Lindsley CW,Zhou Y,Vinson PN,Rodriguez AL,Jones CK,Stauffer SR,Nicoletti F,van Luijtelaar G,Ngomba RT

更新日期：2013-03-01 00:00:00

abstract：:Although there is evidence from in vitro studies to suggest that NO synthesis may be involved in the induction of hippocampal LTP, other in vitro studies and experiments conducted in vivo have provided conflicting results. In agreement with previous work conducted in this laboratory using an i.p. route of administrati...

journal_title：Neuropharmacology

authors： Bannerman DM,Butcher SP,Morris RG

更新日期：1994-11-01 00:00:00

abstract：:The in vivo striatal binding of [3H]SCH 23390, an antagonist of the D1 dopamine receptors, was investigated in mice submitted to pretreatment to either decrease (gammabutyrolactone 750 mg/kg, i.p.) or, increase (3,4-dihydroxyphenylalanine (L-DOPA) 200 mg/kg i.p. plus dexamphetamine 4 mg/kg, s.c.) dopaminergic transmis...

journal_title：Neuropharmacology

authors： Thibaut F,Vaugeois JM,Bonnet JJ,Costentin J

更新日期：1996-03-01 00:00:00

abstract：:Participation of opiate, serotonergic and noradrenergic components in the antinociceptive action of intrathecally administered morphine was evaluated by measuring the ability of subcutaneously administered doses of naloxone, methysergide and phentolamine to alter analgesia. Morphine produced a dose-dependent elevation...

journal_title：Neuropharmacology

authors： Crisp T,Smith DJ

更新日期：1989-10-01 00:00:00