当前位置： SCI文献检索 > NEUROPHARMACOLOGY期刊下所有文献 > Effect of ΔFosB overexpression on opioid and cannabinoid receptor-mediated signaling in the nucleus accumbens.

Effect of ΔFosB overexpression on opioid and cannabinoid receptor-mediated signaling in the nucleus accumbens.

Abstract：

:The stable transcription factor ΔFosB is induced in the nucleus accumbens (NAc) by chronic exposure to several drugs of abuse, and transgenic expression of ΔFosB in the striatum enhances the rewarding properties of morphine and cocaine. However, the mechanistic basis for these observations is incompletely understood. We used a bitransgenic mouse model with inducible expression of ΔFosB in dopamine D(1) receptor/dynorphin-containing striatal neurons to determine the effect of ΔFosB expression on opioid and cannabinoid receptor signaling in the NAc. Results showed that mu opioid-mediated G-protein activity and inhibition of adenylyl cyclase were enhanced in the NAc of mice that expressed ΔFosB. Similarly, kappa opioid inhibition of adenylyl cyclase was enhanced in the ΔFosB expressing mice. In contrast, cannabinoid receptor-mediated signaling did not differ between mice overexpressing ΔFosB and control mice. These findings suggest that opioid and cannabinoid receptor signaling are differentially modulated by expression of ΔFosB, and indicate that ΔFosB expression might produce some of its effects via enhanced mu and kappa opioid receptor signaling in the NAc.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Sim-Selley LJ,Cassidy MP,Sparta A,Zachariou V,Nestler EJ,Selley DE

doi

10.1016/j.neuropharm.2011.08.046

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1470-6

issue

8

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(11)00379-0

journal_volume

61

pub_type

杂志文章

相关文献

NEUROPHARMACOLOGY文献大全
  • Antagonism of alpha-adrenoceptor agonist-induced antinociception in the rat.

    abstract：:The present study investigated the effects of WB4101, a selective alpha 1-adrenoceptor blocking agent, and idazoxan, a selective alpha 2-adrenoceptor blocking agent, on antinociception and sedation in the rat mediated by adrenoceptors. Selective alpha 1-adrenoceptor agonists, e.g. ST587 and methoxamine induced antinoc...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(86)90234-0

    authors： Hayes AG,Skingle M,Tyers MB

    更新日期：1986-04-01 00:00:00

  • Expression and regulation of phospholipase D during neuronal differentiation of PC12 cells.

    abstract：:To assess a possible role for phospholipase D (PLD) in PC12 cell signal transduction and differentiation, we have investigated the expression of PLD in PC12 cells and found that the differentiation factor, nerve growth factor (NGF) increased PLD1 protein expression and phorbol 12-myristate 13 acetate (PMA)-induced PLD...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(01)00070-3

    authors： Min DS,Ahn BH,Rhie DJ,Yoon SH,Hahn SJ,Kim MS,Jo YH

    更新日期：2001-09-01 00:00:00

  • Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: the role of NF-kappa B, JNK and p38 MAPK.

    abstract：:Compelling evidence has shown that in hippocampus tumor necrosis factor alpha (TNF-alpha) at pathological concentration inhibits long-term potentiation (LTP), a synaptic model of learning and memory. In the present work we investigated the role of TNF-alpha in LTP of C-fiber evoked field potentials in spinal dorsal ho...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2006.09.011

    authors： Liu YL,Zhou LJ,Hu NW,Xu JT,Wu CY,Zhang T,Li YY,Liu XG

    更新日期：2007-03-01 00:00:00

  • Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors.

    abstract：:Imaging studies of serotonin transporter binding or tryptophan retention in autistic patients suggest that the brain serotonin system is decreased. However, treatment with drugs which increase serotonin (5-HT) levels, specific serotonin reuptake inhibitors (SSRIs), commonly produce a worsening of the symptoms. In this...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.02.002

    authors： Azmitia EC,Singh JS,Whitaker-Azmitia PM

    更新日期：2011-06-01 00:00:00

  • In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat.

    abstract：:The demonstrated functional interaction of metabotropic glutamate 5 (mGlu₅) receptors with N-methyl-d-aspartate (NMDA) receptors has prompted speculation that their activation may offer a potential treatment for aspects of schizophrenia. Development of selective mGlu₅ agonists has been difficult, but several different...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2012.07.030

    authors： Gilmour G,Broad LM,Wafford KA,Britton T,Colvin EM,Fivush A,Gastambide F,Getman B,Heinz BA,McCarthy AP,Prieto L,Shanks E,Smith JW,Taboada L,Edgar DM,Tricklebank MD

    更新日期：2013-01-01 00:00:00

  • Acute lipophilicity-dependent effect of intravascular simvastatin in the early phase of focal cerebral ischemia.

    abstract：:The acute effects of simvastatin lactone (lipophilic) and simvastatin acid (hydrophilic) on transient focal ischemia were assessed using the isolated guinea pig brain maintained in vitro by arterial perfusion. This new model of cerebral ischemia allows the assessment of the very early phase of the ischemic process, wi...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.01.003

    authors： Beretta S,Pastori C,Sala G,Piazza F,Ferrarese C,Cattalini A,de Curtis M,Librizzi L

    更新日期：2011-05-01 00:00:00

  • Adenosine A(2A) Receptors as novel upstream regulators of BDNF-mediated attenuation of hippocampal Long-Term Depression (LTD).

    abstract：:Hippocampal Long-Term Potentiation (LTP) is facilitated by BDNF, through the activation of tropomyosin-related kinase B (TrkB) receptors. However, an influence of BDNF upon Long-Term Depression (LTD) was also shown. The present work aimed to further evaluate the effect of BDNF and TrkB receptors upon CA1 hippocampal L...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2013.12.010

    authors： Rodrigues TM,Jerónimo-Santos A,Sebastião AM,Diógenes MJ

    更新日期：2014-04-01 00:00:00

  • Induction of Dickkopf-1 contributes to the neurotoxicity of MPP+ in PC12 cells via inhibition of the canonical Wnt signaling pathway.

    abstract：:The secreted glycoprotein Dickkopf-1 (Dkk1), an antagonist of the Wnt/β-catenin pathway, has been implicated in many neurodegenerative diseases. However, it is unknown whether Dkk1 is involved in the pathogenesis of Parkinson's disease (PD). In this study, we discovered that Dkk1 was induced in MPP(+)-treated PC12 cel...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2012.10.031

    authors： Dun Y,Yang Y,Xiong Z,Feng M,Zhang Y,Wang M,Xiang J,Li G,Ma R

    更新日期：2013-04-01 00:00:00

  • Evidence for 5-HT4 receptor subtype involvement in the enhancement of striatal dopamine release induced by serotonin: a microdialysis study in the halothane-anesthetized rat.

    abstract：:The present study, using the in vivo intracerebral microdialysis method, investigated the role of different serotonin receptor subtypes in the control of dopamine (DA) release exerted by serotonin (5-HT) in the striatum of halothane-anesthetized rats. Striatal dialysate DA content was reduced following the blockade of...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(94)00145-i

    authors： Bonhomme N,De Deurwaèrdere P,Le Moal M,Spampinato U

    更新日期：1995-03-01 00:00:00

  • Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons.

    abstract：:The integrity of dynamic actin structures is coupled to a variety of neurological processes. Actin-binding proteins play a critical role in regulating actin structure dynamics. A link between actin-binding proteins and receptor interacting scaffolding proteins may provide a conduit for transmitting signaling events to...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2005.05.022

    authors： Chen Y,Li M

    更新日期：2005-12-01 00:00:00

  • SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals?

    abstract：:SKF 83959 that has a unique antiparkinson profile in animal models of Parkinson's disease is an in vitro dopamine D1 antagonist of receptors coupled to adenylyl cyclase. We hypothesized that SKF 83959, among others, interacts with dopamine D1 receptors coupled to adenylyl cyclase in the nucleus accumbens and the prefr...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(01)00169-1

    authors： Cools AR,Lubbers L,van Oosten RV,Andringa G

    更新日期：2002-02-01 00:00:00

  • Morphine decreases cerebral glucose utilization in limbic and forebrain regions while pain has no effect.

    abstract：:Morphine alters affective states in humans and produces reinforcement in humans and animal subjects. Therefore, the present study was designed to determine whether morphine affected the functional activity in brain structures involved in emotion and motivation. Since opioid-induced analgesia largely reflects an influe...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(91)90195-h

    authors： Cohen SR,Kimes AS,London ED

    更新日期：1991-02-01 00:00:00

  • Geniposide ameliorates cognitive deficits by attenuating the cholinergic defect and amyloidosis in middle-aged Alzheimer model mice.

    abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory deficits and cognitive decline. Amyloid-β (Aβ) deposition and cholinergic defect are widely thought to be the underlying mechanism of learning and memory impairment. Geniposide, which is the main active component of the tradit...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.12.002

    authors： Zhao C,Zhang H,Li H,Lv C,Liu X,Li Z,Xin W,Wang Y,Zhang W

    更新日期：2017-04-01 00:00:00

  • Dopamine and drug addiction: the nucleus accumbens shell connection.

    abstract：:Microdialysis studies in animals have shown that addictive drugs preferentially increase extracellular dopamine (DA) in the n. accumbens (NAc). Brain imaging studies, while extending these finding to humans, have shown a correlation between psychostimulant-induced increase of extracellular DA in the striatum and self-...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2004.06.032

    authors： Di Chiara G,Bassareo V,Fenu S,De Luca MA,Spina L,Cadoni C,Acquas E,Carboni E,Valentini V,Lecca D

    更新日期：2004-01-01 00:00:00

  • Strychnine-like action of the convulsant barbiturate, CHEB.

    abstract：:The effect of 5-(2-cyclohexylideneethyl)-5-ethyl barbituric acid (CHEB) on the isolated spinal cord of the immature rat was examined using extracellular recording. At concentrations less than 20 microM CHEB increased the monosynaptic reflex (MSR) but depressed the reflex at greater concentrations (30-100 microM). At c...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(85)90050-4

    authors： Nicholson GM,Spence I,Johnston GA

    更新日期：1985-06-01 00:00:00

  • A novel 5-HT receptor or a combination of 5-HT receptor subtypes may mediate depression of a spinal monosynaptic reflex in vitro.

    abstract：:The monosynaptic reflex (MSR), recorded in vitro from the neonatal rat spinal cord, was depressed by 5-hydroxytryptamine (5-HT) and 5-HT receptor agonists. The results, together with our previous findings, indicate an apparent rank order of potency: 5-carboxamidotryptamine (5-CT) > sumatriptan > methysergide > 5-HT > ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(94)90188-0

    authors： Crick H,Manuel NA,Wallis DI

    更新日期：1994-07-01 00:00:00

  • Modulation of long-term potentiation in CA1 region of mouse hippocampal brain slices by GABAA receptor benzodiazepine site ligands.

    abstract：:Enhancement of GABAA receptor function with benzodiazepine (BZ) site agonists can disrupt memory formation and hippocampal synaptic plasticity. To investigate this further the effects of the agonist, flunitrazepam, were contrasted with that of the inverse agonist, methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxyl...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(97)00040-3

    authors： Seabrook GR,Easter A,Dawson GR,Bowery BJ

    更新日期：1997-06-01 00:00:00

  • Individual differences in oral nicotine intake in rats.

    abstract：:To study individual differences in nicotine preference and intake, male and female rats were given free access to a choice of oral nicotine (10 or 20 mg/L) or water for 24 h/day for periods of at least six weeks, starting at adolescence or adulthood. A total of 341 rats, were used in four different experiments; weight...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.03.027

    authors： Nesil T,Kanit L,Collins AC,Pogun S

    更新日期：2011-07-01 00:00:00

  • The continuity of dopamine receptor antagonism can dictate the long-term behavioural consequences of a mesolimbic infusion of dopamine.

    abstract：:An infusion of dopamine for 13 days into the nucleus accumbens of rat caused biphasic peaks of hyperactivity responding during infusion and an enhanced locomotor responsiveness to the dopamine agonist (-)N-n-propylnorapomorphine [(-)NPA] after the infusion when rats where initially preselected as low activity responde...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(85)90073-5

    authors： Costall B,Domeney AM,Naylor RJ

    更新日期：1985-03-01 00:00:00

  • Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in dopamine D2 neurons than in D1 neurons in the neostriatum.

    abstract：:Studies described here tested the hypothesis that phosphodiesterase 10A inhibition by a selective antagonist, MP-10, activates the dopamine D2 receptor expressing medium spiny neurons to a greater extent than the D1 receptor expressing neurons. We used regional pattern of c-Fos induction in the neostriatal subregions ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2015.08.008

    authors： Wilson JM,Ogden AM,Loomis S,Gilmour G,Baucum AJ 2nd,Belecky-Adams TL,Merchant KM

    更新日期：2015-12-01 00:00:00

  • Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.

    abstract：:Alpidem is a new anxiolytic of imidazopyridine structure which has a high affinity for the omega 1 (BZ1) modulatory site of the GABAA receptor. The present study investigated whether tolerance and physical dependence develop after repeated treatment with alpidem, as is observed with benzodiazepines. Mice were given al...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(93)90140-x

    authors： Perrault G,Morel E,Sanger DJ,Zivkovic B

    更新日期：1993-09-01 00:00:00

  • Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment.

    abstract：:Clinical neuropathologic studies suggest that the selective vulnerability of hippocampal CA1 pyramidal projection neurons plays a key role in the onset of cognitive impairment during the early phases of Alzheimer's disease (AD). Disruption of this neuronal population likely affects hippocampal pre- and postsynaptic ef...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2013.10.018

    authors： Counts SE,Alldred MJ,Che S,Ginsberg SD,Mufson EJ

    更新日期：2014-04-01 00:00:00

  • Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats: A dual mechanism?

    abstract：:A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alcohol-induced brain neuroinflammation/oxidative stress. Recently, it wa...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2018.12.001

    authors： Rivera-Meza M,Vásquez D,Quintanilla ME,Lagos D,Rojas B,Herrera-Marschitz M,Israel Y

    更新日期：2019-03-01 00:00:00

  • Subunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.

    abstract：:Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in the nervous system and are implicated in many normal and pathological processes. The structural determinants of allostery in nAChRs are not well understood. One class of nAChR allosteric modulators, including the small molecule morantel (Mor...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2014.11.027

    authors： Short CA,Cao AT,Wingfield MA,Doers ME,Jobe EM,Wang N,Levandoski MM

    更新日期：2015-04-01 00:00:00

  • Alpha 2C-adrenoceptor mediated regulation of cortical EEG arousal.

    abstract：:Alpha2-adrenergic drugs modulate cortical arousal and EEG. However, the role of individual alpha2-adrenoceptor (alpha(2)-AR) subtypes in these functions is not clear. We investigated the role of alpha(2C)-ARs in the modulation of baseline cortical EEG activity and EEG responses to the alpha(2)-AR selective agonist, de...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(02)00305-2

    authors： Puoliväli J,Björklund M,Holmberg M,Ihalainen JA,Scheinin M,Tanila H

    更新日期：2002-12-01 00:00:00

  • Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: evidence for altered striatal function.

    abstract：:PDE10A is a newly identified phosphodiesterase that is highly expressed by the medium spiny projection neurons of the striatum. In order to investigate the physiological role of PDE10A in the central nervous system, PDE10A knockout mice (PDE10A(-/-)) were characterized both behaviorally and neurochemically. PDE10A(-/-...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2006.01.012

    authors： Siuciak JA,McCarthy SA,Chapin DS,Fujiwara RA,James LC,Williams RD,Stock JL,McNeish JD,Strick CA,Menniti FS,Schmidt CJ

    更新日期：2006-08-01 00:00:00

  • Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.

    abstract：:Anandamide and 2-arachidonoyl glycerol, referred to as endocannabinoids (eCBs), are the endogenous agonists for the cannabinoid receptor type 1 (CB1). Several pieces of evidence support a role for eCBs in the attenuation of anxiety-related behaviours, although the precise mechanism has remained uncertain. The fatty ac...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2007.07.005

    authors： Moreira FA,Kaiser N,Monory K,Lutz B

    更新日期：2008-01-01 00:00:00

  • Norepinephrine and (Na+, K+)-ATPase: evidence for stabilization by lithium or imipramine.

    abstract：:These experiments examined the effects of lithium and imipramine on the regulation by norepinephrine in vivo of (Na+, K+)-ATPase in brain and heart. The binding of ouabain and the activity of K+-phosphatase were used as indices of (Na+, K+)-ATPase. In the cerebral cortex, imipramine prevented, and lithium reduced, the...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(88)90042-1

    authors： Swann AC

    更新日期：1988-03-01 00:00:00

  • (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks.

    abstract：:3,4-Methlylenedioxymethamphetamine (MDMA) administration (4 x 15 mg/kg) on a single day has been shown to cause path integration deficits in rats. While most animal experiments focus on single binge-type models of MDMA use, many MDMA users take the drug on a recurring basis. The purpose of this study was to compare th...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2008.07.006

    authors： Skelton MR,Able JA,Grace CE,Herring NR,Schaefer TL,Gudelsky GA,Vorhees CV,Williams MT

    更新日期：2008-12-01 00:00:00

  • Chronic nicotine differentially alters cocaine-induced locomotor activity in adolescent vs. adult male and female rats.

    abstract：:Tobacco use is prevalent in the adolescent population. It is a major concern because tobacco is highly addictive and has also been linked to illicit drug use. There is not much research, however, on the interaction between nicotine and other stimulant drugs in animal models of early adolescence. This study examined th...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2003.09.024

    authors： Collins SL,Izenwasser S

    更新日期：2004-03-01 00:00:00